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Article ; Online: Buried esophageal adenocarcinoma after radiofrequency ablation with pagetoid spreading.

Pocci, Marco / Alfieri, Rita / Fassan, Matteo / Realdon, Stefano / Scapinello, Antonio

2023 Volume 99, Issue 4, Page(s) 642–643

MeSH term(s)	Humans ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Radiofrequency Ablation ; Catheter Ablation ; Barrett Esophagus/pathology
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.10.019
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Article ; Online: Forward to a methodological proposal to support cancer patients: the dialogics' contribution for the precision care.

Pinto, Eleonora / Alfieri, Rita / Orrù, Luisa / Dalla Riva, Marta Silvia / Turchi, Gian Piero

Medical oncology (Northwood, London, England)

2022 Volume 39, Issue 5, Page(s) 75

Abstract: In scientific context, the first step for scientific theoretical and methodological production is the epistemological analysis. What are assumptions for interaction between oncology and psychology? What are the conditions for psycho-oncological ... ...

Abstract	In scientific context, the first step for scientific theoretical and methodological production is the epistemological analysis. What are assumptions for interaction between oncology and psychology? What are the conditions for psycho-oncological contribution in treating cancer? Furthermore, what are epistemological observations about the current developments in cancer field? And what are implications for sciences treating patients with neoplasms? Due to advances in oncology and in sciences supporting oncology, epistemological questions focus on the object of study of the integration between oncology and psychology. Therefore, the purpose of this study is to describe a proposal of theoretical and methodological frame suitable for current clinical and research needs in cancer patients asking for psychological support. Epistemological analysis lets the health professionals and researchers observe there are sciences using formal languages and sciences using ordinary language. Currently, personalized approach is pursued by oncology, identifying specific patients' characteristics to define the proper treatment process: not only tumor characteristics but also behavioral and psychological features. Cancer patients features can be found in patients' narrations about neoplasms: narration represents the core of clinical and research in psychoncology. Therefore when formalized, language provides the connection between oncology and psychology. Language used by patients and all the roles involved in the care of cancer patients can become a measure of these patients' features. Dialogics science measuring the ordinary language allows the ordinary language formalization, pursuing a personalized medicine.
MeSH term(s)	Humans ; Knowledge ; Language ; Neoplasms/psychology ; Neoplasms/therapy ; Philosophy, Medical ; Precision Medicine/methods ; Quality of Life ; Social Support
Language	English
Publishing date	2022-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-021-01644-1
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Article ; Online: Detection of LINE-1 hypomethylation in cfDNA of Esophageal Adenocarcinoma Patients.

Boldrin, Elisa / Curtarello, Matteo / Dallan, Marco / Alfieri, Rita / Realdon, Stefano / Fassan, Matteo / Saggioro, Daniela

International journal of molecular sciences

2020 Volume 21, Issue 4

Abstract: DNA methylation plays an important role in cancer development. Cancer cells exhibit two types of DNA methylation alteration: site-specific hypermethylation at promoter of oncosuppressor genes and global DNA hypomethylation. This study evaluated the ... ...

Abstract	DNA methylation plays an important role in cancer development. Cancer cells exhibit two types of DNA methylation alteration: site-specific hypermethylation at promoter of oncosuppressor genes and global DNA hypomethylation. This study evaluated the methylation patterns of long interspersed nuclear element (LINE-1) sequences which, due to their relative abundance in the genome, are considered a good surrogate indicator of global DNA methylation. LINE-1 methylation status was investigated in the cell-free DNA (cfDNA) of 21 patients, 19 with esophageal adenocarcinoma (EADC) and 2 with Barrett's esophagus (BE). The two BE patients and one EADC patient were also analyzed longitudinally. Methylation status was analyzed using restriction enzymes and DNA amplification. This methodology was chosen to avoid bisulfite conversion, which we considered inadequate for cfDNA analysis. Indeed, cfDNA is characterized by poor quality and low concentration, and bisulfite conversion might worsen these conditions. Results showed that hypomethylated LINE-1 sequences are present in EADC cfDNA. Furthermore, longitudinal studies in BE suggested a correlation between methylation status of LINE-1 sequences in cfDNA and progression to EADC. In conclusion, our study indicated the feasibility of our methodological approach to detect hypomethylation events in cfDNA from EADC patients, and suggests LINE-1 methylation analysis as a new possible molecular assay to integrate into patient monitoring.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adult ; Aged ; Barrett Esophagus/genetics ; Barrett Esophagus/pathology ; Cell-Free Nucleic Acids/genetics ; DNA Methylation ; Disease Progression ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Feasibility Studies ; Female ; Humans ; Long Interspersed Nucleotide Elements/genetics ; Male ; Middle Aged ; Monitoring, Physiologic/methods
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2020-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21041547
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Article: p53/

