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Article ; Online: Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor

Nazanin Vaziri / Laleh Shariati / Ali Zarrabi / Ali Farazmand / Shaghayegh Haghjooy Javanmard

Life, Vol 11, Iss 1298, p

2021 Volume 1298

Abstract: Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer remains largely unknown. In ... ...

Abstract	Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer remains largely unknown. In this study, an in vitro investigation is conducted to determine the crosstalk between breast cancer cells and fibroblasts. Based on the results, cancer-associated fibroblasts are producers of LIF in the cocultivation system with breast cancer cells. Treatment with the CAF-CM and human LIF protein significantly promoted stemness through the dedifferentiation process and regaining of stem-cell-like properties. In addition, the results indicate that activation of LIFR signaling in breast cancer cells in the existence of CAF-secreted LIF can induce Nanog and Oct4 expression and increase breast cancer stem cell markers CD24−/CD44+. In contrast, suppression of the LIF receptor by human LIF receptor inhibition antibody decreased the cancer stem cell markers. We found that LIF was frequently overexpressed by CAFs and that LIF expression is necessary for dedifferentiation of breast cancer cell phenotype and regaining of cancer stem cell properties. Our results suggest that targeting LIF/LIFR signaling might be a potent therapeutic strategy for breast cancer and the prevention of tumor recurrence.
Keywords	breast cancer ; leukemia inhibitory factor ; cancer stem cell ; cancer-associated fibroblasts ; LIF/LIFR signaling pathway ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Vitro Analysis of Nine MicroRNAs in CD8+ T Cells of Asthmatic Patients and the Effects of Two FDA-approved Drugs

Mohsen Badalzadeh / Marzieh Mazinani / Zahra Pourpak / Hassan Heidarnazhad / Esmaeil Mortaz / Mostafa Moin / Ali Farazmand

Iranian Journal of Allergy, Asthma and Immunology, Vol 18, Iss

2019 Volume 4

Abstract: In this study, we first tried to determine whether the expression level of 9 miRNAs in the peripheral blood CD8+ T cells of asthmatic patients varies from that of controls, and secondly, we investigated the effects of fluticasone furoate and vilanterol ... ...

Abstract	In this study, we first tried to determine whether the expression level of 9 miRNAs in the peripheral blood CD8+ T cells of asthmatic patients varies from that of controls, and secondly, we investigated the effects of fluticasone furoate and vilanterol on the expression level of these miRNAs. Fifteen subjects including 8 healthy individuals and 7 asthmatic patients were included in this study. CD8+T cells were isolated from participants' peripheral blood by a negative selection method using magnetic-activated cell sorting (MACS). The expression of 9 miRNAs was examined between the healthy individuals and asthmatic patients. Then the expression level of 9 miRNAs before and after treatment with the drugs was examined by quantitative real-time PCR. No significant changes in the expression level of 9 miRNAs were observed in asthmatic patients compared to the healthy controls. Fluticasone and vilanterol, in combination, had the greatest effect on miRNA expression. MiR-150 and miR-106a were the most and the least miRNAs, respectively, present in CD8+ T cells of patients and controls. MiR-106a and miR-126 had a positive correlation in CD8+ cells of asthmatic patients. Although no significant difference in the expression level of studies miRNAs was observed, the correlations among miRNAs were significant. Therefore, we suggest that the correlation between miRNAs would be a very important factor in physiological and pathological conditions in healthy individuals and asthmatic patients. Such a miRNA-miRNA correlation network can be even more critical than any changes in the variation of their expression in the CD8+ T cells.
Keywords	Fluticasone furoate ; MicroRNAs ; Vilanterol ; CD8 T cells ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Osmolyte Type and the Osmolarity Level Affect Chondrogenesis of Mesenchymal Stem Cells

Ahmadyan, Sorour / Mahboubeh Kabiri / Hana Hanaee-Ahvaz / Ali Farazmand

Applied biochemistry and biotechnology. 2018 June, v. 185, no. 2

2018

Abstract: The inductive effects of increased osmolarity on chondrogenesis are well approved. However, the effects of the osmolyte agent invoked to induce hyperosmolarity are largely neglected. Herein, we scrutinized how hyperosmotic conditions acquired by addition ...

