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Article: Plasma amino acids in major depressive disorder: between pathology to pharmacology.

Gammoh, Omar / Aljabali, Alaa A A / Tambuwala, Murtaza M

EXCLI journal

2024 Volume 23, Page(s) 62–78

Abstract: Addressing the formidable challenge posed by the development of effective and personalized interventions for major depressive disorder (MDD) necessitates a comprehensive comprehension of the intricate role that plasma amino acids play and their ... ...

Abstract	Addressing the formidable challenge posed by the development of effective and personalized interventions for major depressive disorder (MDD) necessitates a comprehensive comprehension of the intricate role that plasma amino acids play and their implications in MDD pathology and pharmacology. Amino acids, owing to their indispensable functions in neurotransmission, metabolism, and immune regulation, emerge as pivotal entities in this intricate disorder. Our primary objective entails unraveling the underlying mechanisms and unveiling tailored treatments through a meticulous investigation into the interplay between plasma amino acids, MDD, and pharmacological strategies. By conducting a thorough and exhaustive review of the existing literature, we have identified pertinent studies on plasma amino acids in MDD, thereby uncovering noteworthy disturbances in the profiles of amino acids among individuals afflicted by MDD when compared to their healthy counterparts. Specifically, disruptions in the metabolism of tryptophan, phenylalanine, and tyrosine, which serve as precursors to essential neurotransmitters, have emerged as prospective biomarkers and critical contributors to the pathophysiology of depression. Amnio acids play an essential role in MDD and could represent an attractive pharmacological target, more studies are further required to fully reveal their underlying mechanisms.
Language	English
Publishing date	2024-01-04
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2023-6767
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Article ; Online: The crosstalk between subjective fibromyalgia, mental health symptoms and the use of over-the-counter analgesics in female Syrian refugees: a cross-sectional web-based study.

Gammoh, Omar / Aljabali, Alaa A A / Tambuwala, Murtaza M

Rheumatology international

2024 Volume 44, Issue 4, Page(s) 715–723

Abstract: Suboptimal fibromyalgia management with over-the-counter analgesics leads to deteriorated outcomes for pain and mental health symptoms especially in low-income countries hosting refugees. To examine the association between the over-the-counter analgesics ...

Abstract	Suboptimal fibromyalgia management with over-the-counter analgesics leads to deteriorated outcomes for pain and mental health symptoms especially in low-income countries hosting refugees. To examine the association between the over-the-counter analgesics and the severity of fibromyalgia, depression, anxiety and PTSD symptoms in a cohort of Syrian refugees. This is a cross-sectional study. Fibromyalgia was assessed using the patient self-report survey for the assessment of fibromyalgia. Depression was measured using the Patient Health Questionnaire-9, insomnia severity was measured using the insomnia severity index (ISI-A), and PTSD was assessed using the Davidson trauma scale (DTS)-DSM-IV. Data were analyzed from 291. Among them, 221 (75.9%) reported using acetaminophen, 79 (27.1%) reported using non-steroidal anti-inflammatory drugs (NSAIDs), and 56 (19.2%) reported receiving a prescription for centrally acting medications (CAMs). Fibromyalgia screening was significantly associated with using NSAIDs (OR 3.03, 95% CI 1.58-5.80, p = 0.001). Severe depression was significantly associated with using NSAIDs (OR 2.07, 95% CI 2.18-3.81, p = 0.02) and CAMs (OR 2.74, 95% CI 1.30-5.76, p = 0.008). Severe insomnia was significantly associated with the use of CAMs (OR 3.90, 95% CI 2.04-5.61, p < 0.001). PTSD symptoms were associated with the use of CAMs (β = 8.99, p = 0.001) and NSAIDs (β = 10.39, p < 0.001). Improper analgesics are associated with poor fibromyalgia and mental health outcomes, prompt awareness efforts are required to address this challenge for the refugees and health care providers.
MeSH term(s)	Humans ; Female ; Mental Health ; Cross-Sectional Studies ; Stress Disorders, Post-Traumatic/drug therapy ; Fibromyalgia/diagnosis ; Fibromyalgia/drug therapy ; Refugees ; Sleep Initiation and Maintenance Disorders ; Syria ; Depression/drug therapy ; Analgesics/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal ; Internet
Chemical Substances	Analgesics ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-023-05521-0
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Zs.A 1639: Show issues

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Article ; Online: Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic.

