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  1. Article ; Online: Where will we get the next generation of medicinal chemists?

    Allen, Dave

    Drug discovery today

    2016  Volume 21, Issue 5, Page(s) 704–706

    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Editorial
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2016.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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  2. Article ; Online: Computational application of internationally harmonized defined approaches to skin sensitization: DASS App.

    To, Kimberly T / Strickland, Judy / Reinke, Emily / Borrel, Alexandre / Truax, Jim / Maldonado, Heather / Allen, Dave / Kleinstreuer, Nicole

    BMC bioinformatics

    2024  Volume 25, Issue 1, Page(s) 4

    Abstract: Background: Chemically induced skin sensitization, or allergic contact dermatitis, is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause skin sensitization for many chemical products. ... ...

    Abstract Background: Chemically induced skin sensitization, or allergic contact dermatitis, is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause skin sensitization for many chemical products. Defined approaches for skin sensitization (DASS) identify potential chemical skin sensitizers by integrating data from multiple non-animal tests based on human cells, molecular targets, and computational model predictions using standardized data interpretation procedures. While several DASS are internationally accepted by regulatory agencies, the data interpretation procedures vary in logical complexity, and manual application can be time-consuming or prone to error.
    Results: We developed the DASS App, an open-source web application, to facilitate user application of three regulatory testing strategies for skin sensitization assessment: the Two-out-of-Three (2o3), the Integrated Testing Strategy (ITS), and the Key Event 3/1 Sequential Testing Strategy (KE 3/1 STS) without the need for software downloads or computational expertise. The application supports upload and analysis of user-provided data, includes steps to identify inconsistencies and formatting issues, and provides predictions in a downloadable format.
    Conclusion: This open-access web-based implementation of internationally harmonized regulatory guidelines for an important public health endpoint is designed to support broad user uptake and consistent, reproducible application. The DASS App is freely accessible via https://ntp.niehs.nih.gov/go/952311 and all scripts are available on GitHub ( https://github.com/NIEHS/DASS ).
    MeSH term(s) Animals ; Humans ; Mobile Applications ; Animal Testing Alternatives/methods ; Skin ; Dermatitis, Allergic Contact/etiology
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-023-05617-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Standardizing Extracted Data Using Automated Application of Controlled Vocabularies.

    Foster, Caroline / Wignall, Jessica / Kovach, Samuel / Choksi, Neepa / Allen, Dave / Trgovcich, Joanne / Rochester, Johanna R / Ceger, Patricia / Daniel, Amber / Hamm, Jon / Truax, Jim / Blake, Bevin / McIntyre, Barry / Sutherland, Vicki / Stout, Matthew D / Kleinstreuer, Nicole

    Environmental health perspectives

    2024  Volume 132, Issue 2, Page(s) 27006

    Abstract: Background: Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. ... ...

    Abstract Background: Extraction of toxicological end points from primary sources is a central component of systematic reviews and human health risk assessments. To ensure optimal use of these data, consistent language should be used for end point descriptions. However, primary source language describing treatment-related end points can vary greatly, resulting in large labor efforts to manually standardize extractions before data are fit for use.
    Objectives: To minimize these labor efforts, we applied an augmented intelligence approach and developed automated tools to support standardization of extracted information via application of preexisting controlled vocabularies.
    Methods: We created and applied a harmonized controlled vocabulary crosswalk, consisting of Unified Medical Language System (UMLS) codes, German Federal Institute for Risk Assessment (BfR) DevTox harmonized terms, and The Organization for Economic Co-operation and Development (OECD) end point vocabularies, to roughly 34,000 extractions from prenatal developmental toxicology studies conducted by the National Toxicology Program (NTP) and 6,400 extractions from European Chemicals Agency (ECHA) prenatal developmental toxicology studies, all recorded based on the original study report language.
    Results: We automatically applied standardized controlled vocabulary terms to 75% of the NTP extracted end points and 57% of the ECHA extracted end points. Of all the standardized extracted end points, about half (51%) required manual review for potential extraneous matches or inaccuracies. Extracted end points that were not mapped to standardized terms tended to be too general or required human logic to find a good match. We estimate that this augmented intelligence approach saved
    Discussion: Augmenting manual efforts with automation tools increased the efficiency of producing a findable, accessible, interoperable, and reusable (FAIR) dataset of regulatory guideline studies. This open-source approach can be readily applied to other legacy developmental toxicology datasets, and the code design is customizable for other study types. https://doi.org/10.1289/EHP13215.
    MeSH term(s) Humans ; Female ; Pregnancy ; Systematic Reviews as Topic ; Vocabulary, Controlled ; Household Articles ; Intelligence ; Research Design
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP13215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1360: Show issues Location:
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  4. Book ; Online: Play Golf the Pebble Beach Way

