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Article ; Online: Complicated appendicitis increases the hospital length of stay.

Alotaibi, Abdulrahman Muaod / Alfawaz, Mohammed / Felemban, Lina / Moshref, Leena / Moshref, Rana

Surgery open science

2022 Volume 9, Page(s) 64–68

Abstract: Background: There are insufficient data from Saudi Arabia regarding appendectomy outcomes and hospital length of stay. Further, there is a need to compare the length of stay of Saudi patients and the literature. The purpose is to evaluate the surgical ... ...

Abstract	Background: There are insufficient data from Saudi Arabia regarding appendectomy outcomes and hospital length of stay. Further, there is a need to compare the length of stay of Saudi patients and the literature. The purpose is to evaluate the surgical outcomes and hospital length of stay for complicated appendicitis and simple appendicitis. Method: This is a single-center retrospective review of patients who had undergone an appendectomy between 2016 and 2018. The patients were divided into 2 groups: complicated appendicitis versus simple appendicitis. Results: Of 449 patients who underwent appendectomy, 60 (13.4%) had complicated appendicitis. The complicated appendicitis was significantly associated with increased age, pain duration, neutrophilia, high C-reactive protein, fecalith presence, and free fluid. The incidence rate of surgical site infection was 5.8% (identified in 26 patients). Compared to simple appendicitis, complicated appendicitis was associated more with wound infection (1.8% vs 10%, respectively, P = .001), postoperative collection (1.2% vs 11.6%, respectively, P = .001), and readmission within 30 days (2.3% vs 13.4%, respectively, P = .001). By multivariate analysis, factors associated more with increased hospitalization were pain duration (hazard ratio = 2.37, 95% confidence interval = 1.09-5.16, P = .029), operative time (hazard ratio = 2.09, 95% confidence interval = 1.04-4.21, P = .038), and complicated appendicitis (hazard ratio = 6.61, 95% confidence interval = 2.67-14.21, P = .001). Conclusion: Complicated appendicitis correlates with significant morbidity, readmission rate, and 6 times more hospital LOS than simple appendicitis. This review might help in appreciating the burden of complicated appendicitis on hospital length of stay, which needs allocating patients and planning the discharge day for hospitals with limited beds.
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Journal Article
ISSN	2589-8450
ISSN (online)	2589-8450
DOI	10.1016/j.sopen.2022.05.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence of Iatrogenic Vitamin D Toxicity Among the Saudi Population of Vitamin D Users Due to Overcorrection.

Aljehani, Faisal / Qashqari, Mohammed B / Alghamdi, Mohammed K / Saadi, Abdalaziz I / Alreasini, Mohamed Y / Alsolami, Enad / Alfawaz, Mohammed

Cureus

2023 Volume 15, Issue 4, Page(s) e37521

Abstract: Background Despite abundant sunlight exposure, vitamin D deficiency remains a major challenge in Saudi Arabia. Meanwhile, the widespread use of vitamin D supplements has prompted concerns about toxicity, which although rare, can have severe health ... ...

Abstract	Background Despite abundant sunlight exposure, vitamin D deficiency remains a major challenge in Saudi Arabia. Meanwhile, the widespread use of vitamin D supplements has prompted concerns about toxicity, which although rare, can have severe health consequences. Objective The objective of this cross-sectional study was to analyze the prevalence and associated factors of iatrogenic vitamin D toxicity among the Saudi population of vitamin D users due to overcorrection. Methods An online questionnaire was used to collect data from 1,677 participants across all regions of Saudi Arabia. The questionnaire included responses on the prescription, duration of vitamin D intake, dosage, frequency, history of vitamin D toxicity, symptom onset, and duration. Results One thousand six hundred and seventy-seven responses were included across all regions of Saudi Arabia. A majority of participants were female (66.7%) and around half were aged 18-25 years. A history of vitamin D use was reported by 63.8% of participants, and 48% were still using vitamin D supplements. Most participants (79.3%) consulted a physician, and 84.8% had taken a vitamin D test before using the supplement. Commonly reported motives for taking vitamin D included vitamin D deficiency (72.1%), lack of sun exposure (26.1%), and hair loss (20.6%). Symptoms of overdose were reported by 6.6% of participants, with 3.3% having an overdose and 2.1% experiencing both overdose and symptoms. Conclusion This study showed that although a large portion of the Saudi population is taking vitamin D supplements, the prevalence of vitamin D toxicity is relatively low. However, this prevalence should not be ignored, and further research is needed to understand the factors contributing to vitamin D toxicity in order to minimize its occurrence.
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.37521
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Article: Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient.

Bukhari, Nedal / Azam, Faisal / Alfawaz, Mohammed / Zahrani, Mohammed

Case reports in genetics

2019 Volume 2019, Page(s) 5150725

Abstract: Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU ...