Alzoubi, Lorca / Aljabali, Alaa A A / Tambuwala, Murtaza M

AAPS PharmSciTech

2023 Volume 24, Issue 8, Page(s) 228

Abstract: This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, and medical device production. It also assesses economic, environmental, and ethical considerations. In our ...

Abstract	This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, and medical device production. It also assesses economic, environmental, and ethical considerations. In our review of the literature, we employed a comprehensive search strategy, utilizing well-known databases like PubMed and Google Scholar. Our chosen keywords encompassed essential topics, including 3D printing, personalized medicine, nanotechnology, and related areas. We first screened article titles and abstracts and then conducted a detailed examination of selected articles without imposing any date limitations. The articles selected for inclusion, comprising research studies, clinical investigations, and expert opinions, underwent a meticulous quality assessment. This methodology ensured the incorporation of high-quality sources, contributing to a robust exploration of the role of 3D printing in the realm of healthcare. The review highlights 3D printing's potential in healthcare, including customized drug delivery systems, patient-specific implants, prosthetics, and biofabrication of organs. These innovations have significantly improved patient outcomes. Integration of nanotechnology has enhanced drug delivery precision and biocompatibility. 3D printing also demonstrates cost-effectiveness and sustainability through optimized material usage and recycling. The healthcare sector has witnessed remarkable progress through 3D printing, promoting a patient-centric approach. From personalized implants to radiation shielding and drug delivery systems, 3D printing offers tailored solutions. Its transformative applications, coupled with economic viability and sustainability, have the potential to revolutionize healthcare. Addressing material biocompatibility, standardization, and ethical concerns is essential for responsible adoption.
MeSH term(s)	Humans ; Precision Medicine ; Tissue Engineering/methods ; Printing, Three-Dimensional ; Drug Delivery Systems ; Power, Psychological
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-023-02682-w
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Article ; Online: COVID-19 in 2021.

Lundstrom, Kenneth / Aljabali, Alaa A A

Viruses

2021 Volume 13, Issue 10

Abstract: The Special Issue on Vaccines and Therapeutics against Coronaviruses, which was launched in early 2021, has attracted the scientific community at large, and more than 20 manuscripts have been accepted for publication.[ ... ]. ...

Abstract	The Special Issue on Vaccines and Therapeutics against Coronaviruses, which was launched in early 2021, has attracted the scientific community at large, and more than 20 manuscripts have been accepted for publication.[...].
MeSH term(s)	Angiotensin-Converting Enzyme 2 ; Animals ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Vaccines ; Drug Discovery ; Humans ; Mutation ; Publications ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism
Chemical Substances	COVID-19 Vaccines ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-10-18
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13102098
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Article ; Online: Magnetosomes as Potential Nanocarriers for Cancer Treatment.

Alsharedeh, Rawan / Alshraiedeh, Nid'a / Aljabali, Alaa A / Tambuwala, Murtaza M

Current drug delivery

2023

Abstract: Magnetotactic bacteria (MTBs) and their organelles, magnetosomes, are intriguing options that might fulfill the criteria of using bacterial magnetosomes (BMs). The ferromagnetic crystals contained in BMs can condition the magnetotaxis of MTBs, which is ... ...

