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  1. Article ; Online: Isolated Vaginal Bleeding Before the Onset of Puberty.

    Allen, Natalie G / Kaplowitz, Paul B

    Endocrinology and metabolism clinics of North America

    2024  Volume 53, Issue 2, Page(s) 211–216

    Abstract: Isolated vaginal bleeding before the onset of puberty is a rare presentation of isosexual precocity. In most cases, isolated vaginal bleeding without an abnormal genital examination is self-limited with resolution usually within 1 to 3 episodes. Watchful ...

    Abstract Isolated vaginal bleeding before the onset of puberty is a rare presentation of isosexual precocity. In most cases, isolated vaginal bleeding without an abnormal genital examination is self-limited with resolution usually within 1 to 3 episodes. Watchful waiting is appropriate in most patients who do not have persistent bleeding, other signs of puberty, or signs/symptoms of an underlying etiology. Workup for patients with concerning features may include puberty hormone levels and/or transabdominal and transperineal ultrasound.
    MeSH term(s) Humans ; Female ; Uterine Hemorrhage/etiology ; Puberty, Precocious/diagnosis ; Puberty, Precocious/etiology ; Puberty/physiology ; Child
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pediatric Acne Vulgaris: A Guide for Recognition, Examination, Referral, and Treatment.

    Scott, Jennifer B / Allen, Natalie G / Zaenglein, Andrea L

    Pediatric annals

    2024  Volume 53, Issue 4, Page(s) e115–e120

    Abstract: Acne is a common skin condition in adolescent patients but much less common in childhood. Pediatric providers should be familiar with the varying presentations in the pediatric population and recognize when additional physical signs of hyperandrogenism ... ...

    Abstract Acne is a common skin condition in adolescent patients but much less common in childhood. Pediatric providers should be familiar with the varying presentations in the pediatric population and recognize when additional physical signs of hyperandrogenism are present. This article details the pathogenesis and presentation of acne in infancy, mid-childhood, and preadolescence. The differential diagnosis is discussed and recommendations for initial workup, referral, and treatment are provided.
    MeSH term(s) Adolescent ; Child ; Humans ; Acne Vulgaris/diagnosis ; Acne Vulgaris/etiology ; Acne Vulgaris/therapy ; Hyperandrogenism ; Diagnosis, Differential ; Referral and Consultation
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20240205-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Novel Variant in

    Yu, Yunting / Lee, Peter A / Huerta-Saenz, Lina / Allen, Natalie G

    JCEM case reports

    2023  Volume 1, Issue 5, Page(s) luad103

    Abstract: Differences of sex development (DSDs) are a spectrum of congenital clinical conditions involving the development of gonadal, chromosomal, and anatomical sex. The physical presentation provides incomplete clues because underlying etiologies may present ... ...

    Abstract Differences of sex development (DSDs) are a spectrum of congenital clinical conditions involving the development of gonadal, chromosomal, and anatomical sex. The physical presentation provides incomplete clues because underlying etiologies may present with similar findings. We describe an 8-year-old boy from the Dominican Republic originally diagnosed with congenital adrenal hyperplasia (CAH). He was prescribed oral hydrocortisone and fludrocortisone, with irregular adherence. During infancy, he had human chorionic gonadotropin injections to stimulate phallic growth. After migrating to the United States, medications became depleted but without adrenal crisis. Laboratory testing with high-dose adrenocorticotropin stimulation study ruled out CAH. Careful examination noted an underdeveloped bifid scrotum, bilaterally undescended testicles, a 2-cm phallus, severe penoscrotal hypospadias, and chordee. Subsequently, he had a 2-stage bilateral orchiopexy and surgical repair of penoscrotal hypospadias and chordee. Genetic testing for 46,XY DSD revealed a novel, dominant, heterozygous, likely pathogenic variant (c.102 + 1G > C) in the
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differences of Sex Development: What Neonatologists Need to Know.

    Allen, Natalie G / Krishna, Kanthi Bangalore / Lee, Peter A

    Clinics in perinatology

    2022  Volume 49, Issue 1, Page(s) 207–218

    Abstract: Differences of sex development (DSD) refer to rare conditions in which an individual's sex development is different from typical male or female development. The neonatologist is often the first health care provider to interact with parents of newborns ... ...

