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  1. Article ; Online: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study.

    Ekman-Joelsson, Britt-Marie / Brandström, Per / Allén, Maria / Andersson, Bengt / Wåhlander, Håkan / Mellgren, Karin / Ekwall, Olov

    Cardiology in the young

    2022  Volume 33, Issue 5, Page(s) 787–792

    Abstract: Post-transplantation lymphoproliferative disorder is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus function in ... ...

    Abstract Post-transplantation lymphoproliferative disorder is a potentially mortal complication after heart transplantation in children. As the immune system plays a crucial role in the development of lymphoma, we explored the influence of thymus function in relation to immunosuppressive treatment in organ-transplanted children and healthy control subjects. A prospective case-control study was performed at a single centre, in which 36 children who had undergone heart transplantation were compared to two control groups: 34 kidney-transplanted children and 33 healthy age- and sex-matched children. T- and B-lymphocyte subtypes and monocytes were analysed by flow cytometry, and T-cell receptor excision circles were assessed using quantitative polymerase chain reaction. Heart-transplanted children had a lymphocyte profile characterised by reduced or absent thymic function with low numbers of T-cell receptor excision circles and total and naïve T cells, together with immune activation against the allograft. Despite similar immunosuppressive treatment, the kidney-transplanted group showed an activated T-lymphocyte compartment.
    MeSH term(s) Humans ; Child ; Cross-Sectional Studies ; Case-Control Studies ; T-Lymphocytes ; Immunosuppressive Agents ; Receptors, Antigen, T-Cell ; Kidney
    Chemical Substances Immunosuppressive Agents ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951122001743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunological differences between heart- and kidney-transplanted children: a cross-sectional study - CORRIGENDUM.

    Ekman-Joelsson, Britt-Marie / Brandström, Per / Allén, Maria / Andersson, Bengt / Wåhlander, Håkan / Mellgren, Karin / Ekwall, Olov

    Cardiology in the young

    2022  Volume 33, Issue 5, Page(s) 842

    MeSH term(s) Humans ; Child ; Cross-Sectional Studies ; Kidney Transplantation ; Graft Rejection ; Heart ; Kidney
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951122002347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: The Routledge Portuguese Bilingual Dictionary

    Allen, Maria F

    Portuguese-English and English-Portuguese

    (Routledge Bilingual Dictionaries)

    2011  

    Abstract: This comprehensive and up-to-date bilingual dictionary will be the ideal reference for translators and students ... ...

    Series title Routledge Bilingual Dictionaries
    Abstract This comprehensive and up-to-date bilingual dictionary will be the ideal reference for translators and students alike
    Language English
    Size Online-Ressource (785 p)
    Publisher Taylor & Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415434348 ; 0415434343
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article: Institutions and investments by emerging-economy multinationals in developed economies

    Allen, Matthew M. C / Allen, Maria L

    The rise of multinationals from emerging economies : achieving a new balance , p. 83-98

    solar PV firms and the role of political authorities in Germany

    2015  , Page(s) 83–98

    Author's details Matthew M. C. Allen and Maria L. Allen
    Keywords Multinationales Unternehmen ; Subvention ; Erneuerbare Energie ; Internationaler Wettbewerb ; Photovoltaik ; Industrie ; Deutschland
    Language English
    Publisher Palgrave Macmillan
    Publishing place Houndmills, Basingstoke Hampshire [u.a.
    Document type Article
    ISBN 978-1-137-47310-3 ; 1-137-47310-X
    Database ECONomics Information System

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  5. Article ; Online: Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.

    Gao, Lin / OConnell, Mary / Allen, Maria / Liesveld, Jane / McDavid, Andrew / Anolik, Jennifer H / Looney, Richard J

    Cytokine

    2019  Volume 132, Page(s) 154725

    Abstract: Background: We have previously shown that SLE BMSC have decreased proliferation, increased ROS, increased DNA damage and repair (DDR), a senescence associated secretory phenotype, and increased senescence-associated β-galactosidase. We have also shown ... ...

