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  1. Article ; Online: Beyond the labyrinth: Reevaluating contralateral hearing impacts in Ménière's disease.

    Alfonso, Scarpa / Mario, Carucci / Massimo, Ralli / Claudia, Cassandro / Pietro, De Luca / Giovanni, Salzano / Pasquale, Viola / Giuseppe, Chiarella / Antonio, Salzano Francesco

    American journal of otolaryngology

    2024  Volume 45, Issue 2, Page(s) 104224

    MeSH term(s) Humans ; Meniere Disease ; Ear, Inner ; Hearing
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104224
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  2. Article ; Online: Sedation with Intranasal Dexmedetomidine in the Pediatric Population for Auditory Brainstem Response Testing

    Pasquale Marra / Arianna Di Stadio / Vito Colacurcio / Alfonso Scarpa / Ignazio La Mantia / Francesco Antonio Salzano / Pietro De Luca

    Healthcare, Vol 10, Iss 287, p

    Review of the Existing Literature

    2022  Volume 287

    Abstract: Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response ... ...

    Abstract Background: Intranasal dexmedetomidine (IN DEX) is a relatively new sedative agent with supporting evidence on its efficacy and safety, which can be used for procedural sedation in children, and could have a major role in auditory brainstem response testing, especially in the case of non-cooperative children. The goal of this systematic review is to assess the role of IN DEX in ABR testing, evaluating the reported protocol, potential, and limits. Methods: We performed a comprehensive search strategy on PubMed, Scopus, and Google Scholar, including studies in English on the pediatric population, without time restrictions. Results: Six articles, published between 2016 and 2021, were included in the systematic review. Sedation effectiveness was high across the studies, except for one study; 3 μg/kg was the dosing most often used. A comparison group was present in three studies, with oral chloral hydrate as the drug of comparison. Adverse effects were rarely reported. Conclusion: This systematic review showed how IN DEX can represent an adequate sedative for children undergoing ABR testing; larger and more rigorous trials are warranted in order to recommend its systematic utilization.
    Keywords intranasal dexmedetomidine ; auditory brainstem response ; ABR ; sedation ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Dermal Substitutes and Skin Grafts in the Reconstruction of Post-Traumatic Total Scalp Avulsion

    Marzia Petrocelli / Giulia Togo / Silvia Ricci / Flavia Zeneli / Sebastiano Cutrupi / Annamaria Baietti / Paola Bonavolontà / Luigi Califano / Luigi Angelo Vaira / Alfonso Scarpa / Arianna Di Stadio / Giovanni Salzano

    Journal of Clinical Medicine, Vol 12, Iss 2167, p

    A Case Series

    2023  Volume 2167

    Abstract: Although scalp defects can vary in size and thickness, scalp avulsion represents a rare occurrence. This type of lesion may have different origins, but it is usually related to long hair being caught in agricultural machinery. The management of full- ... ...

    Abstract Although scalp defects can vary in size and thickness, scalp avulsion represents a rare occurrence. This type of lesion may have different origins, but it is usually related to long hair being caught in agricultural machinery. The management of full-thickness scalp defects poses a challenge to the head and neck surgeon due to the possible involvement of neurovascular structures and scar retraction, which can affect the esthetic restoration of the area. Several algorithms for the choice of scalp reconstruction have been proposed in the literature and different techniques are available for extensive scalp defect reconstruction (local soft tissue flap, microvascular free flap, and skin graft combined with dermal substitutes), based upon the scalp defect type. Here we describe six cases of patients with total scalp avulsion, which required a combined reconstruction with a split-thickness skin graft (STSG) and Integra ® matrix immediately after the trauma.
    Keywords scalp avulsion ; scalp reconstruction ; split-thickness skin graft (STSG) ; dermal substitutes ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Locoregional Flaps for the Reconstruction of Midface Skin Defects

    Giovanni Salzano / Francesco Maffìa / Luigi Angelo Vaira / Umberto Committeri / Chiara Copelli / Fabio Maglitto / Alfonso Manfuso / Vincenzo Abbate / Paola Bonavolontà / Alfonso Scarpa / Luigi Califano / Giovanni Dell’Aversana Orabona

    Journal of Clinical Medicine, Vol 12, Iss 3700, p

    A Collection of Key Surgical Techniques

    2023  Volume 3700

    Abstract: Background: The reconstruction of midface skin defects represents a challenge for the head and neck surgeon due to the midface’s significant role in defining important facial traits. Due to the high complexity of the midface region, there is no ... ...

