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Article ; Online: Herbal Remedies as Potential in Cartilage Tissue Engineering

Constanze Buhrmann / Ali Honarvar / Mohsen Setayeshmehr / Saeed Karbasi / Mehdi Shakibaei / Ali Valiani

Molecules, Vol 25, Iss 3075, p

An Overview of New Therapeutic Approaches and Strategies

2020 Volume 3075

Abstract: It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of ...

Abstract	It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of the major causes that drive the production of inflammatory mediators and thus of matrix-degrading enzymes. OA is a challenging disease for doctors due to the limitation of the joint cartilage’s capacity to repair itself. Though new treatment approaches, in particular with mesenchymal stem cells (MSCs) that integrate the tissue engineering (TE) of cartilage tissue, are promising, they are not only expensive but more often do not lead to the regeneration of joint cartilage. Therefore, there is an increasing need for novel, safe, and more effective alternatives to promote cartilage joint regeneration and TE. Indeed, naturally occurring phytochemical compounds (herbal remedies) have a great anti-inflammatory, anti-oxidant, and anabolic potential, and they have received much attention for the development of new therapeutic strategies for the treatment of inflammatory diseases, including the prevention of age-related OA and cartilage TE. This paper summarizes recent research on herbal remedies and their chondroinductive and chondroprotective effects on cartilage and progenitor cells, and it also emphasizes the possibilities that exist in this research area, especially with regard to the nutritional support of cartilage regeneration and TE, which may not benefit from non-steroidal anti-inflammatory drugs (NSAIDs).
Keywords	herbal remedies ; cartilage ; tissue engineering ; osteoarthritis ; curcumin ; icariin ; Organic chemistry ; QD241-441
Subject code	616
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: بررسي تأثير عصاره‌ی انار در بیان پروتئین کلاژن نوع II، نشانگر ویژه‌ی غضروف در روند کندروژنز سلول‌هاي بنيادي

Mehri Katani / Behzad Zolfaghari / Mitra Soleimani / Ali Valiani / Batool Hashemibeni

مجله دانشکده پزشکی اصفهان, Vol 35, Iss 453, Pp 1540-

2018 Volume 1545

Abstract: مقدمه: بافت غضروف، فاقد عروق و اعصاب است و قابلیت ترمیم ندارد. در مهندسی بافت غضروف، از سلول‌های بنیادی و عوامل رشد استفاده می‌شود. در این مطالعه، تأثیر عصاره‌ی انار به عنوان عامل غضروف‌ساز سلول‌های بنیادی مشتق از بافت چربی بررسی گردید. روش‌ها: سلول‌های ... ...

Abstract	مقدمه: بافت غضروف، فاقد عروق و اعصاب است و قابلیت ترمیم ندارد. در مهندسی بافت غضروف، از سلول‌های بنیادی و عوامل رشد استفاده می‌شود. در این مطالعه، تأثیر عصاره‌ی انار به عنوان عامل غضروف‌ساز سلول‌های بنیادی مشتق از بافت چربی بررسی گردید. روش‌ها: سلول‌های بنیادی مشتق از چربی انسانی، سومین پاساژ سلولی در محیط کشت القای کندروژنیک در داربست فیبرین به مدت 2 هفته تحت تأثیر عصاره‌ی انار کشت داده شدند. روش‌های (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) و Western blot برای بررسی سلول‌های تمایز یافته به کار رفت. یافته‌ها: سلول‌های بنیادی تحت تأثیر عصاره‌ی انار به کندروسیت تمایز یافتند و تولید کلاژن نوع II توسط سلول‌های متمایز شده به اثبات رسید. نتیجه‌گیری: عصاره‌ی انار، یک القا کننده‌ی مناسب جهت بیان پروتئین کلاژن نوع II در سلول‌های بنیادی مشتق از چربی است.
Keywords	Chondrogenesis ; Stem cells ; Pomegranate ; Type II collagen ; Medicine ; R ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2018-01-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of genistein on apoptosis and proliferation of hepatocellular Carcinoma Hepa1-6 Cell Line

Masumeh Sanaei / Fraidoon Kavoosi / Ali Valiani / Mohamed Amin Ghobadifar

International Journal of Preventive Medicine, Vol 9, Iss 1, Pp 12-

2018 Volume 12

Abstract: Background: One of the main causes of mortality is hepatocellular carcinoma (HCC) which accounts for the third leading cause of deaths and one in forty deaths worldwide. The flavonoids, natural antioxidant compounds, account for a major group of ... ...

