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  1. Article: Patterns of diseases and preventive measures among domestic hajjis from Central, Saudi Arabia.

    Al-Jasser, Fahad S / Kabbash, Ibrahim A / Almazroa, Mohammad A / Memish, Ziad A

    Saudi medical journal

    2012  Volume 33, Issue 8, Page(s) 879–886

    Abstract: Objectives: To identify the occurrence of upper respiratory tract infections (URTI), diarrheal diseases and trauma during the Hajj season, and the practice of some preventive measures by pilgrims.: Methods: A cross-sectional study during November and ...

    Abstract Objectives: To identify the occurrence of upper respiratory tract infections (URTI), diarrheal diseases and trauma during the Hajj season, and the practice of some preventive measures by pilgrims.
    Methods: A cross-sectional study during November and December 2009 among hajjis registered while visiting Primary Health Care Centers of Riyadh, Kingdom of Saudi Arabia to get mandatory meningococcal meningitis vaccination. On return from hajj, hajjis were contacted on telephone to collect information on occurrence of URTI and diarrhea along with other associated activities in Hajj.
    Results: Out of 1507 hajjis, 54.7% developed symptoms; 97% reported upper respiratory tract symptoms, and 9.3% reported diarrheal symptoms. Those <40 years of age were more likely to develop an URTI. The incidence of diarrheal diseases or trauma was not statistically associated with age. No statistical difference for educational level was found for URTI or trauma, but there was a statistically significant difference for diarrheal diseases. There was no statistical difference for nationality in relation to diarrheal diseases and trauma, but there was a statistically significant difference for URTI. There was a statistically significant difference of URTI between those pilgrims who used the face mask most of the time and those who used it sometimes.
    Conclusion: Upper respiratory tract infections is a common health problem among studied domestic hajjis. Generally, there is room for improvement in the adoption of preventive measures by hajjis; and there is still limited information on the use of facemasks in spite of the fact that using it significantly decreases the risk for URTI.
    MeSH term(s) Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Ceremonial Behavior ; Cohort Studies ; Cross-Sectional Studies ; Diarrhea/epidemiology ; Diarrhea/prevention & control ; Drinking Water ; Educational Status ; Feeding Behavior ; Female ; Hand Disinfection ; Humans ; Islam ; Male ; Masks/utilization ; Middle Aged ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Risk Factors ; Saudi Arabia/epidemiology ; Smoking/epidemiology ; Travel ; Wounds and Injuries/epidemiology ; Wounds and Injuries/prevention & control ; Young Adult
    Chemical Substances Drinking Water
    Language English
    Publishing date 2012-08
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Get a license, buckle up, and slow down: risky driving patterns among saudis.

    El Bcheraoui, Charbel / Basulaiman, Mohammed / Tuffaha, Marwa / Daoud, Farah / Robinson, Margaret / Jaber, Sara / Mikhitarian, Sarah / Wilson, Shelley / Memish, Ziad A / Al Saeedi, Mohammad / Almazroa, Mohammad A / Mokdad, Ali H

    Traffic injury prevention

    2015  Volume 16, Issue 6, Page(s) 587–592

    Abstract: Introduction: Road traffic injuries are the largest cause of loss of disability-adjusted life years for men and women of all ages in the Kingdom of Saudi Arabia, but data on driving habits there are lacking. To inform policymakers on drivers' abilities ... ...

    Abstract Introduction: Road traffic injuries are the largest cause of loss of disability-adjusted life years for men and women of all ages in the Kingdom of Saudi Arabia, but data on driving habits there are lacking. To inform policymakers on drivers' abilities and driving habits, we analyzed data from the Saudi Health Interview Survey 2013.
    Methods: We surveyed a representative sample of 5,235 Saudi males aged 15 years or older on wearing seat belts, exceeding speed limits, and using a handheld cell phone while driving. Male and female respondents were surveyed on wearing seat belts as passengers.
    Results: Among Saudi males, 71.7% reported having had a driver's license, but more than 43% of unlicensed males drove a vehicle. Among drivers, 86.1% engaged in at least one risky behavior while driving. Older and unlicensed drivers were more likely to take risks while driving. This risk decreased among the more educated, current smokers, and those who are physically active. Up to 94.9% and 98.5% of respondents reported not wearing a seat belt in the front and the back passenger seats, respectively.
    Discussion: The high burden of road traffic injuries in the Kingdom is not surprising given our findings. Our study calls for aggressive monitoring and enforcement of traffic laws. Awareness and proper education for drivers and their families should be developed jointly by the Ministries of Health, Interior Affairs, and Education and provided through their channels.
    MeSH term(s) Acceleration ; Accidents, Traffic/statistics & numerical data ; Adolescent ; Adult ; Automobile Driving/legislation & jurisprudence ; Automobile Driving/psychology ; Automobile Driving/statistics & numerical data ; Cell Phone/instrumentation ; Cell Phone/utilization ; Equipment Design ; Female ; Habits ; Health Surveys ; Humans ; Licensure/statistics & numerical data ; Male ; Middle Aged ; Risk-Taking ; Saudi Arabia/epidemiology ; Seat Belts/utilization ; Wounds and Injuries/epidemiology ; Young Adult
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2089818-6
    ISSN 1538-957X ; 1538-9588
    ISSN (online) 1538-957X
    ISSN 1538-9588
    DOI 10.1080/15389588.2014.990090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014.

