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Article: Heavy metal toxicity in poultry: a comprehensive review.

Aljohani, Abdullah S M

2023 Volume 10, Page(s) 1161354

Abstract: Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources and from anthropogenic production of fertilizers, industrial activities, ...

Abstract	Arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) have been recognized as most toxic heavy metals that are continuously released into the environment, both from natural sources and from anthropogenic production of fertilizers, industrial activities, and waste disposal. Therefore, As, Cd, Hg, and Pb are found in increasing concentrations in bodies of water, fodder, feed, and in the tissues of livestock, including poultry, in the surroundings of industrial areas, leading to metabolic, structural, and functional abnormalities in various organs in all animals. In poultry, bioaccumulation of As, Pb, Cd, and Hg occurs in many organs (mainly in the kidneys, liver, reproductive organs, and lungs) as a result of continuous exposure to heavy metals. Consumption of Cd lowers the efficiency of feed conversion, egg production, and growth in poultry. Chronic exposure to As, Pb, Cd, and Hg at low doses can change the microscopic structure of tissues (mainly in the brain, liver, kidneys, and reproductive organs) as a result of the increased content of these heavy metals in these tissues. Histopathological changes occurring in the kidneys, liver, and reproductive organs are reflected in their negative impact on enzyme activity and serum biochemical parameters. Metal toxicity is determined by route of exposure, length of exposure, and absorbed dosage, whether chronic and acute. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry and the associated histopathological changes and toxic concentrations in different tissues.
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1161354
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Article ; Online: Studying the Bioactive Components and Phytochemicals of the Methanol Extract of Rhanterium epapposum Oliv.

El-Ashmawy, Ibrahim M / Aljohani, Abdullah S M / Soliman, Amal S

Applied biochemistry and biotechnology

2023

Abstract: Rhanterium epapposum Oliv. (locally known as Al-Arfaj) belongs to the family Asteraceae. This study was designed to discover the bioactive components and phytochemicals of the methanol extract of the aerial parts of Rhanterium epapposum, using Agilent ... ...

Abstract	Rhanterium epapposum Oliv. (locally known as Al-Arfaj) belongs to the family Asteraceae. This study was designed to discover the bioactive components and phytochemicals of the methanol extract of the aerial parts of Rhanterium epapposum, using Agilent Gas Chromatography-Mass Spectrometry (GC-MS), while the mass spectra of the compounds found in the extract matched with the National Institute of Standards and Technology (NIST08 L). GC-MS analysis of the methanol extract of Rhanterium epapposum aerial parts showed presence of sixteen compounds. The major compounds among these were 9,12,15-octadecatrienoic acid, (Z, Z, Z)- (9.89), n-hexadecenoic acid (8.44), 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one (6.60), benzene propanoic acid, β-amino-4-methoxy- (6.12), 1.4-isopropyl-1,6-dimethyl-1,2,3,4,4 a,7,8,8a-octahedron-1-naphthalenol (6.00), 1-dodecanol, 3,7,11-trimethyl- (5.64), and 9,12-octadecadienoic acid (Z, Z)- (4.84), whereas the minor compounds were 9-Octadecenoic acid, (2-phenyl-1,3-dioxolan-4-yl)methyl ester, trans- (3.63), Butanoic acid (2.93), Stigmasterol (2.92), 2-Naphthalenemethanol (2.66), (2,6,6-Trimethylcyclohex-1-phenylmethanesulfonyl)benzene (2.45), 2-(Ethylenedioxy) ethylamine, N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]- (2.00), 1-Heptatriacotanol (1.69), Ocimene (1.59), and β-Sitosterol (1.25). Furthermore, the study was extended to determine the phytochemicals in the methanol extract of Rhanterium epapposum, which indicated the positive presence of saponins, flavonoids, and phenolic compounds. Moreover, quantitative analysis revealed the presence of high content of flavonoids, total phenolic, and tannins. This study outcome suggests a podium of using Rhanterium epapposum aerial parts as a herbal remedy for various diseases especially cancers, hypertension, and diabetes.
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	392344-7
ISSN	1559-0291 ; 0273-2289
ISSN (online)	1559-0291
ISSN	0273-2289
DOI	10.1007/s12010-023-04574-y
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Article: UPLC/ESI-MS Phytochemical Screening of

Alhumaydhi, Fahad A / Aljohani, Abdullah S M / Elsharkawy, Eman R

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 4718854

Abstract: Herbal plants represent a new source of hypoglycemic antidiabetic drugs; haematological and histopathological studies of methanol extract ... ...

