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  1. Article: Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via

    Rizvi, Syed Mohd Danish / Almazni, Ibrahim A / Moawadh, Mamdoh S / Alharbi, Zeyad M / Helmi, Nawal / Alqahtani, Leena S / Hussain, Talib / Alafnan, Ahmed / Moin, Afrasim / Elkhalifa, AbdElmoneim O / Awadelkareem, Amir Mahgoub / Khalid, Mohammad / Tiwari, Rohit Kumar

    Frontiers in chemistry

    2024  Volume 12, Page(s) 1352009

    Abstract: Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally ... ...

    Abstract Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it is resistant to conventional therapeutic regimens. In this study, the anti-cancer potential of garcinol, a naturally derived benzophenone, was assessed against GBM. During the analysis, we observed a reduction in the viability of rat glioblastoma C6 cells at a concentration of 30 µM of the extract (
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2024.1352009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of the Antiasthmatic Activity of

    Ali, Muddassar / Salma, Umme / Khan, Irfan Amir / Ahmad, Taseer / Bashir, Kashif / Khan, Taous / Mahnashi, Mater H / Alhasaniah, Abdulaziz H / Al Awadh, Ahmed A / Almazni, Ibrahim A / Alshahrani, Mohammed M / Shah, Abdul Jabbar

    BioMed research international

    2022  Volume 2022, Page(s) 7011789

    Abstract: ... Carissa ... ...

    Abstract Carissa opaca
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/7011789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Homozygous Missense Variant in the N-Terminal Region of ANK3 Gene Is Associated with Developmental Delay, Seizures, Speech Abnormality, and Aggressive Behavior.

    Younus, Muhammad / Rasheed, Memoona / Lin, Zhaohan / Asiri, Saeed A / Almazni, Ibrahim A / Alshehri, Mohammed Ali / Shafiq, Sarfraz / Iqbal, Imran / Khan, Amjad / Ullah, Hanif / Umair, Muhammad / Waqas, Ahmed

    Molecular syndromology

    2022  Volume 14, Issue 1, Page(s) 11–20

    Abstract: Introduction: Intellectual disability (ID) is a lifelong disability that affects an individual‧s learning capacity and adaptive behavior. Such individuals depend on their families for day-to-day survival and pose a significant challenge to the ... ...

    Abstract Introduction: Intellectual disability (ID) is a lifelong disability that affects an individual‧s learning capacity and adaptive behavior. Such individuals depend on their families for day-to-day survival and pose a significant challenge to the healthcare system, especially in developing countries. ID is a heterogeneous condition, and genetic studies are essential to unravel the underlying cellular pathway for brain development and functioning.
    Methods: Here we studied a female index patient, born to a consanguineous Pakistani couple, showing clinical symptoms of ID, ataxia, hypotonia, developmental delay, seizures, speech abnormality, and aggressive behavior. Whole exome sequencing (WES) coupled with Sanger sequencing was performed for molecular diagnosis. Further, 3D protein modeling was performed to see the effect of variant on protein structure.
    Results: WES identified a novel homozygous missense variant (c.178T>C; p.Tyr60His) in the
    Conclusion: Our finding supports the clinical and genetic diversity of the
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2546218-0
    ISSN 1661-8777 ; 1661-8769
    ISSN (online) 1661-8777
    ISSN 1661-8769
    DOI 10.1159/000526381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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