Abstract	Background: One of the main causes of mortality is hepatocellular carcinoma (HCC) which accounts for the third leading cause of deaths and one in forty deaths worldwide. The flavonoids, natural antioxidant compounds, account for a major group of polyphenolic compounds. One of the major isoflavones in soybean is genistein (GE) which can inhibit proliferation and induce apoptosis. Isoflavones, major type of phenolic materials, derived from dietary plants and medicinal herbs play a significant role in cancer prevention and treatment. Correlation between dietary habits and cancer risk including breast, prostate, and colon cancer has been reported. Various bioactivities of these compounds such as anticarcinogenic and antioxidant are responsible for their chemopreventive activities by which induce migration, proliferation, cell cycle arrest, and apoptosis. GE, one of the major isoflavones, is considered as a potent chemopreventive agent against cancer. The aim of this study was to investigate the inhibitory and apoptotic effects of GE on HCC Hepa1-6 cell line. Methods: Cell viability assay and cell cycle analysis with flow cytometry were used to evaluate proliferative and apoptotic effect GE. Results: GE inhibited the growth of Hepa1-6 cells and induced apoptosis with a concentration and time-dependent fashion. During GE treatment for 24, the half maximal inhibitory concentration (IC50) was 20 μM, and the maximum inhibition of cell growth was 52% (P < 0.01). The percentage of apoptotic cells with a concentration of 20 μM of GE after 24, 48, and 72 h was 35, 42, and 65%, respectively (P < 0.01). Conclusions: Our finding clearly indicated that GE can significantly inhibit proliferation of hepatocellular carcinoma Hepa 1-6 cell line and induce apoptosis in this cell line.
Keywords	Apoptosis ; genistein ; hepatocellular carcinoma ; proliferation ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of TGF-β3 and avocado/soybean unsaponifiable on chondrogenesis of human adipose-derived stem cells on poly (lactic-co-glycolic) acid/ hyaluronic acid hybrid scaffold

Majid Pourentezari / Zynolabedin Sharifian / Mohammad Mardani / Ali Valiani / Mohammad Zamani Rarani / Mohsen Setayesh Mehr / Fatemeh Eini / Batul Hashemibeni

Iranian Journal of Basic Medical Sciences, Vol 24, Iss 1, Pp 24-

2021 Volume 29

Abstract: Objective(s): Avocado/soybean unsaponifible (ASU) possesses properties including chondroprotective, anticatabolic, and anabolic. The goal behind this research was to detect the effect of ASU and TGF-β3 on the chondrogenesis of human adipose-derived stem ... ...

Abstract	Objective(s): Avocado/soybean unsaponifible (ASU) possesses properties including chondroprotective, anticatabolic, and anabolic. The goal behind this research was to detect the effect of ASU and TGF-β3 on the chondrogenesis of human adipose-derived stem cells (hADSCs) on poly (lactic-co-glycolic) acid (PLGA)/ hyaluronic acid (PLGA/HA) hybrid scaffold.Materials and Methods: First hADSCs were seeded in PLGA/Hyaluronic acid scaffold and cultured in chondrogenic media. These cells were assigned into 4 groups: control, TGFβ-3, ASU, and TGFβ-3+ASU. The viability was assessed separately by MTT. Real-time PCR was used to quantify the expression of chondrogenic specific genes [Sox9, collagen type II (ColII), Aggrecan (AGG)] and collagen type X (ColX). Moreover, Western blotting was employed to evaluate protein expression levels of collagens type II and X.Results: These findings indicated a significant increase in the proliferation and survival of hADSCs differentiated cells by ASU compared with the control group (P=0.008). Real-time PCR results revealed significant differences in the expression of AGG, SOX9, ColII, and ColX genes in the control group when compared with other groups (ASU, TGF-β3, and TGF-β3+ASU). ColII protein production significantly dropped in the TGF-β3 group in comparison with the TGF-β3+ASU group (0.000). The ColII (P=0.002) and ColX (P=0.002) protein production proved significantly higher in the TGF-β3+ASU group compared with the ASU group.Conclusion: Using the synergist form TGFβ-3, ASU induces chondrogenesis in hADSCs in PLGA/HA composite scaffold. This can be deduced with reduction of special markers of hyaline cartilage in comparison with ASU and decreased hypertrophic marker compared with TGF-β3.
Keywords	avocado soybean chondrogenesis human adipose ; derived stem cells hyaluronic acid poly (lactic ; co ; glycolic acid) transforming growth factor beta unsaponifiable ; Medicine ; R
Subject code	500
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of teaching integrated course of physical examination and radiological anatomy in practical limb anatomy on medical students’ learning outcomes

