Article: Apolipoprotein L1 risk genotypes in Ghanaian patients with systemic lupus erythematosus: a prospective cohort study.
2023 Volume 8, Issue 1
Abstract: Objective: Two apolipoprotein L1 (: Methods: This was a prospective cohort study of 100 SLE outpatients who sought care at Korle bu Teaching Hospital in Accra, Ghana. Adult patients who met 4 American College of Rheumatology criteria for SLE were ... ...
| Abstract | Objective: Two apolipoprotein L1 ( Methods: This was a prospective cohort study of 100 SLE outpatients who sought care at Korle bu Teaching Hospital in Accra, Ghana. Adult patients who met 4 American College of Rheumatology criteria for SLE were genotyped for APOL1 and followed longitudinally for SLE activity as measured by the Safety of Estrogens in Lupus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) hybrid and organ injury as measured by the Systemic Lupus International Collaborating Clinics Damage Index (SDI) at baseline and every 6 months for 1 year. Outcomes of interest were kidney function, SDI and case fatality. Results: Assuming a recessive inheritance, the Conclusion: APOL1 |
|---|---|
| MeSH term(s) | Adult ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Apolipoprotein L1/genetics ; Female ; Genotype ; Ghana ; Humans ; Longitudinal Studies ; Lupus Erythematosus, Systemic/genetics ; Male ; Prospective Studies ; United States |
| Chemical Substances | APOL1 protein, human ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Apolipoprotein L1 |
| Language | English |
| Publishing date | 2023-07-10 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2779620-6 |
| ISSN | 2053-8790 |
| ISSN | 2053-8790 |
| DOI | 10.1136/lupus-2020-000460 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.