    Alraddadi, Basem M / Watson, John T / Almarashi, Abdulatif / Abedi, Glen R / Turkistani, Amal / Sadran, Musallam / Housa, Abeer / Almazroa, Mohammad A / Alraihan, Naif / Banjar, Ayman / Albalawi, Eman / Alhindi, Hanan / Choudhry, Abdul Jamil / Meiman, Jonathan G / Paczkowski, Magdalena / Curns, Aaron / Mounts, Anthony / Feikin, Daniel R / Marano, Nina /
    Swerdlow, David L / Gerber, Susan I / Hajjeh, Rana / Madani, Tariq A

    Emerging infectious diseases

    2016  Volume 22, Issue 1, Page(s) 49–55

    Abstract: Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history ... ...

    Abstract Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of MERS-CoV.
    MeSH term(s) Adult ; Aged ; Animals ; Camelus/virology ; Case-Control Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/etiology ; Coronavirus Infections/virology ; Female ; Humans ; Male ; Middle Aged ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Risk Factors ; Saudi Arabia/epidemiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2201.151340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Seroprevalence of Alkhurma and other hemorrhagic fever viruses, Saudi Arabia.

    Memish, Ziad A / Albarrak, Ali / Almazroa, Mohammad A / Al-Omar, Ibrahim / Alhakeem, Rafat / Assiri, Abdullah / Fagbo, Shamsudeen / MacNeil, Adam / Rollin, Pierre E / Abdullah, Nageeb / Stephens, Gwen

    Emerging infectious diseases

    2011  Volume 17, Issue 12, Page(s) 2316–2318

    Abstract: A 2009 deployment of military units from several Saudi Arabian provinces to Jazan Province, Saudi Arabia, enabled us to evaluate exposure to Alkhurma, Crimean-Congo, dengue, and Rift Valley hemorrhagic fever viruses. Seroprevalence to all viruses was low; ...

    Abstract A 2009 deployment of military units from several Saudi Arabian provinces to Jazan Province, Saudi Arabia, enabled us to evaluate exposure to Alkhurma, Crimean-Congo, dengue, and Rift Valley hemorrhagic fever viruses. Seroprevalence to all viruses was low; however, Alkhurma virus seroprevalence was higher (1.3%) and less geographically restricted than previously thought.
    MeSH term(s) Antibodies, Viral/blood ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/immunology ; Communicable Diseases, Emerging/virology ; Dengue/epidemiology ; Dengue/immunology ; Dengue/virology ; Encephalitis Viruses, Tick-Borne/immunology ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/immunology ; Hemorrhagic Fever, Crimean/virology ; Hemorrhagic Fevers, Viral/epidemiology ; Hemorrhagic Fevers, Viral/immunology ; Hemorrhagic Fevers, Viral/virology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Kyasanur Forest Disease/epidemiology ; Kyasanur Forest Disease/immunology ; Kyasanur Forest Disease/virology ; Male ; Military Personnel ; Rift Valley Fever/epidemiology ; Rift Valley Fever/immunology ; Rift Valley Fever/virology ; Saudi Arabia/epidemiology ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2011-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid1712.110658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition.