    Abstract Background: The reconstruction of midface skin defects represents a challenge for the head and neck surgeon due to the midface’s significant role in defining important facial traits. Due to the high complexity of the midface region, there is no possibility to use one definitive flap for all purposes. For moderate defects, the most common reconstructive techniques are represented by regional flaps. These flaps can be defined as donor tissue with a pedunculated axial blood supply not necessarily adjacent to the defect. The aim of this study is to highlight the more common surgical techniques adopted for midface reconstruction, providing a focus on each technique with its description and indications. Methods: A literature review was conducted using PubMed, an international database. The target of the research was to collect at least 10 different surgical techniques. Results: Twelve different techniques were selected and cataloged. The flaps included were the bilobed flap, rhomboid flap, facial-artery-based flaps (nasolabial flap, island composite nasal flap, retroangular flap), cervicofacial flap, paramedian forehead flap, frontal hairline island flap, keystone flap, Karapandzic flap, Abbè flap, and Mustardè flap. Conclusions: The study of the facial subunits, the location and size of the defect, the choice of the appropriate flap, and respect for the vascular pedicles are the key elements for optimal outcomes.
    Keywords head and neck reconstruction ; midface skin defects ; midface locoregional flaps ; pedunculated flaps ; Medicine ; R
    Subject code 380
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Vestibular Disorders after Kidney Transplantation

    Pasquale Viola / Vincenzo Marcelli / Domenico Sculco / Davide Pisani / Alfredo Caglioti / Filippo Ricciardiello / Alfonso Scarpa / Alessia Astorina / Giuseppe Tortoriello / Luca Gallelli / Giovambattista De Sarro / Giuseppe Chiarella

    International Journal of Environmental Research and Public Health, Vol 19, Iss 2260, p

    Focus on the Pathophysiological Mechanisms Underlying the Vertical Nystagmus Associated with Tacrolimus-Related Hypomagnesamia

    2022  Volume 2260

    Abstract: The purpose of this paper is to present the case of a patient undergoing kidney transplantation who developed limb tremor dizziness and vertical nystagmus (ny) during Tacrolimus (TAC) therapy and to investigate the pathophysiological mechanisms ... ...

    Abstract The purpose of this paper is to present the case of a patient undergoing kidney transplantation who developed limb tremor dizziness and vertical nystagmus (ny) during Tacrolimus (TAC) therapy and to investigate the pathophysiological mechanisms underlying the balance disorder. This case study regards a 51-year old kidney transplant male patient with hand tremors and lower limbs asthenia associated with dizziness and nausea. The symptoms started two months after the beginning of intravenous TAC for renal transplantation. The pure-tone audiometry showed a mild symmetrical high-frequencies down-sloping sensorineural hearing loss. Acoustic emittance measures showed a normal tympanogram; stapedial reflexes were normally elicited. The Auditory Brainstem Responses (ABR) and Cervical Vestibular Evoked Myogenic Potentials (c-VEMPs) were bilaterally normally evoked. The bedside vestibular examination showed spontaneous down-beating stationary persistent, omni-positional nystagmus, not inhibited by fixation. The Head-Shaking Test accentuates the spontaneous ny. The horizontal clinical head impulse test was negative, bilaterally. A biochemical blood test revealed a decrease in Magnesium (Mg) levels (0.8 mg/dL; normal range 1.58–2.55). The integration of Mg induced both a plasma levels normalization and an improvement of clinical symptoms. This case suggests that TAC treatment can induce a Mg depletion that caused the transient cerebellar lesion. Therefore, the monitoring of serum electrolytes during immunosuppressive treatment appears to be a useful tool in order to reduce the central system symptomatology.
    Keywords vertical nystagmus ; hypomagnesemia ; tacrolimus ; kidney transplantation ; vestibular disorder ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Sudden sensorineural hearing loss and COVID-19

    Pietro De Luca / Ettore Cassandro / Alfonso Scarpa / Claudia Cassandro / Massimo Ralli / Federico Maria Gioacchini / Massimo Re / Giuseppe Chiarella

    International Journal of Infectious Diseases, Vol 101, Iss , Pp 201-

    2020  Volume 202

    Keywords Sudden sensorineural hearing loss ; COVID-19 ; Pandemic ; Sudden deafness ; PCR ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Cribriform adenocarcinoma of the tongue with cervical lymph nodes involvement

    Pietro De Luca / Domenico Tassone / Luca deCampora / Matteo Simone / Pasquale Marra / Vito Colacurcio / Leopoldo Costarelli / Alfonso Scarpa / Claudio Viti / Angelo Camaioni

    Clinical Case Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)

    Report of an extremely rare tumor and focus about differential diagnosis with polymorphous adenocarcinoma

    2021  

    Abstract: Abstract Cribriform adenocarcinoma is a rare tumor that arise in tongue and minor salivary glands. Previously, only 56 case have been described. In this paper, we report a case of a 83‐year‐old man and we focus about the differential diagnosis with ... ...

