Article: Transcription in haploid male germ cells.
International review of cytology
2004 Volume 237, Page(s) 1–56
Abstract: Major modifications in chromatin organization occur in spermatid nuclei, resulting in a high degree of DNA packaging within the spermatozoon head. However, before arrest of transcription during midspermiogenesis, high levels of mRNA are found in round ... ...
| Abstract | Major modifications in chromatin organization occur in spermatid nuclei, resulting in a high degree of DNA packaging within the spermatozoon head. However, before arrest of transcription during midspermiogenesis, high levels of mRNA are found in round spermatids. Some transcripts are the product of genes expressed ubiquitously, whereas some are generated from male germ cell-specific gene homologs of somatic cell genes. Others are transcript variants derived from genes with expression regulated in a testis-specific fashion. The haploid genome of spermatids also initiates the transcription of testis-specific genes. Various general transcription factors, distinct promoter elements, and specific transcription factors are involved in transcriptional regulation. After meiosis, spermatids are genetically but not phenotypically different, because of transcript and protein sharing through cytoplasmic bridges connecting spermatids of the same generation. Interestingly, different types of mRNAs accumulate in the sperm cell nucleus, raising the question of their origin and of a possible role after fertilization. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/ultrastructure ; Gene Expression Regulation, Developmental/genetics ; Genes, Regulator/genetics ; Haploidy ; Humans ; Male ; Meiosis/genetics ; RNA, Messenger/genetics ; Spermatids/growth & development ; Spermatids/metabolism ; Spermatids/ultrastructure ; Spermatogenesis/genetics ; Spermatozoa/growth & development ; Spermatozoa/metabolism ; Spermatozoa/ultrastructure ; Transcription, Genetic/genetics | |||||
| Chemical Substances | RNA, Messenger | |||||
| Language | English | |||||
| Publishing date | 2004 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 209869-6 | |||||
| ISSN | 0074-7696 | |||||
| ISSN | 0074-7696 | |||||
| DOI | 10.1016/S0074-7696(04)37001-4 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uc I Zs.317: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.