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Article: Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.

Al-Dulaimi, Nuhad Mohammed / Mohammed, Mahmood Jassim / Mutlk, Saad T / Al-Rawi, Khalid F / Ali, Hameed Hussein / Aldahham, Bilal J M / Al-Ani, Faisal / Al-Ani, Osamah / Hamed, Yaqout A / Ali, Aus T

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

2024 Volume 73, Issue 1, Page(s) 223–232

Abstract: Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 ... ...

Title translation	Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19.
Abstract	Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hyperferritinemia ; Prospective Studies ; COVID-19 ; Ferritins ; Prognosis
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2024-01-07
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1187133-7
ISSN	1210-7816 ; 0009-0530
ISSN	1210-7816 ; 0009-0530
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Article: Hyperferritinemia as a factor associated with poor prognosis in COVID-19 patients.

Al-Dulaimi, Nuhad Mohammed / Mohammed, Mahmood Jassim / Mutlk, Saad T / Al-Rawi, Khalid F / Ali, Hameed Hussein / Aldahham, Bilal J M / Al-Ani, Faisal / Al-Ani, Osamah / Hamed, Yaqout A / Ali, Aus T

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

2024 Volume 72, Issue 5, Page(s) 223–232

Title translation	Hyperferitinemie jako faktor spojený se špatnou prognózou u pacientů s COVID-19.
Abstract	Worldwide, hundreds of millions of people have been infected with COVID-19 since December 2019; however, about 20% or less developed severe symptoms. The main aim of the current study was to assess the relationship between the severity of Covid-19 and different clinical and laboratory parameters. A total number of 466 Arabs have willingly joined this prospective cohort. Out of the total number, 297 subjects (63.7%) had negative COVID-19 tests, and thus, they were recruited as controls, while 169 subjects (36.3%) who tested positive for COVID-19 were enrolled as cases. Out of the total number of COVID-19 patients, 127 (75.15%) presented with mild symptoms, and 42 (24.85%) had severe symptoms. The age range for the participants was 20 to 82 years. Compared with controls, the severity of the disease was associated with significantly high ferritin levels (P < 0.001). The severity of the disease was also associated with a significant increase in C-reactive protein (P < 0.001), D-dimer (P < 0.001), white blood cell count (WBC) (P < 0.01), IgM (P < 0.001), and Granulocytes (P < 0.01). In addition, severe COVID-19 symptoms in the current study were associated with a significant decrease in lymphocytes (P < 0.01). There was a four-fold increase in serum ferritin levels in COVID-19 patients presented with severe symptoms upon admission. The former was associated with significantly high levels of CRP and D-dimer. Thus, hyperferritinemia, together with high CRP and D-dimer concentrations, may serve as reliable predictors for disease severity and poor prognosis in Arabs with COVID-19.
MeSH term(s)	Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Hyperferritinemia ; Prospective Studies ; COVID-19 ; Ferritins ; Prognosis
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2024-01-09
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1187133-7
ISSN	1210-7816 ; 0009-0530
ISSN	1210-7816 ; 0009-0530
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Article ; Online: OAS1, OAS2 and OAS3 restrict intracellular M. tb replication and enhance cytokine secretion.

Leisching, Gina / Cole, Victoria / Ali, Aus T / Baker, Bienyameen

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2019 Volume 80S, Page(s) S77–S84

Abstract: The 2',5' (OASs) are known as mediators of the antiviral response system through activation of the RNA cleavage pathway. Interestingly, we observe OAS1, OAS2 and OAS3 upregulation in a number of gene expression signatures which discriminate active TB ... ...