Abstract	Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy. She was found to be heterozygous for rs371313778, c.2434G>A. This finding prompted restarting 5-FU at 50% dose reduction with further titration in subsequent cycles. We herein report the first case of rs371313778, c.2434G>A (p.Val812lle)
Language	English
Publishing date	2019-08-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2664417-4
ISSN	2090-6552 ; 2090-6544
ISSN (online)	2090-6552
ISSN	2090-6544
DOI	10.1155/2019/5150725
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Article: Clinical Characteristics of Celiac Disease Patients in Qassim Region.

Alfawaz, Mohammed / Alkhiari, Resheed / Albuhayjani, Abdulaziz Abdulrahman / Albarrak, Abdulmajeed / Alharbi, Muath Yousef / Aldubaiyan, Adi Abdulaziz R / Alkharraz, Abdullah Hamad / Alolayan, Omar Abdulaziz / Alrasheedi, Omar / Almutairi, Nawaf / Aljehani, Faisal / Alsolami, Enad / Alghamdi, Waleed / Jawa, Hani

Journal of family medicine and primary care

2024 Volume 13, Issue 3, Page(s) 827–832

Abstract: Objective: It is well known that celiac disease has a negative influence on patients' health and quality of life. It has a wide range of presentation from symptomless to multiple organ dysfunction but mainly gastrointestinal symptoms. Consequently, it ... ...

Abstract	Objective: It is well known that celiac disease has a negative influence on patients' health and quality of life. It has a wide range of presentation from symptomless to multiple organ dysfunction but mainly gastrointestinal symptoms. Consequently, it is considered a main cause of mortality, morbidity, and health burden. We aim to evaluate the quality of life affected in gluten-free diet and to identify the serological characteristics of celiac disease patients in the Qassim Region of Saudi Arabia and King Fahad Specialist Hospital. Methods: This is a cross-sectional-based study conducted in King Fahad Specialist Hospital, Saudi Arabia, composed of 58 patients with celiac disease for 9 years between August 2011 and August 2020. Results: Fifty-eight patents were included (79.3% females and 65.5% married), who were divided according to their ages into five groups. Abdominal pain, diarrhea, and/or weight loss were the major patient complaints. A total of 64% of the patients had a +ve (tTG) IgA test at the time of diagnosis, while 17% were -ve. Of the studied patients, 78% reported that they had undergone a duodenal biopsy sampling. No other significant abnormalities were detected between females and males or among the five diagnosed age groups. Conclusion: Patients with celiac disease reported poor health-related quality of life across the board. However, social interaction, emotional role functioning, and emotional well-being were the most important factors.
Language	English
Publishing date	2024-04-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_895_23
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Article: Retraction: Lipoma of the Pancreas: A Rare Incidental Tumor.

Alzarie, Mashhour F / Alhaddab, Abdullah A / Aljafar, Faris A / Alzahrani, Muhannad M / Abdelaziz, Doaa M / Aleidan, Abdullah A / Alduraibi, Khalil I / Alfawaz, Mohammed A / Khoja, Mohammed T / Alshahrani, Abdulwahab A / Alhassoun, Hamad Y / Alshaibi, Amal M / Alghizzi, Abdullah A / Aljohani, Mazen D / Al-Hawaj, Faisal

Cureus

2024 Volume 16, Issue 1, Page(s) r106

Abstract: This retracts the article DOI: 10.7759/cureus.20122.]. ...

Abstract	[This retracts the article DOI: 10.7759/cureus.20122.].
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.r106
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Article: Changes in Phytochemical Compounds and Antioxidant Activity of Two Irradiated Sorghum (Sorghum bicolor (L.) Monech) Cultivars during the Fermentation and Cooking of Traditional Sudanese Asida

Mohamed, Layla K. / Sulieman, Mashair A. / Yagoub, Abu ElGasim A. / Mohammed, Mohammed A. / Alhuthayli, Haya F. / Mohamed Ahmed, Isam A. / Almaiman, Salah A. / Alfawaz, Mohammed A. / Osman, Magdi A. / Hassan, Amro B.

Fermentation. 2022 Jan. 30, v. 8, no. 2

2022

Abstract: This study investigated the chemical changes of phytochemicals and antioxidant activity during the preparation of traditional Sudanese asida prepared from gamma-radiated (1.0 and 2.0 kGy) flour of two sorghum cultivars (Tabat and Wad Ahmed). For both ... ...

