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  1. Article ; Online: Developing Metal Complexes for Captopril Quantification in Tablets Using Potentiometric and Conductometric Methods.

    Al-Farhan, Badriah Saad / Alfarsi, Anas / Abdel-Rahman, Laila H / Naggar, Ahmed H / Farghaly, Othman A

    ACS omega

    2023  Volume 8, Issue 2, Page(s) 2773–2779

    Abstract: Potentiometric and conductometric methods were successfully applied to elucidate the interaction of 10 ions, viz., ... ...

    Abstract Potentiometric and conductometric methods were successfully applied to elucidate the interaction of 10 ions, viz., Cr
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterization of Gold-Enhanced Titania: Boosting Cell Proliferation and Combating Bacterial Infestation.

    Amna, Touseef / Shamshi Hassan, M / Algethami, Jari S / Aljuaid, Alya / Alfarsi, Anas / Alnefaie, Rasha / Sheikh, Faheem A / Khil, Myung-Seob

    Tissue engineering and regenerative medicine

    2024  

    Abstract: Background: In this study an approach was made to efficaciously synthesize gold enhanced titania nanorods by electrospinning. This study aims to address effects of gold enhanced titania nanorods on muscle precursor cells. Additionally, implant related ... ...

    Abstract Background: In this study an approach was made to efficaciously synthesize gold enhanced titania nanorods by electrospinning. This study aims to address effects of gold enhanced titania nanorods on muscle precursor cells. Additionally, implant related microbial infections are prime cause of various disastrous diseases. So, there is predictable demand for synthesis of novel materials with multifunctional adaptability.
    Methods: Herein, gold nanoparticles were attached on titania nanorods and described using many sophisticated procedures such as XRD, SEM, EDX and TEM. Antimicrobial studies were probed against Gram-negative Escherichia coli. C2C12 cell lines were exposed to various doses of as-prepared gold enhanced titania nanorods in order to test in vitro cytotoxicity and proliferation. Cell sustainability was assessed through Cell Counting Kit-8 assay at regular intervals. A phase-contrast microscope was used to examine morphology of exposed C2C12 cells and confocal laser scanning microscope was used to quantify cell viability.
    Results: The findings indicate that titania nanorods enhanced with gold exhibit superior antimicrobial efficacy compared to pure titania. Furthermore, newly synthesized gold-enhanced titania nanorods illustrate that cell viability follows a time and concentration dependent pattern.
    Conclusion: Consequently, our study provides optimistic findings indicating that titania nanorods adorned with gold hold significant potential as foundational resource for developing forthcoming antimicrobial materials, suitable for applications both in medical and biomedical fields. This work also demonstrates that in addition to being extremely biocompatible, titania nanorods with gold embellishments may be used in a range of tissue engineering applications in very near future.
    Language English
    Publishing date 2024-03-23
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2677535-9
    ISSN 2212-5469 ; 1738-2696
    ISSN (online) 2212-5469
    ISSN 1738-2696
    DOI 10.1007/s13770-024-00630-8
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  3. Article: RETRACTED: Ahmed et al. Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route.

    Ahmed, Osama A A / Fahmy, Usama A / Badr-Eldin, Shaimaa M / Aldawsari, Hibah M / Awan, Zuhier A / Asfour, Hani Z / Kammoun, Ahmed K / Caruso, Giuseppe / Caraci, Filippo / Alfarsi, Anas / Al-Ghamdi, Raniyah A / Al-Ghamdi, Rawan A / Alhakamy, Nabil A

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: The Journal retracts the article "Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route" [ ... ]. ...

    Abstract The Journal retracts the article "Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route" [...].
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020174
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  4. Article: RETRACTED: Alhakamy et al. Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity.

    Alhakamy, Nabil A / Ahmed, Osama A A / Kurakula, Mallesh / Caruso, Giuseppe / Caraci, Filippo / Asfour, Hani Z / Alfarsi, Anas / Eid, Basma G / Mohamed, Amir I / Alruwaili, Nabil K / Abdulaal, Wesam H / Fahmy, Usama A / Alhadrami, Hani A / Eldakhakhny, Basmah M / Abdel-Naim, Ashraf B

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The journal retracts the article "Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity" [ ... ]. ...