Abstract	Magnetotactic bacteria (MTBs) and their organelles, magnetosomes, are intriguing options that might fulfill the criteria of using bacterial magnetosomes (BMs). The ferromagnetic crystals contained in BMs can condition the magnetotaxis of MTBs, which is common in water storage facilities. This review provides an overview of the feasibility of using MTBs and BMs as nanocarriers in cancer treatment. More evidence suggests that MTBs and BMs can be used as natural nanocarriers for conventional anticancer medicines, antibodies, vaccine DNA, and siRNA. In addition to improving the stability of chemotherapeutics, their usage as transporters opens the possibilities for the targeted delivery of single ligands or combinations of ligands to malignant tumors. Magnetosome magnetite crystals are different from chemically made magnetite nanoparticles (NPs) because they are strong single-magnetic domains that stay magnetized even at room temperature. They also have a narrow size range and a uniform crystal morphology. These chemical and physical properties are essential for their usage in biotechnology and nanomedicine. Bioremediation, cell separation, DNA or antigen regeneration, therapeutic agents, enzyme immobilization, magnetic hyperthermia, and contrast enhancement of magnetic resonance are just a few examples of the many uses for magnetite-producing MTB, magnetite magnetosomes, and magnetosome magnetite crystals. From 2004 to 2022, data mining of the Scopus and Web of Science databases showed that most research using magnetite from MTB was carried out for biological reasons, such as in magnetic hyperthermia and drug delivery.
Language	English
Publishing date	2023-06-19
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/1567201820666230619155528
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Zs.A 6415: Show issues

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Article ; Online: Recent updates in curcumin delivery.

Obeid, Mohammad A / Alsaadi, Manal / Aljabali, Alaa A

Journal of liposome research

2022 Volume 33, Issue 1, Page(s) 53–64

Abstract: Curcumin is a natural component extracted from the rhizomes of turmeric ( ...

Abstract	Curcumin is a natural component extracted from the rhizomes of turmeric (
MeSH term(s)	Curcumin/therapeutic use ; Liposomes ; Gold ; Metal Nanoparticles ; Drug Delivery Systems
Chemical Substances	Curcumin (IT942ZTH98) ; Liposomes ; Gold (7440-57-5)
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645173-1
ISSN	1532-2394 ; 0898-2104
ISSN (online)	1532-2394
ISSN	0898-2104
DOI	10.1080/08982104.2022.2086567
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Zs.A 2539: Show issues

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Article ; Online: Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials.

Al-Kofahi, Taqwa / Altrad, Bahaa / Amawi, Haneen / Aljabali, Alaa A / Abul-Haija, Yousef M / Obeid, Mohammad A

Therapeutic delivery

2024 Volume 15, Issue 2, Page(s) 109–118

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Paclitaxel/pharmacology ; Liposomes ; Metformin ; Drug Compounding ; Cell Line, Tumor
Chemical Substances	Paclitaxel (P88XT4IS4D) ; Liposomes ; Metformin (9100L32L2N)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ISSN	2041-6008
ISSN (online)	2041-6008
DOI	10.4155/tde-2023-0089
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Article ; Online: Precision epidemiology at the nexus of mathematics and nanotechnology: Unraveling the dance of viral dynamics.

Aljabali, Alaa A A / Obeid, Mohammad A / El-Tanani, Mohamed / Mishra, Vijay / Mishra, Yachana / Tambuwala, Murtaza M

Gene

2024 Volume 905, Page(s) 148174

Abstract: The intersection of mathematical modeling, nanotechnology, and epidemiology marks a paradigm shift in our battle against infectious diseases, aligning with the focus of the journal on the regulation, expression, function, and evolution of genes in ... ...

Abstract	The intersection of mathematical modeling, nanotechnology, and epidemiology marks a paradigm shift in our battle against infectious diseases, aligning with the focus of the journal on the regulation, expression, function, and evolution of genes in diverse biological contexts. This exploration navigates the intricate dance of viral transmission dynamics, highlighting mathematical models as dual tools of insight and precision instruments, a theme relevant to the diverse sections of Gene. In the context of virology, ethical considerations loom large, necessitating robust frameworks to protect individual rights, an aspect essential in infectious disease research. Global collaboration emerges as a critical pillar in our response to emerging infectious diseases, fortified by the predictive prowess of mathematical models enriched by nanotechnology. The synergy of interdisciplinary collaboration, training the next generation to bridge mathematical rigor, biology, and epidemiology, promises accelerated discoveries and robust models that account for real-world complexities, fostering innovation and exploration in the field. In this intricate review, mathematical modeling in viral transmission dynamics and epidemiology serves as a guiding beacon, illuminating the path toward precision interventions, global preparedness, and the collective endeavor to safeguard human health, resonating with the aim of advancing knowledge in gene regulation and expression.
MeSH term(s)	Humans ; Communicable Diseases/epidemiology ; Models, Theoretical ; Mathematics
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148174
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Zs.A 1357: Show issues

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Article ; Online: Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide.

