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  1. Article: A synergistic blend of

    Sinha, Swaraj / Alluri, Krishnaraju Venkata / Somepalli, Venkateswarlu / Golakoti, Trimurtulu / Sengupta, Krishanu

    Food & nutrition research

    2023  Volume 67

    Abstract: Background: A proprietary combination of : Objective: This study assessed the underlying mechanisms of the ergogenic potential of LI80020F4 in : Methods: The individual extracts and their combination (LI80020F4) were assessed for nitrite ... ...

    Abstract Background: A proprietary combination of
    Objective: This study assessed the underlying mechanisms of the ergogenic potential of LI80020F4 in
    Methods: The individual extracts and their combination (LI80020F4) were assessed for nitrite production in EAhy926 human endothelial cells. Subsequent experiments evaluated the effect of LI80020F4 in myotube formation in C2C12 mouse myoblasts, expression of mammalian target of rapamycin (mTOR) signaling proteins, myogenic factors, and mitochondrial functions in L6 rat myoblasts.Moreover, adult male ICR mice were randomly assigned (
    Results: LI80020F4 increased nitrite production in EAhy926 cells in a dose-dependent manner. LI80020F4 induced C2C12 myotube formation, increased mitochondrial biogenesis, upregulated the expressions of activated mTOR and other mitochondria and myogenic proteins, and mitigated H
    Conclusion: LI80020F4 increases nitric oxide production in the endothelial cells, mitochondrial biogenesis and function, upregulates skeletal muscle growth-related protein expressions and reduces oxidative stress; together, it explains the basis of the ergogenic potential of LI80020F4.
    Language English
    Publishing date 2023-10-30
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2418338-6
    ISSN 1654-661X
    ISSN 1654-661X
    DOI 10.29219/fnr.v67.9750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Toxicological Assessments of a Proprietary Blend of

    Madireddy, Ravi Kumar / Alluri, Krishnaraju Venkata / Somepalli, Venkateswarlu / Golakoti, Trimurtulu / Sengupta, Krishanu

    Journal of toxicology

    2022  Volume 2022, Page(s) 3903943

    Abstract: ... LN18178 ( ... ...

    Abstract LN18178 (Tesnor
    Language English
    Publishing date 2022-05-06
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495098-1
    ISSN 1687-8205 ; 1687-8191
    ISSN (online) 1687-8205
    ISSN 1687-8191
    DOI 10.1155/2022/3903943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Synergistic Botanical Composition Increases Resting Energy Expenditure and Reduces Adiposity in High-Fat Diet-Fed Rats.

    Kundimi, Sreenath / Chinta, Gopichand / Alluri, Krishnaraju Venkata / Golakoti, Trimurtulu / Veeramachaneni, Sudipta / Ramanathan, Guru / Sengupta, Krishanu

    Journal of the American Nutrition Association

    2023  Volume 43, Issue 3, Page(s) 286–295

    Abstract: Objective: An imbalance between dietary energy intake and energy expenditure may result in body fat gain or obesity. Increasing resting energy expenditure (REE) is an attractive strategy for managing body fat gain. The objective of the current study was ...

    Abstract Objective: An imbalance between dietary energy intake and energy expenditure may result in body fat gain or obesity. Increasing resting energy expenditure (REE) is an attractive strategy for managing body fat gain. The objective of the current study was to generate proof-of-concept data on a synergistic composition (LN19183) of
    Method: In
    Results: In 3T3-L1 adipocytes, LN19183 synergistically increased FGF-21 production and dose-dependently increased β3-AR and UCP-1 protein expression. In HFD-fed rats, both doses of LN19183 supplementation significantly (
    Conclusions: LN19183 reduces body fat mass and weight gain via increased REE and fat oxidation in HFD-fed obese rats.
    MeSH term(s) Rats ; Mice ; Male ; Animals ; Adiposity ; Diet, High-Fat/adverse effects ; Rats, Sprague-Dawley ; Obesity/drug therapy ; Weight Gain ; Energy Metabolism
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 2769-707X
    ISSN (online) 2769-707X
    DOI 10.1080/27697061.2023.2280777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males

    Konda, Manikyeswara Rao / Alluri, Krishnaraju Venkata / Janardhanan, Prason Kumar / Trimurtulu, Golakoti / Sengupta, Krishanu

    Journal of the International Society of Sports Nutrition. 2018 Dec., v. 15, no. 1

    2018  

    Abstract: BACKGROUND: A proprietary composition GMCT contains extracts of two popular Asian herbs viz., Garcinia mangostana (GM) fruit rind and Cinnamomum tamala (CT) leaf. We systematically evaluated physical performance and muscle strength enhancing ability of ... ...