Abstract	The inductive effects of increased osmolarity on chondrogenesis are well approved. However, the effects of the osmolyte agent invoked to induce hyperosmolarity are largely neglected. Herein, we scrutinized how hyperosmotic conditions acquired by addition of different osmolytes would impact chondrogenesis. We briefly assessed whether such conditions would differentially affect hypertrophy and angiogenesis during MSC chondrogenesis. Chondrogenic and hypertrophic marker expression along with VEGF secretion during adipose-derived (AD)-MSC chondrogenesis under three osmolarity levels (350, 450, and 550 mOsm) using three different osmolytes (NaCl, sorbitol, and PEG) were assessed. MTT assay, qRT-PCR, immunocytochemistry, Alcian Blue staining, ELISA, and ALP assays proved osmolyte-type dependent effects of hyperosmolarity on chondrogenesis, hypertrophy, and angiogenesis. At same osmolarity level, PEG had least cytotoxic/cytostatic effect and most prohibitive effects on angiogenesis. As expected, all hyperosmolar conditions led to enhanced chondrogenesis with slightly varying degrees. PEG and sorbitol had higher chondro-promotive and hypertrophy-suppressive effects compared to NaCl, while NaCl had exacerbated hypertrophy. We observed that TonEBP was involved in osmoadaptation of all treatments in varying degrees. Of importance, we highlighted differential effects of hyperosmolarity obtained by different osmolytes on the efficacy of chondrogenesis and more remarkably on the induction/suppression of cartilage pathologic markers. Our study underlies the need for a more vigilant exploitation of physicobiochemical inducers in order to maximize chondrogenesis while restraining unwanted hypertrophy and angiogenesis.
Keywords	angiogenesis ; cartilage ; chondrogenesis ; cytotoxicity ; enzyme-linked immunosorbent assay ; hypertrophy ; immunocytochemistry ; osmolarity ; osmotolerance ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; secretion ; sodium chloride ; sorbitol ; staining ; stem cells ; vascular endothelial growth factors
Language	English
Dates of publication	2018-06
Size	p. 507-523.
Publishing place	Springer US
Document type	Article
ZDB-ID	392344-7
ISSN	0273-2289
ISSN	0273-2289
DOI	10.1007/s12010-017-2647-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Protein Profiling of Gonads of Males and Sex Reversed Males in Nemacheilus angorae

Maryam Cheraghzadeh / Ali Farazmand / Nasrin Motamed

Current Research Journal of Biological Sciences, Vol 5, Iss 1, Pp 19-

2013 Volume 25

Abstract: In the present study a proteomics approach has been taken to analyze differential protein expression between mature male and sex reversed male of Nemacheilus angorae In regard to the fruitful studies of sex reversal in mammalian species and the fact that ...

Abstract	In the present study a proteomics approach has been taken to analyze differential protein expression between mature male and sex reversed male of Nemacheilus angorae In regard to the fruitful studies of sex reversal in mammalian species and the fact that some major sex determination molecules are conserved among vertebrates, Nemacheilus angorae (Angorae loach) seems to be a good model system in studying molecules involved in sex differentiation.N. angorae is a teleports fish exhibiting a spontaneous sex reversal (male to female) pattern. The gonads of adult individuals were dissected and used for histological investigation and protein analysis. Proteins were next analyzed using two-dimensional gel electrophoresis and the distinguished spots have been compared in two experimental samples. Among them, 23 differentially expressed proteins spots were identified by MALDI-TOF/TOF analysis. Two spots in sex reversed testis with high score showed significant similarity to Vasa (assembling of the pole plasm and the pronuclear region of the oocyte) and Proline 4-hydroxylase proteins. Vasa are involved in germ cell development both in invertebrates and vertebrates. This data could be considered as starting base for subsequent studies to identify proteins involved in sex reversal and differentiation at different stages of gonadal maturation in fish.
Keywords	Nemacheilus angorae ; protein profile ; sex reversal ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	590
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Maxwell Science Publication
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Downregulation of miR-542-3p Contributes to Apoptosis Resistance in Dermal Fibroblasts from Systemic Sclerosis Patients via Survivin Overexpression

