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Article ; Online: Ideal Lifestyle to Have Healthy Lungs

Ali Abdolahinia / Mohsen Naseri / Soodeh Tahmasbi / Parisa Adimi / Makan Sadr / Ali Akbar Velayati

Traditional and Integrative Medicine, Vol 7, Iss

Persian Medicine Viewpoint

2022 Volume 1

Abstract: Persian medicine introduces six essential principles to maintain health and improve the breathing of the patients with pulmonary diseases. Adherence to each of these principles plays an important role in having healthy lungs. The purpose of this study ... ...

Abstract	Persian medicine introduces six essential principles to maintain health and improve the breathing of the patients with pulmonary diseases. Adherence to each of these principles plays an important role in having healthy lungs. The purpose of this study was to review the scientific evidence of the mentioned recommendations while discussing the Persian medicine recommendations. Accordingly, suggestions related to maintaining lung health were extracted from the main sources of Persian medicine. In addition, similar topics were searched in PubMed, Scopus, Google Scholar, Web of Science, and SID databases. Then, results were expressed separately in each aspect of the six essential principles. These recommendations which are the result of hundreds-of-years-experience of Iranian physicians could be useful; however, future experimental investigations are needed to approve their safety and efficacy along with the possible mechanisms of action.
Keywords	Lifestyle ; Pulmonary diseases ; Persian medicine ; Respiratory system ; Lung ; Public aspects of medicine ; RA1-1270
Subject code	001
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Two Successful Bone Functions in Patients with Chronic Granulomatous Disease Marrow Transplantations Improved Lung

Mahsa Rekabi / Farhad Seif / Farzad Nouri / Alireza Mahdaviani / Ali Akbar Velayati

Case Reports in Clinical Practice, Vol 7, Iss

2022 Volume 1

Abstract: Chronic Granulomatous Disease (CGD) is a rare inherited primary immune deficiency disorder with defective respiratory burst activity in phagocytes, resulting in recurrent pyogenic infections. In this study, we described two CGD patients who had done bone ...

Abstract	Chronic Granulomatous Disease (CGD) is a rare inherited primary immune deficiency disorder with defective respiratory burst activity in phagocytes, resulting in recurrent pyogenic infections. In this study, we described two CGD patients who had done bone marrow transplantation (BMT). As Bone marrow transplantation (BMT) is the definitive treatment of the disease, we evaluated the function of their lungs before and after BMT. In both patients, the BMT was from their siblings. In case 1, the patient’s pulmonary function (PFT) before BMT was: FEV1: 34, FVC: 40, FEV1 / FVC: 72%, and after BMT was: FEV1: 66, FVC: 40 by 49, FEV1 / FVC: 64%. In case 2, the patient’s PFT before BMT was: FEV1: 22, FVC: 36, FEV1 / FVC: 41%, and after BMT was: FEV1: 47, FVC: 33, FEV1/FVC: 43%. BMT significantly improved their Pulmonary Problems and Preclinical (PFT). In addition, after BMT, both patients’ well-tolerated clinical signs and the infection rate, and the number of hospitalizations in both patients decreased.
Keywords	Bone marrow transplantation ; Chronic granulomatous disease ; Lung function ; Patient’s pulmonary function ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Allergic shiners in a patient with cough-variant asthma

Mahsa Rekabi / Nasim Raad / Atefeh Abedini / Sepideh Darougar / Ali Akbar Velayati

Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-

a case report

2022 Volume 4

Abstract: Abstract Background Chronic cough, with a duration of coughing of more than 8 weeks in adults, affects 5–10% of the general population. One of the most common causes of chronic cough is cough-variant asthma, which accounts for approximately one-third of ... ...

Abstract	Abstract Background Chronic cough, with a duration of coughing of more than 8 weeks in adults, affects 5–10% of the general population. One of the most common causes of chronic cough is cough-variant asthma, which accounts for approximately one-third of cases. This phenotype of asthma is characterized by extreme sensitivity of the neuronal pathways mediating cough to environmental irritants, which results in an urge to cough. This case is an example of cough-variant asthma presenting with allergic shiners due to her severe cough. Case presentation A 38-year-old Iranian woman, who was well before the start of the coronavirus disease 2019 pandemic, presented with a nonproductive hacking cough that had begun after excessive use of antiseptic solutions. The only positive finding on physical examination was a reddish-purple rash on and around the eyelids mimicking a heliotrope rash, which had probably evolved due to the severity of the cough. The results of the pulmonary function test were within normal limits. Methacholine challenge test and chest x-ray were both normal. Chest high-resolution computed tomography revealed hyperinflation and tree-in-bud opacities. All other laboratory tests were normal. Because of the reversibility in her pulmonary function test, despite normal baseline parameters, asthma treatment was initiated, resulting in disappearance of the cough and the eye discoloration, being indicative of the correct diagnosis and proper treatment. Conclusion Patients with cough-variant asthma may often have no other classic symptoms of asthma other than cough.
Keywords	Cough-variant asthma ; Chronic cough ; Asthma ; Allergic shiners ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence of non-tuberculosis mycobacteria among samples deposited from the National Tuberculous Reference Laboratory of Iran (2011-2018)

Saman Ayoubi / Parissa Farnia / Poopak Farnia / Jafar Aghajani / Jalaledin Ghanavi / Ali Akbar Velayati

Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 10, Pp 451-

2021 Volume 455

Abstract: Objective: To investigate the prevalence of non-tuberculosis mycobacteria (NTM) among the samples deposited from the National Tuberculosis Reference Laboratory of Iran between 2011 and 2018. Methods: The study evaluated the prevalence of NTM among ... ...