Abstract	The 2',5' (OASs) are known as mediators of the antiviral response system through activation of the RNA cleavage pathway. Interestingly, we observe OAS1, OAS2 and OAS3 upregulation in a number of gene expression signatures which discriminate active TB from latent TB infection, however their biological role during bacterial infection has not yet been elucidated. We observed that the expression of these genes was associated with pathogenicity and virulence of mycobacteria as infection with Mycobacterium bovis BCG failed to significantly induce OAS expression. Further, we observed that after silencing of these genes, M. tb CFU counts increased significantly 96h post-infection in comparison to the respective controls. Luminex revealed that OAS silencing significantly decreased IL-1β, TNF-α and MCP-1 and had no effect of IL-10 secretion. We show for the first time that OAS1, 2 and 3 restrict intracellular pathogenic mycobacterial replication and enhance pro-inflammatory cytokine secretion.
MeSH term(s)	2',5'-Oligoadenylate Synthetase/genetics ; 2',5'-Oligoadenylate Synthetase/metabolism ; Cell Line ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression Regulation, Enzymologic/physiology ; Gene Silencing ; Humans ; Mycobacterium bovis ; Mycobacterium tuberculosis/physiology ; Tumor Necrosis Factor-alpha
Chemical Substances	Cytokines ; Tumor Necrosis Factor-alpha ; OAS1 protein, human (EC 2.7.7.-) ; OAS2 protein, human (EC 2.7.7.-) ; 2',5'-Oligoadenylate Synthetase (EC 2.7.7.84) ; OAS3 protein, human (EC 2.7.7.84)
Language	English
Publishing date	2019-02-26
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2019.02.029
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Zs.A 4516: Show issues

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Article: Body fat distribution and insulin resistance.

Ali, Aus T / Crowther, Nigel J

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

2005 Volume 95, Issue 11, Page(s) 878–880

MeSH term(s)	Body Fat Distribution ; Humans ; Insulin Resistance/physiology ; Metabolic Syndrome/physiopathology ; Obesity/ethnology ; Obesity/physiopathology
Language	English
Publishing date	2005-11
Publishing country	South Africa
Document type	Journal Article ; Review
ZDB-ID	390968-2
ISSN	2078-5135 ; 0256-9574 ; 0038-2469
ISSN (online)	2078-5135
ISSN	0256-9574 ; 0038-2469
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Ua VI Zs.406: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 645: Show issues

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Article ; Online: Ethnic differences in pre-adipocyte intracellular lipid accumulation and alkaline phosphatase activity.

Ali, Aus T / Chirambo, George / Penny, Clement / Paiker, Janice E / Ikram, Faisel / Psaras, George / Crowther, Nigel J

Clinica chimica acta; international journal of clinical chemistry

2015 Volume 438, Page(s) 382–387

Abstract: Alkaline phosphatase (ALP) increases lipid accumulation in human pre-adipocytes. This study was performed to assess whether ethnic differences in the prevalence of obesity in African and European females are related to differences in pre-adipocyte lipid ... ...

Abstract	Alkaline phosphatase (ALP) increases lipid accumulation in human pre-adipocytes. This study was performed to assess whether ethnic differences in the prevalence of obesity in African and European females are related to differences in pre-adipocyte lipid accretion and ALP activity. Pre-adipocytes were isolated from 13 black and 14 white females. Adipogenesis was quantified using the lipid dye, Oil red O, whilst ALP activity was assayed in cell extracts on day zero and 12days after initiating adipogenesis. Lipid levels (OD units/mg protein) were lower in pre-adipocytes from white than black females on day 0 (0.36±0.05 versus 0.44±0.03, respectively; p<0.0005) and day 12 (1.18±0.14 versus 1.80±0.22, respectively; p<0.0005), as was ALP activity (mU/mg protein) on day zero (36.5±5.8 versus 136.4±10.9, respectively; p<0.0005) and day 12 (127±16 versus 278±27, respectively; p<0.0005). Treatment of pre-adipocytes with histidine, an ALP inhibitor, blocked lipid accumulation. Thus, lipid uptake is higher in pre-adipocytes isolated from black compared to white females which parallels the obesity prevalence rates in these population groups. The reason for higher fat accumulation in pre-adipocytes isolated from black females may be related to higher ALP activity.
MeSH term(s)	Adipocytes/drug effects ; Adipocytes/enzymology ; Adipocytes/pathology ; Adipogenesis/drug effects ; Adult ; African Continental Ancestry Group ; Alkaline Phosphatase/antagonists & inhibitors ; Alkaline Phosphatase/metabolism ; Azo Compounds ; Body Mass Index ; Cell Differentiation ; European Continental Ancestry Group ; Female ; Histidine/pharmacology ; Humans ; Lipid Metabolism/drug effects ; Middle Aged ; Obesity/ethnology ; Obesity/metabolism ; Obesity/physiopathology ; Prevalence ; Primary Cell Culture ; South Africa/epidemiology
Chemical Substances	Azo Compounds ; Histidine (4QD397987E) ; Alkaline Phosphatase (EC 3.1.3.1) ; oil red O (G7S71FND9B)
Language	English
Publishing date	2015-01-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2014.09.022
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Ud II Zs.173: Show issues

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Article: The relationship between anthropometry and serum concentrations of alkaline phosphatase isoenzymes, liver-enzymes, albumin, and bilirubin.