Pegah Vahidi Manesh / Ali Farazmand / Farhad Gharibdoost / Negar Vanaki / Shayan Mostafaei / Hoda Kavosi / Mohammad Bagher Mahmoudi / Mahdi Mahmoudi

Iranian Journal of Allergy, Asthma and Immunology, Vol 18, Iss

2019 Volume 2

Abstract: Systemic sclerosis (SSc) is characterized by excessive production of collagens by fibroblasts that leads to vast fibrosis. Resistance to apoptosis is one of the possible underlying mechanisms of fibrosis in these patients. Survivinis involved in ... ...

Abstract	Systemic sclerosis (SSc) is characterized by excessive production of collagens by fibroblasts that leads to vast fibrosis. Resistance to apoptosis is one of the possible underlying mechanisms of fibrosis in these patients. Survivinis involved in inhibition of apoptosis and aberrantly functions in SSc. Since dysregulation of survivin-targeting microRNAs (miRNAs) has frequently been observed in cancer and some autoimmune disorders, this study aimed to investigate their expression status in dermal fibroblasts from SSc patients. DiffuseSSc patients were selected according to American College of Rheumatology criteria. Isolated fibroblasts from 10 SSc and 10 healthy skin biopsies were cultured. After examining purity of the cells, mRNA and miRNAs extraction was performed followed by complementary DNA (cDNA) synthesis. Relative expressions ofsurvivin mRNA, miR-16-5p, miR-320a, miR-218-5p, miR-708-5p and miR-542-3p were analyzed using real time PCR. Survivin mRNA expression was significantly 1.85-fold upregulated in fibroblasts from SSc patients compared with healthy controls (p=0.046). Among the studied miRNAs, miR-542-3p expression was significantly decreased (p=0.033), while enhanced expression of miR-708-5p was observed in SSc fibroblasts (p=0.05) in comparison to healthy subjects. Downregulation of miR-542-3p significantly correlated with survivin overexpression (r=˗0.45, p=0.049). Downregulation of miR-542-3p that is correlated with higher surviving expression levels might be a possible cause of apoptosis resistance in SSc fibroblasts, hence providing a new understanding of the disease pathogenesis.
Keywords	Apoptosis ; miR-542-3p ; Survivin ; Systemic sclerosis ; Medicine ; R
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population

Zahra Mehraji / Ali Farazmand / Alireza Esteghamati / Sina Noshad / Maryam Sadr / Somayeh Amirzargar / Mir Saeed Yekaninejad / Aliakbar Amirzargar

Iranian Journal of Immunology, Vol 14, Iss 3, Pp 223-

2017 Volume 230

Abstract: Background : Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility ...

Abstract	Background : Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. Objective : To identify HLA polymorphisms that might confer susceptibility or protect against GD. Methods : Eighty unrelated patients with a confirmed diagnosis of GD were included in the case group. The control group consisted of 180 unrelated healthy individuals with normal thyroid function tests. The polymerase chain reaction with sequence specific primers (PCR-SSP) method was used for HLA typing. Results: Frequencies of HLA-A68 (15.6% vs. 4.2%, p=0.004) and B08 (8.8% vs. 2.5, p=0.030) were significantly higher in patients with GD compared with healthy controls. No patients with GD had HLA-A33, whereas it was found in 7.0% of the controls (p=0.011). HLA-DQB10201 was significantly less frequent among patients with GD (15.6% vs. 26.8%, p=0.040). Additionally, patients with GD were significantly less bound to have HLA-DQA10201 (6.2% vs. 15.1%, p=0.045). Concerning allelic distributions, no noticeable difference was found between GD patients with and without Graves’ ophthalmopathy (p>0.05 in all cases). Conclusion : In the Iranian population, HLA-A68 and -B08 confer susceptibility to GD, whereas HLA-A33, -DQB10201, and -DQA10201 appear to have protective roles.
Keywords	Association ; Graves’ Disease ; Graves’ ophthalmopathy ; HLA ; Polymorphism ; Iran ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Polymorphism of killer cell immunoglobulin-like receptors (KIR) and their HLA ligands in Graves’ disease