Abstract	Herbal plants represent a new source of hypoglycemic antidiabetic drugs; haematological and histopathological studies of methanol extract of
Language	English
Publishing date	2021-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/4718854
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Article ; Online: In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated from

Aljohani, Abdullah S M / Alhumaydhi, Fahad A / Rauf, Abdur / Hamad, Essam M / Rashid, Umer

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 11

Abstract: Micromeria ... ...

Abstract	Micromeria biflora
MeSH term(s)	Analgesics/therapeutic use ; Anti-Inflammatory Agents/chemistry ; Carrageenan/adverse effects ; Edema/chemically induced ; Edema/drug therapy ; Edema/metabolism ; Humans ; Hypnotics and Sedatives/therapeutic use ; Lamiaceae ; Molecular Docking Simulation ; Plant Extracts/chemistry
Chemical Substances	Analgesics ; Anti-Inflammatory Agents ; Hypnotics and Sedatives ; Plant Extracts ; Carrageenan (9000-07-1)
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27113377
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Article: Gold-Nanoparticle-Conjugated Citrate Inhibits Tumor Necrosis Factor-

Aljohani, Abdullah S M / Abdellatif, Ahmed A H / Rasheed, Zafar / Abdulmonem, Waleed Al

Journal of biomedical nanotechnology

2022 Volume 18, Issue 2, Page(s) 581–588

Abstract: One of the leading causes of death worldwide is cancer. Excessive production of tumor necrosis factor (TNF)- ...

Abstract	One of the leading causes of death worldwide is cancer. Excessive production of tumor necrosis factor (TNF)-
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Citrates ; Citric Acid ; Female ; Gold ; Humans ; Metal Nanoparticles ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Citrates ; NF-kappa B ; Tumor Necrosis Factor-alpha ; Citric Acid (2968PHW8QP) ; Gold (7440-57-5)
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2022.3266
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Article: In Vivo Anti-Inflammatory, Analgesic, Sedative, Muscle Relaxant Activities and Molecular Docking Analysis of Phytochemicals from

Aljohani, Abdullah S M / Alhumaydhi, Fahad A / Rauf, Abdur / Hamad, Essam M / Rashid, Umer

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7495867

Abstract: Euphorbia ... ...

Abstract	Euphorbia pulcherrima
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7495867
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Article ; Online: Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine-Induced Sperm Quality Degeneration in Male Rats.

Ammar Aldaddou, Wael / Aljohani, Abdullah S M / Adewale Ahmed, Idris / Al-Wabel, Naser A / El-Ashmawy, Ibrahim M

Chemistry & biodiversity

2023 Volume 20, Issue 7, Page(s) e202300115

Abstract: Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to ... ...

Abstract	Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other certain biochemical enzymes. Thus, the current study is aimed at evaluating the potential health benefits of S. officinalis L. methanol extract on lead and nicotine hydrogen tartrate-induced sperm quality degeneration in male rats and also identifying some of the non-polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography-mass spectrometry (GC/MS). In the study, fifty-four mature male albino rats of about 220-250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. The rats were anesthetized after the experimental period and then sacrificed. Blood samples were collected while the epididymis, testicle, and accessory sex organs (prostates and seminal vesical) were taken for histopathological studies. Twelve major compounds were identified through the GC/MS analysis of S. officinalis L. methanol extract. Lead and nicotine toxicity had a great effect on the rats' sperm quality causing a significant (p<0.05) decrease in the quantity of sperm and sperm motility as well as an upsurge in the abnormalities of the sperm and a reduction in the length & diameter of seminiferous tubules and size & weight of sexual organs (accessory sex glands, epididymis, and testis). The administration of S. officinalis L. methanol extract, however, had a positive impact on the sexual organ weights, semen quality & quantity, and rats' fertility, thus, ameliorating the adversative effects of both lead and nicotine. Further evaluation and isolation of the bioactive components are recommended as potential drug leads.
MeSH term(s)	Rats ; Male ; Animals ; Methanol ; Nicotine/pharmacology ; Salvia officinalis ; Semen Analysis ; Tartrates/pharmacology ; Rats, Wistar ; Sperm Count/methods ; Sperm Motility ; Seeds ; Spermatozoa ; Plant Extracts/pharmacology
Chemical Substances	Methanol (Y4S76JWI15) ; Nicotine (6M3C89ZY6R) ; Tartrates ; Plant Extracts
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300115
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Article ; Online: Novel mutation in alpha-spectrin gene in Saudi patients with hereditary spherocytosis.