    Abstract BACKGROUND: A proprietary composition GMCT contains extracts of two popular Asian herbs viz., Garcinia mangostana (GM) fruit rind and Cinnamomum tamala (CT) leaf. We systematically evaluated physical performance and muscle strength enhancing ability of GMCT in a preclinical mouse model followed by a 42-days double-blind placebo controlled human trial in resistance trained adult males. METHODS: Four groups of Swiss albino mice (20–30 g body weight) (n = 6) were fed a standard laboratory diet and given Carboxymethylcellulose sodium (CMC), 150 mg/kg GMCT (GMCT-150), 300 mg/kg GMCT (GMCT-300) or 50 mg/kg Oxymetholone (OXY) via oral gavage for 21 days. On day 22, the animals’ physical performance and muscle strength were assessed in a forced swimming test (FST) and forelimb grip strength experiment, respectively. In the human trial, thirty-eight resistance-trained young adults (mean age 26.32 ± 4.39 years, body weight 67.79 ± 12.84 kg, BMI 22.92 ± 3.54 kg/m2) completed the trial. The participants received either GMCT (n = 19; 800 mg daily) or matched placebo (n = 19) for 42 days. As primary variables, 1-RM bench press, 1-RM leg press, and leg extension repetitions were measured at baseline and on days 14, 28 and 42 of the intervention. Anthropometric parameters and serum markers such as free testosterone, insulin-like growth factor 1 (IGF-1), insulin and lactate were also measured before and after the intervention. RESULTS: GMCT-300 mice showed significant improvement in swimming time (GMCT: 395.3 ± 81.70 s vs. CMC: 271.6 ± 56.86 s; p = 0.0166), distance (GMCT: 341.22 ± 65.88 m vs. CMC: 260.84 ± 49.15 m; p = 0.0461) and grip strength (GMCT: 43.92 ± 6.97 N vs. CMC: 35.0 ± 6.92 N; p = 0.0490), compared with the CMC group. At the end of the 42-day human trial, the per protocol analyses reveal that mean changes from baseline 1-RM bench press (GMCT: 23.47 ± 10.07 kg vs. PL: 3.42 ± 2.06 kg; p < 0.0001), leg press (GMCT: 29.32 ± 16.17 kg vs. PL: 5.21 ± 1.72 kg; p < 0.0001), number of leg extension repetitions (GMCT: 6.58 ± 2.57 vs. PL: 2.05 ± 1.22; p < 0.0001) in GMCT group were significantly improved, compared with placebo. Intergroup difference analyses show that the changes from baseline left arm (GMCT: 1.09 ± 0.36 cm vs. PL: 0.68 ± 0.42 cm; p = 0.0023), right arm (GMCT: 1.50 ± 0.44 cm vs. PL: 1.11 ± 0.43 cm; p = 0.0088) circumference and lean mass (GMCT: 2.29 ± 2.09 kg vs. PL: 0.52 ± 2.58 kg; p = 0.0404) in GMCT group were also significantly improved, compared with placebo. In comparison to placebo, GMCT supplementation did not improve free testosterone, IGF-1, insulin or lactate levels. Parameters of clinical biochemistry, hematology, urine and vital signs of the participants were within the normal range. CONCLUSION: GMCT supplementation is effective in increasing muscle strength, muscle size and, total lean mass, as well as endurance performance. Trial Registration. Clinical Trial Registry of India (CTRI/2015/01/005374), Registered on Jan 07, 2015; CTRI Website URL - http://ctri.nic.in
    Keywords Cinnamomum tamala ; Garcinia mangostana ; albino ; animal models ; blood serum ; body mass index ; body weight ; carboxymethylcellulose ; clinical trials ; diet ; fatigue strength ; forced swimming test ; fruit peels ; hematology ; herbs ; humans ; insulin ; insulin-like growth factor I ; laboratory animals ; lactic acid ; leaves ; males ; mice ; muscle strength ; muscles ; placebos ; protocols ; sports nutrition ; swimming ; testosterone ; urine ; young adults
    Language English
    Dates of publication 2018-12
    Size p. 50.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2162810-5
    ISSN 1550-2783
    ISSN 1550-2783
    DOI 10.1186/s12970-018-0257-4
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males.

