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  1. Article ; Online: Evaluating the risk-benefit ratio of immunotherapy according to liver-functional reserve in advanced HCC: the dark side of the moon.

    Cabibbo, Giuseppe / Celsa, Ciro / Alimenti, Eleonora / Iavarone, Massimo

    Hepatology (Baltimore, Md.)

    2023  Volume 77, Issue 4, Page(s) 1074–1077

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Moon ; Immunotherapy/adverse effects
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter: immune-mediated inflammatory diseases and inflammatory bowel disease-are we ready for a Copernican revolution?

    Bezzio, Cristina / Alimenti, Eleonora / Saibeni, Simone

    Alimentary pharmacology & therapeutics

    2022  Volume 56, Issue 9, Page(s) 1429–1430

    MeSH term(s) Chronic Disease ; Humans ; Inflammatory Bowel Diseases/drug therapy
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cancer Risk in Patients Treated with the JAK Inhibitor Tofacitinib: Systematic Review and Meta-Analysis.

    Bezzio, Cristina / Vernero, Marta / Ribaldone, Davide Giuseppe / Alimenti, Eleonora / Manes, Gianpiero / Saibeni, Simone

    Cancers

    2023  Volume 15, Issue 8

    Abstract: Tofacitinib is approved for several immune-mediated inflammatory diseases, but safety concerns have recently been raised. We searched PubMed (accessed on 27 February 2023) for original articles regarding tofacitinib's cancer risk when used for rheumatoid ...

    Abstract Tofacitinib is approved for several immune-mediated inflammatory diseases, but safety concerns have recently been raised. We searched PubMed (accessed on 27 February 2023) for original articles regarding tofacitinib's cancer risk when used for rheumatoid arthritis, ulcerative colitis, Crohn's disease, psoriatic arthritis, and ankylosing spondylitis. Of the 2047 initial records, 22 articles describing 26 controlled studies (including 22 randomized controlled trials) were selected. In the comparison between tofacitinib and any control treatment, the relative risk (RR) for any cancer was 1.06 (95% CI, 0.86-1.31;
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Low-Baseline PD1+ Granulocytes Predict Responses to Atezolizumab-Bevacizumab in Hepatocellular Carcinoma.

    Giovannini, Catia / Suzzi, Fabrizia / Tovoli, Francesco / Bruccoleri, Mariangela / Marseglia, Mariarosaria / Alimenti, Eleonora / Fornari, Francesca / Iavarone, Massimo / Piscaglia, Fabio / Gramantieri, Laura

    Cancers

    2023  Volume 15, Issue 6

    Abstract: Introduction: Immune check point inhibitors have recently entered the armamentarium of advanced hepatocellular carcinoma (HCC) treatment. Among them, the combination of atezolizumab plus bevacizumab has pushed it a step forward; however, a number of ... ...

    Abstract Introduction: Immune check point inhibitors have recently entered the armamentarium of advanced hepatocellular carcinoma (HCC) treatment. Among them, the combination of atezolizumab plus bevacizumab has pushed it a step forward; however, a number of patients still present primary non-responses without any biomarker to predict responses to different options. Here, we aimed to identify a putative baseline biomarker to predict the response to atezolizumab-bevacizumab, by investigating whether baseline PD1+ and PD-L1+ peripheral granulocyte percentages might offer a non-invasive, cheap, and easily feasible assay.
    Methods: A prospective Italian cohort of 34 patients treated by atezolizumab-bevacizumab was tested to assay the baseline percentage of peripheral granulocytes and their PD1 and PD-L1 expression. The neutrophil to lymphocyte ratio (NLR) was also considered, and all data were compared with the clinical course of patients.
    Results: A low-baseline PD1+ peripheral granulocyte percentage turned out to predict responder patients (mean ±SD of PD1+ granulocyte percentage in responders versus non-responders: 9.9 ± 9.1 vs. 29.2 ± 17.6; student's
    Conclusions: A low-baseline PD1+ peripheral granulocyte percentage is associated with responses to atezolizumab-bevacizumab treatment in advanced HCC. These findings encourage evaluating this minimally invasive, cheap, and easy test in further independent cohorts and outlining the relevance of innate immunity in the response to immune-checkpoint inhibitors.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061661
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  5. Article: Impact of Sarcopenia on the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib.