Alshomar, Ahmad / Ahmed, Ahmed A / Rasheed, Zafar / Alhumaydhi, Fahad A / Alsagaby, Suliman / Aljohani, Abdullah S M / Alkhamiss, Abdullah S / Alghsham, Ruqaih / Althwab, Sami A / Khan, Muhammad Ismail / Fernández, Nelson / Al Abdulmonem, Waleed

Nucleosides, nucleotides & nucleic acids

2024 , Page(s) 1–20

Abstract: Hereditary spherocytosis (HS) is the most common hereditary hemolytic disorder induced by red blood cell (RBC) membrane defect. This study was undertaken to determine mutations in genes associated with RBC membrane defect in patients with HS such as α- ... ...

Abstract	Hereditary spherocytosis (HS) is the most common hereditary hemolytic disorder induced by red blood cell (RBC) membrane defect. This study was undertaken to determine mutations in genes associated with RBC membrane defect in patients with HS such as α-spectrin gene (SPTA1), β-spectrin gene (SPTB), ankyrin gene (ANK1), band 3 anion transport gene (SLC4A1) and erythrocyte membrane protein band 4.1 gene (EPB41). Blood samples were collected from 23 unrelated patients with HS. Patients were diagnosed according to the guidelines from the British Society for Hematology. All hematological examinations for the determination of RBC abnormalities and osmotic fragility tests were conducted. Genomic DNA were extracted from peripheral blood cells and coding exons of known genes for hereditary spherocytosis were enriched using Roche/KAPA sequence capture technology and sequenced on an Illumina system
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2008956-9
ISSN	1532-2335 ; 1525-7770
ISSN (online)	1532-2335
ISSN	1525-7770
DOI	10.1080/15257770.2024.2310703
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Article ; Online: The impact of different levels of wheat diets on hepatic oxidative stress, immune response, and lipid metabolism in Tibetan sheep (Ovis aries).

Ma, Boyan / Raza, Sayed Haidar Abbas / Pant, Sameer D / Gao, Zhanhong / Zhang, Fengshuo / Wang, Zhiyou / Hou, Shengzhen / Alkhateeb, Mariam Abdulaziz / Al Abdulmonem, Waleed / Alharbi, Yousef Mesfer / Aljohani, Abdullah S M / Gui, Linsheng

BMC veterinary research

2024 Volume 20, Issue 1, Page(s) 26

Abstract: Background: Compared with corn, wheat contains higher crude protein, amino acids concentration. However, wheat contains a mass of anti-nutritional factors, resulting in increased of the digesta viscosity and impaired the intestinal function in ruminant.! ...

