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  1. Article: Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors.

    Redwan, Elrashdy M / Aljadawi, Abdullah A / Uversky, Vladimir N

    Biology

    2022  Volume 11, Issue 7

    Abstract: In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR- ... ...

    Abstract In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the prevalence of intrinsic disorder. Mapping of the intrinsic disorder to the HCV-TLR interactome and to the TLR-based pathways of human innate immune response to the HCV infection demonstrates that substantial levels of intrinsic disorder are characteristic for proteins involved in the regulation and execution of these innate immunity pathways and in HCV-TLR interaction. Disordered regions, being commonly enriched in sites of various posttranslational modifications, may play important functional roles by promoting protein-protein interactions and support the binding of the analyzed proteins to other partners such as nucleic acids. It seems that this system represents an important illustration of the role of intrinsic disorder in virus-host warfare.
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11071091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protein Intrinsic Disorder and Evolvability of MERS-CoV.

    Uversky, Vladimir N / Redwan, Elrashdy M / Aljadawi, Abdullah A

    Biomolecules

    2021  Volume 11, Issue 4

    Abstract: Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused by one of the human coronaviruses, MERS-CoV [ ... ]. ...

    Abstract Middle East Respiratory Syndrome (MERS) is a viral respiratory disease caused by one of the human coronaviruses, MERS-CoV [...].
    MeSH term(s) Animals ; Coronavirus Infections/virology ; Genome, Viral ; Humans ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/genetics ; Middle East Respiratory Syndrome Coronavirus/chemistry ; Middle East Respiratory Syndrome Coronavirus/genetics ; Open Reading Frames ; Viral Proteins/chemistry ; Viral Proteins/genetics
    Chemical Substances Intrinsically Disordered Proteins ; Viral Proteins
    Language English
    Publishing date 2021-04-20
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11040608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hepatitis C Virus Infection and Intrinsic Disorder in the Signaling Pathways Induced by Toll-Like Receptors

    Redwan, Elrashdy M. / Aljadawi, Abdullah A. / Uversky, Vladimir N.

    Biology. 2022 July 21, v. 11, no. 7

    2022  

    Abstract: In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR- ... ...

    Abstract In this study, we examined the interplay between protein intrinsic disorder, hepatitis C virus (HCV) infection, and signaling pathways induced by Toll-like receptors (TLRs). To this end, 10 HCV proteins, 10 human TLRs, and 41 proteins from the TLR-induced downstream pathways were considered from the prevalence of intrinsic disorder. Mapping of the intrinsic disorder to the HCV-TLR interactome and to the TLR-based pathways of human innate immune response to the HCV infection demonstrates that substantial levels of intrinsic disorder are characteristic for proteins involved in the regulation and execution of these innate immunity pathways and in HCV-TLR interaction. Disordered regions, being commonly enriched in sites of various posttranslational modifications, may play important functional roles by promoting protein–protein interactions and support the binding of the analyzed proteins to other partners such as nucleic acids. It seems that this system represents an important illustration of the role of intrinsic disorder in virus–host warfare.
    Keywords Hepatitis C virus ; hepatitis C ; humans ; innate immunity
    Language English
    Dates of publication 2022-0721
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11071091
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Simple and efficient protocol for immunoglobulin Y purification from chicken egg yolk.

    Redwan, Elrashdy M / Aljadawi, Abdullah A / Uversky, Vladimir N

    Poultry science

    2020  Volume 100, Issue 3, Page(s) 100956

    Abstract: Besides being a common food component broadly consumed worldwide, egg yolk immunoglobulin Y (IgY) has essential therapeutic potentials. In fact, in a time of ever-increasing risk of antibiotic resistance, it is crucial to find new ways to battle ... ...

