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  1. Article ; Online: Targeting BMPR2 Trafficking with Chaperones: An Important Step toward Precision Medicine in Pulmonary Arterial Hypertension.

    Andruska, Adam / Ali, Mohammed Khadem / Spiekerkoetter, Edda

    American journal of respiratory cell and molecular biology

    2020  Volume 63, Issue 2, Page(s) 137–138

    MeSH term(s) Bone Morphogenetic Protein Receptors, Type II ; Cysteine ; Familial Primary Pulmonary Hypertension ; Humans ; Precision Medicine ; Pulmonary Arterial Hypertension
    Chemical Substances BMPR2 protein, human (EC 2.7.11.30) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2020-0130ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: The Human Respiratory Microbiome: Current Understandings and Future Directions.

    Zhao, Lan / Luo, Jun-Li / Ali, Mohammed Khadem / Spiekerkoetter, Edda / Nicolls, Mark R

    American journal of respiratory cell and molecular biology

    2022  Volume 68, Issue 3, Page(s) 245–255

    Abstract: Microorganisms colonize the human body. The lungs and respiratory tract, previously believed to be sterile, harbor diverse microbial communities and the genomes of bacteria (bacteriome), viruses (virome), and fungi (mycobiome). Recent advances in ... ...

    Abstract Microorganisms colonize the human body. The lungs and respiratory tract, previously believed to be sterile, harbor diverse microbial communities and the genomes of bacteria (bacteriome), viruses (virome), and fungi (mycobiome). Recent advances in amplicon and shotgun metagenomic sequencing technologies and data-analyzing methods have greatly aided the identification and characterization of microbial populations from airways. The respiratory microbiome has been shown to play roles in human health and disease and is an area of rapidly emerging interest in pulmonary medicine. In this review, we provide updated information in the field by focusing on four lung conditions, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis. We evaluate gut, oral, and upper airway microbiomes and how they contribute to lower airway flora. The discussion is followed by a systematic review of the lower airway microbiome in health and disease. We conclude with promising research avenues and implications for evolving therapeutics.
    MeSH term(s) Humans ; Lung/microbiology ; Asthma ; Pulmonary Disease, Chronic Obstructive/microbiology ; Microbiota ; Cystic Fibrosis/microbiology
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0208TR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L

    Biswas, Nripendra Nath / Saha, Subarna / Ali, Mohammed Khadem

    Hainan Medical University Asian Pacific Journal of Tropical Biomedicine. 2014 Oct., v. 4

    2014  

    Abstract: To investigate potential antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L. in different in vivo and in vitro experimental models.In vitro DPPH radical scavenging assay was used to evaluate the ... ...

    Abstract To investigate potential antioxidant, antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Mentha arvensis L. in different in vivo and in vitro experimental models.In vitro DPPH radical scavenging assay was used to evaluate the antioxidant activity of the plant extract. In vivo analgesic activity was carried out by acetic acid-induced writhing test in Swiss albino mice. All studies in mice were undertaken at the doses of 250 and 500 mg/kg body weight. Antibacterial activity was studied by disk diffusion assay against some Gram-positive and Gram-negative bacterial strains. Brine shrimp lethality assay was used to investigate cytotoxicity effects of the plant extract.The extract showed free radical scavenging activity in the DPPH assay (IC50∼41 μg/mL) compared to the standard antioxidant ascorbic acid (IC50∼19 μg/mL). The extract also produced prominent antimicrobial activity against Salmonella typhi, Salmonella paratyphi, Shigella boydii, Streptococcus pyogenes and Streptococcus aureus compared to standard drug kanamycin at the dose of 30 μg/disc. The extract exhibited lethality against the brine shrimp nauplii with the LC50 values of 40 μg/mL, and also 90% mortality (LC90) value was found to be 160 μg/mL. In analgesic test, the extract demonstrated statistically significant (P<0.01) analgesic effect in acetic acid induced writhing in white albino mice at both dose levels.These results suggest that the ethanolic extract of Mentha arvensis L. has potential antioxidant, antibacterial, cytotoxic and analgesic activities that support the ethnopharmacological uses of this plant.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Artemia ; Gram-negative bacteria ; Mentha arvensis ; Salmonella Typhi ; Shigella boydii ; Streptococcus pyogenes ; acetic acid ; albino ; analgesic effect ; antibacterial properties ; antioxidant activity ; ascorbic acid ; body weight ; cytotoxicity ; death ; disk diffusion antimicrobial test ; drugs ; free radical scavengers ; kanamycin ; lethal concentration 50 ; mortality ; nauplii ; plant extracts ; traditional medicine ; writhing test
    Language English
    Dates of publication 2014-10
    Size p. 792-797.
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2221-1691
    DOI 10.12980/APJTB.4.2014C1298
    Database NAL-Catalogue (AGRICOLA)

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