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  1. Article ; Online: Less iron improves MDS haematopoiesis.

    Gyan, Emmanuel / Almeida, Antonio M

    British journal of haematology

    2019  Volume 187, Issue 1, Page(s) 11–12

    MeSH term(s) Bone Marrow Cells ; DNA Damage ; Deferasirox ; Hematopoiesis ; Humans ; Iron ; Iron Chelating Agents ; Iron Overload ; Oxidative Stress
    Chemical Substances Iron Chelating Agents ; Iron (E1UOL152H7) ; Deferasirox (V8G4MOF2V9)
    Language English
    Publishing date 2019-06-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
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  2. Article ; Online: Optimizing treatments in rare diseases: will our evidence come from registry data?

    Almeida, Antonio M

    Leukemia research

    2014  Volume 38, Issue 4, Page(s) 421–422

    MeSH term(s) Antimetabolites, Antineoplastic/therapeutic use ; Azacitidine/therapeutic use ; Female ; Humans ; Leukemia, Myelomonocytic, Chronic/drug therapy ; Leukemia, Myelomonocytic, Chronic/mortality ; Male
    Chemical Substances Antimetabolites, Antineoplastic ; Azacitidine (M801H13NRU)
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2014.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1321: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Combination of Elacridar with Imatinib Modulates Resistance Associated with Drug Efflux Transporters in Chronic Myeloid Leukemia.

    Alves, Raquel / Gonçalves, Ana Cristina / Jorge, Joana / Almeida, António M / Sarmento-Ribeiro, Ana Bela

    Biomedicines

    2022  Volume 10, Issue 5

    Abstract: Multidrug resistance (MDR) development has emerged as a complication that compromises the success of several chemotherapeutic agents. In chronic myeloid leukemia (CML), imatinib resistance has been associated with changes ... ...

    Abstract Multidrug resistance (MDR) development has emerged as a complication that compromises the success of several chemotherapeutic agents. In chronic myeloid leukemia (CML), imatinib resistance has been associated with changes in
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10051158
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  4. Article: Acute myeloid leukemia in the older adults.

    Almeida, Antonio M / Ramos, Fernando

    Leukemia research reports

    2016  Volume 6, Page(s) 1–7

    Abstract: AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult ... ...

    Abstract AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult therapeutic challenge. In this context, it is important to assess carefully patient- as well as disease-associated prognostic features with validated tools. The fittest patients should be considered for curative therapy, such as bone marrow transplantation, whereas low intensity options may be more appropriate for frail patients. Here we review how to assess patients with elderly AML and the treatments options available for them.
    Language English
    Publishing date 2016-06-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2016.06.001
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  5. Article: Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia-From Molecular Mechanisms to Clinical Relevance.

    Alves, Raquel / Gonçalves, Ana Cristina / Rutella, Sergio / Almeida, António M / De Las Rivas, Javier / Trougakos, Ioannis P / Sarmento Ribeiro, Ana Bela

    Cancers

    2021  Volume 13, Issue 19

    Abstract: Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy recognized to be associated with a ... ...

    Abstract Resistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy recognized to be associated with a genetic alteration, the t(9;22)(q34;q11). This translocation originates the
    Language English
    Publishing date 2021-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13194820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A systematic literature review of disease burden and clinical efficacy for patients with relapsed or refractory acute myeloid leukemia.

    Oliva, Esther Natalie / Ronnebaum, Sarah M / Zaidi, Omer / Patel, Dipen A / Nehme, Salem Abi / Chen, Clara / Almeida, Antonio M

    American journal of blood research

    2021  Volume 11, Issue 4, Page(s) 325–360

    Abstract: Acute myeloid leukemia (AML) is a rapidly progressive hematological malignancy that is difficult to cure. The prognosis is poor and treatment options are limited in case of relapse. A comprehensive assessment of current disease burden and the clinical ... ...

    Abstract Acute myeloid leukemia (AML) is a rapidly progressive hematological malignancy that is difficult to cure. The prognosis is poor and treatment options are limited in case of relapse. A comprehensive assessment of current disease burden and the clinical efficacy of non-intensive therapies in this population are lacking. We conducted two systematic literature reviews (SLRs). The first SLR (disease burden) included observational studies reporting the incidence and economic and humanistic burden of relapsed/refractory (RR) AML. The second SLR (clinical efficacy) included clinical trials (phase II or later) reporting remission rates (complete remission [CR] or CR with incomplete hematologic recovery [CRi]) and median overall survival (mOS) in patients with RR AML or patients with
    Language English
    Publishing date 2021-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2620435-6
    ISSN 2160-1992
    ISSN 2160-1992
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  7. Article ; Online: Generalized skin reactions in patients with MDS and CMML treated with azacitidine: Effective management with concomitant prednisolone.

    Almeida, Antonio M / Pierdomenico, Francesca

    Leukemia research

    2012  Volume 36, Issue 9, Page(s) e211–3

    MeSH term(s) Aged ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Azacitidine/administration & dosage ; Azacitidine/adverse effects ; Exanthema/chemically induced ; Exanthema/diagnosis ; Exanthema/drug therapy ; Female ; Humans ; Leukemia, Myelomonocytic, Chronic/drug therapy ; Male ; Myelodysplastic Syndromes/drug therapy ; Prednisolone/administration & dosage ; Treatment Outcome
    Chemical Substances Antimetabolites, Antineoplastic ; Prednisolone (9PHQ9Y1OLM) ; Azacitidine (M801H13NRU)
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2012.04.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1321: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis.