    Allen, Dave / Small, Laird

    Lose Five Strokes Without Changing Your Swing

    2010  

    Abstract: Director of the Pebble Beach Golf Academy, Laird Small, teaches golfers how to improve their score by changing their mental approach to the game and answers key questions such as How do you manage first-tee jitters? What questions should you ask yourself ...

    Abstract Director of the Pebble Beach Golf Academy, Laird Small, teaches golfers how to improve their score by changing their mental approach to the game and answers key questions such as How do you manage first-tee jitters? What questions should you ask yourself before every approach shot? How do you read tricky lies and get out of trouble? How can you think like an architect? and How do you bounce back after a bad hole? He shares anecdotes and lessons he learned from some of the greatest champions in golf-including Nicklaus, Watson, Palmer, Miller, and Woods-and how they navigated th
    Language English
    Size Online-Ressource ()
    Publisher Triumph Books
    Publishing place Chicago
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781600783296 ; 1600783295
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action.

    Pamies, David / Leist, Marcel / Coecke, Sandra / Bowe, Gerard / Allen, Dave / Gstraunthaler, Gerhard / Bal-Price, Anna / Pistollato, Francesca / DeVries, Rob / Hartung, Thomas / Stacey, Glyn

    ALTEX

    2020  Volume 37, Issue 3, Page(s) 490–492

    MeSH term(s) Animal Testing Alternatives ; Animals ; Cell Culture Techniques/standards ; Guidelines as Topic ; Humans ; Stakeholder Participation ; Tissue Culture Techniques/standards
    Language English
    Publishing date 2020-07-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 165707-0
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    ISSN 1868-596X ; 1018-4562 ; 0946-7785
    DOI 10.14573/altex.2007091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2971: Show issues Location:
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  6. Article ; Online: Passive, continuous monitoring of carbon dioxide geostorage using muon tomography.

    Gluyas, Jon / Thompson, Lee / Allen, Dave / Benton, Charlotte / Chadwick, Paula / Clark, Sam / Klinger, Joel / Kudryavtsev, Vitaly / Lincoln, Darren / Maunder, Ben / Mitchell, Cathryn / Nolan, Sam / Paling, Sean / Spooner, Neil / Staykov, Lazar / Telfer, Sam / Woodward, David / Coleman, Max

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2018  Volume 377, Issue 2137

    Abstract: Carbon capture and storage is a transition technology from a past and present fuelled by coal, oil and gas and a planned future dominated by renewable energy sources. The technology involves the capture of carbon dioxide emissions from fossil fuel power ... ...

    Abstract Carbon capture and storage is a transition technology from a past and present fuelled by coal, oil and gas and a planned future dominated by renewable energy sources. The technology involves the capture of carbon dioxide emissions from fossil fuel power stations and other point sources, compression of the CO
    Language English
    Publishing date 2018-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2018.0059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  7. Article: Comparison of radiographic osteoarthritis scores in dogs less than 24 months or greater than 24 months following tibial plateau leveling osteotomy.

    DeLuke, Andrea M / Allen, Dave A / Wilson, Eric R / Lineberger, Jayce A / Lehenbauer, Terry W / Fabiani, Michelle / Poteet, Brian A

    The Canadian veterinary journal = La revue veterinaire canadienne

    2013  Volume 53, Issue 10, Page(s) 1095–1099

    Abstract: Radiographic osteoarthritis scores were determined in 60 dogs up to 3 years following tibial plateau leveling osteotomy. Radiographs taken immediately following surgery and at long-term follow-up 1 to 3 years later were evaluated by 2 certified ... ...

