LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Coeliac and cardiovascular disease: a possible relationship between two apparently separate conditions.

    Bernardi, Nicola / Sciatti, Edoardo / Pancaldi, Edoardo / Alghisi, Fabio / Drera, Andrea / Falco, Raffaele / Vizzardi, Enrico

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2022  Volume 93, Issue 2

    Abstract: Coeliac disease (CD) is an autoimmune condition with a high prevalence among general population and multisystemic involvement: a more complex scene than a merely gastrointestinal disease. Therefore, an early diagnosis and treatment with a gluten-free ... ...

    Abstract Coeliac disease (CD) is an autoimmune condition with a high prevalence among general population and multisystemic involvement: a more complex scene than a merely gastrointestinal disease. Therefore, an early diagnosis and treatment with a gluten-free diet is mainly important to reduce mortality and comorbidities. Together with autoimmune diseases (as Hashimoto thyroiditis, insulin-dependent diabetes mellitus, autoimmune liver disease and connective tissue diseases), also an accelerated progression of atherosclerosis and a higher prevalence of heart disease have been reported in coeliacs. In the present paper we tried to collect from literature the emergent data on the probable relationship between coeliac and cardiovascular disease, focusing on pathophysiological bases of vascular injury. Data and opinions on the development of cardiovascular risk in patients with CD are conflicting. However, the major evidence supports the theory of an increased cardiovascular risk in CD, due to many mechanisms of myocardial injury, such as chronic malabsorption, abnormalities of intestinal permeability, and direct immune response against self-proteins. The conclusions that come from these data suggest the utility of a careful cardiovascular follow up in coeliac patients.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Autoimmune Diseases ; Celiac Disease/complications ; Celiac Disease/epidemiology ; Celiac Disease/diagnosis ; Intestines ; Diabetes Mellitus, Type 1
    Language English
    Publishing date 2022-07-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2022.2366
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 65: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Endothelial function evaluation in idiopathic vs. ischemic dilated cardiomyopathy.

    Pancaldi, Edoardo / Tedino, Chiara / Riccardi, Mauro / Alghisi, Fabio / Cimino, Giuliana / Pascariello, Greta / Calvi, Emiliano / Sciatti, Edoardo / Vizzardi, Enrico / Metra, Marco

    American journal of cardiovascular disease

    2022  Volume 12, Issue 3, Page(s) 136–142

    Abstract: Aims: In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy ( ...

    Abstract Aims: In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy (ICM), it is still not clear whether the connection with ED is linked to HF itself or to atherosclerosis. The aim is to determine the presence of ED in subjects with idiopathic dilated cardiomyopathy (IDCM) compared to ICM.
    Methods: In this observational study 107 patients were enrolled, 65 of them suffering from IDCM and 42 from ICM. ED was assessed as peripheral arterial tonometry by means of EndoPAT device. The Reactive Hyperaemia Index (RHI) was calculated, ED being established with RHI values ≤1.67 and normal endothelial function >2.00 (grey area between 1.67 and 2.00).
    Results: ED, expressed both as RHI ≤1.67 and RHI ≤2.00, showed a similar prevalence in the two groups. However, they differed as regards sex, dyslipidemia and statin use.
    Conclusion: Endothelial function, evaluated through peripheral artery tonometry, seems equally compromised in patients with IDCM and ICM.
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616844-3
    ISSN 2160-200X
    ISSN 2160-200X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Study of endothelial function and vascular stiffness in patients affected by dilated cardiomyopathy on treatment with sacubitril/valsartan.

    Amore, Ludovica / Alghisi, Fabio / Pancaldi, Edoardo / Pascariello, Greta / Cersosimo, Angelica / Cimino, Giuliana / Bernardi, Nicola / Calvi, Emiliano / Lombardi, Carlo Mario / Sciatti, Edoardo / Vizzardi, Enrico / Metra, Marco

    American journal of cardiovascular disease

    2022  Volume 12, Issue 3, Page(s) 125–135

    Abstract: Background: The multiple beneficial effects of sacubitril/valsartan in the treatment of heart failure with reduced ejection fraction are vastly known, but still no or few mentions have been made regarding its effects on endothelial dysfunction and ... ...