    Abstract Background: We have previously shown that SLE BMSC have decreased proliferation, increased ROS, increased DNA damage and repair (DDR), a senescence associated secretory phenotype, and increased senescence-associated β-galactosidase. We have also shown SLE BMSC produce increased amounts of interferon beta (IFNβ), have increased mRNA for several genes induced by IFNβ, and have a pro-inflammatory feedback loop mediated by a MAVS. To better understand the phenotype of SLE BMSC we conducted mRNA sequencing.
    Methods: Patients fulfilling SLE classification criteria and age and sex matched healthy controls were recruited under an Institutional Review Board approved protocol. Bone marrow aspirates and peripheral blood samples were obtained. BMSC were isolated and grown in tissue culture. Early passage BMSC were harvested and mRNA samples were sent for RNAseq. Serum samples were assayed for IFNβ by ELISA.
    Results: On the basis of top differentially expressed genes between SLE and healthy controls, SLE patients with high levels of serum IFNβ clustered together while SLE patients with low levels of IFNβ clustered with healthy controls. Those genes differentially expressed in SLE patients generally belonged to known IFN pathways, and showed a strong overlap with the set of genes differentially expressed in IFNβ high subjects, per se. Moreover, gene expression changes induced by treating healthy BMSC with exogenous IFNβ were remarkably similar to gene expression differences in SLE IFNβ high vs low BMSC.
    Conclusions: BMSCs from SLE patients are heterogeneous. A subgroup of SLE BMSC is distinguished from other SLE BMSC and from controls by increased levels of mRNAs induced by type I interferons. This subgroup of SLE patients had increased levels of IFNβ in vivo.
    Language English
    Publishing date 2019-05-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2019.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dual bronchodilators in Bronchiectasis study (DIBS): protocol for a pragmatic, multicentre, placebo-controlled, three-arm, double-blinded, randomised controlled trial studying bronchodilators in preventing exacerbations of bronchiectasis.

    Morton, Miranda / Wilson, Nina / Homer, Tara Marie / Simms, Laura / Steel, Alison / Maier, Rebecca / Wason, James / Ternent, Laura / Abouhajar, Alaa / Allen, Maria / Joyce, Richard / Hildreth, Victoria / Lakey, Rachel / Cherlin, Svetlana / Walker, Adam / Devereux, Graham / Chalmers, James D / Hill, Adam T / Haworth, Charles /
    Hurst, John R / De Soyza, Anthony

    BMJ open

    2023  Volume 13, Issue 8, Page(s) e071906

    Abstract: Introduction: Bronchiectasis is a long-term lung condition, with dilated bronchi, chronic inflammation, chronic infection and acute exacerbations. Recurrent exacerbations are associated with poorer clinical outcomes such as increased severity of lung ... ...

    Abstract Introduction: Bronchiectasis is a long-term lung condition, with dilated bronchi, chronic inflammation, chronic infection and acute exacerbations. Recurrent exacerbations are associated with poorer clinical outcomes such as increased severity of lung disease, further exacerbations, hospitalisations, reduced quality of life and increased risk of death. Despite an increasing prevalence of bronchiectasis, there is a critical lack of high-quality studies into the disease and no treatments specifically approved for its treatment. This trial aims to establish whether inhaled dual bronchodilators (long acting beta agonist (LABA) and long acting muscarinic antagonist (LAMA)) taken as either a stand-alone therapy or in combination with inhaled corticosteroid (ICS) reduce the number of exacerbations of bronchiectasis requiring treatment with antibiotics during a 12 month treatment period.
    Methods: This is a multicentre, pragmatic, double-blind, randomised controlled trial, incorporating an internal pilot and embedded economic evaluation. 600 adult patients (≥18 years) with CT confirmed bronchiectasis will be recruited and randomised to either inhaled dual therapy (LABA+LAMA), triple therapy (LABA+LAMA+ICS) or matched placebo, in a 2:2:1 ratio (respectively). The primary outcome is the number of protocol defined exacerbations requiring treatment with antibiotics during the 12 month treatment period.
    Ethics and dissemination: Favourable ethical opinion was received from the North East-Newcastle and North Tyneside 2 Research Ethics Committee (reference: 21/NE/0020). Results will be disseminated in peer-reviewed publications, at national and international conferences, in the NIHR
    Trial registration number: ISRCTN15988757.
    MeSH term(s) Adult ; Humans ; Bronchodilator Agents/therapeutic use ; Quality of Life ; Adrenergic beta-2 Receptor Agonists ; Muscarinic Antagonists ; Bronchiectasis/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Administration, Inhalation ; Drug Therapy, Combination ; Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Chemical Substances Bronchodilator Agents ; Adrenergic beta-2 Receptor Agonists ; Muscarinic Antagonists ; Adrenal Cortex Hormones ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-071906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prevalence of allergic disease in Old Order Mennonites in New York.

    Martina, Camille / Looney, R John / Marcus, Carolina / Allen, Maria / Stahlhut, Richard

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2016  Volume 117, Issue 5, Page(s) 562–563.e1

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2016.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Traditional Farming Lifestyle in Old Older Mennonites Modulates Human Milk Composition.

