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  1. Book: The etiology of atopic dermatitis

    Allen, Herbert B.

    2015  

    Author's details Herbert B. Allen
    Language English
    Size XVIII, 117 S. : zahlr. Ill.
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018523346
    ISBN 978-1-4471-6544-6 ; 1-4471-6544-6 ; 9781447165453 ; 1447165454
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 387 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: A Novel Approach to the Treatment and Prevention of Alzheimer's Disease Based on the Pathology and Microbiology.

    Allen, Herbert B

    Journal of Alzheimer's disease : JAD

    2021  Volume 84, Issue 1, Page(s) 61–67

    Abstract: Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer's disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, ... ...

    Abstract Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer's disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, mostly via neuronal pathways and the entorhinal circulation. These organisms easily pass through the blood-brain barrier and have an affinity for neural tissue. Once in the brain, the spirochetes make intra- and extracellular biofilms, and it is the biofilms that create the pathology. Specifically, it is the intracellular biofilms that are ultimately responsible for neurofibrillary tangles and dendritic disintegration. The extracellular biofilms are responsible for the inflammation that initially is generated by the first responder, Toll-like receptor 2. The hypothesis that arises from this work is two-pronged: one is related to prevention; the other to treatment. Regarding prevention, it is very likely possible that AD could be prevented by periodic administration of penicillin (PCN), which would kill the spirochetes before they made biofilms; this would prevent the disease and would not allow any of the above deleterious changes generated by the biofilms to occur. As regards treatment, it may be possible to slow or prevent further decline in early AD by administration of PCN together with a biofilm disperser. The disperser would disrupt the biofilm coating and enable the PCN to kill the spirochetes. This protocol could be administered in a trial with the control arm utilizing the current treatment. The progress of the treatment could be evaluated by one of the current blood tests that is semi-quantitative. The specific protocols are listed.
    MeSH term(s) Alzheimer Disease/microbiology ; Alzheimer Disease/pathology ; Biofilms ; Borrelia burgdorferi/isolation & purification ; Brain/microbiology ; Brain/pathology ; Humans ; Inflammation ; Neurons/metabolism ; Penicillins/therapeutic use ; Plaque, Amyloid/pathology ; Plaque, Amyloid/prevention & control ; Treponema denticola/isolation & purification ; tau Proteins/metabolism
    Chemical Substances Penicillins ; tau Proteins
    Language English
    Publishing date 2021-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-210429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Dermatology terminology

    Allen, Herbert B.

    2010  

    Author's details Herbert B. Allen
    Language English
    Size XX, 197 S. : zahlr. Ill., 203 mm x 127 mm
    Publisher Springer
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016182483
    ISBN 978-1-84882-839-1 ; 9781848828407 ; 1-84882-839-X ; 1848828403
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 54 order for loan Magazin

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  4. Book ; Online: An Infectious Origin of Alzheimer's Disease: An End for This Devastating Disorder?

    Miklossy, Judith / Tanzi, Rudolph / McCully, Kilmer / Perry, George / Cotman, Carl / Crean, StJohn / Richard Chapman, Matthew / Fulop, Tamas / McGeer, Patrick / David Moir, Robert / Allen, Herbert B.

    2020  

    Keywords Science: general issues ; Neurosciences ; Alzheimer's disease ; Amyloid ; Bacteria ; Infection ; Spirochetes ; Dementia ; Pathogens ; Biofilm ; Senile plaque ; Beta amyloid ; Tau ; Inflammation ; Bacterial amyloid ; HSV1 ; Virus
    Size 1 electronic resource (190 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231440
    ISBN 9782889639038 ; 2889639037
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Alzheimer's Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention.

    Allen, Herbert B

    Journal of Alzheimer's disease : JAD

    2016  Volume 53, Issue 4, Page(s) 1271–1276

    Abstract: Alzheimer's disease (AD) is an infectious disease caused by spirochetes, and these spirochetes form biofilms, which attract the innate immune system. The innate immune system first responder, Toll-like receptor 2, generates both NF-κB and TNF-α which try ...

    Abstract Alzheimer's disease (AD) is an infectious disease caused by spirochetes, and these spirochetes form biofilms, which attract the innate immune system. The innate immune system first responder, Toll-like receptor 2, generates both NF-κB and TNF-α which try to kill the spirochetes in the biofilm, but cannot penetrate the "slime". NF-κB is also responsible for the generation of amyloid-β (Aβ) which itself is anti-microbial. Aβ cannot penetrate the biofilm either, and its accumulation leads to destruction of the cerebral neurocircuitry. Treatment with penicillin (as in tertiary syphilis, the comparator to AD) is outlined; a biofilm dispersing agent may need to be added to the protocol.
    MeSH term(s) Alzheimer Disease/immunology ; Alzheimer Disease/pathology ; Alzheimer Disease/prevention & control ; Alzheimer Disease/therapy ; Amyloid beta-Peptides/metabolism ; Biofilms/drug effects ; Humans ; Immunity, Innate/drug effects ; Spirochaetales/drug effects ; Spirochaetales/physiology
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2016-07-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-160388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: The Role of Rifampin in Leprosy : Leprosy Through a New Lens.