    Biselli, Maurizio / Reggidori, Nicola / Iavarone, Massimo / Renzulli, Matteo / Lani, Lorenzo / Granito, Alessandro / Piscaglia, Fabio / Lorenzini, Stefania / Alimenti, Eleonora / Vara, Giulio / Caraceni, Paolo / Sangiovanni, Angelo / Marignani, Massimo / Gigante, Elia / Brandi, Nicolò / Gramenzi, Annagiulia / Trevisani, Franco

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with ... ...

    Abstract Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with Sorafenib.
    Methods: A total of 328 patients were retrospectively analyzed. All patients had an abdominal CT scan within 8 weeks prior to the start of treatment. Two cohorts of patients were analyzed: the "Training Group" (215 patients) and the "Validation Group" (113 patients). Sarcopenia was defined by reduced skeletal muscle index, calculated from an L3 section CT image.
    Results: Sarcopenia was present in 48% of the training group and 50% of the validation group. At multivariate analysis, sarcopenia (HR: 1.47,
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061080
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  6. Article ; Online: Circulating CD8 lymphocytes predict response to atezolizumab-bevacizumab in hepatocellular carcinoma.

    Gramantieri, Laura / Suzzi, Fabrizia / Bassi, Cristian / D'Abundo, Lucilla / Tovoli, Francesco / Bruccoleri, Mariangela / Marseglia, Mariarosaria / Alimenti, Eleonora / Fornari, Francesca / Negrini, Massimo / Iavarone, Massimo / Piscaglia, Fabio / Giovannini, Catia

    European journal of immunology

    2023  Volume 54, Issue 2, Page(s) e2350637

    Abstract: Due to the lack of biomarkers predictive of response to atezolizumab-bevacizumab, the standard of care for advanced HCC, we analyzed baseline and early on-treatment variation of peripheral lymphocyte populations of 37 prospective patients treated by ... ...

    Abstract Due to the lack of biomarkers predictive of response to atezolizumab-bevacizumab, the standard of care for advanced HCC, we analyzed baseline and early on-treatment variation of peripheral lymphocyte populations of 37 prospective patients treated by atezolizumab-bevacizumab and in 15 prospective patients treated by sorafenib or lenvatinib (TKIs). RNAseq analysis followed by RT-PCR validation on patients-derived PBMC was also performed. At first imaging, re-evaluation 13 patients receiving atezolizumab-bevacizumab, showed an objective response, 17 stable disease, while 7 were nonresponders. Baseline CD8+ and CD8+PD-L1+ peripheral lymphocytes were lower in responders versus nonresponders (T-test, p = 0.012 and 0.004, respectively). At 3 weeks, 28 of 30 responders displayed a rise of CD8+PD1+ lymphocytes with a positive mean fold change of 4.35 (±5.6 SD), whereas 6 of 7 nonresponders displayed a negative fold change of 0.89 (±0.84 SD). These changes were not observed in patients treated by TKIs. TRIM56, TRIM16, TRIM64, and Ki67 mRNAs were validated as upregulated in responders versus nonresponders after 3 weeks after treatment start, providing possible evidence of immune activation. Baseline CD8+ and CD8+PD-L1+ peripheral lymphocytes and early changes in CD8+PD1+ lymphocytes predict response to atezolizumab-bevacizumab providing noninvasive markers to complement clinical practice in the very early phases of treatment of HCC patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Bevacizumab/therapeutic use ; B7-H1 Antigen ; Liver Neoplasms ; Prospective Studies ; Leukocytes, Mononuclear ; CD8-Positive T-Lymphocytes ; Biomarkers, Tumor ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases ; Antibodies, Monoclonal, Humanized
    Chemical Substances atezolizumab (52CMI0WC3Y) ; Bevacizumab (2S9ZZM9Q9V) ; B7-H1 Antigen ; Biomarkers, Tumor ; TRIM16 protein, human (EC 2.3.2.27) ; Tripartite Motif Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; TRIM56 protein, human (EC 2.3.2.27) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-12-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350637
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  7. Article ; Online: Prevalence, incidence and clinical features of SARS-CoV-2 infection in adult coeliac patients.

