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  1. Article ; Online: Prevalence of Thiamine Deficiency in Pregnancy and its impact on fetal outcome in an area endemic for thiamine deficiency.

    Kareem, Ozaifa / Mufti, Samiya / Nisar, Sobia / Tanvir, Masood / Muzaffer, Umar / Ali, Nahida / Sheikh, Ishfaq Ahmad / Bader, Ghulam Nabi

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 5, Page(s) e0011324

    Abstract: Background: Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. ... ...

    Abstract Background: Pregnancy is a metabolically challenging state with increased nutritional demand. Thiamine is an important cofactor in various metabolic pathways and thus its deficiency could have a serious impact on both maternal and fetal outcomes. Kashmir has thiamine deficiency in endemic proportions, with multiple reports of infantile beriberi, postpartum neuropathy, and gastric beriberi. This prompted us to assess the extent of the burden of thiamine deficiency during pregnancy.
    Methods: This cross-sectional study was conducted for a period of two years in pregnant women attending the antenatal clinic. A demographic, clinical, biochemical, and dietary assessment was done in all participants. The whole blood thiamine levels were assessed by high-performance liquid chromatography.
    Results: A total of 492 participants were included in the study with a mean age of 30.30±4.57 years and a mean BMI of 24.25±3.32 Kg/m2. The mean whole blood thiamine level of all participants was 133.29±14.32 nmol/L. Low thiamine status was present in 38.2% (n = 188) of participants. Participants with low thiamine had poor perinatal outcomes, with 3.1% (n = 6) reporting early infant death.
    Conclusion: A high prevalence of thiamine deficiency occurs in pregnant women of Kashmir. Low thiamine is associated with poor nutritional status as well as poor perinatal outcomes.
    Trial registration: CTRI/2022/07/044217.
    MeSH term(s) Infant ; Female ; Humans ; Pregnancy ; Adult ; Beriberi/complications ; Prevalence ; Cross-Sectional Studies ; Thiamine Deficiency/epidemiology ; Thiamine Deficiency/complications ; Thiamine
    Chemical Substances Thiamine (X66NSO3N35)
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implications of Shrinking Cryosphere Under Changing Climate on the Streamflows in the Lidder Catchment in the Upper Indus Basin, India

    Romshoo, Shakil Ahmad / Ali Nahida / Dar Reyaz A / Marazi Asif / Rashid Irfan / Zaz Sumira N

    Arctic, antarctic, and alpine research. 2015 Nov., v. 47, no. 4

    2015  

    Abstract: Lidder tributary in the Upper Indus Basin (UIB) of the Himalayas, an important source of surface and ground water, is experiencing clear indications of climate change. In the basin, minimum, maximum, and average temperatures are showing a significant ... ...

    Abstract Lidder tributary in the Upper Indus Basin (UIB) of the Himalayas, an important source of surface and ground water, is experiencing clear indications of climate change. In the basin, minimum, maximum, and average temperatures are showing a significant increasing trend in all the four seasons. Precipitation is showing insignificant decrease over time in the basin. However, the proportion of snow is decreasing and correspondingly, the proportion of rains is increasing. The temperature projections also show increasing trends for the end of this century. The time-series analysis of the Normalized Difference Snow Index (NDSI) shows a depletion of the snow-cover in the region. Furthermore, during the past 51 years, the glacier area in the basin has decreased from 46.09 km² in 1962 to 33.43 km² in 2013, a depletion of 27.47%. As a result of glacier recession in the basin, the streamflow fed predominantly by snowmelt and glacier melt, is showing a statistically significant decline since the mid-1990s. The declining streamflows have potential to adversely affect agriculture, energy production, tourism, and even domestic water supplies. The Snowmelt Runoff Model (SRM) was tested for estimating the runoff from this glaciated basin on an operational basis. The average simulated runoff 11.94 m³ s⁻¹ at the outlet is in concordance with the average measured runoff 13.51 m³ s⁻¹ showing R² of 0.82. The model could thus be used for snowmelt runoff estimation, on an operational basis, for judicious utilization of the depleting water resources in the region.
    Keywords basins ; climate change ; energy ; glaciers ; melting ; runoff ; snow ; snowmelt ; Snowmelt Runoff Model ; stream flow ; temperature ; time series analysis ; tourism ; water supply ; watersheds ; India
    Language English
    Dates of publication 2015-11
    Size p. 627-644.
    Publishing place Institute of Arctic and Alpine Research (INSTAAR), University of Colorado
    Document type Article
    ZDB-ID 2045941-5
    ISSN 1938-4246 ; 1523-0430
    ISSN (online) 1938-4246
    ISSN 1523-0430
    DOI 10.1657%2FAAAR0014-088
    Database NAL-Catalogue (AGRICOLA)

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