    Murray, Christopher J L / Barber, Ryan M / Foreman, Kyle J / Abbasoglu Ozgoren, Ayse / Abd-Allah, Foad / Abera, Semaw F / Aboyans, Victor / Abraham, Jerry P / Abubakar, Ibrahim / Abu-Raddad, Laith J / Abu-Rmeileh, Niveen M / Achoki, Tom / Ackerman, Ilana N / Ademi, Zanfina / Adou, Arsène K / Adsuar, José C / Afshin, Ashkan / Agardh, Emilie E / Alam, Sayed Saidul /
    Alasfoor, Deena / Albittar, Mohammed I / Alegretti, Miguel A / Alemu, Zewdie A / Alfonso-Cristancho, Rafael / Alhabib, Samia / Ali, Raghib / Alla, François / Allebeck, Peter / Almazroa, Mohammad A / Alsharif, Ubai / Alvarez, Elena / Alvis-Guzman, Nelson / Amare, Azmeraw T / Ameh, Emmanuel A / Amini, Heresh / Ammar, Walid / Anderson, H Ross / Anderson, Benjamin O / Antonio, Carl Abelardo T / Anwari, Palwasha / Arnlöv, Johan / Arsic Arsenijevic, Valentina S / Artaman, Al / Asghar, Rana J / Assadi, Reza / Atkins, Lydia S / Avila, Marco A / Awuah, Baffour / Bachman, Victoria F / Badawi, Alaa / Bahit, Maria C / Balakrishnan, Kalpana / Banerjee, Amitava / Barker-Collo, Suzanne L / Barquera, Simon / Barregard, Lars / Barrero, Lope H / Basu, Arindam / Basu, Sanjay / Basulaiman, Mohammed O / Beardsley, Justin / Bedi, Neeraj / Beghi, Ettore / Bekele, Tolesa / Bell, Michelle L / Benjet, Corina / Bennett, Derrick A / Bensenor, Isabela M / Benzian, Habib / Bernabé, Eduardo / Bertozzi-Villa, Amelia / Beyene, Tariku J / Bhala, Neeraj / Bhalla, Ashish / Bhutta, Zulfiqar A / Bienhoff, Kelly / Bikbov, Boris / Biryukov, Stan / Blore, Jed D / Blosser, Christopher D / Blyth, Fiona M / Bohensky, Megan A / Bolliger, Ian W / Bora Başara, Berrak / Bornstein, Natan M / Bose, Dipan / Boufous, Soufiane / Bourne, Rupert R A / Boyers, Lindsay N / Brainin, Michael / Brayne, Carol E / Brazinova, Alexandra / Breitborde, Nicholas J K / Brenner, Hermann / Briggs, Adam D / Brooks, Peter M / Brown, Jonathan C / Brugha, Traolach S / Buchbinder, Rachelle / Buckle, Geoffrey C / Budke, Christine M / Bulchis, Anne / Bulloch, Andrew G / Campos-Nonato, Ismael R / Carabin, Hélène / Carapetis, Jonathan R / Cárdenas, Rosario / Carpenter, David O / Caso, Valeria / Castañeda-Orjuela, Carlos A / Castro, Ruben E / Catalá-López, Ferrán / Cavalleri, Fiorella / Çavlin, Alanur / Chadha, Vineet K / Chang, Jung-Chen / Charlson, Fiona J / Chen, Honglei / Chen, Wanqing / Chiang, Peggy P / Chimed-Ochir, Odgerel / Chowdhury, Rajiv / Christensen, Hanne / Christophi, Costas A / Cirillo, Massimo / Coates, Matthew M / Coffeng, Luc E / Coggeshall, Megan S / Colistro, Valentina / Colquhoun, Samantha M / Cooke, Graham S / Cooper, Cyrus / Cooper, Leslie T / Coppola, Luis M / Cortinovis, Monica / Criqui, Michael H / Crump, John A / Cuevas-Nasu, Lucia / Danawi, Hadi / Dandona, Lalit / Dandona, Rakhi / Dansereau, Emily / Dargan, Paul I / Davey, Gail / Davis, Adrian / Davitoiu, Dragos V / Dayama, Anand / De Leo, Diego / Degenhardt, Louisa / Del Pozo-Cruz, Borja / Dellavalle, Robert P / Deribe, Kebede / Derrett, Sarah / Des Jarlais, Don C / Dessalegn, Muluken / Dharmaratne, Samath D / Dherani, Mukesh K / Diaz-Torné, Cesar / Dicker, Daniel / Ding, Eric L / Dokova, Klara / Dorsey, E Ray / Driscoll, Tim R / Duan, Leilei / Duber, Herbert C / Ebel, Beth