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  1. AU="Alison D. Augustine"
  2. AU="Khandait, Harshwardhan"
  3. AU="Sabino, Raquel"
  4. AU="Dlugosz, Sascha"
  5. AU="Sandra Geschka"
  6. AU="de Bruin, Natalie"
  7. AU="Lecia V. Sequist"
  8. AU=Ezechukwu Ifunanya
  9. AU=Kantarjian Hagop AU=Kantarjian Hagop
  10. AU="Yao, Xiaomin"
  11. AU=Dwork A J AU=Dwork A J
  12. AU="Tang, Xiaoxiao"
  13. AU="Gulez, Nesrin"
  14. AU="Perrine Gaub"
  15. AU="Pier-Alexandre Tardif"
  16. AU="Aksu, Tuana" AU="Aksu, Tuana"
  17. AU="Mukherjee, Mousumi"
  18. AU=Qualliotine Jesse R
  19. AU="Lookzadeh, Somayeh"
  20. AU=Cartwright Bethany R.
  21. AU="Kappenberger, Alina-Sophie"
  22. AU=Luukinen H
  23. AU="Przybylski, Bartłomiej"
  24. AU="Lisda Amalia" AU="Lisda Amalia"
  25. AU="Ahmed S.M. Al-Janabi"
  26. AU="Yamaguchi, Hiromi"
  27. AU="Boyatzis, Chris J"

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  1. Artikel ; Online: Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes

    Al Ozonoff / Naresh Doni Jayavelu / Shanshan Liu / Esther Melamed / Carly E. Milliren / Jingjing Qi / Linda N. Geng / Grace A. McComsey / Charles B. Cairns / Lindsey R. Baden / Joanna Schaenman / Albert C. Shaw / Hady Samaha / Vicki Seyfert-Margolis / Florian Krammer / Lindsey B. Rosen / Hanno Steen / Caitlin Syphurs / Ravi Dandekar /
    Casey P. Shannon / Rafick P. Sekaly / Lauren I. R. Ehrlich / David B. Corry / Farrah Kheradmand / Mark A. Atkinson / Scott C. Brakenridge / Nelson I. Agudelo Higuita / Jordan P. Metcalf / Catherine L. Hough / William B. Messer / Bali Pulendran / Kari C. Nadeau / Mark M. Davis / Ana Fernandez Sesma / Viviana Simon / Harm van Bakel / Seunghee Kim-Schulze / David A. Hafler / Ofer Levy / Monica Kraft / Chris Bime / Elias K. Haddad / Carolyn S. Calfee / David J. Erle / Charles R. Langelier / Walter Eckalbar / Steven E. Bosinger / IMPACC Network / Bjoern Peters / Steven H. Kleinstein / Elaine F. Reed / Alison D. Augustine / Joann Diray-Arce / Holden T. Maecker / Matthew C. Altman / Ruth R. Montgomery / Patrice M. Becker / Nadine Rouphael

    Nature Communications, Vol 15, Iss 1, Pp 1-

    results from the IMPACC study

    2024  Band 17

    Abstract: Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. ... ...

    Abstract Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients

    Al Ozonoff / Joanna Schaenman / Naresh Doni Jayavelu / Carly E. Milliren / Carolyn S. Calfee / Charles B. Cairns / Monica Kraft / Lindsey R. Baden / Albert C. Shaw / Florian Krammer / Harm van Bakel / Denise A. Esserman / Shanshan Liu / Ana Fernandez Sesma / Viviana Simon / David A. Hafler / Ruth R. Montgomery / Steven H. Kleinstein / Ofer Levy /
    Christian Bime / Elias K. Haddad / David J. Erle / Bali Pulendran / Kari C. Nadeau / Mark M. Davis / Catherine L. Hough / William B. Messer / Nelson I. Agudelo Higuita / Jordan P. Metcalf / Mark A. Atkinson / Scott C. Brakenridge / David Corry / Farrah Kheradmand / Lauren I.R. Ehrlich / Esther Melamed / Grace A. McComsey / Rafick Sekaly / Joann Diray-Arce / Bjoern Peters / Alison D. Augustine / Elaine F. Reed / Matthew C. Altman / Patrice M. Becker / Nadine Rouphael

    EBioMedicine, Vol 83, Iss , Pp 104208- (2022)

    Results from the IMPACC study

    2022  

    Abstract: Summary: Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods: Immunophenotyping Assessment ...

    Abstract Summary: Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods: Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients from 20 hospitals across the United States. Disease severity was assessed using a 7-point ordinal scale based on degree of respiratory illness. Patients were prospectively surveyed for 1 year after discharge for post-acute sequalae of COVID-19 (PASC) through quarterly surveys. Demographics, comorbidities, radiographic findings, clinical laboratory values, SARS-CoV-2 PCR and serology were captured over a 28-day period. Multivariable logistic regression was performed. Findings: The median age was 59 years (interquartile range [IQR] 20); 711 (61%) were men; overall mortality was 14%, and 228 (20%) required invasive mechanical ventilation. Unsupervised clustering of ordinal score over time revealed distinct disease course trajectories. Risk factors associated with prolonged hospitalization or death by day 28 included age ≥ 65 years (odds ratio [OR], 2.01; 95% CI 1.28–3.17), Hispanic ethnicity (OR, 1.71; 95% CI 1.13–2.57), elevated baseline creatinine (OR 2.80; 95% CI 1.63– 4.80) or troponin (OR 1.89; 95% 1.03–3.47), baseline lymphopenia (OR 2.19; 95% CI 1.61–2.97), presence of infiltrate by chest imaging (OR 3.16; 95% CI 1.96–5.10), and high SARS-CoV2 viral load (OR 1.53; 95% CI 1.17–2.00). Fatal cases had the lowest ratio of SARS-CoV-2 antibody to viral load levels compared to other trajectories over time (p=0.001). 589 survivors (51%) completed at least one survey at follow-up with 305 (52%) having at least one symptom consistent with PASC, most commonly dyspnea (56% among symptomatic patients). Female sex was the only associated risk factor for PASC. Interpretation: Integration of PCR cycle threshold, and antibody values with demographics, comorbidities, and ...
    Schlagwörter COVID-19 ; SARS-CoV-2 ; Viral load ; Antibody ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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