Boldrin, Elisa / Piano, Maria Assunta / Bernaudo, Francesco / Alfieri, Rita / Biasin, Maria Raffaella / Montagner, Isabella Monia / Volpato, Alice / Mattara, Genny / Lamacchia, Francesco / Magni, Giovanna / Rosato, Antonio / Scapinello, Antonio / Pilati, Pierluigi / Curtarello, Matteo

Cancers

2023 Volume 15, Issue 10

Abstract: Chromosomal instability (CIN) is very frequent in gastroesophageal adenocarcinoma (GEA) and it is characterized ... ...

Abstract	Chromosomal instability (CIN) is very frequent in gastroesophageal adenocarcinoma (GEA) and it is characterized by
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15102783
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Article ; Online: MSI Analysis in Solid and Liquid Biopsies of Gastroesophageal Adenocarcinoma Patients: A Molecular Approach.

Boldrin, Elisa / Piano, Maria Assunta / Alfieri, Rita / Mazza, Marcodomenico / Vassallo, Loretta / Scapinello, Antonio / Pilati, Pierluigi / Curtarello, Matteo

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: Gastroesophageal adenocarcinoma (GEA) patients with the microsatellite instability (MSI) subtype emerged as optimal candidates for immunotherapy. To date, immunohistochemistry (IHC) is the gold standard for MSI assessment in formalin-fixed paraffin- ... ...

Abstract	Gastroesophageal adenocarcinoma (GEA) patients with the microsatellite instability (MSI) subtype emerged as optimal candidates for immunotherapy. To date, immunohistochemistry (IHC) is the gold standard for MSI assessment in formalin-fixed paraffin-embedded (FFPE) specimens. However, IHC, although useful for diagnostic typing, cannot be used to analyze cell-free DNA (cfDNA) in liquid biopsy, a tool that could overcome tumor heterogeneity and enable longitudinal monitoring. In order to find an alternative diagnostic method to IHC, we analyzed 86 retrospective GEAs FFPE samples with multiplex PCR. Moreover, to verify the feasibility of MSI detection in liquid biopsy, cfDNA samples of five patients that resulted in having MSI in a prospective cohort of 35 patients were evaluated by multiplex PCR, real-time PCR and droplet digital PCR (ddPCR). Analysis of FFPE showed 100% concordance between multiplex PCR and IHC (Cohen's Kappa agreement = 1). On the contrary, only ddPCR was able to detect MSI in cfDNAs of T3/T4 GEA patients. In conclusion, data highlight the molecular analysis as an optimal alternative to IHC for the diagnostic typing and suggest that the ddPCR assay can be considered as the most reliable and promising molecular approach to detect MSI in the cfDNA of GEA patients.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Cell-Free Nucleic Acids/genetics ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/pathology ; Female ; Humans ; Liquid Biopsy/methods ; Male ; Microsatellite Instability ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
Chemical Substances	Cell-Free Nucleic Acids
Language	English
Publishing date	2021-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147244
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Article: Managing the Consequences of Oncological Major Surgery: A Short- and Medium-Term Skills Assessment Proposal for Patient and Caregiver through M.A.D.I.T. Methodology.

