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  1. Article ; Online: Enhanced survival of Lacticaseibacillus rhamnosus in simulated gastrointestinal conditions using layer-by-layer encapsulation.

    Chehreara, Afsaneh / Tabandeh, Fatemeh / Otadi, Maryam / Alihosseini, Afshar / Partovinia, Ali

    Biotechnology letters

    2022  Volume 44, Issue 11, Page(s) 1277–1286

    Abstract: Objective: The release behavior of Lacticaseibacillus rhamnosus from single bilayer microcapsules of alginate-chitosan (AC) and its double bilayer (ACAC) was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Methods ... ...

    Abstract Objective: The release behavior of Lacticaseibacillus rhamnosus from single bilayer microcapsules of alginate-chitosan (AC) and its double bilayer (ACAC) was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Methods Multilayer polyelectrolyte AC microcapsules were fabricated using the layer-by-layer (LbL) self-assembly technique through electrostatic interactions. Results AC and ACAC microcapsules kept their integrity and mechanical stability in simulated gastric conditions. Bacterial cells remained inside microcapsules in SGF and dissolution of microcapsules was observed in SIF. To improve the bacterial survivability, L. rhamnosus was co-encapsulated in a double bilayer of AC hydrogels with calcium carbonate as an antacid agent. Conclusions The LbL self-assembly technology provides stable and target release for ACAC microcapsules. Therefore, the double bilayer polyelectrolyte microcapsules have a remarkable potential for successful application in the targeted and controlled delivery of different probiotics and drugs.
    MeSH term(s) Capsules ; Hexuronic Acids ; Polyelectrolytes ; Glucuronic Acid ; Lactobacillus rhamnosus ; Alginates ; Chitosan ; Probiotics
    Chemical Substances Capsules ; Hexuronic Acids ; Polyelectrolytes ; Glucuronic Acid (8A5D83Q4RW) ; Alginates ; Chitosan (9012-76-4)
    Language English
    Publishing date 2022-09-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-022-03289-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhanced survival of Lacticaseibacillus rhamnosus in simulated gastrointestinal conditions using layer-by-layer encapsulation

    Chehreara, Afsaneh / Tabandeh, Fatemeh / Otadi, Maryam / Alihosseini, Afshar / Partovinia, Ali

    Biotechnol Lett. 2022 Nov., v. 44, no. 11 p.1277-1286

    2022  

    Abstract: OBJECTIVE: The release behavior of Lacticaseibacillus rhamnosus from single bilayer microcapsules of alginate-chitosan (AC) and its double bilayer (ACAC) was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Methods ... ...

    Abstract OBJECTIVE: The release behavior of Lacticaseibacillus rhamnosus from single bilayer microcapsules of alginate-chitosan (AC) and its double bilayer (ACAC) was investigated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Methods Multilayer polyelectrolyte AC microcapsules were fabricated using the layer-by-layer (LbL) self-assembly technique through electrostatic interactions. Results AC and ACAC microcapsules kept their integrity and mechanical stability in simulated gastric conditions. Bacterial cells remained inside microcapsules in SGF and dissolution of microcapsules was observed in SIF. To improve the bacterial survivability, L. rhamnosus was co-encapsulated in a double bilayer of AC hydrogels with calcium carbonate as an antacid agent. Conclusions The LbL self-assembly technology provides stable and target release for ACAC microcapsules. Therefore, the double bilayer polyelectrolyte microcapsules have a remarkable potential for successful application in the targeted and controlled delivery of different probiotics and drugs.
    Keywords antacids ; calcium carbonate ; electrolytes ; encapsulation ; gastric juice ; gastrointestinal system ; hydrogels ; intestinal secretions ; probiotics
    Language English
    Dates of publication 2022-11
    Size p. 1277-1286.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-022-03289-0
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Analysis of Dynamics Targeting CNT-Based Drug Delivery through Lung Cancer Cells: Design, Simulation, and Computational Approach.

    Sohrabi, Nafiseh / Alihosseini, Afshar / Pirouzfar, Vahid / Pedram, Maysam Zamani

    Membranes

    2020  Volume 10, Issue 10

    Abstract: Nowadays, carbon nano (CN) structures and specifically carbon nanotubes (CNTs), because of the nanotube's nanoscale shape, are widely used in carrier and separation applications. The conjugation of CNTs with polysaccharide, proteins, drugs, and magnetic ... ...

    Abstract Nowadays, carbon nano (CN) structures and specifically carbon nanotubes (CNTs), because of the nanotube's nanoscale shape, are widely used in carrier and separation applications. The conjugation of CNTs with polysaccharide, proteins, drugs, and magnetic nanoparticles provides a chance for smart targeting and trajectory manipulation, which are used in the crucial field of life science applications, including for cancer disease diagnostics and treatments. Providing an optimal procedure for delivering a drug to a specific area based on mathematical criteria is key in systemic delivery design. Trajectory guidance and applied force control are the main parameters affected by systemic delivery. Moreover, a better understanding of the tissue parameters and cell membrane molecular behaviour are other factors that can be indirectly affected by the targeted delivery. Both sides are an essential part of successful targeting. The lung is one of the challenging organs for drug delivery inside the human body. It has a large surface area with a thin epithelium layer. A few severe diseases directly involve human lung cells, and optimal and successful drug delivery to the lung for the treatment procedure is vital. In this paper, we studied functionalized CNTs' targeted delivery via crossing through the lung cell membrane. Molecular dynamics (MD) software simulated all the interaction forces. Mathematical modelling of the cell membrane and proposed delivery system based on the relation of velocity and force has been considered. Dynamics equations for CNTs were defined in the time and frequency domain using control theory methods. The proposed delivery system consists of two main parts: crossing through the cell membrane and targeting inside the cell. For both steps, a mathematical model and a proper magnetic field profile have been proposed. The designed system provides criteria for crossing through the cell membrane within 30 s to 5 min and a translocation profile of 1 to 100 Å.
    Language English
    Publishing date 2020-10-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes10100283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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