    Abstract The journal retracts the article "Chitosan-Based Microparticles Enhance Ellagic Acid's Colon Targeting and Proapoptotic Activity" [...].
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: RETRACTED: Awan et al. The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells.

    Awan, Zuhier A / Fahmy, Usama A / Badr-Eldin, Shaimaa M / Ibrahim, Tarek S / Asfour, Hani Z / Al-Rabia, Mohammed W / Alfarsi, Anas / Alhakamy, Nabil A / Abdulaal, Wesam H / Al Sadoun, Hadeel / Helmi, Nawal / Noor, Ahmad O / Caraci, Filippo / Almasri, Diena M / Caruso, Giuseppe

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The journal retracts the article, "The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells" [ ... ]. ...

    Abstract The journal retracts the article, "The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells" [...].
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Retraction Note: Fluvastatin-Loaded Emulsomes Exhibit Improved Cytotoxic and Apoptosis in Prostate Cancer Cells.

    Alhakamy, Nabil A / Badr-Eldin, Shaimaa M / Aldawsari, Hibah M / Alfarsi, Anas / Neamatallah, Thikryat / Okbazghi, Solomon Z / Fahmy, Usama A / Ahmad, Osama A A / Eid, Basma G / Mahdi, Wael Ali / Alghaith, Adel F / Alshehri, Sultan / Md, Shadab

    AAPS PharmSciTech

    2023  Volume 24, Issue 5, Page(s) 128

    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-023-02591-y
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  7. Article ; Online: Sounding out stability of enteric coated dosage forms using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS).

    O'Mahoney, Niamh / Alfarsi, Anas / O'Sullivan, Haley / McSweeney, Seán / Crean, Abina / Fitzpatrick, Dara

    International journal of pharmaceutics

    2021  Volume 602, Page(s) 120614

    Abstract: Stability testing is essential in the pharmaceutical industry to determine product shelf- life and the conditions under which drug products should be stored. Stability testing involves a complex set of procedures, considerable cost, time, and scientific ... ...

    Abstract Stability testing is essential in the pharmaceutical industry to determine product shelf- life and the conditions under which drug products should be stored. Stability testing involves a complex set of procedures, considerable cost, time, and scientific expertise to build quality, efficacy and safety in a drug formulation. This paper highlights a new complementary approach to stability testing called Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS). BARDS measurements are based on reproducible changes in the compressibility of a solvent during dissolution. It is monitored acoustically via associated changes in the frequency of induced acoustic resonances. This study presents a novel approach to track the change of various drug formulations to determine the formulation's stability. Pellets, tablet and multiple-unit pellet system (MUPS) formulations were investigated to examine the effect of polymer coating and formulation core degradation over time. In combination with minimal usage of Ultra Violet - Visible Spectroscopy, BARDS can effectively track these changes. The technique offers a rapid approach to characterizing pharmaceutical formulations. BARDS can enable rapid development of solid drug formulation dissolution and disintegration testing as an In-Process Control test and drug stability analysis. The data show that a solid oral dose formulation has an intrinsic acoustic signature specific to the method of manufacture, excipient composition and elapsed time since the production of a product. BARDS data are also indicative of which aspect of a formulation may be unstable, whether a coating, sub-coating or core. It is potentially a time-efficient, cost-effective and greener approach to testing coating stability, disintegration and overall formulation stability.
    MeSH term(s) Acoustics ; Excipients ; Solubility ; Spectrum Analysis ; Tablets
    Chemical Substances Excipients ; Tablets
    Language English
    Publishing date 2021-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2021.120614
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Synthesis, DFT, Biological and Molecular Docking Analysis of Novel Manganese(II), Iron(III), Cobalt(II), Nickel(II), and Copper(II) Chelate Complexes Ligated by 1-(4-Nitrophenylazo)-2-naphthol.