Abstract	Background: Compared with corn, wheat contains higher crude protein, amino acids concentration. However, wheat contains a mass of anti-nutritional factors, resulting in increased of the digesta viscosity and impaired the intestinal function in ruminant. Objective: This study aimed to investigate the effects of substitution of different amounts of wheat for corn on hepatic metabolism in the Tibetan lamb. Methods: Ninety Tibetan lambs (Body weight = 12.37 ± 0.92 kg) were randomly assigned to three groups: 0% wheat diet (Control), 10% wheat diet (Low group), and 15% wheat diet (High group). The feeding trial lasted for 130 d, including a 10 d adaption period. Hepatic gene expression profiling was performed via RNA sequencing after the conclusion of the feeding trials. Results: Results showed that greater level of glutathione peroxidase levels in L group compared with those of the C and H groups (P < 0.05). The immune indexes, including interleukin-1β (IL-1β), immunoglobulin A (IgA), and IgM were also elevated in L group compared with the other groups (P < 0.05). Compared with H group, the hepatocytes were arranged radially, and hepatic plates anastomosed with each other to form a labyrinth-like structure in L group. Transcriptomic analysis showed 872 differentially expressed genes (DEG) between H and L group, of which 755 were down-regulated and 117 were up-regulated. Through Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, 32 pathways were significantly enriched (Q-value < 0.05), such as the cAMP signaling pathway, Th1 and Th2 cell differentiation, leukocyte transendothelial migration, platelet activation and adipocytokine signaling pathway. Additionally, the expression of comment DEGs were verified via quantitative reverse-transcription polymerase chain reaction. Conclusion: In summary, our findings suggest that wheat can be supplemented up to 10% in Tibetan sheep, contributing to improve the hepatic oxidative stress, immune response and lipid metabolism through regulating the expression of related genes.
MeSH term(s)	Sheep ; Animals ; Triticum ; Sheep, Domestic ; Lipid Metabolism ; Tibet ; Oxidative Stress ; Diet/veterinary ; Immunity
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	2191675-5
ISSN	1746-6148 ; 1746-6148
ISSN (online)	1746-6148
ISSN	1746-6148
DOI	10.1186/s12917-023-03874-z
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Article ; Online: Antifungal and Antiproliferative Activity of Pistagremic Acid and Flavonoids Extracted from the Galls of Pistacia chinensis subsp. integerrima.

Rauf, Abdur / Anyanwu, Margrate / Aliiri, Ahmad A / Alanazi, Hamdan A H / Alharbi, Abdulrahman M A / Wadood, Abdul / Aljohani, Abdullah S M / Muhammad, Naveed / Samad, Abdus / Shah, Syed Uzair Ali / Gianoncelli, Alessandra / Ribaudo, Giovanni

Chemistry & biodiversity

2024 Volume 21, Issue 2, Page(s) e202301815

Abstract: Pistacia chinensis subsp. integerrima (J.L. Stewart) Rech. f. is a plant known for its therapeutic applications in traditional medicine, which are related to its antimicrobial, anticancer, antioxidant, anti-inflammatory, analgesic, antidiarrheal, and ... ...

Abstract	Pistacia chinensis subsp. integerrima (J.L. Stewart) Rech. f. is a plant known for its therapeutic applications in traditional medicine, which are related to its antimicrobial, anticancer, antioxidant, anti-inflammatory, analgesic, antidiarrheal, and muscle relaxant properties. The galls of P. chinensis are rich in triterpenes and flavonoids, and we here report the extraction of pistagremic acid (1), apigenin (2) and sakuranetin (3) from this source. The isolated compounds were tested against Aspergillus flavus, Candida albicans, Candida glabrata, Fusarium solani, Microsporum canis and Trichoderma longibrachiatum. The results highlighted the antimicrobial activity of flavonoids 2 and 3, suggesting that this class of molecules may be responsible for the effect related to the traditional use. On the other hand, when the compounds and the extract were tested for their antiproliferative activity on a panel of 4 human cancer cell lines, the triterpene pistagremic acid (1) showed a higher potential, thus demonstrating a different bioactivity profile. Structure-based docking and molecular dynamics simulations were used to help the interpretation of experimental results. Taken together, the here reported findings pave the way for the rationalization of the use of P. chinensis extracts, highlighting the contributions of the different components of galls to the observed bioactivity.
MeSH term(s)	Humans ; Antifungal Agents/pharmacology ; Pistacia ; Triterpenes/pharmacology ; Flavonoids/pharmacology ; Plant Extracts
Chemical Substances	Antifungal Agents ; pistagremic acid ; Triterpenes ; Flavonoids ; Plant Extracts
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301815
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