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  1. Article: Metastasiertes Pankreaskarzinom. Update. Aufgrund seinersteigenden Inzidenz könnte das duktale Pankreaskarzinom schon ab 2030 den zweitgrößten Anteil an der Tumor-Gesamtmortalitätin Deutschland aufweisen

    Algül, Hana

    TZM-News

    2022  Volume 24, Issue 1, Page(s) 10

    Language German
    Document type Article
    ZDB-ID 1497189-6
    ISSN 1437-8019
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5602: Show issues Location:
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  2. Article ; Online: Hourglass, a compass navigating global and regional heterogeneity of pancreatic cancer

    Bakırdöğen, Derya / Görgülü, Kıvanç / Algül, Hana

    The Journal of pathology

    2024  Volume 263, Issue 1, Page(s) 5–7

    Abstract: Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires ... ...

    Abstract Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires extensive statistical analysis. As a user-friendly software, Hourglass, simplifies multiparametric dataset analysis through intuitive data visualization and statistical tools. Systemic analysis of interleukin-6 (IL-6)/pStat3 signaling pathway through Hourglass revealed differences in regional immune cell composition within tumors. Moreover, these regional disparities were partially mediated by sex. Overall, Hourglass simplifies information extraction from complex datasets, resolving overlooked regional and global spatial tumor differences. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Signal Transduction ; Software ; United Kingdom
    Language English
    Publishing date 2024-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Herrschinger Hämato-Onkologie-Symposium 2020. Update Pankreaskarzinom. Hana Algül, Klinikum rechts der Isar der TU München. Das Pankreaskarzinom gehört trotz intensiver Bemühungen nach wie vor zu den Malignomen mit der höchsten Mortalität

    Algül, Hana

    TZM-News : Sonderausgabe

    2020  Volume -, Issue 1, Page(s) 4

    Language German
    Document type Article
    ZDB-ID 2711416-8
    Database Current Contents Medicine

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  4. Book ; Thesis: Charakterisierung der NF-kappa-B-Rel-Kaskade im exokrinen Pankreas

    Algül, Hana

    2001  

    Author's details vorgelegt von Hana Algül
    Language German
    Size IV, 95 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2001
    HBZ-ID HT013455909
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 3890 order for loan Magazin

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  5. Article: Pankreas- und Gallengangskarzinom

    Algül, Hana

    TZM-News

    2019  Volume 21, Issue 3, Page(s) 27

    Language German
    Document type Article
    ZDB-ID 1497189-6
    ISSN 1437-8019
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Pathogenese der akuten Pankreatitis.

    Sendler, Matthias / Algül, Hana

    Der Internist

    2021  Volume 62, Issue 10, Page(s) 1034–1043

    Abstract: Acute pancreatitis is characterized by the autodigestion of the pancreas by its own digestive enzymes. The pathophysiological onset of the disease occurs in the acinar cells. The normally inactive precursors of secreted proteases are prematurely ... ...

    Title translation Pathogenesis of acute pancreatitis.
    Abstract Acute pancreatitis is characterized by the autodigestion of the pancreas by its own digestive enzymes. The pathophysiological onset of the disease occurs in the acinar cells. The normally inactive precursors of secreted proteases are prematurely activated and as a result digest the cells from within. The activation of trypsinogen to trypsin represents the key event as active trypsin activates further digestive enzymes and can therefore initiate the activation of the complete protease cascade. This premature activation of proteases results in the cell death of acinar cells and in the induction of a strong proinflammatory immune response. Cells of the innate immune system migrate into the damaged organ and potentiate the local damage again via the release of inflammatory cytokines, such as tumor necrosis factor alpha and reactive oxygen species. Concomitant to the local immune reaction, a systemic activation of the immune system also occurs, which can develop into a systemic inflammatory response syndrome (SIRS). In the course of the SIRS severe complications such as organ failure can occur. The consequence of this pronounced SIRS in the later course of the disease is a strong immunological counter-regulation, the so-called compensatory anti-inflammatory reaction syndrome (CARS). In the course of this immunosuppression commensal bacteria from the intestines can colonize the pancreatic necrosis. The outcome of the SIRS/CARS balance is decisive for the course and the prognosis of the patient.
    MeSH term(s) Acute Disease ; Humans ; Pancreas ; Pancreatitis, Acute Necrotizing/diagnosis ; Trypsinogen
    Chemical Substances Trypsinogen (9002-08-8)
    Language German
    Publishing date 2021-09-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01158-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Relevance of tumor boards for the inclusion of patients in oncological clinical trials.

