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  1. AU="Allegorico, E"
  2. AU="Anwer, W."
  3. AU="Li, Yuehong"
  4. AU="Gibbons, Alison B"
  5. AU="Barber, Galt P"
  6. AU="Noonan, Megan A"
  7. AU="Tseng L."
  8. AU="Guay, Joanne"
  9. AU="Paradise, Chris"
  10. AU="Hofmann, Nina"
  11. AU="Kaleagasi, Hakan"
  12. AU="Giulianelli, G"
  13. AU="Sanoj Punnen"

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  1. Artikel ; Online: Blood lactate in mild and moderate ARDS secondary to SARS COV 2.

    Pagano, A / Porta, G / Bosso, G / Allegorico, E / Serra, C / Mercurio, V / Sansone, G / Orefice, S / Numis, F G

    The American journal of emergency medicine

    2023  Band 66, Seite(n) 73–75

    Abstract: Background and objectives: Elevated blood lactate levels are associated with poor outcome in several critical conditions. Patients with SARS-CoV-2 rarely develop hyperlactatemia. The purpose of this study is to evaluate the trend of lactatemia in ... ...

    Abstract Background and objectives: Elevated blood lactate levels are associated with poor outcome in several critical conditions. Patients with SARS-CoV-2 rarely develop hyperlactatemia. The purpose of this study is to evaluate the trend of lactatemia in patients affected by mild/moderate SARS-Co V-2-ARDS and if it affected prognosis.
    Methods: We analyzed blood lactate levels in thirty-eight patients with severe SARS-CoV-2 infection admitted to COVID Care Unit of Santa Maria delle Grazie Hospital, Pozzuoli.
    Results: Twenty patients survived and were discharged at home and 18 patients died. Despite severe hypoxia that affected all patients enrolled, T0 lactate was within normal values. All survivors showed a significant increase in lactate concentration the day prior to clinical improvement. In not-survivors levels of lactate did not increase significantly.
    Conclusion: In our study, patients who survive SARS CoV-2 ARDS have a fleeting increase in lactate, which precedes clinical improvement by one day.
    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; COVID-19/complications ; RNA, Viral ; Respiratory Distress Syndrome/etiology ; Lactic Acid
    Chemische Substanzen RNA, Viral ; Lactic Acid (33X04XA5AT)
    Sprache Englisch
    Erscheinungsdatum 2023-01-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.01.032
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  2. Artikel ; Online: Comment on: Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation.

    Milione, S / Allegorico, E / Altruda, C

    European review for medical and pharmacological sciences

    2018  Band 22, Heft 17, Seite(n) 5411–5412

    Mesh-Begriff(e) 17-Hydroxysteroid Dehydrogenases/biosynthesis ; 17-Hydroxysteroid Dehydrogenases/genetics ; Animals ; Cell Proliferation/physiology ; Gene Expression ; Inflammation/genetics ; Inflammation/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Peroxisomal Multifunctional Protein-2/biosynthesis ; Peroxisomal Multifunctional Protein-2/genetics ; Rats
    Chemische Substanzen 17-Hydroxysteroid Dehydrogenases (EC 1.1.-) ; Hsd17b4 protein, rat (EC 1.1.1.119) ; Peroxisomal Multifunctional Protein-2 (EC 4.2.1.107)
    Sprache Englisch
    Erscheinungsdatum 2018-09-18
    Erscheinungsland Italy
    Dokumenttyp Letter
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201809_15798
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  3. Artikel ; Online: Lung ultrasound-guided PEEP titration in COVID-19 patients treated with CPAP.

    Bosso, Giorgio / Sansone, Gennaro / Papillo, Martina / Giaquinto, Alessandro / Orefice, Silvia / Allegorico, Enrico / Serra, Claudia / Minerva, Valentina / Mercurio, Valentina / Cannavacciuolo, Francesca / Dello Vicario, Ferdinando / Porta, Giovanni / Pagano, Antonio / Numis, Fabio Giuliano

    Journal of basic and clinical physiology and pharmacology

    2023  Band 34, Heft 5, Seite(n) 677–682

    Abstract: Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 ... ...

