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Article ; Online: Comparison of Rapid Antigen Detection Test with Reverse Transcription Polymerase Chain Reaction in Highly Suspected COVID-19 Patients.

Afridi, Muhammad Abdur Rahman / Ali, Zafar / Iqbal, Naveed

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 9, Page(s) 1058–1061

Abstract: Objective: To compare Rapid Antigen Test (RAT) with Reverse Transcription Polymerase Chain Reaction (RT-PCR) in highly suspected COVID-19 patients and to determine its diagnostic parameters.: Study design: Hospital-based, descriptive/observational ... ...

Abstract	Objective: To compare Rapid Antigen Test (RAT) with Reverse Transcription Polymerase Chain Reaction (RT-PCR) in highly suspected COVID-19 patients and to determine its diagnostic parameters. Study design: Hospital-based, descriptive/observational study. Place and Duration of the Study: Department of Medicine/COVID Complex, Medical Teaching Institution/Lady Reading Hospital, Peshawar, Khyber Pakhtunkhwa, Pakistan, from October 2021 to April 2022. Methodology: A total of 300 highly suspected cases of COVID-19 of either gender admitted in the COVID Complex of the hospital, were included. Data from the patients, including RAT and RT-PCR for COVID-19, were collected retrospectively. RT-PCR was used as the reference test and compared with RAT. Diagnostic statistics of RAT, with their respective 95% confidence intervals were calculated for RAT in diagnosing COVID-19, with significance at p ≤0.05. Results: Among the 300 patients, 137 (45.7%) were males and 163 (54.3%) were females. The mean age was 56.80 ± 13.72 years. On screening, 138 (46%) patients tested positive and 162 (54%) were negative by RAT; whereas 213 (71%) tested positive and 87 (29%) were negative on RT-PCR. The sensitivity and specificity of RAT were 54.5% (95% CI: 47.52%-61.28%) and 74.7% (95% CI: 64.25%-83.42%), respectively. Positive predicted value was 84.1% (95% CI: 78.26%-88.53%) and negative predictive value was 40.1% (95% CI: 35.63%-44.79%). The positive likelihood ratio was 2.15 (95% CI: 1.47-3.15). The negative likelihood-ratio was 0.61(95% CI: 0.50-0.74). The overall accuracy was 60.33% (95% CI: 54.55%-65.91%). Conclusion: There was a low sensitivity and specificity of the RAT for COVID-19, with an overall accuracy of 60.33%, compared with RT-PCR. Key words: COVID-19, Rapid Antigen Test, Sensitivity, Specificity, RT-PCR.
MeSH term(s)	Female ; Male ; Humans ; Adult ; Middle Aged ; Aged ; COVID-19/diagnosis ; Reverse Transcriptase Polymerase Chain Reaction ; Retrospective Studies ; Reverse Transcription ; Hospitals, Teaching ; COVID-19 Testing
Language	English
Publishing date	2023-06-21
Publishing country	Pakistan
Document type	Observational Study ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.09.1058
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Article: Association of different blood groups in patients with Dengue fever and their relationship with the severity of the illness.

Iqbal, Naveed / Afridi, Muhammad Abdur Rahman / Ali, Zafar / Rafiq, Adnan

Pakistan journal of medical sciences

2023 Volume 39, Issue 5, Page(s) 1301–1306

Abstract: Objective: To determine the association of different blood groups in patients with Dengue fever and their relationship with the severity of the illness.: Methods: A hospital-based descriptive study was conducted in the Dengue Isolation Ward of Lady ... ...

Abstract	Objective: To determine the association of different blood groups in patients with Dengue fever and their relationship with the severity of the illness. Methods: A hospital-based descriptive study was conducted in the Dengue Isolation Ward of Lady Reading Hospital Peshawar from March 2020 to September 2020. Patients with Dengue fever were included in the study. The severity of the illness was categorized as "Dengue fever (DF)", "Dengue hemorrhagic fever (DHF)", and "Dengue shock syndrome (DSS)". The patients' blood groups were determined as A, B, AB, and O groups. All the data were recorded and analyzed using SPSS® version 23. Chi-square ( Results: Out of 160 patients, 119(74.4%) were males; the patient's mean age was 38.09±15.68 SD, IQR=25 years. Greater proportion (28%) of the young men (up to 40 years) was affected compared to 9% young women. Fever (99%) and body aches (96%) were the most common presentation of DF, complicated by bleeding in 30.6% and shock in 9.4% of the patients. The majority (63.1%) of the patients had DF; 27.5% had DHF, and 9.4% had DSS. Sixty three (39.4%) patients had blood Group-B and 5.6% had Group-AB ( Conclusion: Patients with blood Group-B were more frequent and AB was least commonly affected by the Dengue-virus infections. However, no association was found between a particular blood group and disease severity. Greater proportions of the younger men had Dengue infections.
Language	English
Publishing date	2023-09-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.5.7275
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Article: Syntheses and structural characterization of divalent metal complexes (Co, Ni, Pd and Zn) of sterically hindered thiourea ligand and a theoretical insight of their interaction with SARS-CoV-2 enzyme.