    Dapper, Hendrik / Dantes, Maurice / Herschbach, Peter / Algül, Hana / Heinemann, Volker

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 10, Page(s) 7601–7608

    Abstract: Introduction: Major national and international oncological societies generally recommend treating a significant proportion of oncological patients in clinical trials to improve therapy strategies for cancer patients. At cancer centers, the ... ...

    Abstract Introduction: Major national and international oncological societies generally recommend treating a significant proportion of oncological patients in clinical trials to improve therapy strategies for cancer patients. At cancer centers, the recommendation about the appropriate therapy for the individual tumor patient is usually made in interdisciplinary case discussions in multidisciplinary tumor boards (MDT). In this study, we examined the impact of MDTs for the inclusion of patients in therapy trials.
    Methodology: A prospective, explorative study of the Comprehensive Cancer Center Munich (CCCM) was conducted at both university hospitals in 2019. In the first phase, various MDTs' case discussions about oncological situations and their decisions regarding possible therapy trials were recorded in a structured manner. In the second phase, the actual inclusion rates of patients in therapy trials and reasons for non-inclusion were examined. Finally, the data of the respective university hospitals were anonymized, pooled and analyzed.
    Results: A total of 1797 case discussions were reviewed. Therapy recommendations were made in 1527 case presentations. 38 (2.5%) of 1527 patients were already included in a therapy trial at the time of case presentation. The MDTs recommended inclusion of an additional 107 cases (7%), for a therapy trial. Of these patients, 41 were finally enrolled in a therapy trial which resulted in a total recruitment rate of 5.2%. Despite MDTs' recommendations, 66 patients were not included in a therapy trial. The main reason for non-inclusion was insufficient inclusion or existing exclusion criteria (n = 18, 28%). In 48% of all cases (n = 31), the reason for non-inclusion could not be determined.
    Conclusion: The potential of MDTs as an instrument for the inclusion of patients in therapy trials is high. To increase the enrollment of patients in oncological therapy trials, structural measures such as the central use of trial administration and MTB software in addition to standardized tumor board discussions must be established to ensure a seamless flow of information about actual recruiting trials and the current status of trial participation of patients.
    MeSH term(s) Humans ; Medical Oncology ; Neoplasms/therapy ; Prospective Studies ; Clinical Trials as Topic
    Language English
    Publishing date 2023-03-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04559-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Inzidenz und Risikofaktoren der Post-ERCP-Pankreatitis

    Schwab, Miriam Brigitta Clara Theresia Verfasser] / [Algül, Hana [Akademischer Betreuer] / Algül, Hana [Gutachter] / Paprottka, Philipp [Gutachter]

    Retrospektive Auswertung von Inzidenz und Risikofaktoren der Post-ERCP-Pankreatitis bei einem selektiven Patientengut, das zum ersten Mal eine ERCP erhalten hat

    2023  

    Author's details Miriam Brigitta Clara Theresia Schwab ; Gutachter: Hana Algül, Philipp Paprottka ; Betreuer: Hana Algül
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Gallenwegskarzinom. BILCAP-Studie zur adjuvanten Capecitabin-Therapie

    Algül, Hana

    TZM-News

    2017  Volume 19, Issue 3, Page(s) 11

    Language German
    Document type Article
    ZDB-ID 1497189-6
    ISSN 1437-8019
    Database Current Contents Medicine

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  10. Article ; Online: Chemotherapy of pancreatic cancer in patients with poor performance.

    Schulz, Dominik / Algül, Hana

    Chinese clinical oncology

    2019  Volume 8, Issue S1, Page(s) S22

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Humans ; Male ; Pancreatic Neoplasms/drug therapy ; Prognosis
    Language English
    Publishing date 2019-08-20
    Publishing country China
    Document type Editorial
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3865
    ISSN (online) 2304-3873
    ISSN 2304-3865
    DOI 10.21037/cco.2019.08.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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