    Abstract Objectives: An increasing number of COVID-19 patients were treated with continuous positive airways pressure (CPAP). To evaluate the clinical effects of personalized positive end-expiratory pressure (PEEP) compared to standard fixed PEEP in COVID-19 patients requiring CPAP.
    Methods: This is a single center, prospective, randomized clinical study. Sixty-three COVID-19 patients with hypoxemic respiratory failure and bilateral pneumonia were randomized in two Groups: Group A received CPAP with fixed PEEP of 10 cm H
    Results: Thirty-two patients were enrolled in
    Conclusions: Lung ultrasound-guided PEEP trial is associated with lower mortality in COVID-19 patients treated with CPAP. Identifying the best PEEP is useful to increase oxygenation and reduce the incidence of complications.
    Mesh-Begriff(e) Humans ; Pneumothorax ; Prospective Studies ; COVID-19/therapy ; Lung/diagnostic imaging ; Ultrasonography, Interventional
    Sprache Englisch
    Erscheinungsdatum 2023-07-20
    Erscheinungsland Germany
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2023-0165
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  4. Artikel ; Online: The impact of a non-restrictive Antimicrobial Stewardship Program in the emergency department of a secondary-level Italian hospital.

    Monari, Caterina / Onorato, Lorenzo / Allegorico, Enrico / Minerva, Valentina / Macera, Margherita / Bosso, Giorgio / Calò, Federica / Pagano, Antonio / Russo, Teresa / Sansone, Gennaro / D'Isanto, Marina / Casciotta, Antonio / Vanni, Monica / Numis, Fabio Giuliano / Coppola, Nicola

    Internal and emergency medicine

    2023  Band 19, Heft 2, Seite(n) 493–500

    Abstract: Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation ... ...

    Abstract Evidence supporting the effectiveness of Antimicrobial Stewardship (AMS) Programs in the emergency department (ED) setting is limited. We conducted a prospective cohort study to assess the efficacy of an AMS program in an ED and a short-stay observation unit. The intervention included periodic prospective audits (twice a week), conducted by four infectious disease consultants. Primary outcomes included the difference in the hospital mortality rate, antibiotic consumption, and the incidence of bloodstream infections (BSI) caused by multidrug resistant (MDR) bacteria, before March 2020-February 2021 and after March 2021-February 2022 when the program was implemented. Interrupted time-series analysis was performed to assess the effect of our program. During the 12-month program, we performed 152 audits and evaluated 366 antibiotic therapies out of a total of 853 patients admitted. In the intervention period, we observed a non-statistically significant decrease in total antibiotic consumption, with a change in level of - 31.2 defined daily dose/100 patient-days (PD) (p = 0.71). Likewise, we found no significant variations in the rate of BSI due to MDR Gram-positive (CT - 0.02 events/PD, p = 0.84), MDR Gram-negative bacteria (CT 0.08, p = 0.71), or Candida spp. (CT 0.008, p = 0.86). Conversely, we found a significant decrease in the mortality rate between the pre- and post-intervention periods (- 1.98 deaths/100 PD, CI - 3.9 to - 0.007, p = 0.049). The Antibiotic Stewardship Program in the ED was associated with a significant decrease in the mortality rate. More high-quality studies are needed to determine the most effective ASP strategies in this unique setting.
    Mesh-Begriff(e) Humans ; Antimicrobial Stewardship ; Prospective Studies ; Anti-Bacterial Agents/therapeutic use ; Hospitals ; Emergency Service, Hospital ; Italy
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-09-12
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03418-1
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  5. Artikel ; Online: Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2.

    Pagano, A / Porta, G / Bosso, G / Allegorico, E / Serra, C / Dello Vicario, F / Minerva, V / Russo, T / Altruda, C / Arbo, P / Mercurio, V / Numis, F G

    Respiratory physiology & neurobiology

    2020  Band 280, Seite(n) 103489

    Abstract: Background: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound ... ...