    Abstract Abstract Cribriform adenocarcinoma is a rare tumor that arise in tongue and minor salivary glands. Previously, only 56 case have been described. In this paper, we report a case of a 83‐year‐old man and we focus about the differential diagnosis with polymorphous adenocarcinoma.
    Keywords base of the tongue ; CATMSG ; cribriform adenocarcinoma of the tongue ; minor salivary glands ; polymorphous adenocarcinoma ; salivary glands tumor ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  8. Article ; Online: Neuropsychological profile of hearing-impaired patients and the effect of hearing aid on cognitive functions

    Sofia Cuoco / Arianna Cappiello / Alfonso Scarpa / Donato Troisi / Maria Autuori / Sara Ponticorvo / Claudia Cassandro / Renzo Manara / Fabrizio Esposito / Gabriella Santangelo / Paolo Barone / Ettore Cassandro / Maria Teresa Pellecchia

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    an exploratory study

    2021  Volume 9

    Abstract: Abstract Few studies have investigated the neuropsychological profile of Hearing Loss (HL) subjects and the effects of hearing-aid on cognitive decline. We investigated the neuropsychological profile of HL patients at baseline and compared the ... ...

    Abstract Abstract Few studies have investigated the neuropsychological profile of Hearing Loss (HL) subjects and the effects of hearing-aid on cognitive decline. We investigated the neuropsychological profile of HL patients at baseline and compared the neuropsychological profiles of patients with and without hearing-aid at 6 month. Fifty-six HL patients and 40 healthy subjects (HC) underwent neuropsychological and behavioral examination and were compared at baseline. Changes at follow-up were compared between HL patients with (N = 25) and without (N = 31) hearing-aids. At baseline, significant differences between HL and HC were found in MOCA test, Raven's Coloured Progressive Matrices (CPM) and SF-36. Among mild-HL patients, patients with hearing-aid significantly improved on the Clock Drawing Test (CDT) as compared to patients without hearing-aid. Our findings indicate that hearing loss is associated with both a reduced efficiency of the global cognitive state and a worse quality of life as compared to HC, supporting the association between HL and cognitive impairment. Moreover, only patients with mild-HL shows some cognitive improvement after using hearing-aid, suggesting that rehabilitative strategies may be more effective to delay cognitive decline in such patients. However, we cannot exclude that hearing-aids may affect cognitive decline in more severe-HL, but a longer follow-up is needed.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Hearing Loss and Cognitive Impairment

    Antonella Bisogno / Alfonso Scarpa / Stefano Di Girolamo / Pietro De Luca / Claudia Cassandro / Pasquale Viola / Filippo Ricciardiello / Antonio Greco / Marco De Vincentiis / Massimo Ralli / Arianna Di Stadio

    Life, Vol 11, Iss 1102, p

    Epidemiology, Common Pathophysiological Findings, and Treatment Considerations

    2021  Volume 1102

    Abstract: In recent years, there has been increasing research interest in the correlation between hearing impairment and cognitive decline, two conditions that have demonstrated a strong association. Hearing loss appears as a risk factor for cognitive impairment, ... ...

    Abstract In recent years, there has been increasing research interest in the correlation between hearing impairment and cognitive decline, two conditions that have demonstrated a strong association. Hearing loss appears as a risk factor for cognitive impairment, especially among certain populations, notably nursing home residents. Furthermore, hearing loss has been identified as a modifiable age-related condition linked to dementia, and it has been estimated that midlife hearing loss, if eliminated, might decrease the risk of dementia in the general population. Several mechanisms have been suggested to explain the pathologic connections between hearing loss and dementia; however, clear evidence is missing, and the common pathophysiological basis is still unclear. In this review, we discussed current knowledge about the relationship between hearing loss and dementia, and future perspectives in terms of the effects of hearing rehabilitation for early prevention of cognitive decline.
    Keywords hearing loss ; dementia ; hearing aid ; cognitive impairment ; Alzheimer’s disease ; epidemiology ; Science ; Q
    Subject code 390
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Poorly Differentiated Neuroendocrine Larynx Carcinoma

    Filippo Ricciardiello / Michela Falco / Giuseppe Tortoriello / Ferdinando Riccardi / Raul Pellini / Brigida Iorio / Giuseppe Russo / Giuseppe Longo / Ciro Coppola / Takashi Takeuchi / Anna Grimaldi / Marianna Abate / Marianna Scrima / Alessia Maria Cossu / Raffaele Addeo / Alessandro Ottaiano / Alfonso Scarpa / Amedeo Boscaino / Giovanni Motta /
    Michele Caraglia / Marco Bocchetti / Gabriella Misso

    Journal of Clinical Medicine, Vol 10, Iss 2019, p

    Clinical Features and miRNAs Signature—A New Goal for Early Diagnosis and Therapy?

    2021  Volume 2019

    Abstract: Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which ... ...

    Abstract Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological and clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five of which were defined as well-moderately differentiated neuroendocrine carcinomas, and five that were defined as poorly differentiated neuroendocrine carcinomas, according to the latest WHO classification. Clinical features were analyzed and compared between the two subgroups together with a microRNA study which evidenced a peculiar signature likely related to poorly differentiated larynx neuroendocrine carcinomas. These findings may offer new useful insights for clinicians to improve diagnosis efficiency, therapy response, and patients’ outcome for this aggressive neoplasm.
    Keywords neuroendocrine ; larynx ; squamous ; poorly differentiated ; carcinoma ; miRNA ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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