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  1. Article ; Online: The pancreatic β-cell in ageing: Implications in age-related diabetes.

    Tudurí, Eva / Soriano, Sergi / Almagro, Lucía / Montanya, Eduard / Alonso-Magdalena, Paloma / Nadal, Ángel / Quesada, Ivan

    Ageing research reviews

    2022  Volume 80, Page(s) 101674

    Abstract: The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases with ageing. T2D generally results from progressive impairment of the pancreatic islets to adapt β-cell mass and function in the setting of insulin resistance and ... ...

    Abstract The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases with ageing. T2D generally results from progressive impairment of the pancreatic islets to adapt β-cell mass and function in the setting of insulin resistance and increased insulin demand. Several studies have shown an age-related decline in peripheral insulin sensitivity. However, a precise understanding of the pancreatic β-cell response in ageing is still lacking. In this review, we summarize the age-related alterations, adaptations and/or failures of β-cells at the molecular, morphological and functional levels in mouse and human. Age-associated alterations include processes such as β-cell proliferation, apoptosis and cell identity that can influence β-cell mass. Age-related changes also affect β-cell function at distinct steps including electrical activity, Ca
    MeSH term(s) Aging/metabolism ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Insulin/metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Mice
    Chemical Substances Insulin
    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2022.101674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
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  2. Article ; Online: The Effects of Aging on Male Mouse Pancreatic β-Cell Function Involve Multiple Events in the Regulation of Secretion: Influence of Insulin Sensitivity.

    Tudurí, Eva / Soriano, Sergi / Almagro, Lucía / García-Heredia, Anabel / Rafacho, Alex / Alonso-Magdalena, Paloma / Nadal, Ángel / Quesada, Ivan

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2021  Volume 77, Issue 3, Page(s) 405–415

    Abstract: Aging is associated with a decline in peripheral insulin sensitivity and an increased risk of impaired glucose tolerance and type 2 diabetes. During conditions of reduced insulin sensitivity, pancreatic β cells undergo adaptive responses to increase ... ...

    Abstract Aging is associated with a decline in peripheral insulin sensitivity and an increased risk of impaired glucose tolerance and type 2 diabetes. During conditions of reduced insulin sensitivity, pancreatic β cells undergo adaptive responses to increase insulin secretion and maintain euglycemia. However, the existence and nature of β-cell adaptations and/or alterations during aging are still a matter of debate. In this study, we investigated the effects of aging on β-cell function from control (3-month-old) and aged (20-month-old) mice. Aged animals were further categorized into 2 groups: high insulin sensitive (aged-HIS) and low insulin sensitive (aged-LIS). Aged-LIS mice were hyperinsulinemic, glucose intolerant, and displayed impaired glucose-stimulated insulin and C-peptide secretion, whereas aged-HIS animals showed characteristics in glucose homeostasis similar to controls. In isolated β cells, we observed that glucose-induced inhibition of KATP channel activity was reduced with aging, particularly in the aged-LIS group. Glucose-induced islet NAD(P)H production was decreased in aged mice, suggesting impaired mitochondrial function. In contrast, voltage-gated Ca2+ currents were higher in aged-LIS β cells, and pancreatic islets of both aged groups displayed increased glucose-induced Ca2+ signaling and augmented insulin secretion compared with controls. Morphological analysis of pancreas sections also revealed augmented β-cell mass with aging, especially in the aged-LIS group, as well as ultrastructural β-cell changes. Altogether, these findings indicate that aged mouse β cells compensate for the aging-induced alterations in the stimulus-secretion coupling, particularly by adjusting their Ca2+ influx to ensure insulin secretion. These results also suggest that decreased peripheral insulin sensitivity exacerbates the effects of aging on β cells.
    MeSH term(s) Aging ; Animals ; Calcium ; Diabetes Mellitus, Type 2 ; Glucose ; Insulin/pharmacology ; Insulin Resistance ; Insulin-Secreting Cells ; Islets of Langerhans/physiology ; Male ; Mice
    Chemical Substances Insulin ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glab276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Induction of viral interference by IPNV-carrier cells on target cells: A cell co-culture study.

    Parreño, Ricardo / Torres, Susana / Almagro, Lucía / Belló-Pérez, Melissa / Estepa, Amparo / Perez, Luis

    Fish & shellfish immunology

    2016  Volume 58, Page(s) 483–489

    Abstract: IPNV is a salmonid birnavirus that possesses the ability to establish asymptomatic persistent infections in a number of valuable fish species. The presence of IPNV may interfere with subsequent infection by other viruses. In the present study we show ... ...

    Abstract IPNV is a salmonid birnavirus that possesses the ability to establish asymptomatic persistent infections in a number of valuable fish species. The presence of IPNV may interfere with subsequent infection by other viruses. In the present study we show that an IPNV-carrier cell line (EPC
    MeSH term(s) Animals ; Birnaviridae Infections/immunology ; Birnaviridae Infections/veterinary ; Birnaviridae Infections/virology ; Cell Line ; Coculture Techniques/veterinary ; Cyprinidae ; Fish Diseases/immunology ; Fish Diseases/virology ; Infectious pancreatic necrosis virus/physiology ; Viral Interference
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2016.09.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5917: Show issues

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  4. Article ; Online: Restricted replication of viral hemorrhagic septicemia virus (VHSV) in a birnavirus-carrier cell culture.

    Parreño, Ricardo / Almagro, Lucía / Belló-Pérez, Melissa / Medina-Gali, Regla M / Estepa, Amparo / Perez, Luis

    Archives of virology

    2017  Volume 162, Issue 4, Page(s) 1037–1041

    Abstract: Viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV) are economically important pathogens of the salmonid aquaculture industry. In previous work we demonstrated that a cell line persistently infected with IPNV ( ... ...

    Abstract Viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV) are economically important pathogens of the salmonid aquaculture industry. In previous work we demonstrated that a cell line persistently infected with IPNV (EPC
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Line ; Fish Diseases/virology ; Infectious pancreatic necrosis virus/genetics ; Infectious pancreatic necrosis virus/growth & development ; Infectious pancreatic necrosis virus/physiology ; Novirhabdovirus/genetics ; Novirhabdovirus/growth & development ; Novirhabdovirus/physiology ; Rhabdoviridae Infections/veterinary ; Rhabdoviridae Infections/virology ; Salmonidae/virology ; Virus Cultivation ; Virus Replication
    Language English
    Publishing date 2017-04
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-016-3193-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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