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Article ; Online: Pharmacological evaluations of amide carboxylates as potential anti-Alzheimer agents: anti-radicals, enzyme inhibition, simulation and behavioral studies in animal models.

Mahnashi, Mater H / Ali, Saqib / M Alshehri, Osama / Almazni, Ibrahim Abdullah / Asiri, Saeed Ahmed / Sadiq, Abdul / Zafar, Rehman / Jan, Muhammad Saeed

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–20

Abstract: Alzheimer's disease (AD) is a neurological disorder that progresses gradually but irreversibly leading to dementia and is difficult to prevent and treat. There is a considerable time window in which the progression of the disease can be intervened. ... ...

Abstract	Alzheimer's disease (AD) is a neurological disorder that progresses gradually but irreversibly leading to dementia and is difficult to prevent and treat. There is a considerable time window in which the progression of the disease can be intervened. Scientific advances were required to help the researchers to identify the effective methods for the prevention and treatment of disease. This research was designed to investigate potential mediators for the remedy of AD, five new carboxylate amide zinc complexes (AAZ9-AAZ13) were synthesized and characterized by spectroscopic and physicochemical techniques. The biological evaluation was carried out based on the cholinesterase inhibitory mechanism. The preparation methodology provided the effective synthesis of targeted moieties. The
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2251052
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Article: Insights from the molecular docking analysis of SGLT2 and FIMH to combat uropathogenicity.

Abdulaal, Wesam H / Bakhrebah, Muhammed A / Nassar, Majed S / Almazni, Ibrahim Abdullah / Almutairi, Wael Abdullah / Natto, Zuhair S / Khattab, Amin K

Bioinformation

2022 Volume 18, Issue 11, Page(s) 1044–1049

Abstract: SGLT2 inhibitors are a novel class of FDA approved anti-diabetes drugs. They act by blocking the SGLT2 protein, which prevents glucose reabsorption, leading in enhance glucose excretion and lower blood glucose levels. In diabetic patients, SGLT2 ... ...

Abstract	SGLT2 inhibitors are a novel class of FDA approved anti-diabetes drugs. They act by blocking the SGLT2 protein, which prevents glucose reabsorption, leading in enhance glucose excretion and lower blood glucose levels. In diabetic patients, SGLT2 inhibitors have been linked to urinary tract infections (UTIs). Therefore, the development of novel SGLT2 inhibitors with no adverse effects is a need of time. With this purpose, in this study, 48164natural compounds from ZINC database were screened targeting both the SGLT2 and FimH protein using insilico approaches. FimH has been discovered as a promising target for preventing and treating UTIs. The hit compounds ZINC69481892, ZINC1612996, and ZINC4039265 exhibited strong binding with both SGLT2 and FimH with binding energies values of -9.88, -8.96, and -10.57 kcal/mol for SGLT2, and -7.86, -7.01, and -8.92 kcal/mol for FimH, which is higher than that of controls (-6.78 kcal/mol (Empaglifozolin for SGLT2) and -5.14 kcal/mol (Heptyl α-d-mannopyranoside for FimH)). Hits were found to bind with key residues of both SGLT2 and FimH protein. In addition, physiochemical properties showed that these compounds have good drug-likeness properties. Therefore, we anticipate that if these compounds are investigated further, might be potential SGLT2 inhibitors with less uropathogenic adverse effects.
Language	English
Publishing date	2022-11-30
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/973206300181044
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Article: Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an

Hussain, Talib / Alafnan, Ahmed / Almazni, Ibrahim Abdullah / Helmi, Nawal / Moin, Afrasim / Baeissa, Hanadi M / Awadelkareem, Amir Mahgoub / Elkhalifa, AbdElmoneim O / Bakhsh, Tahani / Alzahrani, Abdulrahman / Alghamdi, Rashed Mohammed / Khalid, Mohammad / Tiwari, Rohit Kumar / Rizvi, Syed Mohd Danish

Frontiers in pharmacology

2024 Volume 14, Page(s) 1325184

Abstract: At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attributes of an ... ...

