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Article ; Online: Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin.

Ali, Iman A Mohammed / Ahmed, Ali Ben / Al-Ahmed, Hazim Ismail

2023 Volume 13, Issue 1, Page(s) 2256

Abstract: The present study used physics to synthesize silver nanoparticles using aqueous extract of fresh garlic as reducing and as a stabilizing agent silver nitrate solution. This method has proven to be environmentally friendly and safe for the synthesis of ... ...

Abstract	The present study used physics to synthesize silver nanoparticles using aqueous extract of fresh garlic as reducing and as a stabilizing agent silver nitrate solution. This method has proven to be environmentally friendly and safe for the synthesis of stable silver nanoparticles. The acquisition of silver nanoparticles was confirmed by optical detection, that is, by changing the color of the liquid to transparent orange and then blackish brown. Then, the characterization was confirmed using other assays. In this study, it was found that the absorption peak of silver nanoparticles was at a wavelength of 420 nm and the particle size ranged between [50-350] nm. The surface roughness of silver oxide/silver nanoparticles was 9.32 nm with an average square roughness of 21.19 nm, and the energy dispersive spectra showed that the absorption peak was in the region of 3 keV, indicating that the nanoparticles contained crystalline silver. In this study, the stability of the silver nanoparticles was good, as ZP reached (- 19.5). The results confirm that the conductivity increases with the increase in frequency due to the high energy of the photons, which causes the electrons to vibrate in the energy levels and thus increase the energy in the mitochondria and increase the movement of sperm in the Diabetic mice treated with doses of silver nanoparticles. The toxic effect of silver nanoparticles has been evaluated in other studies, in addition to evaluating antioxidants, antifungals, treating cancer cells, regulating cholesterol levels, the effect of these nanoparticles on sex cells in pregnant female mice, heart tension, and many other tests. In this study, the activities and efficacy of silver nanoparticles on sperms were determined in male mice with diabetes caused by STZ, and the treatment period was long (35 days) so that the evaluation period was a complete life cycle of male sex cells and within a long period of time and at an average nano size. This has not been studied in other previous studies. The results indicate that the biosynthesis of silver nanoparticles using garlic plant led to positive results on sperm treatments by contributing to an increase in the number of sperm with reactivation and a decrease in abnormalities in addition to a decrease in mortality due to diabetes. This is evidence that the synthesis of silver nanoparticles using garlic plant size (50-350 nm) can treat impotence and be used in the future in the treatment of many diseases without side effects.
MeSH term(s)	Male ; Animals ; Mice ; Metal Nanoparticles/chemistry ; Metformin/pharmacology ; Diabetes Mellitus, Experimental/drug therapy ; Semen ; Silver ; Spermatozoa ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Green Chemistry Technology/methods ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Metformin (9100L32L2N) ; Silver (3M4G523W1G) ; Plant Extracts
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29412-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin.

Ali, Iman A Mohammed / Ahmed, Ali Ben / Al-Ahmed, Hazim Ismail

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6659

Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33579-0
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Article ; Online: Prophylactic tranexamic acid at delivery: if not now, when?

Bamber, J H / Ali, I A M

International journal of obstetric anesthesia

2021 Volume 49, Page(s) 103232

MeSH term(s)	Antifibrinolytic Agents/therapeutic use ; Humans ; Postpartum Hemorrhage/prevention & control ; Tranexamic Acid/therapeutic use
Chemical Substances	Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2021-11-02
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1086024-1
ISSN	1532-3374 ; 0959-289X
ISSN (online)	1532-3374
ISSN	0959-289X
DOI	10.1016/j.ijoa.2021.103232
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Article ; Online: Immunochemistry-Based Diagnosis of Extrapulmonary Tuberculosis: A Strategy for Large-Scale Production of MPT64-Antibodies for Use in the MPT64 Antigen Detection Test.

Hoel, Ida Marie / Ali, Iman A Mohammed / Ishtiaq, Sheeba / Sviland, Lisbet / Wiker, Harald / Mustafa, Tehmina

Antibodies (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract: Tuberculosis (TB) is a global health problem. The immunohistochemistry (IHC)-based MPT64 antigen detection test has shown promising results for diagnosing extrapulmonary TB in previous studies. However, the anti-MPT64 antibody currently used in the test ... ...