Ali, Aus T / Paiker, Janice E / Crowther, Nigel J

American journal of clinical pathology

2006 Volume 126, Issue 3, Page(s) 437–442

Abstract: Alkaline phosphatase (ALP) is present in human preadipocytes. The aim of this study was to determine the relationship between anthropometry and serum levels of ALP isoenzymes, liver enzymes, albumin, and bilirubin. Anthropometric variables; serum total, ... ...

Abstract	Alkaline phosphatase (ALP) is present in human preadipocytes. The aim of this study was to determine the relationship between anthropometry and serum levels of ALP isoenzymes, liver enzymes, albumin, and bilirubin. Anthropometric variables; serum total, bone, liver, and intestinal ALP levels; and alanine aminotransferase (ALT), albumin, total protein, total bilirubin, and g-glutamyltransferase serum levels were measured in 100 volunteers. The levels (given as median [interquartile range]) for total (74.0 U/L [30.0 U/L] vs 62.0 U/L [22.0 U/L]; P <.05) and liver ALP (37.3 U/L [14.6 U/L] vs 26.1 U/L [12.0 U/L]; P < .05) were higher in obese than in lean subjects. The levels of the other ALP isoenzymes and blood analytes were not significantly different between these groups. Albumin and ALT were the only blood proteins studied with serum levels that correlated significantly with waist circumference. This present study demonstrates a relationship between abdominal obesity and serum ALT levels and between body mass index and ALP levels. These findings suggest that serum ALP, particularly liver ALP, is derived from adipose and hepatic tissue.
MeSH term(s)	Adult ; Age Factors ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Bilirubin/blood ; Body Mass Index ; Eating ; Female ; Humans ; Isoenzymes/blood ; Levamisole/pharmacology ; Male ; Middle Aged ; Obesity/blood ; Serum Albumin/analysis ; Sex Characteristics
Chemical Substances	Isoenzymes ; Serum Albumin ; Levamisole (2880D3468G) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1) ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2006-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/9N346GXX67B6PX5W
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Article: The effect of alkaline phosphatase inhibitors on intracellular lipid accumulation in preadipocytes isolated from human mammary tissue.

Ali, Aus T / Penny, Clem B / Paiker, Janice E / Psaras, George / Ikram, Faisel / Crowther, Nigel J

Annals of clinical biochemistry

2006 Volume 43, Issue Pt 3, Page(s) 207–213

Abstract: Background: A previous study has demonstrated that alkaline phosphatase (AP) may play a role in the control of intracellular lipid accumulation in the rodent preadipocyte cell line, 3T3-L1. The present study investigated whether AP may have a similar ... ...

Abstract	Background: A previous study has demonstrated that alkaline phosphatase (AP) may play a role in the control of intracellular lipid accumulation in the rodent preadipocyte cell line, 3T3-L1. The present study investigated whether AP may have a similar function in preadipocytes isolated from human mammary gland tissue. Methods: Preadipocyte maturation was induced in the presence or absence of the tissue non-specific AP inhibitors levamisole and histidine, and the tissue-specific AP inhibitor PheGlyGly. Cellular AP activity and adipogenesis were both assessed at 0 and 12 days post-induction of differentiation. Results: After differentiation, AP activity increased 5.1 +/- 1.3-fold in the absence and 8.9 +/- 2.8-fold (P < 0.05) in the presence of levamisole. However, adipogenesis increased 1.95 +/- 0.11-fold in the absence but only 1.36 +/- 0.06-fold (P < 0.001) in the presence of levamisole. There was a 4.2 +/- 2.2-fold increase in AP activity in the absence and a 0.51 +/- 0.46-fold (P < 0.05) decrease in the presence of histidine. Adipogenesis increased 2.09 +/- 0.35-fold in the absence of histidine but only 1.22 +/- 0.30-fold (P < 0.05) in the presence of histidine. PheGlyGly had no effects. Fluorescent microscopy showed AP activity was localized to the triglyceride-containing droplets of the cell. Conclusion: This is the first study to show that tissue non-specific AP inhibitors can block adipogenesis in human preadipocytes.
MeSH term(s)	3T3-L1 Cells ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Alkaline Phosphatase/antagonists & inhibitors ; Alkaline Phosphatase/metabolism ; Animals ; Cell Differentiation ; Enzyme Inhibitors/pharmacology ; Histidine/pharmacology ; Humans ; Levamisole/pharmacology ; Lipid Metabolism ; Lipids/biosynthesis ; Mammary Glands, Human/drug effects ; Mammary Glands, Human/metabolism ; Mice ; Oligopeptides/pharmacology
Chemical Substances	Enzyme Inhibitors ; Lipids ; Oligopeptides ; phenylalanyl-glycyl-glycine (23576-42-3) ; Levamisole (2880D3468G) ; Histidine (4QD397987E) ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2006-05
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1258/000456306776865179
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Zs.A 889: Show issues