Dastmalchi, Romina / Ali Farazmand / Aliakbar Amirzargar / Alireza Esteghamati / Mahdi Mahmoudi / Mohamad Mozafari / Sina Noshad

Molecular biology reports. 2014 Aug., v. 41, no. 8

2014

Abstract: Killer immunoglobulin-like receptors (KIR) play a pivotal role in commencement of both innate and adaptive immunity. Dysregulation of KIRs is associated with an increased risk of autoimmune disorders. This study was designed to assess whether ... ...

Abstract	Killer immunoglobulin-like receptors (KIR) play a pivotal role in commencement of both innate and adaptive immunity. Dysregulation of KIRs is associated with an increased risk of autoimmune disorders. This study was designed to assess whether polymorphisms in KIR gene family and their respective HLA class I ligands confer protection or susceptibly to Graves’ disease (GD). Eighty patients with confirmed GD (cases) and 176 healthy unrelated subjects (controls) were recruited. Using a polymerase chain reaction sequence-specific primer directed method (PCR-SSP), presence or absence of KIR genes and their HLA ligands were determined. No significant differences were observed between case and control groups regarding individual KIR gene frequencies (p > 0.05 in all cases). The frequency of group A haplotype (the most common KIR haplotype, encompassing 2DL1/2DL3/3DL1/2DS4/2DP1/3DP1/2DL4/3DL2/3DL3), was not different between individuals with and without GD. Moreover, among all other haplotypes (group Bx), no significant differences regarding distribution of centromeric and telomeric gene clusters were identifiable. Inhibitory/activatory gene contents were also comparable between the two groups. Four models of KIR-HLA interaction (inhibition, activation, unrestrained inhibition, and unrestrained activation) were constructed. No combination proved to confer susceptibility to, or offer protection against GD. It seems that the contribution of KIR gene polymorphism to natural killer cell dysfunction and other autoimmune abnormalities observed in GD is limited.
Keywords	adaptive immunity ; genetic polymorphism ; haplotypes ; models ; multigene family ; patients ; polymerase chain reaction ; receptors ; risk ; telomeres
Language	English
Dates of publication	2014-08
Size	p. 5367-5374.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-014-3408-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Leaf indumentum types in Potentilla (Rosaceae) and related genera in Iran

Marzieh B. Faghir / Farideh Attar / Ali Farazmand / Barbara Ertter / Bente Eriksen

Acta Societatis Botanicorum Poloniae, Vol 79, Iss 2, Pp 139-

2011 Volume 145

Abstract: Indumentum types of the leaves in 31 species of Potentilla L. (Rosaceae) and four related genera, especially Tylosperma Botsch., Schistophyllidium (Juz. ex Fed.) Ikonn., Drymocallis Fourr. ex Rydb., and Sibbaldia L. from Iran were investigated. ... ...

Abstract	Indumentum types of the leaves in 31 species of Potentilla L. (Rosaceae) and four related genera, especially Tylosperma Botsch., Schistophyllidium (Juz. ex Fed.) Ikonn., Drymocallis Fourr. ex Rydb., and Sibbaldia L. from Iran were investigated. Indumentum ultrastructure was studied by scanning electron microscopy (SEM). SEM observation revealed three type classes based on leaf indumentum: 1) straight (appressed-erect); 2) straight-erect and crispate, and 3) crispate-floccose. The straight hair character (I type class) is widely distributed among all genera sampled and six sections of Potentilla. In contrast the crispate-floccose indumentum (III type class) is confined to all examined species of sections Speciosae and Pensylvanicae. While some sections especially Rectae (straight and straight-crispate hairs) and Terminales (straight-crispate and floccose-crispate) posses two indumentum type classes. The present survey shows that indumentum types are of systematic importance and may form good key characters for identification purposes.
Keywords	Potentilla ; Tylosperma ; Schistophyllidium ; Drymocallis ; Sibbaldia ; indumentum ; ultrastructure ; classification ; Iran ; Botany ; QK1-989 ; Science ; Q
Subject code	590
Language	English
Publishing date	2011-04-01T00:00:00Z
Publisher	Polish Botanical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FOXP3 Gene Expression in Multiple Sclerosis Patients Pre- and Post Mesenchymal Stem Cell Therapy