    Abstract Background: The multiple beneficial effects of sacubitril/valsartan in the treatment of heart failure with reduced ejection fraction are vastly known, but still no or few mentions have been made regarding its effects on endothelial dysfunction and arterial stiffness.
    Patients and methods: To understand more deeply if sacubitril/valsartan may have a role on endothelial function and arterial stiffness, 15 patients with dilated cardiomyopathy with reduced left ventricular ejection fraction (LVEF) were evaluated through transthoracic echocardiography, peripheral arterial tonometry (EndoPAT
    Results: Aortic stiffness parameters didn't differ after 6 months of treatment. Augmentation pressure (P=0.889), augmentation index (P=0.906) and sphygmic wave velocity (P=0.263) increased slightly, but they weren't found to be statistically significant. Systolic, diastolic, and differential central arterial pressure didn't differ at the beginning and at the end of the study. RHI (reactive hyperemia index) increased significantly after 6 months (P=0.001) as well as augmentation index corrected for 75 bpm. Ejection fraction (32.21% ± 5.7 to 38.43% ± 8.4; P=0.010) and diastolic dysfunction degree (P=0.021) improved. There was an improvement in mitral regurgitation that wasn't statistically significant (P=0.116). TAPSE didn't change while pulmonary systolic arterial pressure increased, although not significantly (22.83 mmHg ± 4 to 27.33 mmHg ± 6; P=0.068) and within the normal range values.
    Conclusions: Even though in a study with a limited number of patients, sacubitril/valsartan improved endothelial function, left ventricular function, MR, and diastolic function significantly in patients with dilated cardiomyopathy and reduced LVEF. It showed no effects on vascular stiffness.
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616844-3
    ISSN 2160-200X
    ISSN 2160-200X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Thrombotic risk in patients with COVID-19.

    Pancaldi, Edoardo / Pascariello, Greta / Cimino, Giuliana / Cersosimo, Angelica / Amore, Ludovica / Alghisi, Fabio / Bernardi, Nicola / Calvi, Emiliano / Lombardi, Carlo Mario / Vizzardi, Enrico / Metra, Marco

    Reviews in cardiovascular medicine

    2021  Volume 22, Issue 2, Page(s) 277–286

    Abstract: Emerging evidences prove that the ongoing pandemic of coronavirus disease 2019 (COVID-19) is strictly linked to coagulopathy even if pneumonia appears as the major clinical manifestation. The exact incidence of thromboembolic events is largely unknown, ... ...

    Abstract Emerging evidences prove that the ongoing pandemic of coronavirus disease 2019 (COVID-19) is strictly linked to coagulopathy even if pneumonia appears as the major clinical manifestation. The exact incidence of thromboembolic events is largely unknown, so that a relative significant number of studies have been performed in order to explore thrombotic risk in COVID-19 patients. Cytokine storm, mediated by pro-inflammatory interleukins, tumor necrosis factor α and elevated acute phase reactants, is primarily responsible for COVID-19-associated hypercoagulopathy. Also comorbidities, promoting endothelial dysfunction, contribute to a higher thromboembolic risk. In this review we aim to investigate epidemiology and clarify the pathophysiological pathways underlying hypercoagulability in COVID-19 patients, providing indications on the prevention of thromboembolic events in COVID-19. Furthermore we aim to reassume the pathophysiological paths involved in COVID-19 infection.
    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/epidemiology ; Host-Pathogen Interactions ; Humans ; Prognosis ; Pulmonary Embolism/blood ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/prevention & control ; Pulmonary Embolism/virology ; Risk Assessment ; Risk Factors ; SARS-CoV-2/pathogenicity ; Venous Thromboembolism/blood ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/virology ; Venous Thrombosis/blood ; Venous Thrombosis/epidemiology ; Venous Thrombosis/prevention & control ; Venous Thrombosis/virology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108910-3
    ISSN 1530-6550
    ISSN 1530-6550
    DOI 10.31083/j.rcm2202035
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top