Abstract	Objective: To investigate the prevalence of non-tuberculosis mycobacteria (NTM) among the samples deposited from the National Tuberculosis Reference Laboratory of Iran between 2011 and 2018. Methods: The study evaluated the prevalence of NTM among specimens from patients with pulmonary tuberculosis symptoms (n=15 771) deposited at the National Tuberculosis Reference Laboratory of Iran from 2011 to 2018. Detection of Mycobacterium (M.) tuberculosis was based on presence of a 190-bp amplicon from IS6110 insertion sequence using Tb1 and Tb2 primers, and amplicon-negative specimens were tested for NTM and M. tuberculosis (refractory to IS6110 amplification) using restriction fragment length polymorphism PCR of hsp65 amplicon fragment. Results: A total of 7 307 (46.33%) M. tuberculosis and 658 (4.17%) NTM specimens were found, the latter mainly comprising M. abscessus (10.18%), M. avium (2.28%), M. chelonae (8.97%), M. intracellulare (10.49%), M. kansasii (4.71%), and M. simiae (56.08%). Conclusions: As treatment for NTM differs from that for M. tuberculosis, accurate detection of Mycobacterium sp. is of public health significance.
Keywords	diagnosis ; iran ; non-tuberculosis mycobacterium ; prevalence ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation of miRNA Functionality in Cystic Fibrosis

Maryam Hassanzad / Poopak Farnia / Jalaledin Ghanavi / Ali Akbar Velayati

مجله دانشکده پزشکی اصفهان, Vol 37, Iss 532, Pp 736-

2019 Volume 746

Abstract: Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The irregularities in miRNA expression have been reported in many pulmonary diseases, including CF. An ... ...

Abstract	Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The irregularities in miRNA expression have been reported in many pulmonary diseases, including CF. An increase or a decrease in miRNA levels has important influences on innate immune responses in respiratory tract of the patients with CF, such as impaired function of the inflammatory responses caused by neutrophils and macrophages, as well as chronic inflammation, which can lead to degradation and fibrosis of the lung tissue in these patients. The presence of a specific biomarker for diagnosis of pulmonary disease, inflammation, and cellular function can be a good candidate for diagnosis of CF. For example, sputum miRNAs can be ideal for checking pulmonary function. Although miRNA is not currently used for treatment or clinical diagnosis of CF, many studies have suggested miRNAs as potential biomarkers for the disease. miRNA-based treatments, that enhance the expression of CFTR, can be a very suitable option for adjusting CFTR levels in clinical trials on patients with CF. In this review article, after describing different miRNA groups, and its mechanism of action for regulation of protein expression, various studies related to miRNA in CF were investigated. In addition, the possibility to apply miRNA as a biomarker in CF, and its role in different miRNA-based therapeutic approaches were discussed.
Keywords	cystic fibrosis ; lung ; mirna ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Persian
Publishing date	2019-09-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The importance of genomic changes of SARS-CoV-2 and its comparison with Iranian-reported COVID-19 sequencing; Whether each country has to design its treatment and vaccine production

Ali Akbar Velayati / Parissa Farnia / Saeid Besharati / Poopak Farnia / Jalaledin Ghanavi

Biomedical and Biotechnology Research Journal, Vol 4, Iss 5, Pp 13-

2020 Volume 18

Abstract: Coronavirus (COVID-19), a type of RNA virus, has a positive, single, sense stranded RNA. Studies of coronaviruses have shown high mutations in the virus's RNA. The more the virus infects people, the more the genome will mutate. In addition, evolutionary ... ...

Abstract	Coronavirus (COVID-19), a type of RNA virus, has a positive, single, sense stranded RNA. Studies of coronaviruses have shown high mutations in the virus's RNA. The more the virus infects people, the more the genome will mutate. In addition, evolutionary and genetic studies have the potential to recombine and easily jump from one host to another host. This means flexibility to adapt to new conditions and proliferation in new host cells. Examination of the hosts of this virus shows their extent. Studies show that the virus closely resembles hosts such as bats and pangolins. Genomic studies on severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and bat coronavirus (RaTG13) showed 96.2% genetic similarity although there are differences in the nucleotides of different hosts. The importance of examining mutated areas in coronaviruses for diagnosis and treatment is necessary because molecular methods such as RT-PCR, although having a specific probe, may not cause a connection between the primer and the specific probe and cause a false-negative response be reported. This issue has led various countries to sequence SARS-CoV-2 for their own countries, eventually leading to the identification of specific drugs and vaccines for their country.
Keywords	covid-19 ; mutations ; severe acute respiratory syndrome coronavirus-2 ; Biotechnology ; TP248.13-248.65 ; covid19
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation of the hypothesis of biofilm formation in coronavirus (COVID-19)