    Abstract Radiographic osteoarthritis scores were determined in 60 dogs up to 3 years following tibial plateau leveling osteotomy. Radiographs taken immediately following surgery and at long-term follow-up 1 to 3 years later were evaluated by 2 certified radiologists using a modified 32-point osteoarthritis scale. Changes in osteoarthritis scores were evaluated by paired t-tests and regression analysis. Sub-groups of dogs were formed to evaluate if osteoarthritis scores changed differently for follow-up periods of < 24 months compared with those > 24 months. There was a significant increase in osteoarthritis score from post-operative to follow-up evaluations for all dogs studied. Regression analysis of the relationship of months after surgery to change in osteoarthritis score was not significant. These results indicate that osteoarthritis did progress following tibial plateau leveling osteotomy, but not in a linear fashion over time.
    MeSH term(s) Animals ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery ; Dogs ; Female ; Male ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/surgery ; Osteoarthritis/veterinary ; Osteotomy/veterinary ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/veterinary ; Radiography ; Stifle/diagnostic imaging ; Stifle/surgery ; Tibia/diagnostic imaging ; Tibia/surgery ; Treatment Outcome
    Language English
    Publishing date 2013-03-28
    Publishing country Canada
    Document type Comparative Study ; Journal Article
    ZDB-ID 41603-4
    ISSN 0008-5286
    ISSN 0008-5286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 572: Show issues Location:
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  8. Book: What ́s so super about super?

    Allen, Dave E

    (Working paper series / School of Economics and Finance, Curtin University of Technology ; 92.17)

    1992  

    Author's details by Dave E. Allen
    Series title Working paper series / School of Economics and Finance, Curtin University of Technology ; 92.17
    Language English
    Size 27, III S
    Document type Book
    ISBN 186342153X ; 9781863421539
    Database ECONomics Information System

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  9. Article ; Online: The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sources.

    Knight, Marian / Pierce, Matthias / Allen, Dave / Kurinczuk, Jennifer J / Spark, Patsy / Roberts, David J / Murphy, Michael F

    British journal of haematology

    2011  Volume 152, Issue 4, Page(s) 460–468

    Abstract: Fetomaternal alloimmune thrombocytopenia (FMAIT) is the most common cause of severe neonatal thrombocytopenia in otherwise well, term infants. First pregnancies are often severely affected. This descriptive, population-based national study was undertaken ...

    Abstract Fetomaternal alloimmune thrombocytopenia (FMAIT) is the most common cause of severe neonatal thrombocytopenia in otherwise well, term infants. First pregnancies are often severely affected. This descriptive, population-based national study was undertaken in order to inform the case for antenatal screening. Cases were identified using three sources and capture-recapture techniques used to generate a robust incidence estimate. One hundred and seventy three cases were identified between October 2006 and September 2008. An extra 20 cases were estimated from capture-recapture analysis, giving an estimated incidence of clinically detected FMAIT of 12·4 cases per 100 000 total births (95%confidence interval: 10·7, 14·3). Fifty-two cases (30%) were known at the start of pregnancy; 120 (70%) were unknown (n=115) or unrecognized (n=5). Unknown cases were more likely to experience a haemorrhagic complication (67% vs. 5%) (P<0·001) and more likely to have an intracranial haemorrhage (20% vs. 4%) (P=0·014) than known cases receiving antenatal management. In view of the incidence of severe disease identified, further assessment of the case for antenatal screening is important. There were a number of cases in which the significance of a history of FMAIT in a previous sibling was not recognized and there is a need to raise awareness of the importance of this diagnosis.
    MeSH term(s) Female ; Gestational Age ; Hemorrhage/epidemiology ; Humans ; Incidence ; Infant, Newborn ; Platelet Count ; Population Surveillance ; Pregnancy ; Pregnancy Outcome ; Prenatal Diagnosis ; Prognosis ; Thrombocytopenia, Neonatal Alloimmune/diagnosis ; Thrombocytopenia, Neonatal Alloimmune/epidemiology ; United Kingdom/epidemiology
    Language English
    Publishing date 2011-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/j.1365-2141.2010.08540.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.182: Show issues Location:
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  10. Book: Riding the yield curve

    Ang, Sharon / Allen, Dave / Alles, Lakshman

    an analysis of international evidence

    (IRIC discussion paper series ; 99,01)

    1999  

    Author's details Sharon Ang, Lakshman Alles and Dave Allen
    Series title IRIC discussion paper series ; 99,01
    Keywords Portfolio-Investition ; Portfolio-Management ; Kapitaleinkommen ; Finanzmarkt ; Australien
    Language English
    Size I, 31 S, graph. Darst
    Publishing place Perth, WA
    Document type Book
    ISBN 1863426973 ; 9781863426978
    Database ECONomics Information System

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