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  1. Article ; Online: FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity.

    Kraman, Matthew / Faroudi, Mustapha / Allen, Natalie L / Kmiecik, Katarzyna / Gliddon, Daniel / Seal, Claire / Koers, Alexander / Wydro, Mateusz M / Batey, Sarah / Winnewisser, Julia / Young, Lesley / Tuna, Mihriban / Doody, Jacqueline / Morrow, Michelle / Brewis, Neil

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 26, Issue 13, Page(s) 3333–3344

    Abstract: Purpose: Although programmed death-ligand 1 (PD-L1) antibody-based therapy has improved the outcome of patients with cancer, acquired resistance to these treatments limits their clinical efficacy. FS118 is a novel bispecific, tetravalent antibody (mAb!## ...

    Abstract Purpose: Although programmed death-ligand 1 (PD-L1) antibody-based therapy has improved the outcome of patients with cancer, acquired resistance to these treatments limits their clinical efficacy. FS118 is a novel bispecific, tetravalent antibody (mAb
    Experimental design: This study characterizes the binding activity and immune function of FS118 in cell lines and human peripheral blood mononuclear cells and further investigates its antitumor activity and mechanism of action using a surrogate murine bispecific antibody (mLAG-3/PD-L1 mAb
    Results: FS118 demonstrated simultaneous binding to LAG-3 and PD-L1 with high affinity and comparable or better activity than the combination of the single component parts of the mAb
    Conclusions: This study demonstrates a novel benefit of the bispecific approach over a combination of mAbs and supports the further development of FS118 for the treatment of patients with cancer.
    MeSH term(s) Animals ; Antibodies, Bispecific/pharmacology ; Antibody Affinity ; Antigens, CD/metabolism ; Antineoplastic Agents, Immunological/pharmacology ; B7-H1 Antigen/antagonists & inhibitors ; Biomarkers, Tumor ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Immunophenotyping ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Mice ; Protein Binding ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Xenograft Model Antitumor Assays
    Chemical Substances Antibodies, Bispecific ; Antigens, CD ; Antineoplastic Agents, Immunological ; B7-H1 Antigen ; Biomarkers, Tumor ; CD223 antigen ; CD274 protein, human
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics.

    Everett, Katy L / Kraman, Matthew / Wollerton, Francisca P G / Zimarino, Carlo / Kmiecik, Katarzyna / Gaspar, Miguel / Pechouckova, Sarka / Allen, Natalie L / Doody, Jacqueline F / Tuna, Mihriban

    Methods (San Diego, Calif.)

    2018  Volume 154, Page(s) 60–69

    Abstract: The immunoglobulin superfamily protein lymphocyte-activation gene 3 (LAG-3) participates in immune suppression and has been identified as a suitable target for cancer therapies. In order to generate bispecific antibodies targeting LAG-3, Fcabs (Fc-region ...

    Abstract The immunoglobulin superfamily protein lymphocyte-activation gene 3 (LAG-3) participates in immune suppression and has been identified as a suitable target for cancer therapies. In order to generate bispecific antibodies targeting LAG-3, Fcabs (Fc-region with antigen binding) targeting human and murine LAG-3 were generated from phage libraries. These Fcabs bind to LAG-3, inhibiting its interaction with MHC class II, and induce IL-2 production in a T cell assay. Bispecific antibodies, known as mAb
    MeSH term(s) Animals ; Antibodies, Bispecific ; Antigens, CD/immunology ; Humans ; Immunoglobulin Fc Fragments ; Macaca fascicularis/metabolism ; Mice ; Protein Engineering
    Chemical Substances Antibodies, Bispecific ; Antigens, CD ; CD223 antigen ; Immunoglobulin Fc Fragments
    Language English
    Publishing date 2018-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2018.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3239: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Representational difference analysis: critical appraisal and method development for the identification of unique DNA sequences from prokaryotes.

    Allen, Natalie L / Penn, Charles W / Hilton, Anthony C

    Journal of microbiological methods

    2003  Volume 55, Issue 1, Page(s) 73–81

    Abstract: Representational difference analysis (RDA) has great potential for preferential amplification of unique but uncharacterised DNA sequences present in one source such as a whole genome, but absent from a related genome or other complex population of ... ...

    Abstract Representational difference analysis (RDA) has great potential for preferential amplification of unique but uncharacterised DNA sequences present in one source such as a whole genome, but absent from a related genome or other complex population of sequences. While a few examples of its successful exploitation have been published, the method has not been well dissected and robust, detailed published protocols are lacking. Here we examine the method in detail, suggest improvements and provide a protocol that has yielded key unique sequences from a pathogenic bacterial genome.
    MeSH term(s) DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Gene Library ; Nucleic Acid Amplification Techniques/methods ; Sequence Analysis, DNA ; Temperature
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2003-10-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/s0167-7012(03)00117-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1849: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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