    Abstract Background: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown.
    Methods: In March 2020 we treated 18 patients with mild and moderate ARDS secondary to SARS-CoV-2 with non-invasive continuous positive airway pressure therapy (NI-CPAP). All patients underwent lung ultrasound imaging to verify the entity of lung recruitment after NI-CPAP initiation.
    Results: After one hour of treatment we observed a significant improvement in PaO2/FiO2 ratio in 10 patients. Notably, only 50 % of them reached an effective improvement in lung aeration detectable with lung ultrasound. In the other 50 % or patients the improvement in PaO2/FiO2 might be related to blood redistribution and reverse of hypoxic vasoconstriction.
    Conclusion: NI- CPAP is a valid therapeutic option in mild and moderate ARDS secondary SARS-CoV-2. Lung recruitment detected by means of lung ultrasound is a relevant but not the exclusive mechanism that underlies the therapeutic efficacy of NI-CPAP in this clinical setting.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Continuous Positive Airway Pressure/methods ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/therapy ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/therapy ; Prospective Studies ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2020.103489
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  6. Artikel: Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2

    Pagano, A / Porta, G / Bosso, G / Allegorico, E / Serra, C / Dello Vicario, F / Minerva, V / Russo, T / Altruda, C / Arbo, P / Mercurio, V / Numis, F G

    Respir Physiol Neurobiol

    Abstract: BACKGROUND: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound ... ...

    Abstract BACKGROUND: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown. METHODS: In March 2020 we treated 18 patients with mild and moderate ARDS secondary to SARS-CoV-2 with non-invasive continuous positive airway pressure therapy (NI-CPAP). All patients underwent lung ultrasound imaging to verify the entity of lung recruitment after NI-CPAP initiation. RESULTS: After one hour of treatment we observed a significant improvement in PaO2/FiO2 ratio in 10 patients. Notably, only 50 % of them reached an effective improvement in lung aeration detectable with lung ultrasound. In the other 50 % or patients the improvement in PaO2/FiO2 might be related to blood redistribution and reverse of hypoxic vasoconstriction. CONCLUSION: NI- CPAP is a valid therapeutic option in mild and moderate ARDS secondary SARS-CoV-2. Lung recruitment detected by means of lung ultrasound is a relevant but not the exclusive mechanism that underlies the therapeutic efficacy of NI-CPAP in this clinical setting.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #626482
    Datenquelle COVID19

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  7. Artikel ; Online: Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2

    Pagano, A. / Porta, G. / Bosso, G. / Allegorico, E. / Serra, C. / Dello Vicario, F. / Minerva, V. / Russo, T. / Altruda, C. / Arbo, P. / Mercurio, V. / Numis, F. G.

    2020  

    Abstract: Background: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound ... ...

    Abstract Background: During the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown. Methods: In March 2020 we treated 18 patients with mild and moderate ARDS secondary to SARS-CoV-2 with non-invasive continuous positive airway pressure therapy (NI-CPAP). All patients underwent lung ultrasound imaging to verify the entity of lung recruitment after NI-CPAP initiation. Results: After one hour of treatment we observed a significant improvement in PaO2/FiO2 ratio in 10 patients. Notably, only 50 % of them reached an effective improvement in lung aeration detectable with lung ultrasound. In the other 50 % or patients the improvement in PaO2/FiO2 might be related to blood redistribution and reverse of hypoxic vasoconstriction. Conclusion: NI- CPAP is a valid therapeutic option in mild and moderate ARDS secondary SARS-CoV-2. Lung recruitment detected by means of lung ultrasound is a relevant but not the exclusive mechanism that underlies the therapeutic efficacy of NI-CPAP in this clinical setting.
    Schlagwörter Coronavirus ; COVID 19 ; SARS COV 2 ; covid19
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsland it
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2

    Pagano, A. / Porta, G. / Bosso, G. / Allegorico, E. / Serra, C. / Dello Vicario, F. / Minerva, V. / Russo, T. / Altruda, C. / Arbo, P. / Mercurio, V. / Numis, F.G.

    Respiratory Physiology & Neurobiology

    2020  Band 280, Seite(n) 103489

    Schlagwörter Physiology ; General Neuroscience ; Pulmonary and Respiratory Medicine ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2020.103489
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Prevalence and Epidemiological and Clinical Features of Bacterial Infections in a Large Cohort of Patients Hospitalized for COVID-19 in Southern Italy: A Multicenter Study.

