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  1. Article ; Online: SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease.

    Choaib, Ali / Issa, Elio / El Choueiry, Francesca / Eldin, Jade Nasser / Shbaklo, Khodor / Alhajj, Maryline / Sawaya, Ramy Touma / Assi, Ghaith / Nader, Moni / Chatila, Rajaa / Faour, Wissam H

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2022  Volume 72, Issue 2, Page(s) 301–312

    Abstract: Background: SARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure, including the liver. The main mechanism behind this assault is the aggressive cytokine storm that induces ... ...

    Abstract Background: SARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure, including the liver. The main mechanism behind this assault is the aggressive cytokine storm that induces cytotoxicity in various organs. Of interest, hepatic stellate cells (HSC) respond acutely to liver injury through several molecular mechanisms, hence furthering the perpetuation of the cytokine storm and its resultant tissue damage. In addition, hepatocytes undergo apoptosis or necrosis resulting in the release of pro-inflammatory and pro-fibrogenic mediators that lead to chronic liver inflammation.
    Aims: The aim of this review is to summarize available data on SARS-CoV-2-induced liver inflammation in addition to evaluate the potential effect of anti-inflammatory drugs in attenuating SARS-CoV-2-induced liver inflammation.
    Methods: Thorough PubMed search was done to gather and summarize published data on SARS-CoV-2-induced liver inflammation. Additionally, various anti-inflammatory potential treatments were also documented.
    Results: Published data documented SARS-CoV-2 infection of liver tissues and is prominent in most liver cells. Also, histological analysis showed various features of tissues damage, e.g., hepatocellular necrosis, mitosis, cellular infiltration, and fatty degeneration in addition to microvesicular steatosis and inflammation. Finally, the efficacy of the different drugs used to treat SARS-CoV-2-induced liver injury, in particular the anti-inflammatory remedies, are likely to have some beneficial effect to treat liver injury in COVID-19.
    Conclusion: SARS-CoV-2-induced liver inflammation is a serious condition, and drugs with potent anti-inflammatory effect can play a major role in preventing irreversible liver damage in COVID-19.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Cytokine Release Syndrome ; Inflammation ; Liver Diseases ; Anti-Inflammatory Agents/therapeutic use ; Necrosis
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-022-01683-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies.

    Faour, Wissam H / Choaib, Ali / Issa, Elio / Choueiry, Francesca El / Shbaklo, Khodor / Alhajj, Maryline / Sawaya, Ramy Touma / Harhous, Zeina / Alefishat, Eman / Nader, Moni

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2021  Volume 71, Issue 1, Page(s) 39–56

    Abstract: The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and ... ...

    Abstract The COVID-19 pandemic created a worldwide debilitating health crisis with the entire humanity suffering from the deleterious effects associated with the high infectivity and mortality rates. While significant evidence is currently available online and targets various aspects of the disease, both inflammatory and noninflammatory kidney manifestations secondary to COVID-19 infection are still largely underrepresented. In this review, we summarized current knowledge about COVID-19-related kidney manifestations, their pathologic mechanisms as well as various pharmacotherapies used to treat patients with COVID-19. We also shed light on the effect of these medications on kidney functions that can further enhance renal damage secondary to the illness.
    MeSH term(s) Acute Kidney Injury/complications ; Aldosterone/metabolism ; Angiotensins/chemistry ; Antibodies, Monoclonal, Humanized/administration & dosage ; Autopsy ; Biopsy ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/physiopathology ; COVID-19 Vaccines ; Dexamethasone/administration & dosage ; Enoxaparin/administration & dosage ; Heparin/administration & dosage ; Heparin, Low-Molecular-Weight/administration & dosage ; Humans ; Inflammation ; Interleukin 1 Receptor Antagonist Protein/administration & dosage ; Kidney/injuries ; Kidney Diseases/complications ; Kidney Diseases/physiopathology ; Kidney Transplantation ; Lopinavir/administration & dosage ; Pandemics ; Renal Replacement Therapy ; Renin-Angiotensin System ; Ritonavir/administration & dosage ; SARS-CoV-2
    Chemical Substances Angiotensins ; Antibodies, Monoclonal, Humanized ; COVID-19 Vaccines ; Enoxaparin ; Heparin, Low-Molecular-Weight ; Interleukin 1 Receptor Antagonist Protein ; Lopinavir (2494G1JF75) ; Aldosterone (4964P6T9RB) ; Dexamethasone (7S5I7G3JQL) ; Heparin (9005-49-6) ; tocilizumab (I031V2H011) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2021-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-021-01520-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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