Hossain Sadeqi / Ali Valiani / Maryam Avizhgan / Seyed Abbas Ebrahimi / Amirreza Manteghinejad / Pantea Miralai / Athar Omid

BMC Medical Education, Vol 21, Iss 1, Pp 1-

2021 Volume 7

Abstract: Abstract Background In the last few decades, the need to change the curriculum of basic medical science has been further emphasized. The purpose of this study was to evaluate the effects of teaching integrated course of physical examination and ... ...

Abstract	Abstract Background In the last few decades, the need to change the curriculum of basic medical science has been further emphasized. The purpose of this study was to evaluate the effects of teaching integrated course of physical examination and radiological anatomy in practical limb anatomy on medical students’ learning outcomes. Methods This was an experimental study. Medical students (of the 4th semester of medical education) were divided into intervention and control groups. Related topics of physical examination and radiological anatomy were added to the practical limb anatomy courses of the intervention group. Practical knowledge of anatomy, clinical applications of anatomical knowledge, students ‘satisfaction, and students’ attitude toward the anatomy course were assessed at the end of the study. Knowledge retention was assessed three months after the semester. Results The intervention group scored significantly higher mean scores in practical knowledge of anatomy test, clinical applications of anatomical knowledge test and knowledge retention test (P-value < 0.05). In evaluating students’ satisfaction with the course, the intervention group was satisfied with the course and teacher performance and had appropriate attitude (Mean˃4, Max score = 5) towards the application of anatomy in medicine. Conclusions The findings of this study showed that teaching practical anatomy with a clinical integrated approach can improve the practical knowledge of anatomy, knowledge retention, and clinical applications of anatomical knowledge. In addition, an integrated approach was associated with greater student satisfaction and it makes students have appropriate attitude towards the application of anatomy in medicine.
Keywords	Anatomy ; Physical examination ; Radiological anatomy ; Clinical Integration ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	796
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Review on the Neuropathological Effects of Basal Nuclei in the Pathogenesis of Stuttering

Mohammad Javad Saeedi-Borujeni / Ali Valiani

مجله پژوهش در علوم توانبخشی, Vol 11, Iss 4, Pp 301-

2016 Volume 307

Abstract: The basal nuclei are a group of subcortical structures that act as a cohesive functional unit. These nuclei are situated at the base of the forebrain and are strongly connected with the cerebral cortex and thalamus. The basal ganglia are associated with ... ...

Abstract	The basal nuclei are a group of subcortical structures that act as a cohesive functional unit. These nuclei are situated at the base of the forebrain and are strongly connected with the cerebral cortex and thalamus. The basal ganglia are associated with a variety of functions, including voluntary motor control, learning, eye movements, cognitive and emotional functions. The basal nuclei include the motor, cognitive, eye movement, and limbic system circuits. The motor circuit contains a cortico-basal cortical pathway. Stuttering is a disorder in speech production with blocks, repetition, prolongation, or cessation of sound. The main cause of stuttering is unknown. Some speech disorders, such as stuttering, may be the result of disturbances in the circuits between the basal nuclei and the language motor area of the cerebral cortex. Due to their association with the cerebral cortex, especially Broca's area and speech motor cortex, the basal ganglia can influence the motor features of speech. In this review article, the possible relation between stuttering and basal nuclei was discussed.
Keywords	Basal nucleus ; Speech ; Stuttering ; Medicine ; R ; Therapeutics. Pharmacology ; RM1-950
Subject code	796
Language	Persian
Publishing date	2016-03-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: تهیه‌ی داربست نانوالیاف فیبرین/پلی وینیل الکل به روش الکتروریسی جهت کاربرد در مهندسی بافت

Ali Valiani / Ali Samadi / Batool Hashemibeni / Mohammad Rafienia

مجله دانشکده پزشکی اصفهان, Vol 34, Iss 388, Pp 737-

2016 Volume 744

Abstract: مقدمه: امروزه، نانو کامپوزیت‌های پلیمری زیست تخریب پذیر، با دارا بودن خواص مکانیکی و زیست سازگاری مناسب، از اهمیت ویژه‌ای در مهندسی بافت برخوردار هستند. هدف از انجام این مطالعه، ساخت و ارزیابی داربست نانوکامپوزیتی فیبرین/پلی‌وینیل الکل به روش الکتروریسی ... ...