Noor, Awal / Qayyum, Sadaf / Ali, Zafar / Muhammad, Niaz

Journal of molecular structure

2022 Volume 1274, Page(s) 134442

Abstract: Reacting two equivalents of sterically hindered 1,3-bis(2,6-diethylphenyl)thiourea ligand (L) with ... ...

Abstract	Reacting two equivalents of sterically hindered 1,3-bis(2,6-diethylphenyl)thiourea ligand (L) with CoCl
Language	English
Publishing date	2022-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	194476-9
ISSN	0022-2860 ; 0377-046X
ISSN	0022-2860 ; 0377-046X
DOI	10.1016/j.molstruc.2022.134442
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Article ; Online: Transient ST Segment Elevation in Two Patients with COVID-19 and a Normal Transthoracic Echocardiogram.

Asif, Talal / Ali, Zafar

European journal of case reports in internal medicine

2020 Volume 7, Issue 5, Page(s) 1672

Abstract: We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST ... ...

Abstract	We continue to learn about cardiac involvement in patients with COVID-19. These patients can develop acute coronary syndrome and severe myocarditis with a reduced ejection fraction. We describe two critically ill COVID-19 patients who developed ST elevation that resolved on repeat ECG without any intervention. Learning point: ST elevation may occur in critically ill COVID-19 patients.
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2020_001672
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Article: Progressive Multifocal Leukoencephalopathy in a Patient With Classic Hodgkin's Lymphoma Post-Bone Marrow Transplant: A Case Report.

Rehman, Ibad / Ali, Zafar / Rasheed, Sana / Ullah, Irfan / Nashwan, Abdulqadir J

Cureus

2023 Volume 15, Issue 1, Page(s) e33473

Abstract: A 29-year-old male patient underwent an autologous bone marrow transplant. He was initially diagnosed with Hodgkin's lymphoma and treated with 12 cycles of chemotherapy. Three months later, he presented with intermittent fever and underwent an MRI scan ... ...

Abstract	A 29-year-old male patient underwent an autologous bone marrow transplant. He was initially diagnosed with Hodgkin's lymphoma and treated with 12 cycles of chemotherapy. Three months later, he presented with intermittent fever and underwent an MRI scan and a brain biopsy. Eventually, he was diagnosed with progressive multifocal leukoencephalopathy. For effective treatment and a plan of action, such cases necessitate multidisciplinary board meetings with input from experts in surgery, pathology, cancer, and infectious diseases.
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.33473
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Article: Small Cell Neuroendocrine Carcinoma of the Vagina: A Rare Presentation.

Asghar, Asma / Usman, Asma / Sheikh, Ali Zafar / Imran, Honeyia / Siddique, Kashif

Cureus

2023 Volume 15, Issue 7, Page(s) e42387

Abstract: Primary small cell neuroendocrine carcinoma of the vagina is a very rare disease. We present a case study of a 52-year-old female who presented to the hospital with complaints of urinary dribbling, burning micturition, pain, and per vaginal bleeding for ... ...

Abstract	Primary small cell neuroendocrine carcinoma of the vagina is a very rare disease. We present a case study of a 52-year-old female who presented to the hospital with complaints of urinary dribbling, burning micturition, pain, and per vaginal bleeding for three to four months. A firm globular mass of approximately 5-6 cm was felt in the anterior vaginal wall per speculum examination. Diagnosis of small cell neuroendocrine carcinoma was made with tissue biopsy and immunohistochemistry. Diagnostic imaging (MRI, positron emission tomography (PET)-CT) plays a vital role in reaching the diagnosis and understanding the treatment response. The patient received six cycles of chemotherapy with cisplatin and etoposide and radiotherapy, achieving a complete response, with complete regression of the lesion. The patient had no sign of tumor recurrence and locoregional or distant metastases after six months of follow-up. Nowadays, there is no need for surgery in the treatment of vaginal small cell neuroendocrine carcinoma, rather radiotherapy and chemotherapy are the treatment of choice. We report a case of neuroendocrine cancer of the vagina treated at our institution.
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42387
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Article: Unusual Presentation of a Rare Tumor: Histiocytic Sarcoma Presenting as a Finger Growth.