    Konda, Manikyeswara Rao / Alluri, Krishnaraju Venkata / Janardhanan, Prason Kumar / Trimurtulu, Golakoti / Sengupta, Krishanu

    Journal of the International Society of Sports Nutrition

    2018  Volume 15, Issue 1, Page(s) 50

    Abstract: Background: A proprietary composition GMCT contains extracts of two popular Asian herbs viz., Garcinia mangostana (GM) fruit rind and Cinnamomum tamala (CT) leaf. We systematically evaluated physical performance and muscle strength enhancing ability of ... ...

    Abstract Background: A proprietary composition GMCT contains extracts of two popular Asian herbs viz., Garcinia mangostana (GM) fruit rind and Cinnamomum tamala (CT) leaf. We systematically evaluated physical performance and muscle strength enhancing ability of GMCT in a preclinical mouse model followed by a 42-days double-blind placebo controlled human trial in resistance trained adult males.
    Methods: Four groups of Swiss albino mice (20-30 g body weight) (n = 6) were fed a standard laboratory diet and given Carboxymethylcellulose sodium (CMC), 150 mg/kg GMCT (GMCT-150), 300 mg/kg GMCT (GMCT-300) or 50 mg/kg Oxymetholone (OXY) via oral gavage for 21 days. On day 22, the animals' physical performance and muscle strength were assessed in a forced swimming test (FST) and forelimb grip strength experiment, respectively. In the human trial, thirty-eight resistance-trained young adults (mean age 26.32 ± 4.39 years, body weight 67.79 ± 12.84 kg, BMI 22.92 ± 3.54 kg/m
    Results: GMCT-300 mice showed significant improvement in swimming time (GMCT: 395.3 ± 81.70 s vs. CMC: 271.6 ± 56.86 s; p = 0.0166), distance (GMCT: 341.22 ± 65.88 m vs. CMC: 260.84 ± 49.15 m; p = 0.0461) and grip strength (GMCT: 43.92 ± 6.97 N vs. CMC: 35.0 ± 6.92 N; p = 0.0490), compared with the CMC group. At the end of the 42-day human trial, the per protocol analyses reveal that mean changes from baseline 1-RM bench press (GMCT: 23.47 ± 10.07 kg vs. PL: 3.42 ± 2.06 kg; p < 0.0001), leg press (GMCT: 29.32 ± 16.17 kg vs. PL: 5.21 ± 1.72 kg; p < 0.0001), number of leg extension repetitions (GMCT: 6.58 ± 2.57 vs. PL: 2.05 ± 1.22; p < 0.0001) in GMCT group were significantly improved, compared with placebo. Intergroup difference analyses show that the changes from baseline left arm (GMCT: 1.09 ± 0.36 cm vs. PL: 0.68 ± 0.42 cm; p = 0.0023), right arm (GMCT: 1.50 ± 0.44 cm vs. PL: 1.11 ± 0.43 cm; p = 0.0088) circumference and lean mass (GMCT: 2.29 ± 2.09 kg vs. PL: 0.52 ± 2.58 kg; p = 0.0404) in GMCT group were also significantly improved, compared with placebo. In comparison to placebo, GMCT supplementation did not improve free testosterone, IGF-1, insulin or lactate levels. Parameters of clinical biochemistry, hematology, urine and vital signs of the participants were within the normal range.
    Conclusion: GMCT supplementation is effective in increasing muscle strength, muscle size and, total lean mass, as well as endurance performance.
    Trial registration: Clinical Trial Registry of India (CTRI/2015/01/005374), Registered on Jan 07, 2015; CTRI Website URL - http://ctri.nic.in.
    MeSH term(s) Adult ; Animals ; Cinnamomum/chemistry ; Double-Blind Method ; Fruit/chemistry ; Garcinia mangostana/chemistry ; Humans ; Insulin/blood ; Insulin-Like Growth Factor I/analysis ; Lactic Acid/blood ; Male ; Mice ; Muscle Strength/drug effects ; Physical Endurance ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Resistance Training ; Testosterone/blood ; Young Adult
    Chemical Substances IGF1 protein, human ; Insulin ; Plant Extracts ; Lactic Acid (33X04XA5AT) ; Testosterone (3XMK78S47O) ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2018-10-22
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2162810-5
    ISSN 1550-2783 ; 1550-2783
    ISSN (online) 1550-2783
    ISSN 1550-2783
    DOI 10.1186/s12970-018-0257-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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