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Article ; Online: Molecular and clinical significance of FLT3, NPM1, DNMT3A and TP53 mutations in acute myeloid leukemia patients.

Ali, Ayad M / Salih, Gaza F

2023 Volume 50, Issue 10, Page(s) 8035–8048

Abstract: Background: Acute myeloid leukemia (AML) is a type of blood cancer that affects the bone marrow and blood cells. AML is characterized by the rapid growth and accumulation of abnormal white blood cells, known as myeloblasts, which interfere with the ... ...

Abstract	Background: Acute myeloid leukemia (AML) is a type of blood cancer that affects the bone marrow and blood cells. AML is characterized by the rapid growth and accumulation of abnormal white blood cells, known as myeloblasts, which interfere with the production of normal blood cells. Aims: The main aim was to determine the relationship between these genetic alterations and the clinico-haematological parameters and prognostic factors with therapy for Iraqi patients with AML. Methods: We used Sanger Sequencing to detect the mutations in 76 AML patients. Clinical data of AML patients were retrospectively analysed to compare the prognosis of each gene mutation group. Results: Somatic mutations were identified in 47.4% of the enrolled patients in a core set of pathogenic genes, including FLT3 (18 patients, 23.7%), DNMT3A (14, 18.4%), NPM1 (11, 14.5%) and TP53 (5, 6.8%). As multiple mutations frequently coexisted in the same patient, we classified patients into 10 further groups. Two novel mutations were detected in FLT3-ITD, with new accession numbers deposited into NCBI GenBank (OP807465 and OP807466). These two novel mutations were computationally analysed and predicted as disease-causing mutations. We found significant differences between patients with and without the detected mutations in disease progression after induction therapy (remission, failure and death; pv = < 0.001) and statistically significant differences were reported in total leukocyte count (pv = < 0.0001). Conclusion: These genes are among the most frequently mutated genes in AML patients. Understanding the molecular and clinical significance of these mutations is important for guiding treatment decisions and predicting patient outcomes.
MeSH term(s)	Humans ; Nucleophosmin ; Retrospective Studies ; Clinical Relevance ; Leukemia, Myeloid, Acute/genetics ; Mutation/genetics ; DNA Modification Methylases/genetics ; fms-Like Tyrosine Kinase 3/genetics ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Nucleophosmin (117896-08-9) ; DNA Modification Methylases (EC 2.1.1.-) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; TP53 protein, human ; Tumor Suppressor Protein p53 ; FLT3 protein, human (EC 2.7.10.1)
Language	English
Publishing date	2023-08-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08680-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of asthma control

Ali Ayad Tareq

Medical Journal of Babylon, Vol 18, Iss 2, Pp 147-

An Iraqi cross sectional study

2021 Volume 148

Keywords	Medicine ; R
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health-related quality of life of chronic obstructive pulmonary disease patients

Ali Ayad Tareq

Medical Journal of Babylon, Vol 17, Iss 1, Pp 69-

2020 Volume 78

Abstract: Background: Chronic obstructive pulmonary disease (COPD) is a common health problem, characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities. COPD is usually caused by significant ... ...

Abstract	Background: Chronic obstructive pulmonary disease (COPD) is a common health problem, characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities. COPD is usually caused by significant exposure to noxious particles or gases. Objective: The objective was to assess the impact of COPD on health-related quality of life (HRQOL) of COPD patients. Materials and Methods: In this cross-sectional descriptive study, sixty stable COPD patients without significant comorbidity, not in acute severe exacerbation, who were assessed for HRQOL were interviewed at the Chest Consultant Clinic of Baghdad Teaching Hospital by using 14 questions of Centers for Disease Control and Prevention HRQOL Questionnaire between May 2017 and February 2018. Results: Of the sixty participants (80% male and 20% female), all of them were cigarettes smokers (current 57%, ex– smoker 43%)” mean ± standard deviation (SD) of age 57.4 ± 10.9 years, mean ± SD of their tobacco smoking pack years 61.0 ± 28.7. About 62% of them said that their general health is poor with COPD and 95% of them said they were limited in any way in their activities from the disease. Eighty-five percent of them said that they didn't get enough rest or sleep in the last 30 days due to their illness. Seventy-five percent 75% of them said that shortness of breath due to COPD made it hard to do usual activities in the last month. They needed help for personal care and help for routine needs in life as their answers to questionnaire questions revealed. Statically significant results (P < 0.05) also revealed that the higher COPD severity stage, the lower HRQOL. Conclusions: HRQOL of COPD patients is considerably impacted by this disease and the impaction differs according to the severity stage of COPD, the higher the severity of COPD, the lower the quality of life. As the goal of therapy in COPD is to improve symptoms and quality of life, so assessment of HRQOL is mandatory in all COPD patients and it is important part of ...
Keywords	chronic obstructive pulmonary disease ; health-related quality of life ; tobacco smoking ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of three novel DNMT3A mutations with compromising methylation capacity in human acute myeloid leukaemia.