    Allen, Herbert B / Moschella, Samuel L

    JAMA dermatology

    2017  Volume 153, Issue 3, Page(s) 261–262

    MeSH term(s) Humans ; Leprostatic Agents/therapeutic use ; Leprosy/drug therapy ; Rifampin/therapeutic use ; Treatment Outcome
    Chemical Substances Leprostatic Agents ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2017-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2016.5506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.32: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: The etiology of atopic dermatitis

    Allen, Herbert B

    2015  

    Author's details Herbert B. Allen
    MeSH term(s) Dermatitis, Atopic/etiology
    Language English
    Size xviii, 117 pages :, illustrations (some color), portraits
    Document type Book
    ISBN 9781447165446 ; 1447165446 ; 9781447165453 ; 1447165454
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book ; Online: The Etiology of Atopic Dermatitis

    Allen, Herbert B

    2015  

    Abstract: Atopic dermatitis has been called “the itch that rashes”, and this book reveals what causes the “itch”. It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune ... ...

    Author's details by Herbert B. Allen
    Abstract Atopic dermatitis has been called “the itch that rashes”, and this book reveals what causes the “itch”. It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the “itching” and inflammation in this disease. The Etiology ofAtopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics
    Keywords Allergy ; Dermatology ; Medicine
    Language English
    Size Online-Ressource (XVIII, 117 p. 111 illus., 108 illus. in color), online resource
    Publisher Springer London
    Publishing place London ;s.l
    Document type Book ; Online
    ISBN 9781447165446 ; 9781447165453 ; 1447165446 ; 1447165454
    DOI 10.1007/978-1-4471-6545-3
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis.

    Allen, Herbert B / Jadeja, Saagar / Allawh, Rina M / Goyal, Kavita

    Ear, nose, & throat journal

    2018  Volume 97, Issue 3, Page(s) 79–82

    Abstract: Group A Streptococcus has been identified as a possible etiologic agent in psoriasis in epidemiologic, immunologic, immunopathologic, medical, and surgical studies. Tonsillectomy has been shown to provide considerable relief to 75% of patients with ... ...

    Abstract Group A Streptococcus has been identified as a possible etiologic agent in psoriasis in epidemiologic, immunologic, immunopathologic, medical, and surgical studies. Tonsillectomy has been shown to provide considerable relief to 75% of patients with plaque psoriasis. Even with the substantial evidence supporting group A Streptococcus as a causative pathogen in psoriasis, it is an elusive pathogen because it is not culturable, nor does it exhibit any positive serologic evidence of its presence. One possible reason for the negative cultures and negative serology findings with group A Streptococcus is the development of biofilms. We conducted a pathologic study to determine whether biofilms were present in the tonsillar tissues of 10 patients with psoriasis-6 men and 4 women, aged 25 to 64 years (mean: 48)-and in 10 age- and sex-matched controls with chronic tonsillitis who did not have psoriasis. We found that biofilms were present in every tonsillectomy specimen we examined, including those of the controls. Whereas psoriasis has been considered a "double hit" phenomenon, we believe that the development of skin lesions is likely attributable to the presence of the gene PSORS together with the biofilm in psoriasis patients rather than to the biofilm itself. Biofilms have been identified in both extra- and intracellular locations. We believe our findings add further evidence supporting a microbial pathogenesis of this disease.
    MeSH term(s) Adult ; Biofilms/growth & development ; Case-Control Studies ; Chronic Disease ; Female ; Humans ; Male ; Middle Aged ; Palatine Tonsil/microbiology ; Palatine Tonsil/pathology ; Psoriasis/microbiology ; Psoriasis/pathology ; Streptococcal Infections/microbiology ; Streptococcal Infections/pathology ; Streptococcus pyogenes/physiology ; Tonsillitis/microbiology ; Tonsillitis/pathology
    Language English
    Publishing date 2018-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/014556131809700322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Book ; Online: Dermatology Terminology

    Allen, Herbert B

    2010  

    Abstract: Dermatology is unusual as a medical specialty in that the traditional language of medicine often does not fit the needs of the specialty. The formal language of dermatology is so distinctive, it can take many months to learn, much like a foreign language. ...

    Author's details by Herbert B. Allen
    Abstract Dermatology is unusual as a medical specialty in that the traditional language of medicine often does not fit the needs of the specialty. The formal language of dermatology is so distinctive, it can take many months to learn, much like a foreign language. Similarly, dermatopathology has its own language that differs dramatically from the language of pathology.Dermatology Terminology uniquely describes and catalogs dermatologic diseases with the verbiage dermatologists use when speaking to each other. With many disorders, a description can be reduced to a word, phrase, or acronym, where such a
    Keywords Dermatology ; Emerging infectious diseases ; Medicine
    Language English
    Size Online-Ressource, v.: digital
    Publisher Springer
    Publishing place Dordrecht u.a.
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9781848828391 ; 9781848828407 ; 184882839X ; 1848828403
    DOI 10.1007/978-1-84882-840-7
    Database Former special subject collection: coastal and deep sea fishing

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