    Schiepatti, Annalisa / Alimenti, Eleonora / Maimaris, Stiliano / Nicolardi, Maria Luisa / Manzella La Barbera, Francesca / Baiardi, Paola / Biagi, Federico

    European journal of gastroenterology & hepatology

    2021  Volume 33, Issue 11, Page(s) 1361–1366

    Abstract: Objectives: Data on SARS-CoV-2 disease (COVID-19) in adult coeliac disease (CD) are lacking. The aim of the present study is to evaluate the epidemiology and clinical features of COVID-19 in adult coeliac patients regularly followed-up at our centre ... ...

    Abstract Objectives: Data on SARS-CoV-2 disease (COVID-19) in adult coeliac disease (CD) are lacking. The aim of the present study is to evaluate the epidemiology and clinical features of COVID-19 in adult coeliac patients regularly followed-up at our centre since January 2015.
    Methods: Data about general health status and clinical features of laboratory-confirmed COVID-19 were prospectively collected over the phone. Data about CD were retrospectively collected from clinical notes. Prevalence and incidence of COVID-19 were compared between the coeliac cohort and the figures in the general population of Lombardy, Northern Italy between 20 February to 5 June 2020 provided by the Italian National Institute of Health (Istituto Superiore di Sanità) and the Lombardy regional government.
    Results: Nine out of 324 patients contracted COVID-19, thus resulting in a prevalence of 2.78% [95% confidence interval (CI) 0.98-4.58] and an incidence rate of 8.15/1000 person-month (95% CI 4.24-15.66). Prevalence of COVID-19 ascertained by means of nasal swab was 1.79% (95% CI 0.22-3.35) and the incidence rate 5.26/1000 person-month (95% CI 2.19-12.63), without difference from the general population. Clinical type of CD, age, sex, duration and adherence to a gluten-free diet, and mucosal healing did not differ between coeliac patients with and without COVID-19. None of the 9 patients with COVID-19 required hospitalization.
    Conclusion: Patients with CD do not seem to carry an increased risk of COVID-19 compared to the general population and their disease course is mild.
    MeSH term(s) Adult ; COVID-19 ; Humans ; Incidence ; Italy/epidemiology ; Prevalence ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000001969
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  8. Article ; Online: Determinants and Trends of Adherence to a Gluten-Free Diet in Adult Celiac Patients on a Long-term Follow-up (2000-2020).

    Schiepatti, Annalisa / Maimaris, Stiliano / Nicolardi, Maria Luisa / Alimenti, Eleonora / Vernero, Marta / Costetti, Martina / Costa, Stefania / Biagi, Federico

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 20, Issue 4, Page(s) e741–e749

    Abstract: Background & aims: Data on factors governing long-term adherence to a gluten-free diet (GFD) in celiac disease (CD) are scarce. We aimed to determine trends and clinical predictors of long-term GFD adherence in adult CD.: Methods: Initial and long- ... ...