Maryam Mohajeri / Ali Farazmand / Mandana Mohyeddin Bonab / Behrooz Nikbin / Alireza Minagar

Iranian Journal Of Allergy, Asthma and Immunology, Vol 10, Iss 3, Pp 155-

2011 Volume 161

Abstract: Multiple Sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (CNS), which mainly affects young adults. Activated T lymphocytes promote the neuro-inflammatory cascade of MS by secreting pro- ... ...

Abstract	Multiple Sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (CNS), which mainly affects young adults. Activated T lymphocytes promote the neuro-inflammatory cascade of MS by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. T lymphocytes may trigger the inflammation, which in turn leads to axonal loss and neurodegeneration observed in the course of MS. Currently, there is no cure for MS, however, one of the most promising neuroprotective research tools consists of the use of bone marrow derived mesenchymal stem cells (MSC). This method promotes immune system regulation and possibly induces neurological repair and re-myelination of the damaged axons. Recent studies have shown that MSC exert an immune regulatory function and induce T regulatory-cell proliferation, therefore, it may serve as a potentially useful treatment for immune-mediated diseases such as MS. In this pilot study a group of MS patients underwent MSC therapy and we assayed the expression of an X-linked transcription factor, FoxP3, as a specific marker of T Regulatory cells in peripheral blood, prior to and after the treatment. Using q RT-PCR for measurement of expression of FoxP3 by peripheral blood mononuclear cells, we found that in all subjects, except for one, the expression of FoxP3 at 6 months after intrathecal injection of MSC was significantly higher than the levels prior to treatment. Such significant enhanced expression of FoxP3 associated with clinical stability. Findings from this pilot study further support the potential of bone marrow derived MSC for treatment of MS patients.
Keywords	Mesenchymal Stem Cells (MSC) ; Multiple Sclerosis (MS) ; Transcription Factor (FOXP3) ; T Regulatory Cells (Treg) ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	616
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: FOXP3 Gene Expression in Multiple Sclerosis Patients Pre- and Post Mesenchymal Stem Cell Therapy

Maryam Mohajeri / Ali Farazmand / Mandana Mohyeddin Bonab / Behrooz Nikbin / Alireza Minagar

Iranian Journal of Allergy, Asthma and Immunology, Vol 10, Iss

2011 Volume 3

Abstract	Multiple Sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (CNS), which mainly affects young adults. Activated T lymphocytes promote the neuro-inflammatory cascade of MS by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. T lymphocytes may trigger the inflammation, which in turn leads to axonal loss and neurodegeneration observed in the course of MS. Currently, there is no cure for MS, however, one of the most promising neuroprotective research tools consists of the use of bone marrow derived mesenchymal stem cells (MSC). This method promotes immune system regulation and possibly induces neurological repair and re-myelination of the damaged axons. Recent studies have shown that MSC exert an immune regulatory function and induce T regulatory-cell proliferation, therefore, it may serve as a potentially useful treatment for immune-mediated diseases such as MS. In this pilot study a group of MS patients underwent MSC therapy and we assayed the expression of an X-linked transcription factor, FoxP3, as a specific marker of T Regulatory cells in peripheral blood, prior to and after the treatment. Using q RT-PCR for measurement of expression of FoxP3 by peripheral blood mononuclear cells, we found that in all subjects, except for one, the expression of FoxP3 at 6 months after intrathecal injection of MSC was significantly higher than the levels prior to treatment. Such significant enhanced expression of FoxP3 associated with clinical stability. Findings from this pilot study further support the potential of bone marrow derived MSC for treatment of MS patients.
Keywords	Mesenchymal Stem Cells (MSC) ; Multiple Sclerosis (MS) ; Transcription Factor (FOXP3) ; T Regulatory Cells (Treg) ; Medicine ; R
Subject code	570
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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