Turchi, Gian Piero / Fabbian, Alessandro / Alfieri, Rita / Da Roit, Anna / Marano, Salvatore / Mattara, Genny / Pilati, Pierluigi / Castoro, Carlo / Bassi, Davide / Dalla Riva, Marta Silvia / Orrù, Luisa / Pinto, Eleonora

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 3

Abstract: The effects of cancer surgery and treatment harm patients' life and working ability: major causes of this can be intensified by the postoperative symptoms. This study, the first part of the HEAGIS project (Health and Employment after Gastrointestinal ... ...

Abstract	The effects of cancer surgery and treatment harm patients' life and working ability: major causes of this can be intensified by the postoperative symptoms. This study, the first part of the HEAGIS project (Health and Employment after Gastrointestinal Surgery), proposes a method to assess patients and caregivers' competences in dealing with postoperative course and the related needs to improve the adequate competences. In this observational study, an ad hoc structured interview was conducted with 47 patients and 15 caregivers between the third and fifteenth postoperative day. Oesophageal (38%), esophagogastric junction (13%), gastric (30%), colon (8%) and rectum (11%) cancer patients were considered. Computerized textual data analysis methodology was used to identify levels of competences. Text analysis highlighted three different levels (low, medium and high) of four specific types of patients and caregivers' competences. In particular, the overall trend of the preview of future scenarios and use of resource competences was low. Less critical were situation evaluation and preview repercussion of own actions' competences. Caregivers' trends were similar. The Kruskal-Wallis test did not distinguish any differences in the level of competences related to the characteristics of the participants. Patients and caregivers are not accurate in planning the future after surgery, using personal beliefs rather than referring to physicians, and not recognizing adequate resources. The medium-low competences' trend leads to unexpected critical situations, and patients could not deal with them in a maximally effective way. Both patients and caregivers should be taken over by healthcare professionals to improve patients' competences and make the curative surgery effective in daily life.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12030077
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Article: Critical Competences for the Management of Post-Operative Course in Patients with Digestive Tract Cancer: The Contribution of MADIT Methodology for a Nine-Month Longitudinal Study.

Pinto, Eleonora / Fabbian, Alessandro / Alfieri, Rita / Da Roit, Anna / Marano, Salvatore / Mattara, Genny / Pilati, Pierluigi / Castoro, Carlo / Cavarzan, Marco / Dalla Riva, Marta Silvia / Orrù, Luisa / Turchi, Gian Piero

Behavioral sciences (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: There is a high postoperative morbidity rate after cancer surgery, that impairs patients’ self-management, job condition and economic strength. This paper describes the results of a peculiar psychological intervention on patients undergoing surgery for ... ...

Abstract	There is a high postoperative morbidity rate after cancer surgery, that impairs patients’ self-management, job condition and economic strength. This paper describes the results of a peculiar psychological intervention on patients undergoing surgery for esophageal, gastric and colorectal cancer. The intervention aimed to enhance patients’ competences in the management of postoperative daily life. A narrative approach (M.A.D.I.T.—Methodology for the Analysis of Computerised Text Data) was used to create a questionnaire, Health and Employment after Gastro-Intestinal Surgery—Dialogical Questionnaire, HEAGIS-DQ, that assesses four competences. It was administered to 48 participants. Results were used as guidance for specific intervention, structured on patients’ competence profiles. The intervention lasted nine months after surgery and was structured in weekly to monthly therapeutic sessions. Quality of Life questionnaires were administered too. At the end of the intervention, 94% of patients maintained their job and only 10% of patients asked for financial support. The mean self-perception of health-related quality of life was 71.2. The distribution of three of four competences increased after nine months (p < 0.05). Despite economic difficulties due to lasting symptoms after surgery, and to the current pandemic scenario, a structured intervention with patients let them to resume their jobs and continue activities after surgery.
Language	English
Publishing date	2022-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs12040101
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Article: Putative Clinical Potential of

Boldrin, Elisa / Mazza, Marcodomenico / Piano, Maria Assunta / Alfieri, Rita / Montagner, Isabella Monia / Magni, Giovanna / Scaini, Maria Chiara / Vassallo, Loretta / Rosato, Antonio / Pilati, Pierluigi / Scapinello, Antonio / Curtarello, Matteo

Cancers

2022 Volume 14, Issue 9

Abstract: Anti-HER2 monoclonal antibody trastuzumab improves the survival of those patients with advanced gastroesophageal adenocarcinoma (GEA) exhibiting HER2/ ...