Ali, Ayad M / Salih, Gaza F

Molecular biology reports

2022 Volume 49, Issue 12, Page(s) 11685–11693

Abstract: Background: Acute myeloid leukaemia (AML) is a complex and heterogeneous hematopoietic stem and progenitor cell malignancy characterised by the accumulation of immature blast cells in the bone marrow, blood, and other organs linked to environmental, ... ...

Abstract	Background: Acute myeloid leukaemia (AML) is a complex and heterogeneous hematopoietic stem and progenitor cell malignancy characterised by the accumulation of immature blast cells in the bone marrow, blood, and other organs linked to environmental, genetic, and epigenetic factors. Somatic mutations in the gene DNA (cytosine-5)-methyltransferase 3A (DNMT3A; NM_022552.4) are common in AML patients. Methods: In this study, we used Sanger sequencing to detect the mutations in the DNMT3A gene in 61 Iraqi AML patients, Hence, the protein function and stability within alterations were identified and analyzed using a variety of computational tools with the goal of determining how these changes affect total protein stability, and then the capacity of methylation was analyzed by methylation specific PCR MSP status at CpG islands. Results: Three novel mutations in exon 23 of DNMT3A were identified in 14 patients (22.9%; V877I, N879delA, and L888Q). The V877I and L888Q substitutions are caused by heterozygous C2629G > A and C2663T > A mutations, respectively, while frameshift mutation C2635delA caused protein truncation with stop codon N879T. Methylation was detected in the DNMT3A promoter region in 9 patients carrying DNMT3A mutations (64.28%) by MSP, and we found significant correlations between DNMT3A mutations and promoter methylation (p = 8.52 × 10 Conclusion:* Our findings highlight the importance of studying the effects of DNMT3A methylation alteration in Iraqi populations beyond R882 substitutions in the leukemogenic pathway so that patient treatment can be tailored to prevent therapeutic resistance and relapse.
MeSH term(s)	Humans ; Middle Aged ; DNA Methylation/genetics ; DNA Methyltransferase 3A/genetics ; DNA Modification Methylases/genetics ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Methylation ; Mutation/genetics ; Neoplasm Recurrence, Local/genetics
Chemical Substances	DNA Methyltransferase 3A (EC 2.1.1.37) ; DNA Modification Methylases (EC 2.1.1.-) ; DNMT3A protein, human
Language	English
Publishing date	2022-09-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07977-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Determinants of impact factor and Eigenfactor score in otolaryngology journals.

Ali, Ayad / Phillips, Katie M / Sedaghat, Ahmad R

Laryngoscope investigative otolaryngology

2023 Volume 8, Issue 2, Page(s) 380–393

Abstract: Objective: This study aims to identify determinants of high impact, measured by Impact Factor (IF) and Eigenfactor score, among otolaryngology journals.: Methods: Bibliometric data of "otorhinolaryngology" journals were collected from the Journal ... ...

Abstract	Objective: This study aims to identify determinants of high impact, measured by Impact Factor (IF) and Eigenfactor score, among otolaryngology journals. Methods: Bibliometric data of "otorhinolaryngology" journals were collected from the Journal Citation Reports (JCR) database. For the years 2009-2020, we collected normalized Eigenfactor score, 5-year IF, immediacy index, fraction of IF from journal-self citation, proportion and magnitude of published citable articles, and total citation counts. High-IF and -Eigenfactor journals were considered those within the top-quartile of that metric each respective year. Results: High-IF and -Eigenfactor otolaryngology journals displayed higher 5-year IFs, immediacy indexes, and IF without self-citation ( Conclusion: Sustained publication of impactful articles is the dominant driver of high IF and Eigenfactor score. Eigenfactor score reflects a unique evaluation of otolaryngology journals; ranking otolaryngology journals by their Eigenfactor scores significantly alters journal ranking compared to ranking by IF. Level of evidence: NA.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of three novel DNMT3A mutations with compromising methylation capacity in human acute myeloid leukaemia

Ali, Ayad M. / Salih, Gaza F.

Mol Biol Rep. 2022 Dec., v. 49, no. 12 p.11685-11693

2022

Abstract: BACKGROUND: Acute myeloid leukaemia (AML) is a complex and heterogeneous hematopoietic stem and progenitor cell malignancy characterised by the accumulation of immature blast cells in the bone marrow, blood, and other organs linked to environmental, ... ...