Abstract	Tuberculosis (TB) is a global health problem. The immunohistochemistry (IHC)-based MPT64 antigen detection test has shown promising results for diagnosing extrapulmonary TB in previous studies. However, the anti-MPT64 antibody currently used in the test is in limited supply, and reproduction of a functional antibody is a prerequisite for further large-scale use. Various antigen-adjuvant combinations and immunisation protocols were tested in mice and rabbits to generate monoclonal and polyclonal antibodies. Antibodies were screened in IHC, and the final new antibody was validated on clinical human specimens. We were not able to generate monoclonal antibodies that were functional in IHC, but we obtained multiple functional polyclonal antibodies through careful selection of antigen-adjuvant and comprehensive screening in IHC of both pre-immune sera and antisera. To overcome the limitation of batch-to-batch variability with polyclonal antibodies, the best performing individual polyclonal antibodies were pooled to one final large-volume new anti-MPT64 antibody. The sensitivity of the new antibody was in the same range as the reference antibody, while the specificity was somewhat reduced. Our results suggest that it possible to reproduce a large-volume functional polyclonal antibody with stable performance, thereby securing stable supplies and reproducibility of the MPT64 test, albeit further validation remains to be done.
Language	English
Publishing date	2021-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661514-9
ISSN	2073-4468 ; 2073-4468
ISSN (online)	2073-4468
ISSN	2073-4468
DOI	10.3390/antib10030034
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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

Nepogodiev D. / Bhangu A. / Glasbey J.C. / Li E. / Omar O.M. / Simoes J.F. / Abbott T.E. / Alser O. / Arnaud A.P. / Bankhead-Kendall B.K. / Breen K.A. / Cunha M.F. / Davidson G.H. / Di Saverio S. / Gallo G. / Griffiths E.A. / Gujjuri R.R. / Hutchinson P.J. / Kaafarani H.M. /