Abstract	At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with the initiation and subsequent progression of prostate carcinomas. The present report elucidated the anti-cancerous attributes of an anthraquinone, aloe-emodin (AE), against androgen-independent human prostate cancer DU145 cells. The cytotoxicity profiling of AE showed that it exerted significant cytotoxic effects and increased lactose dehydrogenase levels in DU145 cells (
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1325184
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Article ; Online: Phytochemicals-based β-amyloid cleaving enzyme-1 and MAO-B inhibitors for the treatment of Alzheimer's disease: molecular simulations-based predictions.

Mahnashi, Mater H / Ayaz, Muhammad / Ghufran, Mehreen / Almazni, Ibrahim Abdullah / Alqahtani, Omaish / Alyami, Bandar A / Alqahtani, Yahya S / Khan, Haider Ali / Sadiq, Abdul / Waqas, Muhammad

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–13

Abstract: Alzheimer's disease (AD) is among the highly prevalent neurodegenerative disorder of the aging brain and is allied with cognitive and behavioral abnormalities. Unfortunately, there is very limited drug discovery for the effective management of AD, and ... ...

Abstract	Alzheimer's disease (AD) is among the highly prevalent neurodegenerative disorder of the aging brain and is allied with cognitive and behavioral abnormalities. Unfortunately, there is very limited drug discovery for the effective management of AD, and the clinically approved drugs have limited efficacy. Consequently, there is an immediate demand for the development of new compounds that have the ability to act as multitarget-directed ligands (MTDLs). As major pathological targets of the disease, the current study aimed to investigate lead natural bioactive compounds including apigenin, epigallocatechin-3-gallate, berberine, curcumin, genistein, luteolin, quercetin, resveratrol for their inhibitory potentials against β-amyloid cleaving enzyme-1 (BACE1) and monoamine oxidase-B (MAO-B) enzymes. The study compounds were docked against the target enzymes (MAO-B and BACE1) using MOE software and subsequent molecular dynamics simulations (MDS) studies. The molecular docking analysis revealed that these phytochemicals (MTDLs) showed good interactions with the target enzymes as compared to the reference inhibitors. Among these eight phytocompounds, the epigallocatechin-3-gallate compound was an active inhibitor against both drug targets, with the highest docking scores and good interactions with the active residues of the enzymes. Furthermore, the docking result of the active one inhibitor in complex with the target enzymes (epigallocatechin-3-gallate/BACE1, epigallocatechin-3-gallate/MAO-B, reference/BACE1 and reference/MAO-B) were further validated by MDS. According to the findings of our study, epigallocatechin-3-gallate has the potential to be a candidate for use in the treatment of neurological illnesses like AD. This compound has MTDL potential and may be exploited to create new compounds with disease-modifying features.Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2265494
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Article ; Online: Cardioprotective Potential of Aqueous Extract of

Sajid, Aimen / Ahmad, Taseer / Ikram, Muhammad / Khan, Taous / Shah, Abdul Jabbar / Mahnashi, Mater H / Alhasaniah, Abdulaziz Hassan / Al Awadh, Ahmed Abdullah / Almazni, Ibrahim Abdullah / Alshahrani, Mohammed Merae

Oxidative medicine and cellular longevity

2022 Volume 2022, Page(s) 2112956

Abstract: Ischemic heart disease (IHD) treatments and preventions by using plant extract and its phytochemical constituents have achieved considerable attention globally due to its cardioprotective effects. This study is aimed at investigating the cardioprotective ...