E / Edmond, Karen M / Elshrek, Yousef M / Endres, Matthias / Ermakov, Sergey P / Erskine, Holly E / Eshrati, Babak / Esteghamati, Alireza / Estep, Kara / Faraon, Emerito Jose A / Farzadfar, Farshad / Fay, Derek F / Feigin, Valery L / Felson, David T / Fereshtehnejad, Seyed-Mohammad / Fernandes, Jefferson G / Ferrari, Alize J / Fitzmaurice, Christina / Flaxman, Abraham D / Fleming, Thomas D / Foigt, Nataliya / Forouzanfar, Mohammad H / Fowkes, F Gerry R / Paleo, Urbano Fra / Franklin, Richard C / Fürst, Thomas / Gabbe, Belinda / Gaffikin, Lynne / Gankpé, Fortuné G / Geleijnse, Johanna M / Gessner, Bradford D / Gething, Peter / Gibney, Katherine B / Giroud, Maurice / Giussani, Giorgia / Gomez Dantes, Hector / Gona, Philimon / González-Medina, Diego / Gosselin, Richard A / Gotay, Carolyn C / Goto, Atsushi / Gouda, Hebe N / Graetz, Nicholas / Gugnani, Harish C / Gupta, Rahul / Gupta, Rajeev / Gutiérrez, Reyna A / Haagsma, Juanita / Hafezi-Nejad, Nima / Hagan, Holly / Halasa, Yara A / Hamadeh, Randah R / Hamavid, Hannah / Hammami, Mouhanad / Hancock, Jamie / Hankey, Graeme J / Hansen, Gillian M / Hao, Yuantao / Harb, Hilda L / Haro, Josep Maria / Havmoeller, Rasmus / Hay, Simon I / Hay, Roderick J / Heredia-Pi, Ileana B / Heuton, Kyle R / Heydarpour, Pouria / Higashi, Hideki / Hijar, Martha / Hoek, Hans W / Hoffman, Howard J / Hosgood, H Dean / Hossain, Mazeda / Hotez, Peter J / Hoy, Damian G / Hsairi, Mohamed / Hu, Guoqing / Huang, Cheng / Huang, John J / Husseini, Abdullatif / Huynh, Chantal / Iannarone, Marissa L / Iburg, Kim M / Innos, Kaire / Inoue, Manami / Islami, Farhad / Jacobsen, Kathryn H / Jarvis, Deborah L / Jassal, Simerjot K / Jee, Sun Ha / Jeemon, Panniyammakal / Jensen, Paul N / Jha, Vivekanand / Jiang, Guohong / Jiang, Ying / Jonas, Jost B / Juel, Knud / Kan, Haidong / Karch, André / Karema, Corine K / Karimkhani, Chante / Karthikeyan, Ganesan / Kassebaum, Nicholas J / Kaul, Anil / Kawakami, Norito / Kazanjan, Konstantin / Kemp, Andrew H / Kengne, Andre P / Keren, Andre / Khader, Yousef S / Khalifa, Shams Eldin A / Khan, Ejaz A / Khan, Gulfaraz / Khang, Young-Ho / Kieling, Christian / Kim, Daniel / Kim, Sungroul / Kim, Yunjin / Kinfu, Yohannes / Kinge, Jonas M / Kivipelto, Miia / Knibbs, Luke D / Knudsen, Ann Kristin / Kokubo, Yoshihiro / Kosen, Soewarta / Krishnaswami, Sanjay / Kuate Defo, Barthelemy / Kucuk Bicer, Burcu / Kuipers, Ernst J / Kulkarni, Chanda / Kulkarni, Veena S / Kumar, G Anil / Kyu, Hmwe H / Lai, Taavi / Lalloo, Ratilal / Lallukka, Tea / Lam, Hilton / Lan, Qing / Lansingh, Van C / Larsson, Anders / Lawrynowicz, Alicia E B / Leasher, Janet L / Leigh, James / Leung, Ricky / Levitz, Carly E / Li, Bin / Li, Yichong / Li, Yongmei / Lim, Stephen S / Lind, Maggie / Lipshultz, Steven E / Liu, Shiwei / Liu, Yang / Lloyd, Belinda K / Lofgren, Katherine T / Logroscino, Giancarlo / Looker, Katharine J / Lortet-Tieulent, Joannie / Lotufo, Paulo A / Lozano, Rafael / Lucas, Robyn M / Lunevicius, Raimundas / Lyons, Ronan A / Ma, Stefan / Macintyre, Michael F / Mackay, Mark T / Majdan, Marek / Malekzadeh, Reza / Marcenes, Wagner / Margolis, David J / Margono, Christopher / Marzan, Melvin B / Masci, Joseph R / Mashal, Mohammad