Saeid Besharati / Parissa Farnia / Poopak Farnia / Jalaledin Ghanavi / Ali Akbar Velayati

Biomedical and Biotechnology Research Journal, Vol 4, Iss 5, Pp 99-

2020 Volume 100

Keywords	Biotechnology ; TP248.13-248.65 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Can animals like bats, pangolins, and ticks would be considered as long-term reservoirs of severe acute respiratory syndrome coronavirus 2

Jafar Aghajani / Parissa Farnia / Saman Ayoubi / Poopak Farnia / Jalaledin Ghanavi / Ali Akbar Velayati

Biomedical and Biotechnology Research Journal, Vol 4, Iss 5, Pp 3-

2020 Volume 12

Abstract: In December 2019, there was an outbreak of pneumonia with an unknown cause in Wuhan, Hubei province, China. Within less than 3–4 months, the virus has spread to more than 200 countries. The virus rapidly transmitted from different places of the world ... ...

Abstract	In December 2019, there was an outbreak of pneumonia with an unknown cause in Wuhan, Hubei province, China. Within less than 3–4 months, the virus has spread to more than 200 countries. The virus rapidly transmitted from different places of the world with various cultural traditions. Thereby, the question is remained to be resolved about the main intermediate carrier of diseases in different animals. Studied showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated from horseshoe bats, but its intermediate hosts are still largely unknown. Therefore, the possibility of horseshoe bat infection by ticks is high during the flight between plants or when resting in these places. Female ticks can either feed on horseshoe bat blood for 5–7 days before shedding or can form large aggregations by laying several thousand eggs in the right places or on them. Once they feed on horseshoe bat blood containing SARS-CoV-2, they can transfer the infection to the next generations without the need to reuse infections from the reservoir host. With all the potential features that this creature has, it is mandatory to investigate the presence or absences of SARS-CoV-2, especially when we know that ticks co-exist with that horseshoe bats. These factors highlight the importance of studying the viral epidemiology in the tick population. Thereby, based on the wide distribution of ticks and their co-existence with horseshoe bat, we suggest further studies on ticks that might act as one of the main intermediate hosts in different animals.
Keywords	covid-19 ; horseshoe bats ; intermediate host ; severe acute respiratory syndrome coronavirus 2 ; ticks ; Biotechnology ; TP248.13-248.65 ; covid19
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lifesaving combined treatment in a rapidly progressive COVID-19 pneumonia case with extensive lung involvement

Seyed Mohammad Reza Hashemian / Razieh Farrokhi / Payam Tabarsi / Hamidreza Jamaati / Ali Akbar Velayati

Biomedical and Biotechnology Research Journal, Vol 4, Iss 5, Pp 93-

2020 Volume 95

Abstract: COVID-19 pneumonia has rapid development into a global pandemic. For the infected patients, it is an urgent matter to improve the cure rate and reduce the death rate, but there are no effective antiviral drugs for COVID-19 so far. There is an urgent need ...

Abstract	COVID-19 pneumonia has rapid development into a global pandemic. For the infected patients, it is an urgent matter to improve the cure rate and reduce the death rate, but there are no effective antiviral drugs for COVID-19 so far. There is an urgent need for effective treatment. The current focus has been on the development of novel therapeutics, including antivirals and vaccines. One of these drugs, Favipiravir (Avigan), an antiviral agent approved for use in influenza in Japan, is being studied for the treatment of COVID-19. Herein, we report a patient; a 53 Y/O man without any underlying disease, developed COVID19 pneumonia rapidly and well respond to combination treatment including Dexamethasone, Favipiravir, and IFN-β-1a.
Keywords	covid-19 ; combined treatment ; pneumonia ; global pandemic ; Biotechnology ; TP248.13-248.65 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of geographical information system on public health sciences

Jafar Aghajani / Parissa Farnia / Ali Akbar Velayati

Biomedical and Biotechnology Research Journal, Vol 1, Iss 2, Pp 94-

2017 Volume 100

Abstract: In this brief review, the geographic information systems (GISs) and its beneficial influence in the field of health were discussed and highlighted. Basically, GIS is a computerized system that can significantly add to assess and monitor the effects of ... ...

Abstract	In this brief review, the geographic information systems (GISs) and its beneficial influence in the field of health were discussed and highlighted. Basically, GIS is a computerized system that can significantly add to assess and monitor the effects of environmental factors (namely, population, air pollution, location, climatic changes) on public health problems. The main benefits of GIS in health services are mapping and/or visualizing of disease distribution, which will ultimately improves our understanding of disease diversities and their spatial patterns. Therefore, GIS technology is capable of providing the intra- and inter-logical connection between health, social services, and natural environment.
Keywords	Disease mapping ; geographic information system ; medical geography ; medical informatics ; public health ; Biotechnology ; TP248.13-248.65
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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