Abstract	Ischemic heart disease (IHD) treatments and preventions by using plant extract and its phytochemical constituents have achieved considerable attention globally due to its cardioprotective effects. This study is aimed at investigating the cardioprotective and vascular effects of
MeSH term(s)	Animals ; Calcium ; Cardiotonic Agents/pharmacology ; Creatine Kinase ; Fumaria ; Isoproterenol/toxicity ; Myocardial Infarction/pathology ; Myocardium/pathology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Cardiotonic Agents ; Creatine Kinase (EC 2.7.3.2) ; Isoproterenol (L628TT009W) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2022/2112956
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Article ; Online: Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Emran, Talha Bin / Islam, Fahadul / Mitra, Saikat / Paul, Shyamjit / Nath, Nikhil / Khan, Zidan / Das, Rajib / Chandran, Deepak / Sharma, Rohit / Lima, Clara Mariana Gonçalves / Awadh, Ahmed Abdullah Al / Almazni, Ibrahim Abdullah / Alhasaniah, Abdulaziz Hassan / Guiné, Raquel P F

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 21

Abstract: Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization ... ...

Abstract	Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules.
MeSH term(s)	Animals ; Humans ; Pectins/pharmacology ; Pectins/therapeutic use ; Fruit ; Neoplasms/prevention & control ; Malus ; Dietary Carbohydrates
Chemical Substances	Pectins (89NA02M4RX) ; Dietary Carbohydrates
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27217405
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Article: Curcumin-Encapsulated Nanomicelles Improve Cellular Uptake and Cytotoxicity in Cisplatin-Resistant Human Oral Cancer Cells.

Kumbar, Vijay M / Muddapur, Uday / Bin Muhsinah, Abdullatif / Alshehri, Saad Ali / Alshahrani, Mohammed Merae / Almazni, Ibrahim Abdullah / Kugaji, Manohar S / Bhat, Kishore / Peram, Malleswara Rao / Mahnashi, Mater H / Nadaf, Sameer J / Rooge, Sheetalnath B / Khan, Aejaz Abdullatif / Shaikh, Ibrahim Ahmed

Journal of functional biomaterials

2022 Volume 13, Issue 4

Abstract: Oral cancer has a high mortality rate, which is mostly determined by the stage of the disease at the time of admission. Around half of all patients with oral cancer report with advanced illness. Hitherto, chemotherapy is preferred to treat oral cancer, ... ...

Abstract	Oral cancer has a high mortality rate, which is mostly determined by the stage of the disease at the time of admission. Around half of all patients with oral cancer report with advanced illness. Hitherto, chemotherapy is preferred to treat oral cancer, but the emergence of resistance to anti-cancer drugs is likely to occur after a sequence of treatments. Curcumin is renowned for its anticancer potential but its marred water solubility and poor bioavailability limit its use in treating multidrug-resistant cancers. As part of this investigation, we prepared and characterized Curcumin nanomicelles (CUR-NMs) using DSPE-PEG-2000 and evaluated the anticancer properties of cisplatin-resistant cancer cell lines. The prepared CUR-NMs were sphere-shaped and unilamellar in structure, with a size of 32.60 ± 4.2 nm. CUR-NMs exhibited high entrapment efficiency (82.2%), entrapment content (147.96 µg/mL), and a mean zeta potential of -17.5ζ which is considered moderately stable. The cellular uptake and cytotoxicity studies revealed that CUR-NMs had significantly higher cytotoxicity and cellular uptake in cisplatin drug-resistant oral cancer cell lines and parental oral cancer cells compared to plain curcumin (CUR). The DAPI and FACS analysis corroborated a high percentage of apoptotic cells with CUR-NMs (31.14%) compared to neat CUR (19.72%) treatment. Conclusively, CUR-NMs can potentially be used as an alternative carrier system to improve the therapeutic effects of curcumin in the treatment of cisplatin-resistant human oral cancer.
Language	English
Publishing date	2022-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb13040158
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Article: Application of CRISPR-Cas System to Mitigate Superbug Infections.