Abstract	This study investigated the chemical changes of phytochemicals and antioxidant activity during the preparation of traditional Sudanese asida prepared from gamma-radiated (1.0 and 2.0 kGy) flour of two sorghum cultivars (Tabat and Wad Ahmed). For both cultivars, the irradiation process significantly (p < 0.05) increased the total phenolic content and antioxidant activity of the raw flour, while it caused a significant reduction in total flavonoid content and tannin content. Traditional asida (fermented food) prepared from irradiated sorghum flour caused a significant reduction in TPC, TFC, and tannin content in both sorghum cultivars, while the antioxidant activities (DPPH, reducing power, and H₂O₂ scavenging) were significantly increased in both the Tabat (85.0%, 3.8 mg AAE/g, and 84.6%, respectively) and the Wad Ahmed (89.6%, 3.9 mg AAE/g, and 83.1%, respectively) sorghum cultivar grains, particularly in those processed from 2.0 kGy-irradiated flour. A positive high correlation was observed between gamma radiation (2.0 kGy) and the antioxidant activity of asida prepared from both cultivars. In conclusion, traditional fermented asida obtained from irradiated flour showed high antioxidant activity in both sorghum cultivars.
Keywords	Sorghum bicolor ; antioxidant activity ; cultivars ; fermentation ; fermented foods ; flavonoids ; gamma radiation ; irradiation ; sorghum flour
Language	English
Dates of publication	2022-0130
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2813985-9
ISSN	2311-5637
ISSN	2311-5637
DOI	10.3390/fermentation8020060
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Article ; Online: Carbon nanoparticle induced cytotoxicity in human mesenchymal stem cells through upregulation of TNF3, NFKBIA and BCL2L1 genes.

Periasamy, Vaiyapuri S / Athinarayanan, Jegan / Alfawaz, Mohammed A / Alshatwi, Ali A

Chemosphere

2016 Volume 144, Page(s) 275–284

Abstract: Carbon based nanomaterials, including carbon nanotubes, graphene, nanodiamond and carbon nanoparticles, have emerged as potential candidates for a wide variety of applications because of their unusual electrical, mechanical, thermal and optical ... ...

Abstract	Carbon based nanomaterials, including carbon nanotubes, graphene, nanodiamond and carbon nanoparticles, have emerged as potential candidates for a wide variety of applications because of their unusual electrical, mechanical, thermal and optical properties. However, our understanding of how increased usage of carbon based nanomaterials could lead to harmful effects in humans and other biological systems is inadequate. Our present investigation is focused on the cellular toxicity of carbon nanoparticles (CNPs) on human mesenchymal stem cells (hMSCs). Following exposure to CNPs, cell viability, nuclear morphological changes, apoptosis and cell cycle progression were monitored. Furthermore, the expression of genes involved in both cell death (e.g., P53, TNF3, CDKN1A, TNFRSF1A, TNFSF10, NFKBIA, BCL2L1) and cell cycle regulation (e.g., PCNA, EGR1, E2F1, CCNG1, CCND1, CCNC, CYCD3) were assessed using qPCR. Our results indicated that CNPs reduce cell viability and cause chromatin condensation and DNA fragmentation. Cell cycle analysis indicated that CNPs affect the cell cycle progression. However, the gene expression measurements confirmed that CNPs significantly upregulated the P53, TNF3, CDKNIA, and NFKBIA genes and downregulated the EGR1 gene in hMSCs. Our findings suggest that CNPs reduce cell viability by disrupting the expression of cell death genes in human mesenchymal stem cell (hMSC). The results of this investigation revealed that CNPs exhibited moderate toxicity on hMSCs.
MeSH term(s)	Apoptosis/drug effects ; Apoptosis/genetics ; Carbon/chemistry ; Carbon/toxicity ; Cell Culture Techniques ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Cycle Checkpoints/drug effects ; Cell Survival/drug effects ; Cell Survival/genetics ; Down-Regulation ; Gene Expression/drug effects ; Humans ; I-kappa B Proteins/genetics ; Mesenchymal Stromal Cells/drug effects ; NF-KappaB Inhibitor alpha ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Particle Size ; Transcriptional Activation/drug effects ; Tumor Necrosis Factor-alpha/genetics ; Up-Regulation ; bcl-X Protein/genetics
Chemical Substances	BCL2L1 protein, human ; I-kappa B Proteins ; NFKBIA protein, human ; Tumor Necrosis Factor-alpha ; bcl-X Protein ; NF-KappaB Inhibitor alpha (139874-52-5) ; Carbon (7440-44-0)
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2015.08.018
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Article: Carbon nanoparticle induced cytotoxicity in human mesenchymal stem cells through upregulation of TNF3, NFKBIA and BCL2L1 genes

Periasamy, Vaiyapuri S / Athinarayanan, Jegan / Alfawaz, Mohammed A / Alshatwi, Ali A