Lederhuber H. / Loffler M.W. / Mashbari H.N. / Minaya-Bravo A. / Morton D.G. / Moszkowicz D. / Pata F. / Tsoulfas G. / Venn M.L. / Cox D. / Roslani A.C. / Alakaloko F. / de Vries J.-P.P. / Aaraj M.A. / Abbott S.J. / Abdalla M.O. / Abdelaal A.S. / Ademuyiwa A.O. / Aherne T.M. / Ali O.M. / Alkadeeki G.Z. / Almeida A.C. / Alrahawy M.M. / Ambler G.K. / Alameer E. / Andreani S.M. / De Andres-Asenjo B. / Antonanzas L.L. / Aoun S.G. / Ashoush F.M. / Augestad K.M. / Avellana R.B. / Ayeni F.A. / Ayorinde J.O. / Babu B.H. / Baig M.M. / Bajomo O.M. / Baker O.J. / Baker M.P. / Baldwin A.J. / Ban V.S. / Baron R.D. / Barranquero A.G. / Barry C.P. / DI Bartolomeo A. / Bass G.A. / Bath M.F. / Batjer H.H. / Beamish A.J. / Belgaumkar A.P. / Bence M.N. / Benson R.A. / Bernal-Sprekelsen J.C. / Bhama A.R. / Bhavaraju A.V. / Biffl W.L. / Blundell C.M. / Boddy A.P. / Borgstein A.B. / Bosanquet D.C. / Bosch K.D. / Bouhuwaish A.E. / Bozkurt M.A. / Brathwaite C.E. / Brown B.C. / Brown O.D. / Brown A.K. / Buarque I.L. / Bueno-Canones A.D. / Bulugma M.R. / Burke J.R. / Byrne M.H. / Cagigal-Ortega E.P. / Callcut R.A. / DI Candido F. / Canova M.E. / Carlos W.J. / Caruana E.J. / Cato L.D. / Catton A.B. / Ceretti A.P. / Chase T.J. / Chiara F.D. / Chowdhury A.H. / Chung E.A. / Cicerchia P.M. / Clough E.C. / Coleman N.L. / Collins C.G. / Collins M.L. / Colonna E.T. / Comini L.V. / Coughlin P.A. / Cruzado L.F.-G. / Davidson B.R. / Davies R.J. / Davies E.J. / Davis N.F. / Dawson B.E. / Dean B.J. / Delgado M.G.-C. / Diaz J.J. / Dickson K.E. / Diez-Alonso M.M. / Dixon J.R. / Doe M.J. / Drake T.D. / Drake F.T. / Duffy J.P. / Dunne D.F. / Dunne N.J. / Duran-Munoz-Cruzado V.M. / Durst A.Z. / Eardley N.J. / Edwards J.G. / Elfallal A.H. / Elfiky M.M. / Elliott J.A. / Emile S.H. / Emslie K.M. / Endorf F.W. / Engel J.L. / Enjuto D.T. / Etchill E.W. / Evans J.P. / Fahey B.A. / Faria C.S. / Feo C.V. / Ferguson H.J. / Fernandez B.D. / Fernandez A.G. / Fernandez A.J. / Fernandez-Pacheco B.C. / Fitzgerald J.E. / Fonsi G.B. / Font R.F. / Fowler A.L. / Fretwell K.R. / Fructuoso L.S. / Fusai G.K. / Garcia M.H. / Garcia-Urena M.A. / Gill C.K. / Gisbertz S.S. / Del Giudice R. / Giuffrida M.C. / Di Giuseppe M. / Gomez M.F. / Guariglia C.A. / Hainsworth A.J. / Hall B.J. / Hall J.R. / Hammond J.S. / Haqqani M.H. / Harrison E.M. / Hazelton J.P. / van Heinsbergen M. / Hill A.D. / Hing C.B. / Hirji S.A. / Ho M.W. / Holbrook C.M. / Holme T.J. / Hopkins J.C. / Hopkinson D.N. / Hossain F.S. / Hudson V.E. / Hughes J.L. / Hwang E.S. / Ibrahim M.A. / Isolani S.M. / Jenkinson M.D. / Jenny H.E. / Jeyaretna D.S. / Jones R.P. / Jones A.P. / Jonker P.K. / Jonsson M.L. / Joyce D.P. / Kalkwarf K.J. / Kamarajah S.K. / El Kassas M. / Kavanagh D.O. / Keatley J.M. / Khalefa M.A. / Khan J.S. / Kirmani B.H. / Kisiel A.P. / Kouris S.M. / Kowal M.R. / Labib P.L. / Larkin J.O. / Lauscher J.C. / Leclercq W.K. / Ledesma F.S. / Leite-Moreira A.M. / Leung E.Y. / Lewis S.E. / Lima M.J. / Lin D.J. / Liu H.H. / Lowery A.J. / Lozano S.M. / Luney C.R. / Maia M.M. / Mariani N.M. / Marino M.V. / Marra A.A. / Marsh C.L. / Martin R.C. / McCluney S.J. / McIntyre R.C. / Mckay S.C. / McKevitt K.L. / Meagher A.D. / Mehdi M.Q. / Mehigan B.J. / Gonzalez-De Miguel M. / De Miguel-Ardevines M.-C. / Mills S.J. / Mohan H.M. / Moir J.A. / Monson J.R. / Monteiro J.M. / Montella M.T. / Montesinos C.S. / Morgom M.M. / Moura F.S. / Muguerza J.M. / Murphy S.H. / De Nardi P. / Naumann D.N. / Neary P.C. / Neely D.T. / Ng-Kamstra J.S. / Ngu A.W. / Nguyen T.A. / Nita G.E. / Nunes Q.M. / Nygaard R.M. / O'Meara L.B. / O'Neill J.R. / Okafor B.U. / Olson S.A. / Oo A.Y. / Ormazabal P.C. / Osorio A.L. / Pachl M.J. / Parry J.T. / Patel P.K. / Perez-Sanchez L.E. / Pevidal A.N. / Pezzuto A.P. / Philp M.M. / Pinkney T.D. / Pollok J.M. / Povey M.G. / Poza A.A. / Rajgor A.D. / Rao J.N. / Raptis D.A. / Rice H.E. / Ridgway P.F. / Rivas A.M. / Rodriguez-Sanjuan J.C. / Rogers L.J. / Da Roit A. / Rollett R.A. / Romera J.L. / Rooney S.M. / Roxo V.I. / Le Roy B. / Rubio E.E. / Ruiz C.C. / Ruiz M.L. / Ryan E.J. / Saad A.R. / Saeed S.A. / Salama