    Abstract Background & aims: Data on factors governing long-term adherence to a gluten-free diet (GFD) in celiac disease (CD) are scarce. We aimed to determine trends and clinical predictors of long-term GFD adherence in adult CD.
    Methods: Initial and long-term (>3 years) GFD adherence, clinical characteristics at baseline and follow-up were collected retrospectively from celiac patients followed-up over 20 years (2000-2020). Predictors of long-term GFD adherence at diagnosis, and follow-up were evaluated by multivariate logistic regression.
    Results: 248 patients (37 ± 12 years, 186F, median time on a GFD 90 months) were included. Twenty-five (10.1%) had only short-term follow-up (<3 years) while 223 (89.9%) had initial and long-term dietary assessment. 187/223 (83.9%) patients were initially adherent and 36/223 (16.1%) were not. 17/36 (47.2%) patients initially not adherent become adherent, while only 4/187 (2.1%) initially adherent patients became not adherent. In the long-term, 200/223 (89.7%) were adherent and 21/223 (9.4%) patients were not. Adherence improved more frequently than worsened (OR, 39.5; 95% CI, 11.4-178.5; P < .01). Classical symptoms (diarrhea, weight loss) at diagnosis of CD predicted stricter long-term GFD adherence (OR, 3.27; 95% CI, 1.21-8.81; P = .02), while anemia (OR, 0.31; 95% CI, 0.12-0.82; P = .02) and dermatitis herpetiformis (OR, 0.23; 95% CI, 0.06-0.91; P = .04) predicted poorer long-term adherence. At follow-up, initial GFD adherence (OR, 42.70; 95% CI, 10.70-171.00; P = .04) was the major determinant of long-term GFD adherence.
    Conclusions: GFD adherence changes over time in <10% of patients, generally improving when it does. Major determinants of long-term GFD adherence are classical symptoms at diagnosis and initial adherence to a GFD. Patients with anemia or dermatitis herpetiformis at diagnosis require stricter dietetic input.
    MeSH term(s) Adult ; Celiac Disease/diagnosis ; Diet, Gluten-Free ; Follow-Up Studies ; Humans ; Patient Compliance ; Retrospective Studies
    Language English
    Publishing date 2020-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.12.015
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  9. Article ; Online: Efficacy and safety of lenvatinib in patients with recurrent hepatocellular carcinoma after liver transplantation.

    Bang, Kyunghye / Casadei-Gardini, Andrea / Yoo, Changhoon / Iavarone, Massimo / Ryu, Min-Hee / Park, Sook Ryun / Kim, Hyung-Don / Yoon, Young-In / Jung, Dong-Hwan / Park, Gil-Chun / Ahn, Chul-Soo / Moon, Deok-Bog / Hwang, Shin / Kim, Ki-Hun / Song, Gi-Won / Mazzarelli, Chiara / Alimenti, Eleonora / Chan, Stephen L / De Giorgio, Massimo /
    Ryoo, Baek-Yeol / Lee, Sung-Gyu

    Cancer medicine

    2022  Volume 12, Issue 3, Page(s) 2572–2579

    Abstract: Introduction: Lenvatinib is approved for the treatment of patients with metastatic or recurrent hepatocellular carcinoma (HCC); however, clinical outcomes of lenvatinib therapy in patients with post-liver transplantation (LT) HCC recurrence remain ... ...

    Abstract Introduction: Lenvatinib is approved for the treatment of patients with metastatic or recurrent hepatocellular carcinoma (HCC); however, clinical outcomes of lenvatinib therapy in patients with post-liver transplantation (LT) HCC recurrence remain unclear. We investigated the efficacy and safety of lenvatinib in patients with post-LT HCC recurrence.
    Methods: This multinational, multicenter, retrospective study included 45 patients with recurrent HCC after LT who received lenvatinib at six institutions in three countries (Korea, Italy, and Hong Kong) from June 2017 to October 2021.
    Results: At the time of lenvatinib initiation, 95.6% (n = 43) of patients had Child-Pugh A status, and 35 (77.8%) and 10 (22.2%) participants were classified as having albumin-bilirubin (ALBI) grades 1 and 2, respectively. The objective response rate was 20.0%. With a median follow-up duration of 12.9 months (95% confidence interval [CI]: 11.2-14.7), the median progression-free survival and overall survival (OS) were 7.6 (95% CI: 5.3-9.8) months, and 14.5 (95% CI: 0.8-28.2) months, respectively. Patients with ALBI grade 1 showed significantly better OS (52.3 months, [95% CI: not assessable]) than patients with ALBI grade 2 (11.1 months [95% CI: 0.0-30.4 months], p = 0.003). The most common adverse events were hypertension (n = 25, 55.6%), fatigue (n = 17, 37.8%), and anorexia (n = 14, 31.1%).
    Conclusion: Lenvatinib showed consistent efficacy and toxicity profiles in patients with post-LT HCC recurrence that were comparable to those reported from previous studies among non-LT HCC patients. The baseline ALBI grade correlated with better OS in post-LT lenvatinib-treated patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Liver Transplantation ; Retrospective Studies ; Serum Albumin ; Biomarkers, Tumor ; Bilirubin
    Chemical Substances lenvatinib (EE083865G2) ; Serum Albumin ; Biomarkers, Tumor ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5123
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  10. Article ; Online: SARS-CoV-2 infection in patients with inflammatory bowel disease: comparison between the first and second pandemic waves.

