Artikel ; Online: Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response.
2022 Band 18, Heft 3, Seite(n) e1010091
Abstract: Co-localization and co-transmission of neurotransmitters and neuropeptides is a core property of neural signaling across species. While co-transmission can increase the flexibility of cellular communication, understanding the functional impact on neural ... ...
| Abstract | Co-localization and co-transmission of neurotransmitters and neuropeptides is a core property of neural signaling across species. While co-transmission can increase the flexibility of cellular communication, understanding the functional impact on neural dynamics and behavior remains a major challenge. Here we examine the role of neuropeptide/monoamine co-transmission in the orchestration of the C. elegans escape response. The tyraminergic RIM neurons, which coordinate distinct motor programs of the escape response, also co-express the neuropeptide encoding gene flp-18. We find that in response to a mechanical stimulus, flp-18 mutants have defects in locomotory arousal and head bending that facilitate the omega turn. We show that the induction of the escape response leads to the release of FLP-18 neuropeptides. FLP-18 modulates the escape response through the activation of the G-protein coupled receptor NPR-5. FLP-18 increases intracellular calcium levels in neck and body wall muscles to promote body bending. Our results show that FLP-18 and tyramine act in different tissues in both a complementary and antagonistic manner to control distinct motor programs during different phases of the C. elegans flight response. Our study reveals basic principles by which co-transmission of monoamines and neuropeptides orchestrate in arousal and behavior in response to stress. |
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| Mesh-Begriff(e) | Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Locomotion/physiology ; Neuropeptides/genetics ; Neurotransmitter Agents |
| Chemische Substanzen | Caenorhabditis elegans Proteins ; Neuropeptides ; Neurotransmitter Agents |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-03-03 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2186725-2 |
| ISSN | 1553-7404 ; 1553-7390 |
| ISSN (online) | 1553-7404 |
| ISSN | 1553-7390 |
| DOI | 10.1371/journal.pgen.1010091 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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