Ali, Zafar / Hanif, Faiza

Cureus

2019 Volume 11, Issue 11, Page(s) e6150

Abstract: Histiocytic sarcoma (HS) is a malignant neoplasm with histiocytic differentiation. It presents most commonly at extranodal sites. We report a case of HS in a 15-year-old female with a history of trauma to the right little finger. Radiograph of the hand ... ...

Abstract	Histiocytic sarcoma (HS) is a malignant neoplasm with histiocytic differentiation. It presents most commonly at extranodal sites. We report a case of HS in a 15-year-old female with a history of trauma to the right little finger. Radiograph of the hand was reported as malignant tumor primarily arising from bone and invading soft tissues. Histologically, tumor cells are characterized by abundant eosinophilic cytoplasm and eccentric round to oval nuclei with atypia. One or more small and distinct nucleoli are present. The tumor cells were positive for CD68, S100, CD4 and lymphocyte common antigen, while epithelial membrane antigen, HMB-45, CK AE1/AE3, myogenin, desmin, CD1a, CD21 and SALL-4 were negative thus ruling out rhabdomyosarcoma, extrarenal rhabdoid tumor, Langerhans cell sarcoma and malignant melanoma.
Language	English
Publishing date	2019-11-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.6150
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Article: Giant Filiform Polyposis, A Rare Entity in a Patient of Ulcerative Colitis: A Case Report.

Ali, Zafar / Iltaf, Salma

Cureus

2019 Volume 11, Issue 11, Page(s) e6125

Abstract: Filiform polyposis (FP) of the colon is a distinct and uncommon entity that is occasionally encountered in patients with a history or evidence of inflammatory bowel disease. It is morphologically characterized by multiple, slender, worm-like projections ... ...

Abstract	Filiform polyposis (FP) of the colon is a distinct and uncommon entity that is occasionally encountered in patients with a history or evidence of inflammatory bowel disease. It is morphologically characterized by multiple, slender, worm-like projections consisting of submucosal cores lined with normal mucosa. Here, we report a case of FP in a 43-year-old middle-aged man with a history of inflammatory bowel disease (ulcerative colitis).
Language	English
Publishing date	2019-11-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.6125
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Article: Angiofibroma of Soft Tissue: A Newly Described Entity; A Case Report and Review of Literature.

Ali, Zafar / Anwar, Fatima

Cureus

2019 Volume 11, Issue 11, Page(s) e6225

Abstract: Soft tissue angiofibroma is a relatively recent addition to the ever growing list of benign soft tissue tumors. It usually presents as soft tissue mass in the lower extremities in relation to joints and tendons. The tumor is composed of spindle-shaped ... ...

Abstract	Soft tissue angiofibroma is a relatively recent addition to the ever growing list of benign soft tissue tumors. It usually presents as soft tissue mass in the lower extremities in relation to joints and tendons. The tumor is composed of spindle-shaped fibroblastic cells with arborizing capillaries. We report a case of a 55-year-old female with a lump at the dorsum of left foot. Grossly the tumor was well circumscribed with yellow white cut surface. Microscopically the tumor showed typical features of angiofibroma with myxoid areas near the periphery of the lesion. Prominent vasculature is the integral part of the tumor with numerous small, branching, thin-walled blood vessels, accompanied by medium-sized ectatic vessels. Immunohistochemically the tumor cells are positive for epithelial membrane antigen (EMA). The location of the tumor, lack of cytological atypia, mitosis, and infiltrative margins help differentiate it from a sarcoma.
Language	English
Publishing date	2019-11-24
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.6225
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Article: Primary Kaposiform Hemangioendothelioma of the Humerus: A Case Report.

Ali, Zafar / Qasim, Syed M / Faisal, Farhan / Jameel, Gulfam

Cureus

2022 Volume 14, Issue 1, Page(s) e21262

Abstract: Kaposiform hemangioendothelioma (KHE) is a neoplasm originating mainly from vessels and has a mild proclivity for malignancy. This neoplasm mainly involves somatic soft tissue and retroperitoneum. Histological findings include a nodular arrangement of ... ...

Abstract	Kaposiform hemangioendothelioma (KHE) is a neoplasm originating mainly from vessels and has a mild proclivity for malignancy. This neoplasm mainly involves somatic soft tissue and retroperitoneum. Histological findings include a nodular arrangement of oval-to-spindle cells containing pale cytoplasm. Vascular spaces are in the form of slit-like channels in which red blood cells are evident. Here, we report the case of a two-year-old male who presented with Erb's palsy and a mass lesion in the right humerus. Tissue biopsy features were compatible with KHE.
Language	English
Publishing date	2022-01-15
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.21262
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