Chemosphere. 2016 Feb., v. 144

2016

Abstract	Carbon based nanomaterials, including carbon nanotubes, graphene, nanodiamond and carbon nanoparticles, have emerged as potential candidates for a wide variety of applications because of their unusual electrical, mechanical, thermal and optical properties. However, our understanding of how increased usage of carbon based nanomaterials could lead to harmful effects in humans and other biological systems is inadequate. Our present investigation is focused on the cellular toxicity of carbon nanoparticles (CNPs) on human mesenchymal stem cells (hMSCs). Following exposure to CNPs, cell viability, nuclear morphological changes, apoptosis and cell cycle progression were monitored. Furthermore, the expression of genes involved in both cell death (e.g., P53, TNF3, CDKN1A, TNFRSF1A, TNFSF10, NFKBIA, BCL2L1) and cell cycle regulation (e.g., PCNA, EGR1, E2F1, CCNG1, CCND1, CCNC, CYCD3) were assessed using qPCR. Our results indicated that CNPs reduce cell viability and cause chromatin condensation and DNA fragmentation. Cell cycle analysis indicated that CNPs affect the cell cycle progression. However, the gene expression measurements confirmed that CNPs significantly upregulated the P53, TNF3, CDKNIA, and NFKBIA genes and downregulated the EGR1 gene in hMSCs. Our findings suggest that CNPs reduce cell viability by disrupting the expression of cell death genes in human mesenchymal stem cell (hMSC). The results of this investigation revealed that CNPs exhibited moderate toxicity on hMSCs.
Keywords	DNA fragmentation ; apoptosis ; carbon nanotubes ; cell cycle ; cell viability ; chromatin ; cytotoxicity ; gene expression ; gene expression regulation ; genes ; graphene ; humans ; nanodiamonds ; nanoparticles ; optical properties ; proliferating cell nuclear antigen ; quantitative polymerase chain reaction ; stem cells
Language	English
Dates of publication	2016-02
Size	p. 275-284.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2015.08.018
Database	NAL-Catalogue (AGRICOLA)

Full text online

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Zs.A 2540: Show issues

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Article: Expression of Concern: Lipoma of the Pancreas: A Rare Incidental Tumor.

Cureus

2022 Volume 14, Issue 4, Page(s) x28

Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Expression of Concern
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.x28
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Article ; Online: Impact of optional multidisciplinary tumor board meeting on the mortality of patients with gastrointestinal cancer: A retrospective observational study.

Basendowah, Mohammed / Awlia, Alaa M / Alamoudi, Hanin A / Ali Kanawi, Hala M / Saleem, Abdulaziz / Malibary, Nadim / Hijazi, Hussam / Alfawaz, Mohammed / Alzahrani, Anas H

Cancer reports (Hoboken, N.J.)

2021 Volume 4, Issue 4, Page(s) e1373

Abstract: Background: Multidisciplinary tumor board meetings (MDTs) have shown a positive effect on patient care and play a role in the planning of care. However, there is limited evidence of the association between MDTs and patient mortality and in-hospital ... ...

Abstract	Background: Multidisciplinary tumor board meetings (MDTs) have shown a positive effect on patient care and play a role in the planning of care. However, there is limited evidence of the association between MDTs and patient mortality and in-hospital morbidity for mixed cases of gastrointestinal (GI) cancer. Aim: To evaluate the influence of optional MDTs on care of patients with cancer to determine potential associations between MDTs and patient mortality and morbidity. Methods and results: This was a retrospective observational study at the referral center of King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Among all adult patients diagnosed with GI cancer from January 2017 to June 2019, 130 patients were included. We categorized patients into two groups: 66 in the control group (non-MDT) and 64 in the MDT group. The main outcome measure was overall mortality, measured by survival analysis. The follow-up was 100% complete. Four patients in the MDT group and 13 in the non-MDT group died (P = .04). The median follow-up duration was 294 days (interquartile range [IQR], 140-434) in the non-MDT group compared with 176 days (IQR, 103-466) in the MDT group (P = .20). There were no differences in intensive care unit or hospital length-of-stay or admission rates. The overall mortality at 2 years was 13% (95% confidence interval [CI], 0.06-0.66) in the MDT group and 38% (95% CI, 0.10-0.39) in the non-MDT group (P = .08). The MDT group showed a 72% (adjusted hazard ratio [HR], 0.28; 95% CI, 0.08-0.90; P = .03) decrease in mortality over time compared with the non-MDT group. Conclusions: MDTs were associated with decreased mortality over time. Thus, MDTs have a positive influence on patient care by improving survival and should be incorporated into care.
MeSH term(s)	Adult ; Aged ; Clinical Decision-Making/methods ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/mortality ; Gastrointestinal Neoplasms/therapy ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Patient Admission/statistics & numerical data ; Patient Care Planning ; Patient Care Team/organization & administration ; Retrospective Studies ; Saudi Arabia/epidemiology ; Treatment Outcome
Language	English
Publishing date	2021-03-19
Publishing country	United States
Document type	Journal Article ; Observational Study
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1373
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