    Alves, Raquel / Gonçalves, Ana Cristina / Jorge, Joana / Marques, Gilberto / Ribeiro, André B / Tenreiro, Rita / Coucelo, Margarida / Diamond, Joana / Oliveiros, Bárbara / Pereira, Amélia / Freitas-Tavares, Paulo / Almeida, António M / Sarmento-Ribeiro, Ana Bela

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: Solute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. ...

    Abstract Solute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. These transporters mediate the cellular disposition of tyrosine kinase inhibitors (TKIs), and their genetic variants could affect its function, potentially predisposing patients to chronic myeloid leukaemia (CML) and modulating treatment response. We explored the impact of genetic variability (single nucleotide variants-SNVs) of drug transporter genes (
    MeSH term(s) ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Antineoplastic Agents/pharmacology ; Drug Resistance, Neoplasm/genetics ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Genotype ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Membrane Transport Proteins/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Solute Carrier Family 22 Member 5/genetics
    Chemical Substances ATP-Binding Cassette Transporters ; Antineoplastic Agents ; Membrane Transport Proteins ; Protein Kinase Inhibitors ; SLC22A5 protein, human ; Solute Carrier Family 22 Member 5 ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179815
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  9. Article ; Online: The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways.

    Cardoso, Bruno A / Belo, Hélio / Barata, João T / Almeida, António M

    PloS one

    2015  Volume 10, Issue 12, Page(s) e0143897

    Abstract: The classical BCR-ABL-negative Myeloproliferative Neoplasms (MPN) are a group of heterogeneous haematological diseases characterized by constitutive JAK-STAT pathway activation. Targeted therapy with Ruxolitinib, a JAK1/2-specific inhibitor, achieves ... ...

    Abstract The classical BCR-ABL-negative Myeloproliferative Neoplasms (MPN) are a group of heterogeneous haematological diseases characterized by constitutive JAK-STAT pathway activation. Targeted therapy with Ruxolitinib, a JAK1/2-specific inhibitor, achieves symptomatic improvement but does not eliminate the neoplastic clone. Similar effects are seen with histone deacetylase inhibitors (HDACi), albeit with poorer tolerance. Here, we show that bone marrow (BM) stromal cells (HS-5) protected MPN-derived cell lines (SET-2; HEL and UKE-1) and MPN patient-derived BM cells from the cytotoxic effects of Ruxolitinib and the HDACi Vorinostat. This protective effect was mediated, at least in part, by the secretion of soluble factors from the BM stroma. In addition, it correlated with the activation of signalling pathways important for cellular homeostasis, such as JAK-STAT, PI3K, JNK, MEK-ERK and NF-κB. Importantly, the pharmacological inhibition of JNK and PI3K pathways completely abrogated the BM protective effect on MPN cell lines and MPN patient samples. Our findings shed light on mechanisms of tumour survival and may indicate novel therapeutic approaches for the treatment of MPN.
    MeSH term(s) Adult ; Aged ; Antineoplastic Agents/pharmacology ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Hydroxamic Acids/pharmacology ; MAP Kinase Signaling System/drug effects ; Male ; Middle Aged ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/metabolism ; NF-kappa B/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology ; Signal Transduction/drug effects ; Vorinostat ; Young Adult
    Chemical Substances Antineoplastic Agents ; Hydroxamic Acids ; NF-kappa B ; Protein Kinase Inhibitors ; Pyrazoles ; Vorinostat (58IFB293JI) ; ruxolitinib (82S8X8XX8H) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2015-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0143897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy.

    Lopes-Coelho, Filipa / Martins, Filipa / Hipólito, Ana / Mendes, Cindy / Sequeira, Catarina O / Pires, Rita F / Almeida, António M / Bonifácio, Vasco D B / Pereira, Sofia A / Serpa, Jacinta

    Frontiers in oncology

    2021  Volume 11, Page(s) 656229

    Abstract: The activation of endothelial cells (ECs) is a crucial step on the road map of tumor angiogenesis and expanding evidence indicates that a pro-oxidant tumor microenvironment, conditioned by cancer metabolic rewiring, is a relevant controller of this ... ...

    Abstract The activation of endothelial cells (ECs) is a crucial step on the road map of tumor angiogenesis and expanding evidence indicates that a pro-oxidant tumor microenvironment, conditioned by cancer metabolic rewiring, is a relevant controller of this process. Herein, we investigated the contribution of oxidative stress-induced ferroptosis to ECs activation. Moreover, we also addressed the anti-angiogenic effect of Propranolol. We observed that a ferroptosis-like mechanism, induced by xCT inhibition with Erastin, at a non-lethal level, promoted features of ECs activation, such as proliferation, migration and vessel-like structures formation, concomitantly with the depletion of reduced glutathione (GSH) and increased levels of oxidative stress and lipid peroxides. Additionally, this ferroptosis-like mechanism promoted vascular endothelial cadherin (VE-cadherin) junctional gaps and potentiated cancer cell adhesion to ECs and transendothelial migration. Propranolol was able to revert Erastin-dependent activation of ECs and increased levels of hydrogen sulfide (H
    Language English
    Publishing date 2021-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.656229
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