Abstract	مقدمه: امروزه، نانو کامپوزیت‌های پلیمری زیست تخریب پذیر، با دارا بودن خواص مکانیکی و زیست سازگاری مناسب، از اهمیت ویژه‌ای در مهندسی بافت برخوردار هستند. هدف از انجام این مطالعه، ساخت و ارزیابی داربست نانوکامپوزیتی فیبرین/پلی‌وینیل الکل به روش الکتروریسی و زیستایی سلولی بر روی آن می‌باشد. روش‌ها: داربست نانو کامپوزیتی فیبرین/پلی‌وینیل الکل، با مقدار 5/28 درصد وزنی فیبرین نسبت به پلیمر، با روش الکتروریسی تهیه شد. درصد تخلخل داربست با استفاده از نرم‌افزار Matlab و شکل تخلخل‌ها، پراکندگی آن‌ها و اندازه‌ی نانوالیاف توسط میکروسکوپ الکترونی روبشی مشخص شدند. آزمون جذب آب و اندازه‌گیری زاویه‌ی تماس انجام شد. همچنین، برای ارزیابی زیستایی سلول بر روی داربست از سلول‌های بنیادی مشتق از چربی انسانی استفاده شد. یافته‌ها: میانگین اندازه‌گیری قطر الیاف داربست فیبرین/پلی‌وینیل الکل الکتروریسی شده، 500 نانومتر به دست آمد. متوسط اندازه‌ی تخلخل در نمونه‌ی تهیه شده 1/7 میکرومتر و تخلخل 81/83 درصد به دست آمد. همچنین، میانگین زاویه‌ی تماس 71/31 درجه و میانگین جذب آب 24 ساعته، 5/68 درصد بود. آزمون بررسی زیستایی سلول اختلاف معنی‌داری را نسبت به گروه‌های شاهد نشان داد. نتیجه‌گیری: با توجه به نتایج این مطالعه، می‌توان از داربست الکتروریسی شده‌ی فیبرین/پلی‌وینیل الکل در مهندسی بافت غضروف و عصب استفاده کرد.
Keywords	Nano-fibers ; Fibrin ; Electrospinning ; Scaffold ; Medicine ; R ; Medicine (General) ; R5-920
Language	Persian
Publishing date	2016-08-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of Poly(ε-Caprolactone)/Extracellular Matrix Nanofibers Composite Scaffold for Tissue Engineering

Sahar Ghosouri / Mohsen Setayeshmehr / Asghar Taheri-Kafrani / Parisa Dehghani / Ali Valiani

مجله دانشکده پزشکی اصفهان, Vol 37, Iss 521, Pp 296-

2019 Volume 302

Abstract: Background: Electrospun nanofibers have shown significant potential as an origin for forming cartilage tissue engineering scaffolds. Acellular extracellular matrices have been incorporated into nanofiber scaffolds to more closely replicate the ... ...

Abstract	Background: Electrospun nanofibers have shown significant potential as an origin for forming cartilage tissue engineering scaffolds. Acellular extracellular matrices have been incorporated into nanofiber scaffolds to more closely replicate the extracellular niche. The aim of this study was to investigate the electrospinning of poly(ε-caprolactone)/extracellular matrix (PCL/ECM) and its mechanical and biological behavior for tissue engineering. Methods: PCL and PCL/ECM scaffolds were prepared via electrospinning of the 10% (w/v) solution contain PCL and PCL/ECM by dichloromethane (DCM) and dimethylsulfoxide (DMSO) solutions. The MTT technique was used to study the survival and proliferation of human adipose-derived stem cells in scaffold. The morphology, stability, and scaffold surface properties were studied using scanning electron microscopy, tensile strength test, water absorption, and contact angle measurement. Findings: The PCL/ECM electrospinning scaffold showed significant increase in hydrophobicity, water absorption, and tensile strength compared to PCL electrospinning scaffold. The porosity and diameter of the fibers in the scaffold had a relative reduction. Moreover, the viability and proliferation of cells on the seventh day showed a significant increase. Conclusion: The results of this study showed that adding extracellular matrix to PCL scaffold improves the properties of the scaffold for tissue engineering.
Keywords	Tissue engineering ; Nanofibers ; Poly(sigma-caprolactone) ; Extracellular matrix ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	500
Language	Persian
Publishing date	2019-07-01T00:00:00Z
Publisher	Vesnu Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of the efficacy of Piascledine and transforming growth factor β1 on chondrogenic differentiation of human adipose-derived stem cells in fibrin and fibrin-alginate scaffolds