Abstract	BACKGROUND: Acute myeloid leukaemia (AML) is a complex and heterogeneous hematopoietic stem and progenitor cell malignancy characterised by the accumulation of immature blast cells in the bone marrow, blood, and other organs linked to environmental, genetic, and epigenetic factors. Somatic mutations in the gene DNA (cytosine-5)-methyltransferase 3A (DNMT3A; NM_022552.4) are common in AML patients. METHODS: In this study, we used Sanger sequencing to detect the mutations in the DNMT3A gene in 61 Iraqi AML patients, Hence, the protein function and stability within alterations were identified and analyzed using a variety of computational tools with the goal of determining how these changes affect total protein stability, and then the capacity of methylation was analyzed by methylation specific PCR MSP status at CpG islands. RESULTS: Three novel mutations in exon 23 of DNMT3A were identified in 14 patients (22.9%; V877I, N879delA, and L888Q). The V877I and L888Q substitutions are caused by heterozygous C2629G > A and C2663T > A mutations, respectively, while frameshift mutation C2635delA caused protein truncation with stop codon N879T*. Methylation was detected in the DNMT3A promoter region in 9 patients carrying DNMT3A mutations (64.28%) by MSP, and we found significant correlations between DNMT3A mutations and promoter methylation (p = 8.52 × 10⁵). In addition, we found a significant overrepresentation of DNMT3A methylation status in patients ≥ 50 years old (p = 0.025). CONCLUSION: Our findings highlight the importance of studying the effects of DNMT3A methylation alteration in Iraqi populations beyond R882 substitutions in the leukemogenic pathway so that patient treatment can be tailored to prevent therapeutic resistance and relapse.
Keywords	DNA ; blood ; bone marrow ; epigenetics ; exons ; frameshift mutation ; heterozygosity ; humans ; methylation ; myeloid leukemia ; patients ; promoter regions ; protein content ; relapse ; stem cells ; stop codon ; therapeutics
Language	English
Dates of publication	2022-12
Size	p. 11685-11693.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07977-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Impact of lymphopenia on COVID-19 infection severity

Ali Ayad Tareq / Naqaa Majeed Hameed / Tabarak Saleem Abdulshaheed

Medical Journal of Babylon, Vol 19, Iss 1, Pp 99-

2022 Volume 101

Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparing effects of beetroot juice and Mediterranean diet on liver enzymes and sonographic appearance in patients with non-alcoholic fatty liver disease: a randomized control trials.

Fateh, Hawal Lateef / Rashid, Sameeah Abdulrahman / Muhammad, Sarmad S / Al-Jaf, Sabah H / Ali, Ayad M

Frontiers in nutrition

2023 Volume 10, Page(s) 1181706

Abstract: Background: In both developed and developing countries, non-alcoholic fatty liver disease (NAFLD) has lately risen to the top of the list of chronic liver illnesses. Although there is no permanent cure, early management, diagnosis, and treatment might ... ...

Abstract	Background: In both developed and developing countries, non-alcoholic fatty liver disease (NAFLD) has lately risen to the top of the list of chronic liver illnesses. Although there is no permanent cure, early management, diagnosis, and treatment might lessen its effects. The purpose of conducting the current study is to compare the effects of beetroot juice and the Mediterranean diet on the lipid profile, level of liver enzymes, and liver sonography in patients with NAFLD. Methods: In this randomized controlled trial, 180 people with a mean age of (45.19 ± 14.94) years participated. Participants ranged in age from 19 to 73. The mean weight before intervention was (82.46 ± 5.97) kg, while the mean weight after intervention was roughly (77.88 ± 6.26) kg. The trial lasted for 12 weeks. The participants were split into four groups: control, a Mediterranean diet with beet juice (BJ + MeD), Mediterranean diet alone (MeD), and beetroot juice (BJ). The Mediterranean diet included fruits, vegetables, fish, poultry, and other lean meats (without skin), sources of omega-3 fatty acids, nuts, and legumes. Beetroot juice had 250 mg of beetroot. Data analysis was done using SPSS software (version 26.0). Results: Following the intervention, Serum Bilirubin, alkaline phosphatase (ALP), alanine transaminase (ALT), serum cholesterol (CHOL), triglyceride (TG), and low-density lipoprotein (LDL) levels were significantly decreased in the BJ + MeD, BJ, and MeD groups ( Conclusion: The research findings indicate a significant reduction in hepatic steatosis among the groups receiving beetroot juice (BJ) and beetroot juice combined with the Mediterranean diet (BJ + MeD). This suggests that beetroot juice holds potential as an effective treatment for non-alcoholic fatty liver disease (NAFLD) in adults. Furthermore, the combination of beetroot juice with the Mediterranean diet showed enhanced efficacy in addressing NAFLD.
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1181706
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Article ; Online: Response to comments to the editor on "Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers".

Ali, Ayad M / Tofiq, Ahmed M / Rostam, Hassan M / Ali, Kameran M / Tawfeeq, Hassan M

Journal of medical virology

2023 Volume 95, Issue 5, Page(s) e28820

MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; Patient Acuity
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28820
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Article ; Online: Corrigendum on "Disease severity and efficacy of homologous vaccination among patients infected with SARS-CoV-2 Delta or Omicron VOCs, compared to unvaccinated using main biomarkers".

Ali, Ayad M / Tofiq, Ahmed M / Rostam, Hassan M / Ali, Kameran M / Tawfeeq, Hassan M

Journal of medical virology

2023 Volume 95, Issue 5, Page(s) e28824

Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Published Erratum
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28824
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