Rabaan, Ali A / Al Fares, Mona A / Almaghaslah, Manar / Alpakistany, Tariq / Al Kaabi, Nawal A / Alshamrani, Saleh A / Alshehri, Ahmad A / Almazni, Ibrahim Abdullah / Saif, Ahmed / Hakami, Abdulrahim R / Khamis, Faryal / Alfaresi, Mubarak / Alsalem, Zainab / Alsoliabi, Zainab A / Al Amri, Kawthar Amur Salim / Hassoueh, Amal K / Mohapatra, Ranjan K / Arteaga-Livias, Kovy / Alissa, Mohammed

Microorganisms

2023 Volume 11, Issue 10

Abstract: Multidrug resistance in bacterial strains known as superbugs is estimated to cause fatal infections worldwide. Migration and urbanization have resulted in overcrowding and inadequate sanitation, contributing to a high risk of superbug infections within ... ...

Abstract	Multidrug resistance in bacterial strains known as superbugs is estimated to cause fatal infections worldwide. Migration and urbanization have resulted in overcrowding and inadequate sanitation, contributing to a high risk of superbug infections within and between different communities. The CRISPR-Cas system, mainly type II, has been projected as a robust tool to precisely edit drug-resistant bacterial genomes to combat antibiotic-resistant bacterial strains effectively. To entirely opt for its potential, advanced development in the CRISPR-Cas system is needed to reduce toxicity and promote efficacy in gene-editing applications. This might involve base-editing techniques used to produce point mutations. These methods employ designed Cas9 variations, such as the adenine base editor (ABE) and the cytidine base editor (CBE), to directly edit single base pairs without causing DSBs. The CBE and ABE could change a target base pair into a different one (for example, G-C to A-T or C-G to A-T). In this review, we addressed the limitations of the CRISPR/Cas system and explored strategies for circumventing these limitations by applying diverse base-editing techniques. Furthermore, we also discussed recent research showcasing the ability of base editors to eliminate drug-resistant microbes.
Language	English
Publishing date	2023-09-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11102404
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Article: COVID-19 Vaccine Acceptance and Hesitancy among Migrants, Refugees, and Foreign Workers: A Systematic Review and Meta-Analysis.

Hajissa, Khalid / Mutiat, Hammed-Akanmu / Kaabi, Nawal Al / Alissa, Mohammed / Garout, Mohammed / Alenezy, Anood A / Almaghrabi, Rana H / Alrasheed, Hayam A / Al-Subaie, Maha F / Alhani, Hatem M / Alshehri, Ahmad A / Almazni, Ibrahim Abdullah / Alqahtani, Ali S / Bahwerth, Fayez Saeed / Alqethami, Nourah Hashem / Alzayer, Amal A / Rabaan, Ali A

Vaccines

2023 Volume 11, Issue 6

Abstract: Despite the effectiveness of current vaccines in reducing the spread and severity of SARS-CoV-2 infections, many people, including migrants, refugees, and foreign workers, are hesitant to be vaccinated. This systematic review and meta-analysis (SRMA) was ...

Abstract	Despite the effectiveness of current vaccines in reducing the spread and severity of SARS-CoV-2 infections, many people, including migrants, refugees, and foreign workers, are hesitant to be vaccinated. This systematic review and meta-analysis (SRMA) was conducted to determine the pooled prevalence estimate of the acceptance and hesitancy rates of the COVID-19 vaccine among these populations. A comprehensive search of the peer-reviewed literature indexed in PubMed, Scopus, Science Direct, and Web of Science databases was conducted. Initially, 797 potential records were identified, of which 19 articles met the inclusion criteria. A meta-analysis of proportions using data from 14 studies revealed that the overall acceptance rate of COVID vaccination among 29,152 subjects was 56.7% (95% CI: 44.9-68.5%), while the prevalence of vaccine hesitancy among 26,154 migrants reported in 12 studies was estimated to be 31.7% (95% CI: 44.9-68.5%). The acceptance rate for the COVID-19 vaccination first declined from 77.3% in 2020 to 52.9% in 2021 and then slightly increased to 56.1% in 2022. The most frequent factors influencing vaccine hesitancy were worries about vaccine efficacy and safety. Intensive vaccination campaigns should be implemented to raise vaccination awareness among migrants, which will increase the acceptance rate for the COVID-19 vaccine and result in herd immunity.
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11061070
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