Abstract	Anti-HER2 monoclonal antibody trastuzumab improves the survival of those patients with advanced gastroesophageal adenocarcinoma (GEA) exhibiting HER2/
Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14092180
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Article ; Online: Tumor immune microenvironment in therapy-naive esophageal adenocarcinoma could predict the nodal status.

Kotsafti, Andromachi / Fassan, Matteo / Cavallin, Francesco / Angerilli, Valentina / Saadeh, Luca / Cagol, Matteo / Alfieri, Rita / Pilati, Pierluigi / Castoro, Carlo / Castagliuolo, Ignazio / Scarpa, Melania / Scarpa, Marco

Cancer medicine

2022 Volume 12, Issue 5, Page(s) 5526–5535

Abstract: Background: Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and ... ...

Abstract	Background: Currently, preoperative staging of esophageal adenocarcinoma (EAC) has modest reliability and accuracy for pT and pN stages prediction, which heavily affects overall survival. The interplay among immune checkpoints, oncogenes, and intratumoral and peritumoral immune infiltrating cells could be used to predict loco-regional metastatic disease in early EAC. Methods: We prospectively evaluated immune markers expression and oncogenes status as well as intratumoral and peritumoral immune infiltrating cells populations in esophageal mucosa samples obtained from neoadjuvant therapy-naïve patients who had esophagectomy for EAC. Results: Vascular invasion and high infiltration of lamina propria mononuclear cells resulted associated with nodal metastasis. Low infiltration of activated CD8 Conclusions: Our data suggest that immune surveillance failure is the main driver of nodal metastasis onset. Moreover, nodal metastasis containment also involves the immune microenvironment of the peritumoral healthy tissue.
MeSH term(s)	Humans ; Reproducibility of Results ; Esophageal Neoplasms/pathology ; Adenocarcinoma/pathology ; Lymph Nodes/pathology ; Neoplasm Staging ; Tumor Microenvironment
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5386
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Article ; Online: ctDNA as promising tool for the assessment of minimal residual disease (MRD) and the need of an adjuvant treatment in gastroesophageal adenocarcinoma.

Piva, Vittoria Matilde / De Grandis, Maria Caterina / Zuin, Irene Sole / Angerilli, Valentina / Nappo, Floriana / Alfieri, Rita / Ahcene Djaballah, Selma / Murgioni, Sabina / Bergamo, Francesca / Fassan, Matteo / Valmasoni, Michele / Lonardi, Sara

Updates in surgery

2022 Volume 75, Issue 2, Page(s) 305–312

Abstract: Gastroesophageal adenocarcinoma is a challenging disease due to its poor prognosis and the presence of few therapeutic options. For these reasons, it is mandatory to identify the subgroup of patients who are at high risk for relapse after curative- ... ...

Abstract	Gastroesophageal adenocarcinoma is a challenging disease due to its poor prognosis and the presence of few therapeutic options. For these reasons, it is mandatory to identify the subgroup of patients who are at high risk for relapse after curative-intention surgery. In the last years, liquid biopsy has aroused great interest in cancer treatment for its feasibility and the possibility to capture tumor heterogeneity in a real-time way. In postoperative setting, the interest is directed to the identification of Minimal Residual Disease (MRD), defined as isolated or small cluster of cancer cells that residues after curative-intention surgery, and are undetectable by conventional radiological and clinical exams. This review wants to summarize current evidence on the use of liquid biopsy in gastroesophageal cancer, focusing on the detection of ctDNA in the postoperative setting and its potential role as a guide for treatment decision.
MeSH term(s)	Humans ; Circulating Tumor DNA/genetics ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Neoplasm Recurrence, Local/diagnosis ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Adenocarcinoma/therapy ; Liquid Biopsy ; Biomarkers, Tumor/genetics
Chemical Substances	Circulating Tumor DNA ; Biomarkers, Tumor
Language	English
Publishing date	2022-10-22
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-022-01379-2
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