    Abstract Besides being a common food component broadly consumed worldwide, egg yolk immunoglobulin Y (IgY) has essential therapeutic potentials. In fact, in a time of ever-increasing risk of antibiotic resistance, it is crucial to find new ways to battle infection, and oral administration of preformed specific antibodies represents one of the most attractive approaches against infection. Infectious diseases of bacterial and viral origin in humans and animals can be controlled and passively cured by orally applied IgYs isolated from chicken egg yolks. Despite multiple obvious advantages of oral administration of IgY, harvesting IgY from egg yolk in a pure form is a challenging task. In this study, we developed a fast, simple, cost-effective, and efficient protocol for IgY isolation from chicken egg yolks. First, egg yolk was collected and diluted with 5 volumes of cold distilled water, homogenized, pH adjusted, and centrifuged. Next, the supernatant was collected, to which caprylic acid at concentration of 2% v/v was added, followed by pH adjustment to pH 5.0, centrifugation at 4°C, and collection of the resulting supernatant. This step was repeated twice, with adding 2% v/v of caprylic acid each time. The final supernatant was concentrated using ultrafiltration, and the IgY purity and activities were checked by SDS-PAGE, western blotting, and ELISA. The sequential (2, 2, 2%) addition of caprylic acid yielded IgY with a purity of 63.5, 90.6, and 95.8%, respectively, and reached 97.9% after ultrafiltration at pH 9.0. The IgY activity increased exponentially to reach 99% after the ultrafiltration step. The proposed caprylic-acid-based protocol of IgY purification from the yolk of chicken eggs seems to be simple, fast, direct, and very cheap. This indicates that this protocol has great potential for scale-up processing.
    MeSH term(s) Animals ; Biotechnology/methods ; Chickens/immunology ; Egg Yolk/chemistry ; Immunoglobulins/isolation & purification
    Chemical Substances IgY ; Immunoglobulins
    Language English
    Publishing date 2020-12-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2020.12.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 853: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Household pets and SARS-CoV2 transmissibility in the light of the ACE2 intrinsic disorder status.

    Uversky, Vladimir N / Elrashdy, Fatma / Aljadawi, Abdullah / Redwan, Elrashdy M

    Journal of biomolecular structure & dynamics

    2020  Volume 40, Issue 3, Page(s) 1441–1444

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Animals ; COVID-19/transmission ; Humans ; Pets ; SARS-CoV-2
    Chemical Substances ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Letter
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1821784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?

    Uversky, Vladimir N / Elrashdy, Fatma / Aljadawi, Abdullah / Ali, Syed Moasfar / Khan, Rizwan Hasan / Redwan, Elrashdy M

    Journal of neuroscience research

    2020  Volume 99, Issue 3, Page(s) 750–777

    Abstract: Without protective and/or therapeutic agents the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection known as coronavirus disease 2019 is quickly spreading worldwide. It has surprising transmissibility potential, since it could infect ... ...

    Abstract Without protective and/or therapeutic agents the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection known as coronavirus disease 2019 is quickly spreading worldwide. It has surprising transmissibility potential, since it could infect all ages, gender, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS-CoV-2 infection are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS-CoV-2 components could use to reach the CNS and PNS, utilizing the within-body cross talk between organs. The majority of SARS-CoV-2-infected patients suffer from some neurological manifestations (e.g., confusion, anosmia, and ageusia). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and/or the accompanying immune-mediated responses may be responsible for the observed neurological symptoms. The viral particles and/or its components have been specifically documented in endothelial cells of lung, kidney, skin, and CNS. This means that the blood-endothelial barrier may be considered as the main route for SARS-CoV-2 entry into the nervous system, with the barrier disruption being more logical than barrier permeability, as evidenced by postmortem analyses.
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/virology ; COVID-19/complications ; COVID-19/metabolism ; COVID-19/transmission ; Central Nervous System/metabolism ; Central Nervous System/virology ; Humans ; Nervous System Diseases/etiology ; Nervous System Diseases/metabolism ; Nervous System Diseases/virology ; Olfactory Nerve/metabolism ; Olfactory Nerve/virology ; Peripheral Nervous System/metabolism ; Peripheral Nervous System/virology
    Chemical Substances ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.24752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1232: Show issues Location:
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  7. Article: Household pets and SARS-CoV2 transmissibility in the light of the ACE2 intrinsic disorder status

    Uversky, Vladimir N / Elrashdy, Fatma / Aljadawi, Abdullah / Redwan, Elrashdy M

    J Biomol Struct Dyn

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #780180
    Database COVID19

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  8. Article ; Online: Household pets and SARS-CoV2 transmissibility in the light of the ACE2 intrinsic disorder status

    Uversky, Vladimir N. / Elrashdy, Fatma / Aljadawi, Abdullah / Redwan, Elrashdy M.

    Journal of Biomolecular Structure and Dynamics

    2020  , Page(s) 1–4

    Keywords Molecular Biology ; Structural Biology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2020.1821784
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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