    Bezzio, Cristina / Vernero, Marta / Costa, Stefania / Armuzzi, Alessandro / Fiorino, Gionata / Ardizzone, Sandro / Roselli, Jenny / Carparelli, Sonia / Orlando, Ambrogio / Caprioli, Flavio Andrea / Castiglione, Fabiana / Viganò, Chiara / Ribaldone, Davide G / Zingone, Fabiana / Monterubbianesi, Rita / Imperatore, Nicola / Festa, Stefano / Daperno, Marco / Scucchi, Ludovica /
    Ferronato, Antonio / Pastorelli, Luca / Alimenti, Eleonora / Balestrieri, Paola / Ricci, Chiara / Cappello, Maria / Felice, Carla / Coppini, Francesca / Alvisi, Patrizia / Di Luna, Imma / Gerardi, Viviana / Variola, Angela / Mazzuoli, Silvia / Lenti, Marco Vincenzo / Saibeni, Simone

    BMC gastroenterology

    2023  Volume 23, Issue 1, Page(s) 230

    Abstract: Background: In Italy, the incidence of SARS-CoV-2 infection peaked in April and November 2020, defining two pandemic waves of coronavirus disease 2019 (COVID-19). This study compared the characteristics and outcomes of patients with inflammatory bowel ... ...

    Abstract Background: In Italy, the incidence of SARS-CoV-2 infection peaked in April and November 2020, defining two pandemic waves of coronavirus disease 2019 (COVID-19). This study compared the characteristics and outcomes of patients with inflammatory bowel disease (IBD) and SARS-CoV-2 infections between pandemic waves.
    Methods: Observational longitudinal study of IBD patients with SARS-CoV-2 infection. Patients with established diagnoses of IBD and of SARS-CoV-2 infection were consecutively enrolled in two periods: (i) first wave, from 1 March 2020 to 31 May 2020; and (ii) second wave, from 15 September to 15 December 2020.
    Results: We enrolled 937 IBD patients (219 in the first wave, 718 in the second wave). Patients of the first wave were older (mean ± SD: 46.3 ± 16.2 vs. 44.1 ± 15.4 years, p = 0.06), more likely to have ulcerative colitis (58.0% vs. 44.4%, p < 0.001) and comorbidities (48.9% vs. 38.9%; p < 0.01), and more frequently residing in Northern Italy (73.1% vs. 46.0%, p < 0.001) than patients of the second wave. There were no significant differences between pandemic waves in sex (male: 54.3% vs. 53.3%, p = 0.82) or frequency of active IBD (44.3% vs. 39.0%, p = 0.18). The rates of negative outcomes were significantly higher in the first than second wave: pneumonia (27.8% vs. 11.7%, p < 0.001), hospital admission (27.4% vs. 9.7%, p < 0.001), ventilatory support (11.9% vs. 5.4%, p < 0.003) and death (5.5% vs. 1.8%, p < 0.007).
    Conclusion: Between the first and second SARS-CoV-2 pandemic waves, demographic, clinical and geographical features of IBD patients were different as were the symptoms and outcomes of infection. These differences are likely due to the different epidemiological situations and diagnostic possibilities between the two waves.
    MeSH term(s) Humans ; Male ; COVID-19/epidemiology ; Longitudinal Studies ; Pandemics ; SARS-CoV-2 ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-023-02841-0
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