Batul Hashemibeni / Ali Valiani / Mojtaba Esmaeili / Mohamad Kazemi / Maryam Aliakbari / Farhad Golshan Iranpour

Iranian Journal of Basic Medical Sciences, Vol 21, Iss 2, Pp 212-

2018 Volume 218

Abstract: Objective(s):The aim of this study was to compare the chondrogenic induction potential of Piascledine and TGF-β1 on adipose-derived stem cells (ADSCs) in fibrin and fibrin-alginate scaffolds. Materials and Methods: Human subcutaneous adipose tissues were ...

Abstract	Objective(s):The aim of this study was to compare the chondrogenic induction potential of Piascledine and TGF-β1 on adipose-derived stem cells (ADSCs) in fibrin and fibrin-alginate scaffolds. Materials and Methods: Human subcutaneous adipose tissues were harvested from three patients who were scheduled to undergo liposuction. Isolated ADSCs were proliferated in a culture medium. Then, the cells were seeded in fibrin or fibrin-alginate scaffolds and cultured for 14 days in a chondrogenic medium containing Piascledine, TGF-β1, or both. The rate of cell proliferation and survival was evaluated by using MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assay and the rate of the expression of type II collagen, aggrecan, and type X collagen genes was evaluated by real-time polymerase chain reaction (real-time PCR) method. Results: The MTT results showed that Piascledine is able to enhance the proliferation and survival of ADSCs in fibrin scaffolds in comparison to other groups (P
Keywords	Chondrogenesis Piascledine ; stem cells ; Tissue engineering ; Transforming growth- ; factor beta 1 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cartilage Tissue Engineering Via Icariin and Adipose-derived Stem Cells in Fibrin Scaffold

Maryam Bahrami / Ali Valiani / Noushin Amirpour / Mohammad Zamani Ra Rani / Batool Hashemibeni

Advanced Biomedical Research, Vol 7, Iss 1, Pp 36-

2018 Volume 36

Abstract: Background: Nowadays, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. This study evaluates the function of herbal extracts icariin (ICA), the major pharmacological constituent of herba Epimedium, compared with ... ...

Abstract	Background: Nowadays, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. This study evaluates the function of herbal extracts icariin (ICA), the major pharmacological constituent of herba Epimedium, compared with transforming growth factor β3 (TGFβ3) to prove its potential effect for cartilage tissue engineering. Materials and Methods: ICA, TGFβ3, and TGFβ3 + ICA were added fibrin-cell constructions derived from adipose tissue stem cells. After 14 days, cell viability analyzed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H- tetrazolium bromide assay and the expression of cartilage genes was evaluated with real-time polymerase chain reaction (RT-PCR). Results: The results showed ICA, TGFβ3, and TGFβ3 + ICA increased the rate of proliferation and viability of cells; but there were no significant differences between them (P > 0.05). Furthermore, quantitative RT-PCR analysis demonstrated that cooperation of ICA with TGFβ3 showed a better effect in expression of cartilaginous specific genes and increased Sox9, type II collagen, and aggrecan expression significantly. Furthermore, the results of the expression of type I and X collagens revealed that TGFβ3 increased the expression of them (P < 0.01); However, treatment with ICA + TGFβ3 down regulated the expression of these genes significantly. Conclusion: The results indicated ICA could be a potential factor for chondrogenesis and in cooperation with TGFβ3 could reduce its hypertrophic effects and it is a promising factor for cartilage tissue engineering.
Keywords	Adipose-derived stem cells ; chondrocytes ; chondrogenesis ; icariin ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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