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Article: The relationship between alkaline phosphatase activity and intracellular lipid accumulation in murine 3T3-L1 cells and human preadipocytes.

Ali, Aus T / Penny, Clem B / Paiker, Janice E / Psaras, George / Ikram, Faisel / Crowther, Nigel J

Analytical biochemistry

2006 Volume 354, Issue 2, Page(s) 247–254

Abstract: Alkaline phosphatase (ALP) is expressed in 3T3-L1 preadipocytes, and its activity increases during adipogenesis. The purpose of this study was to determine whether ALP activity could be used as a measure of intracellular lipid accumulation in human ... ...

Abstract	Alkaline phosphatase (ALP) is expressed in 3T3-L1 preadipocytes, and its activity increases during adipogenesis. The purpose of this study was to determine whether ALP activity could be used as a measure of intracellular lipid accumulation in human preadipocytes and 3T3-L1 cells and which of the factors that induce adipogenesis are responsible for stimulating ALP activity. Adipogenesis was initiated in 3T3-L1 cells by incubation with differentiation medium containing insulin, dexamethasone, and 3-isobutyl-1-methylxanthine. The effect of leaving out each of the differentiation medium components was studied. Adipogenesis was also assessed in human preadipocytes and 3T3-L1 cells in the presence of the ALP inhibitor histidine. ALP activity was measured using an automated colorimetric assay and intracellular lipid accumulation was measured using the lipid-specific dye oil red O. Removal of insulin or dexamethasone from the differentiation medium had little effect on either ALP activity or lipid accumulation in 3T3-L1 cells, while removal of IBMX blocked both. Histidine inhibited ALP activity and adipogenesis in human preadipocytes and 3T3-L1 cells. Pearson univariate correlation analysis demonstrated strong correlations between ALP activity and lipid accumulation in human preadipocytes (r=0.78, n=69) and in 3T3-L1 cells (r=0.92, n=27). These data suggest that ALP and fat storage are tightly linked during preadipocyte maturation and that the measurement of ALP activity may be a novel technique for the quantification of intracellular lipid accumulation that is more sensitive and rapid than currently used methods.
MeSH term(s)	1-Methyl-3-isobutylxanthine/pharmacology ; 3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/enzymology ; Adipocytes/metabolism ; Adipogenesis/drug effects ; Adipogenesis/physiology ; Alkaline Phosphatase/metabolism ; Animals ; Cell Differentiation/drug effects ; Culture Media ; Dexamethasone/pharmacology ; Histidine/pharmacology ; Humans ; Insulin/pharmacology ; Intracellular Fluid/metabolism ; Lipid Metabolism ; Mice
Chemical Substances	Culture Media ; Insulin ; Histidine (4QD397987E) ; Dexamethasone (7S5I7G3JQL) ; Alkaline Phosphatase (EC 3.1.3.1) ; 1-Methyl-3-isobutylxanthine (TBT296U68M)
Language	English
Publishing date	2006-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1110-1
ISSN	1096-0309 ; 0003-2697
ISSN (online)	1096-0309
ISSN	0003-2697
DOI	10.1016/j.ab.2006.04.028
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