    Seppo, Antti E / Choudhury, Rakin / Pizzarello, Catherine / Palli, Rohith / Fridy, Sade / Rajani, Puja Sood / Stern, Jessica / Martina, Camille / Yonemitsu, Chloe / Bode, Lars / Bu, Kevin / Tamburini, Sabrina / Piras, Enrica / Wallach, David S / Allen, Maria / Looney, R John / Clemente, Jose C / Thakar, Juilee / Järvinen, Kirsi M

    Frontiers in immunology

    2021  Volume 12, Page(s) 741513

    Abstract: Background: In addition to farming exposures in childhood, maternal farming exposures provide strong protection against allergic disease in their children; however, the effect of farming lifestyle on human milk (HM) composition is unknown.: Objective!# ...

    Abstract Background: In addition to farming exposures in childhood, maternal farming exposures provide strong protection against allergic disease in their children; however, the effect of farming lifestyle on human milk (HM) composition is unknown.
    Objective: This study aims to characterize the maternal immune effects of Old Order Mennonite (OOM) traditional farming lifestyle when compared with Rochester (ROC) families at higher risk for asthma and allergic diseases using HM as a proxy.
    Methods: HM samples collected at median 2 months of lactation from 52 OOM and 29 ROC mothers were assayed for IgA
    Results: HM contains IgA
    Conclusion: Traditional, agrarian lifestyle, and antibiotic use are strong regulators of maternally derived immune and metabolic factors, which may have downstream implications for postnatal developmental programming of infant's gut microbiome and immune system.
    MeSH term(s) Agriculture ; Child, Preschool ; Female ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/immunology ; Humans ; Hypersensitivity, Immediate/epidemiology ; Hypersensitivity, Immediate/immunology ; Immunoglobulin A/metabolism ; Life Style ; Male ; Maternal Exposure/adverse effects ; Milk, Human/immunology ; Milk, Human/metabolism ; Religion ; Rural Population ; United States/epidemiology ; Up-Regulation
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.741513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle.

    Seppo, Antti E / Bu, Kevin / Jumabaeva, Madina / Thakar, Juilee / Choudhury, Rakin A / Yonemitsu, Chloe / Bode, Lars / Martina, Camille A / Allen, Maria / Tamburini, Sabrina / Piras, Enrica / Wallach, David S / Looney, R John / Clemente, Jose C / Järvinen, Kirsi M

    Allergy

    2021  Volume 76, Issue 11, Page(s) 3489–3503

    Abstract: Background: Growing up on traditional, single-family farms is associated with protection against asthma in school age, but the mechanisms against early manifestations of atopic disease are largely unknown. We sought determine the gut microbiome and ... ...

    Abstract Background: Growing up on traditional, single-family farms is associated with protection against asthma in school age, but the mechanisms against early manifestations of atopic disease are largely unknown. We sought determine the gut microbiome and metabolome composition in rural Old Order Mennonite (OOM) infants at low risk and Rochester, NY urban/suburban infants at high risk for atopic diseases.
    Methods: In a cohort of 65 OOM and 39 Rochester mother-infant pairs, 101 infant stool and 61 human milk samples were assessed by 16S rRNA gene sequencing for microbiome composition and qPCR to quantify Bifidobacterium spp. and B. longum ssp. infantis (B. infantis), a consumer of human milk oligosaccharides (HMOs). Fatty acids (FAs) were analyzed in 34 stool and human 24 milk samples. Diagnoses and symptoms of atopic diseases by 3 years of age were assessed by telephone.
    Results: At a median age of 2 months, stool was enriched with Bifidobacteriaceae, Clostridiaceae, and Aerococcaceae in the OOM compared with Rochester infants. B. infantis was more abundant (p < .001) and prevalent, detected in 70% of OOM compared with 21% of Rochester infants (p < .001). Stool colonized with B. infantis had higher levels of lactate and several medium- to long/odd-chain FAs. In contrast, paired human milk was enriched with a distinct set of FAs including butyrate. Atopic diseases were reported in 6.5% of OOM and 35% of Rochester children (p < .001).
    Conclusion: A high rate of B. infantis colonization, similar to that seen in developing countries, is found in the OOM at low risk for atopic diseases.
    MeSH term(s) Bifidobacterium longum subspecies infantis ; Child ; Farms ; Gastrointestinal Microbiome ; Humans ; Infant ; Life Style ; Milk, Human ; Oligosaccharides ; RNA, Ribosomal, 16S/genetics
    Chemical Substances Oligosaccharides ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-05-14
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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