Article: Associated effects of clinical characteristics, risk factors, and comorbidity on disease severity and mortality among patients with COVID-19 in Sulaimani City/ Kurdistan Region of Iraq.
2023 Volume 46, Issue 2, Page(s) 170–185
Abstract: The effects of clinical symptoms, laboratory indicators, and comorbidity status of SARS-CoV-2-infected patients on the severity of disease and the risk of death were investigated. Questionnaires and electronic medical records of 371 hospitalized COVID-19 ...
| Abstract | The effects of clinical symptoms, laboratory indicators, and comorbidity status of SARS-CoV-2-infected patients on the severity of disease and the risk of death were investigated. Questionnaires and electronic medical records of 371 hospitalized COVID-19 patients were used for data collection (demographics, clinical manifestation, comorbidities, laboratory data). Association among categorical variables was determined using Kolmogorov-Smirnov test (P-value ≤0.05). Median age of study population (249 males, 122 females) was 65 years. Roc curves analysis found that age ≥64 years and age ≥67 years are significant cut-offs identifying patients with more severe disease and mortality at 30 days. CRP values at cut-off ≥80.7 and ≥95.8 significantly identify patients with more severe disease and mortality. Patients with more severe disease and risk of death were significantly identified with platelet value at the cut-off ≤160,000, hemoglobin value at the cut-off ≤11.7, D-Dimer values ≥1383 and ≥1270, and with values of neutrophil granulocytes (≥8.2 and ≤2) and lymphocytes (≤2 and ≤2.4). Detailed clinical investigation suggests granulocytes together with lymphopenia may be a potential indicator for diagnosis. Older age, several comorbidities (cancer, cardiovascular diseases, hypertension) and more laboratory abnormalities (CRP, D-Dimer, platelets, hemoglobin) were associated with development of more severity and mortality among COVID-19 patients. |
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| MeSH term(s) | Male ; Female ; Humans ; Aged ; Middle Aged ; COVID-19/epidemiology ; SARS-CoV-2 ; Iraq/epidemiology ; Retrospective Studies ; Comorbidity ; Risk Factors ; Patient Acuity |
| Language | English |
| Publishing date | 2023-05-01 |
| Publishing country | Italy |
| Document type | Journal Article |
| ZDB-ID | 756168-4 |
| ISSN | 1121-7138 ; 0391-5352 |
| ISSN | 1121-7138 ; 0391-5352 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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