    Abstract Differences of sex development (DSD) refer to rare conditions in which an individual's sex development is different from typical male or female development. The neonatologist is often the first health care provider to interact with parents of newborns with DSD and must be familiar with the approach to patients with DSD. In this article, we discuss definition of DSD, initial workup of the patient with DSD, terminology, and controversies in care.
    MeSH term(s) Disorders of Sex Development/diagnosis ; Disorders of Sex Development/therapy ; Female ; Humans ; Infant, Newborn ; Male ; Neonatologists ; Parents
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193116-7
    ISSN 1557-9840 ; 0095-5108
    ISSN (online) 1557-9840
    ISSN 0095-5108
    DOI 10.1016/j.clp.2021.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of gonadotropin-releasing hormone analogs in children.

    Allen, Natalie G / Krishna, Kanthi Bangalore / Lee, Peter A

    Current opinion in pediatrics

    2021  Volume 33, Issue 4, Page(s) 442–448

    Abstract: Purpose of review: In this review, we outline the usage and formulations of gonadotropin-releasing hormone analogs (GnRHas) in central precocious puberty (CPP), short stature, and gender diverse individuals, as well as adverse effects, long-term ... ...

    Abstract Purpose of review: In this review, we outline the usage and formulations of gonadotropin-releasing hormone analogs (GnRHas) in central precocious puberty (CPP), short stature, and gender diverse individuals, as well as adverse effects, long-term outcomes, and monitoring of therapy. There is a particular focus on citing references published within the last 24 months.
    Recent findings: Long-acting formulations of GnRHa now include Federal Drug Administration approval for subcutaneous injections. Significant adverse events continue to be rarely reported; extremely rare events include arterial hypertension and pseudotumor cerebri. There continue to be no significant long-term consequences including the impact upon body mass index and bone mineral density, which appear to be transient. GnRHas have been used in differences of sexual development (DSD) and increasingly in the treatment of adolescent transgender individuals.
    Summary: GnRHas remain as the only fully efficacious therapy for CPP and effectively suppress pubertal hormones in other situations. The use of GnRHa therapy in gender incongruent individuals has proven beneficial and has become a standard of care, whereas use in those with DSDs should still be considered experimental.
    Video abstract: http://links.lww.com/MOP/A62.
    MeSH term(s) Adolescent ; Body Height ; Bone Density ; Child ; Dwarfism ; Gonadotropin-Releasing Hormone ; Humans ; Puberty, Precocious/drug therapy
    Chemical Substances Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Review ; Video-Audio Media
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The vaginal microbiome in women of reproductive age with healthy weight versus overweight/obesity.

    Allen, Natalie G / Edupuganti, Laahirie / Edwards, David J / Jimenez, Nicole R / Buck, Gregory A / Jefferson, Kimberly K / Strauss, Jerome F / Wickham, Edmond P / Fettweis, Jennifer M

    Obesity (Silver Spring, Md.)

    2021  Volume 30, Issue 1, Page(s) 142–152

    Abstract: Objective: The aim of this study was to evaluate the differences between the vaginal microbiome of reproductive-aged women with overweight and obesity (Ow/Ob) compared with healthy weight (HW).: Methods: In this case-control study, a cohort of 367 ... ...

    Abstract Objective: The aim of this study was to evaluate the differences between the vaginal microbiome of reproductive-aged women with overweight and obesity (Ow/Ob) compared with healthy weight (HW).
    Methods: In this case-control study, a cohort of 367 nonpregnant women (18 to 40 years) with Ow/Ob (BMI ≥25 kg/m
    Results: Mean age and BMI of Ow/Ob and HW groups were 26.8 versus 26.7 years and 37.0 versus 22.1 kg/m
    Conclusions: The vaginal microbiome differs in reproductive-aged women with Ow/Ob compared with women with HW, with increased alpha diversity and decreased predominance of Lactobacillus. Observed differences in the vaginal microbiome may partially explain differences in preterm birth and bacterial vaginosis risk between these populations.
    MeSH term(s) Adult ; Case-Control Studies ; Female ; Humans ; Infant, Newborn ; Microbiota ; Obesity ; Overweight ; Premature Birth ; RNA, Ribosomal, 16S/genetics
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-11-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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