H.A. / Salamah A.A. / Sampietro G.M. / Sarma D.R. / Schaffer K.B. / Schnitzbauer A.A. / Scurrah R.J. / Serevina O.L. / Serralheiro P.A. / Sewards J.M. / Shackcloth M.J. / Shaw A.V. / Sheel A.R. / Sica G.S. / De Simone V. / Singh A.A. / Singh R.P. / Skelly B.L. / Smith H.G. / Sohail A.H. / Spalding D.R. / Springford L.R. / Ssentongo A.E. / Steinkamp P.J. / Stevens K.A. / Stewart G.D. / Stylianides N.A. / Sullivan T.B. / Taher A.S. / Tamimy M.S. / Tang A.M. / Tebala G.D. / Tejero-Pintor F.J. / Thaha M.A. / Thomas A.J. / De Toma G. / La Torre F. / Torres A.J. / Townshend D.N. / Trout I.M. / Tucker S.C. / Ubhi H.K. / Vega V.A. / Velmahos G.C. / Velopulos C.G. / Viswanath Y.K. / Vivas A.A. / Wade R.G. / Wadley M.S. / Wall J.J. / Walters A.M. / Warren O.J. / Weerasinghe C.K. / Wilkin R.J. / Williams K.J. / Winter S.C. / Wormald J.C. / Wright F.L. / Xyda S.E. / Young A.L. / Youssef M.M. / Yousuf F.B. / El Youzouri H. / Zappa M.A. / Abate E. / Abdalaziz H. / Abdelkarim M. / Abdou H. / Aboelkassem-Ibrahim A. / Abuown A. / Acebes-Garcia F. / Acharya M. / Adamina M. / Addae-Boateng E. / Aftab R. / Agarwal A. / Aguilar J. / Ahmed Y. / Aitken E. / Al-Azzawi M. / Al-Embideen S. / Al-Masri M. / Al-Najjar H. / Al-Sukaini A. / Alam R. / Alderson D. / Aliyeva Z. / Aljanadi F. / Almasri M. / Alonso-Ortuno P. / Altintoprak F. / Amira G. / Amjad R. / Anania G. / Andabaka T. / Angelou D. / Annamalai S. / Annessi V. / Anthoney J. / Anwar S. / Anwer M. / Aragon-Chamizo J. / Ardito A. / Arigoni M. / Armao T. / Arminio A. / Armstrong L. / Arnaud A. / Asaad P. / Ashcroft J. / Ashmore C. / Asqalan A. / Asti E. / Aubry E. / Aytac E. / Ayuso-Herrera E. / Baeza M. / Bailon-Cuadrado M. / Bakmaz B. / Baldi C. / Baldini E. / Baldo S. / Ballabio M. / Baloyiannis I. / Baltazar G. / Bambina F. / Bandiera A. / Barlow E. / Barmasse R. / Barmpagianni C. / Baronio G. / Barra F. / Bartsch A.-M. / Basgaran A. / Basha A. / Bashkirova V. / Bastazza M. / Baumber R. / Belcher E. / Belvedere A. / Benitez-Linero I. / Bergeat D. / Bernasconi M. / Bhalla A. / Bhutiani N. / Bianco F. / Bisagni P. / Blake I. / Blanco-Colino R. / Blazquez-Martin A. / Boal M. / Bonavina L. / Bonavina G. / Bond-Smith G. / Booth K. / Borges F. / Borghi F. / Bouchagier K. / Bourke G. / Boyle E. / Brachini G. / Brain J. / Brar A. / Breckles L. / Bretagnol F. / Brixton G. / Bruzzaniti P. / Bueser T. / Burnside N. / Caballero A. / Calcerrada-Alises E. / Callahan M. / Camarero E. / Campagnaro T. / Campanelli M. / Candiani M. / Cantalejo-Diaz M. / Cao H. / Capelli P. / Capizzi V. / Carcano G. / Carissimi F. / Carlini M. / Carlucci M. / Carmichael H. / Carrasco M. / Carrillo M. / Carvello M. / Casati M. / Castoro C. / Catalan V. / Cavaleiro S. / Cellerino P. / Centinaio G. / Cernei C. / Cerro C. / Cervellera M. / Chakrabortee S. / Chamberlain S. / Chan J. / Chang G. / Chaudhry D. / Chebaro A. / Chen D. / Chetty G. / Chia Z. / 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G.S. / Mateo-Sierra O. / Martinez-Perez C. / Serrano Gonzalez J. / Hernandez Bartolome M.A. / Diaz Perez D. / Gutierrez Samaniego M. / Galindo Jara P. / Sharma N. / Smart N.J. / Keller D.S.

an international cohort study

2020

Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

Abstract	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p<0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Keywords	Adult ; Aged ; Betacoronavirus ; Coronavirus Infections ; Elective Surgical Procedures ; Emergency Medical Services ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia ; Viral ; Postoperative Complications ; Respiratory Tract Diseases ; Retrospective Studies ; Surgical Procedures ; Operative ; Young Adult ; covid19
Subject code	610 ; 616
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

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an international cohort study

2020

Abstract	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
Keywords	covid19
Language	English
Publisher	Elsevier
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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