Gammoh, Omar / Ibrahim, Aseel / Yehya, Ala / Alqudah, Abdelrahim / Qnais, Esam / Altaber, Sara / Alrob, Osama Abo / Aljabali, Alaa A A / Tambuwala, Murtaza M

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: The study of intercellular adhesion molecule-1 (ICAM-1) and SIRT1, a member of the sirtuin family with nitric oxide (NO), is emerging in depression and anxiety. As with all antidepressants, the efficacy is delayed and inconsistent. Ascorbic acid (AA) and ...

Abstract	The study of intercellular adhesion molecule-1 (ICAM-1) and SIRT1, a member of the sirtuin family with nitric oxide (NO), is emerging in depression and anxiety. As with all antidepressants, the efficacy is delayed and inconsistent. Ascorbic acid (AA) and vitamin D (D) showed antidepressant properties, while etifoxine (Etx), a GABAA agonist, alleviates anxiety symptoms. The present study aimed to investigate the potential augmentation of citalopram using AA, D and Etx and related the antidepressant effect to brain and serum ICAM-1, SIRT1 and NO in an animal model. BALB/c mice were divided into naive, control, citalopram, citalopram + etx, citalopram + AA, citalopram + D and citalopram + etx + AA + D for 7 days. On the 8th day, the mice were restrained for 8 h, followed by a forced swim test and marble burying test before scarification. Whole-brain and serum expression of ICAM-1, Sirt1 and NO were determined. Citalopram's antidepressant and sedative effects were potentiated by ascorbic acid, vitamin D and etifoxine alone and in combination (
MeSH term(s)	Animals ; Mice ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Anxiety/drug therapy ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Citalopram/pharmacology ; Citalopram/therapeutic use ; Depression/drug therapy ; Intercellular Adhesion Molecule-1 ; Nitric Oxide ; Oxazines/pharmacology ; Oxazines/therapeutic use ; Sirtuin 1 ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamins ; Drug Therapy, Combination
Chemical Substances	Antidepressive Agents ; Ascorbic Acid (PQ6CK8PD0R) ; Citalopram (0DHU5B8D6V) ; etifoxine (X24X82MX4X) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Nitric Oxide (31C4KY9ESH) ; Oxazines ; Sirtuin 1 (EC 3.5.1.-) ; Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25041960
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Article ; Online: Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer.

El-Tanani, Mohamed / Nsairat, Hamdi / Aljabali, Alaa A / Matalka, Ismail I / Alkilany, Alaaldin M / Tambuwala, Murtaza M

Expert opinion on drug delivery

2024 Volume 21, Issue 2, Page(s) 309–324

Abstract: Introduction: The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses the potential of dual-loaded liposomal carriers to combat chemoresistance and ... ...

Abstract	Introduction: The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses the potential of dual-loaded liposomal carriers to combat chemoresistance and improve outcomes for breast cancer patients. Areas covered: This review discusses breast cancer chemotherapy resistance and dual-loaded liposomal carriers. Drug efflux pumps, DNA repair pathways, and signaling alterations are discussed as chemoresistance mechanisms. Liposomes can encapsulate several medicines and cargo kinds, according to the review. It examines how these carriers improve medication delivery, cancer cell targeting, and tumor microenvironment regulation. Also examined are dual-loaded liposomal carrier improvement challenges and techniques. Expert opinion: The use of dual-loaded liposomal carriers represents a promising and innovative strategy in the battle against chemotherapy resistance in breast cancer. This article has explored the various mechanisms of chemoresistance in breast cancer, emphasizing the potential of dual-loaded liposomal carriers to overcome these challenges. These carriers offer versatility, enabling the encapsulation and precise targeting of multiple drugs with different modes of action, a crucial advantage when dealing with the complexity of breast cancer treatment.
MeSH term(s)	Humans ; Female ; Liposomes ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Drug Carriers/therapeutic use ; Drug Delivery Systems/methods ; Tumor Microenvironment
Chemical Substances	Liposomes ; Antineoplastic Agents ; Drug Carriers
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2024.2311812
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