    Onorato, Lorenzo / Calò, Federica / Maggi, Paolo / Allegorico, Enrico / Gentile, Ivan / Sangiovanni, Vincenzo / Esposito, Vincenzo / Dell'Isola, Chiara / Calabria, Giosuele / Pisapia, Raffaella / Salomone Megna, Angelo / Masullo, Alfonso / Manzillo, Elio / Russo, Grazia / Parrella, Roberto / Dell'Aquila, Giuseppina / Gambardella, Michele / Di Perna, Felice / Pisaturo, Mariantonietta /
    Coppola, Nicola

    Antibiotics (Basel, Switzerland)

    2023  Band 12, Heft 7

    Abstract: Background: The aim of this study was to evaluate the prevalence of bacterial infections and antimicrobial prescriptions in a large cohort of COVID-19 patients and to identify the independent predictors of infection and antibiotic prescription.: ... ...

    Abstract Background: The aim of this study was to evaluate the prevalence of bacterial infections and antimicrobial prescriptions in a large cohort of COVID-19 patients and to identify the independent predictors of infection and antibiotic prescription.
    Methods: All consecutive patients hospitalized for COVID-19 from March 2020 to May 2021 at 1 of the 17 centers participating in the study were included. All subjects showing a clinical presentation consistent with a bacterial infection with microbiological confirmation (documented infection), and/or a procalcitonin value >1 ng/mL (suspected infection) were considered as having a coinfection (if present at admission) or a superinfection (if acquired after at least 48 h of hospital stay).
    Results: During the study period, of the 1993 patients, 42 (2.1%) presented with a microbiologically documented infection, including 17 coinfections and 25 superinfections, and 267 (13.2%) a suspected infection. A total of 478 subjects (24.5%) received an antibacterial treatment other than macrolides. No independent predictors of confirmed or suspected bacterial infection were identified. On the contrary, being hospitalized during the second wave of the pandemic (OR 1.35, 95% CI 1.18-1.97,
    Conclusions: Our study reported a high rate of antimicrobial prescriptions despite a limited number of documented or suspected bacterial infections among the large cohort of hospitalized COVID-19 patients.
    Sprache Englisch
    Erscheinungsdatum 2023-06-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12071124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Prognostic Value of Creatinine Levels at Admission on Disease Progression and Mortality in Patients with COVID-19-An Observational Retrospective Study.

    Russo, Antonio / Pisaturo, Mariantonietta / Monari, Caterina / Ciminelli, Federica / Maggi, Paolo / Allegorico, Enrico / Gentile, Ivan / Sangiovanni, Vincenzo / Esposito, Vincenzo / Gentile, Valeria / Calabria, Giosuele / Pisapia, Raffaella / Carriero, Canio / Masullo, Alfonso / Manzillo, Elio / Russo, Grazia / Parrella, Roberto / Dell'Aquila, Giuseppina / Gambardella, Michele /
    Ponticiello, Antonio / Onorato, Lorenzo / Coppola, Nicola

    Pathogens (Basel, Switzerland)

    2023  Band 12, Heft 8

    Abstract: Introduction: Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients ... ...

    Abstract Introduction: Acute kidney disease and chronic kidney disease are considered conditions that can increase the mortality and severity of COVID-19. However, few studies have investigated the impact of creatinine levels on COVID-19 progression in patients without a history of chronic kidney disease. The aim of the study was to assess the impact of creatinine levels at hospital admission on COVID-19 progression and mortality.
    Methods: We performed a multicenter, observational, retrospective study involving seventeen COVID-19 Units in the Campania region in southern Italy. All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection confirmed by a positive reverse transcriptase-polymerase chain reaction on a naso-oropharyngeal swab, from 28 February 2020 to 31 May 2021, were enrolled in the CoviCamp cohort.
    Results: Evaluating inclusion/exclusion criteria, 1357 patients were included. Considering in-hospital mortality and creatinine value at admission, the best cut-off point to discriminate a death during hospitalization was 1.115 mg/dL. The logistic regression demonstrated that factors independently associated with mortality were age (OR 1.082, CI: 1.054-1.110), Charlson Comorbidity Index (CCI) (OR 1.341, CI: 1.178-1.526), and an abnormal creatinine value at admission, defined as equal to or above 1.12 mg/dL (OR 2.233, CI: 1.373-3.634).
    Discussion: In conclusion, our study is in line with previous studies confirming that the creatinine serum level can predict mortality in COVID-19 patients and defining that the best cut-off of the creatinine serum level at admission to predict mortality was 1.12 mg/dL.
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12080973
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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