T / Matzopoulos, Richard / Mayosi, Bongani M / Mazorodze, Tasara T / Mcgill, Neil W / Mcgrath, John J / Mckee, Martin / Mclain, Abigail / Meaney, Peter A / Medina, Catalina / Mehndiratta, Man Mohan / Mekonnen, Wubegzier / Melaku, Yohannes A / Meltzer, Michele / Memish, Ziad A / Mensah, George A / Meretoja, Atte / Mhimbira, Francis A / Micha, Renata / Miller, Ted R / Mills, Edward J / Mitchell, Philip B / Mock, Charles N / Mohamed Ibrahim, Norlinah / Mohammad, Karzan A / Mokdad, Ali H / Mola, Glen L D / Monasta, Lorenzo / Montañez Hernandez, Julio C / Montico, Marcella / Montine, Thomas J / Mooney, Meghan D / Moore, Ami R / Moradi-Lakeh, Maziar / Moran, Andrew E / Mori, Rintaro / Moschandreas, Joanna / Moturi, Wilkister N / Moyer, Madeline L / Mozaffarian, Dariush / Msemburi, William T / Mueller, Ulrich O / Mukaigawara, Mitsuru / Mullany, Erin C / Murdoch, Michele E / Murray, Joseph / Murthy, Kinnari S / Naghavi, Mohsen / Naheed, Aliya / Naidoo, Kovin S / Naldi, Luigi / Nand, Devina / Nangia, Vinay / Narayan, K M Venkat / Nejjari, Chakib / Neupane, Sudan P / Newton, Charles R / Ng, Marie / Ngalesoni, Frida N / Nguyen, Grant / Nisar, Muhammad I / Nolte, Sandra / Norheim, Ole F / Norman, Rosana E / Norrving, Bo / Nyakarahuka, Luke / Oh, In-Hwan / Ohkubo, Takayoshi / Ohno, Summer L / Olusanya, Bolajoko O / Opio, John Nelson / Ortblad, Katrina / Ortiz, Alberto / Pain, Amanda W / Pandian, Jeyaraj D / Panelo, Carlo Irwin A / Papachristou, Christina / Park, Eun-Kee / Park, Jae-Hyun / Patten, Scott B / Patton, George C / Paul, Vinod K / Pavlin, Boris I / Pearce, Neil / Pereira, David M / Perez-Padilla, Rogelio / Perez-Ruiz, Fernando / Perico, Norberto / Pervaiz, Aslam / Pesudovs, Konrad / Peterson, Carrie B / Petzold, Max / Phillips, Michael R / Phillips, Bryan K / Phillips, David E / Piel, Frédéric B / Plass, Dietrich / Poenaru, Dan / Polinder, Suzanne / Pope, Daniel / Popova, Svetlana / Poulton, Richie G / Pourmalek, Farshad / Prabhakaran, Dorairaj / Prasad, Noela M / Pullan, Rachel L / Qato, Dima M / Quistberg, D Alex / Rafay, Anwar / Rahimi, Kazem / Rahman, Sajjad U / Raju, Murugesan / Rana, Saleem M / Razavi, Homie / Reddy, K Srinath / Refaat, Amany / Remuzzi, Giuseppe / Resnikoff, Serge / Ribeiro, Antonio L / Richardson, Lee / Richardus, Jan Hendrik / Roberts, D Allen / Rojas-Rueda, David / Ronfani, Luca / Roth, Gregory A / Rothenbacher, Dietrich / Rothstein, David H / Rowley, Jane T / Roy, Nobhojit / Ruhago, George M / Saeedi, Mohammad Y / Saha, Sukanta / Sahraian, Mohammad Ali / Sampson, Uchechukwu K A / Sanabria, Juan R / Sandar, Logan / Santos, Itamar S / Satpathy, Maheswar / Sawhney, Monika / Scarborough, Peter / Schneider, Ione J / Schöttker, Ben / Schumacher, Austin E / Schwebel, David C / Scott, James G / Seedat, Soraya / Sepanlou, Sadaf G / Serina, Peter T / Servan-Mori, Edson E / Shackelford, Katya A / Shaheen, Amira / Shahraz, Saeid / Shamah Levy, Teresa / Shangguan, Siyi / She, Jun / Sheikhbahaei, Sara / Shi, Peilin / Shibuya, Kenji / Shinohara, Yukito / Shiri, Rahman / Shishani, Kawkab / Shiue, Ivy / Shrime, Mark G / Sigfusdottir, Inga D / Silberberg, Donald H / Simard, Edgar P / Sindi, Shireen / Singh, Abhishek / Singh, Jasvinder A / Singh, Lavanya / Skirbekk, Vegard / Slepak, Erica Leigh / Sliwa, Karen / Soneji, Samir / Søreide, Kjetil / Soshnikov, Sergey / Sposato, Luciano A / Sreeramareddy, Chandrashekhar T / Stanaway, Jeffrey D / Stathopoulou, Vasiliki / Stein, Dan J / Stein, Murray B / Steiner, Caitlyn / Steiner, Timothy J / Stevens, Antony / Stewart, Andrea / Stovner, Lars J / Stroumpoulis, Konstantinos / Sunguya, Bruno F / Swaminathan, Soumya / Swaroop, Mamta / Sykes, Bryan L / Tabb, Karen M / Takahashi, Ken / Tandon, Nikhil / Tanne, David / Tanner, Marcel / Tavakkoli, Mohammad / Taylor, Hugh R / Te Ao, Braden J / Tediosi, Fabrizio / Temesgen, Awoke M / Templin, Tara / Ten Have, Margreet / Tenkorang, Eric Y / Terkawi, Abdullah S / Thomson, Blake / Thorne-Lyman, Andrew L / Thrift, Amanda G / Thurston, George D / Tillmann, Taavi / Tonelli, Marcello / Topouzis, Fotis / Toyoshima, Hideaki / Traebert, Jefferson / Tran, Bach X / Trillini, Matias / Truelsen, Thomas / Tsilimbaris, Miltiadis / Tuzcu, Emin M / Uchendu, Uche S / Ukwaja, Kingsley N / Undurraga, Eduardo A / Uzun, Selen B / Van Brakel, Wim H / Van De Vijver, Steven / van Gool, Coen H / Van Os, Jim / Vasankari, Tommi J / Venketasubramanian, N / Violante, Francesco S / Vlassov, Vasiliy V / Vollset, Stein Emil / Wagner, Gregory R / Wagner, Joseph / Waller, Stephen G / Wan, Xia / Wang, Haidong / Wang, Jianli / Wang, Linhong / Warouw, Tati S / Weichenthal, Scott / Weiderpass, Elisabete / Weintraub, Robert G / Wenzhi, Wang / Werdecker, Andrea / Westerman, Ronny / Whiteford, Harvey A / Wilkinson, James D / Williams, Thomas N / Wolfe, Charles D / Wolock, Timothy M / Woolf, Anthony D / Wulf, Sarah / Wurtz, Brittany / Xu, Gelin / Yan, Lijing L / Yano, Yuichiro / Ye, Pengpeng / Yentür, Gökalp K / Yip, Paul / Yonemoto, Naohiro / Yoon, Seok-Jun / Younis, Mustafa Z / Yu, Chuanhua / Zaki, Maysaa E / Zhao, Yong / Zheng, Yingfeng / Zonies, David / Zou, Xiaonong / Salomon, Joshua A / Lopez, Alan D / Vos, Theo

    Lancet (London, England)

    2015  Volume 386, Issue 10009, Page(s) 2145–2191

    Abstract: Background: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of ... ...

    Abstract Background: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development.
    Methods: We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time.
    Findings: Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries.
    Interpretation: Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition--in which increasing sociodemographic status brings structured change in disease burden--is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions.
    Funding: Bill & Melinda Gates Foundation.
    MeSH term(s) Aged ; Chronic Disease/epidemiology ; Communicable Diseases/epidemiology ; Female ; Global Health/statistics & numerical data ; Health Transition ; Humans ; Life Expectancy ; Male ; Middle Aged ; Mortality, Premature ; Quality-Adjusted Life Years ; Socioeconomic Factors ; Wounds and Injuries/epidemiology
    Language English
    Publishing date 2015-08-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(15)61340-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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