    Alghuwainem, Yousef A A / El-Lateef, Hany M Abd / Khalaf, Mai M / Amer, Amer A / Abdelhamid, Antar A / Alzharani, Ahmed A / Alfarsi, Anas / Shaaban, Saad / Gouda, Mohamed / Abdou, Aly

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: Novelmanganese(II), iron(III), cobalt(II), nickel(II), and copper(II) chelates were synthesized and studied using elemental analysis (EA), infrared spectroscopy, mass spectrometry, ultraviolet-visible spectroscopy, and conductivity, as well as magnetic ... ...

    Abstract Novelmanganese(II), iron(III), cobalt(II), nickel(II), and copper(II) chelates were synthesized and studied using elemental analysis (EA), infrared spectroscopy, mass spectrometry, ultraviolet-visible spectroscopy, and conductivity, as well as magnetic measurements and thermogravimetric analysis (TG). The azo-ligand 1-[(4-nitrophenyl)diazenyl]-2-naphthol (HL) chelates to the metal ions via the nitrogen and oxygen centers of the azo group and the hydroxyl, respectively. The amounts of H
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232415614
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  9. Article ; Online: Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation.

    Nazreen, Syed / Almalki, Abdulraheem S A / Elbehairi, Serag Eldin I / Shati, Ali A / Alfaifi, Mohammad Y / Elhenawy, Ahmed A / Alsenani, Nawaf I / Alfarsi, Anas / Alhadhrami, Abdulrahman / Alqurashi, Esam A / Alam, Mohammad Mahboob

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The final compounds were screened for cytotoxicity against MDA-MB-231, SKOV3, and A549 cell lines ... ...

    Abstract In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The final compounds were screened for cytotoxicity against MDA-MB-231, SKOV3, and A549 cell lines and EGFR for inhibitory activities. Compounds
    MeSH term(s) Drug Screening Assays, Antitumor ; Erlotinib Hydrochloride/pharmacology ; Protein Kinase Inhibitors/chemistry ; ErbB Receptors/metabolism ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Molecular Docking Simulation ; Cell Proliferation ; Apoptosis ; Cell Cycle Checkpoints ; Benzimidazoles/pharmacology ; Doxorubicin/pharmacology ; Structure-Activity Relationship
    Chemical Substances Erlotinib Hydrochloride (DA87705X9K) ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; Antineoplastic Agents ; Benzimidazoles ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27206899
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    Zs.MO 81: Show issues

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  10. Article ; Online: Sounding out falsified medicines from genuine medicines using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS).

    Alfarsi, Anas / Caillet, Céline / Fawbert, Garry / Lawrence, Simon / Krüse, Jacob / McSweeney, Seán / O'Mahony, Marcus / Dondorp, Arjen / Newton, Paul N / Fitzpatrick, Dara

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 12643

    Abstract: The trade in falsified medicine has increased significantly and it is estimated that global falsified sales have reached $100 billion in 2020. The EU Falsified Medicines Directive states that falsified medicines do not only reach patients through illegal ...

    Abstract The trade in falsified medicine has increased significantly and it is estimated that global falsified sales have reached $100 billion in 2020. The EU Falsified Medicines Directive states that falsified medicines do not only reach patients through illegal routes but also via the legal supply chain. Falsified medicines can contain harmful ingredients. They can also contain too little or too much active ingredient or no active ingredient at all. BARDS (Broadband Acoustic Resonance Dissolution Spectroscopy) harnesses an acoustic phenomenon associated with the dissolution of a sample (tablet or powder). The resulting acoustic spectrum is unique and intrinsic to the sample and can be used as an identifier or signature profile. BARDS was evaluated in this study to determine whether a product is falsified or genuine in a rapid manner and at lower cost than many existing technologies. A range of genuine and falsified medicines, including falsified antimalarial tablets from south-east Asia, were tested, and compared to their counterpart genuine products. Significant differences between genuine and falsified doses were found in their acoustic signatures as they disintegrate and dissolve. Principal component analysis was employed to differentiate between the genuine and falsified medicines. This demonstrates that the tablets and capsules included here have intrinsic acoustic signatures which could be used to screen the quality of medicines.
    MeSH term(s) Counterfeit Drugs/analysis ; Powders/analysis ; Spectrum Analysis/methods ; Tablets/analysis
    Chemical Substances Counterfeit Drugs ; Powders ; Tablets
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90323-2
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