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  1. Article ; Online: Influence of rosmarinic acid and Salvia officinalis extracts on melanogenesis of B16F10 cells

    Karina B. Oliveira / Érika Palú / Almeriane M. Weffort-Santos / Brás H. Oliveira

    Revista Brasileira de Farmacognosia, Vol 23, Iss 2, Pp 249-

    2013  Volume 258

    Abstract: Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been ...

    Abstract Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been described. Salvia officinalis L., Lamiaceae, is a widely used food spice that contains high amounts of phenol derivates, including rosmarinic acid. The aim of this work was to evaluate the contribution of rosmarinic acid in the melanogenic activity of sage extracts. Fluid and aqueous extracts of sage and purified rosmarinic acid were assayed for B16F10 cytotoxicity and, then, evaluated on melanin production and tyrosinase activity. While sage extracts showed a concentration-dependent ability to significantly increase melanin production without necessarily changing the enzymatic activity, rosmarinic acid showed a dual behavior on melanogenesis, increasing melanin biosynthesis and tyrosinase activity at low concentrations and decreasing it at higher levels. Rosmarinic acid may collaborate with sage extracts activity on melanogenesis, although other compounds may be involved. This is the first time that a dual action of rosmarinic acid on melanogenesis is reported, which may be useful in further studies for therapeutic formulations to treat skin pigmentation disorders.
    Keywords melanin ; melanogenesis ; rosmarinic acid ; Salvia officinalis ; tyrosinase ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 571 ; 500
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Sociedade Brasileira de Farmacognosia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Influence of rosmarinic acid and Salvia officinalis extracts on melanogenesis of B16F10 cells

    Oliveira, Karina B / Almeriane M. Weffort-Santos / Brás H. Oliveira / Érika Palú

    Sociedade Brasileira de Farmacognosia Revista Brasileira de Farmacognosia. 2013 Mar., Apr., v. 23, no. 2

    2013  

    Abstract: Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been ...

    Abstract Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been described. Salvia officinalis L., Lamiaceae, is a widely used food spice that contains high amounts of phenol derivates, including rosmarinic acid. The aim of this work was to evaluate the contribution of rosmarinic acid in the melanogenic activity of sage extracts. Fluid and aqueous extracts of sage and purified rosmarinic acid were assayed for B16F10 cytotoxicity and, then, evaluated on melanin production and tyrosinase activity. While sage extracts showed a concentration-dependent ability to significantly increase melanin production without necessarily changing the enzymatic activity, rosmarinic acid showed a dual behavior on melanogenesis, increasing melanin biosynthesis and tyrosinase activity at low concentrations and decreasing it at higher levels. Rosmarinic acid may collaborate with sage extracts activity on melanogenesis, although other compounds may be involved. This is the first time that a dual action of rosmarinic acid on melanogenesis is reported, which may be useful in further studies for therapeutic formulations to treat skin pigmentation disorders.
    Keywords cytotoxicity ; enzyme activity ; melanin ; melanogenesis ; pigmentation ; polyphenols ; rosmarinic acid ; sage ; Salvia officinalis ; spices
    Language English
    Dates of publication 2013-03
    Size p. 249-258.
    Publishing place Elsevier Editora Ltda.
    Document type Article
    ISSN 0102-695X
    DOI 10.1590/S0102-695X2012005000135
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Influence of rosmarinic acid and Salvia officinalis extracts on melanogenesis of B16F10 cells

    Karina B. Oliveira / Érika Palú / Almeriane M. Weffort-Santos / Brás H. Oliveira

    Revista Brasileira de Farmacognosia, Iss ahead, p

    2012  

    Abstract: Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been ...

    Abstract Melanin is a photoprotective skin pigment, and pathologies characterized by hypo or hyperpigmentation are common. New compounds that regulate melanogenesis are, therefore, opportune, and many natural products with this property, as polyphenols, have been described. Salvia officinalis L., Lamiaceae, is a widely used food spice that contains high amounts of phenol derivates, including rosmarinic acid. The aim of this work was to evaluate the contribution of rosmarinic acid in the melanogenic activity of sage extracts. Fluid and aqueous extracts of sage and purified rosmarinic acid were assayed for B16F10 cytotoxicity and, then, evaluated on melanin production and tyrosinase activity. While sage extracts showed a concentration-dependent ability to significantly increase melanin production without necessarily changing the enzymatic activity, rosmarinic acid showed a dual behavior on melanogenesis, increasing melanin biosynthesis and tyrosinase activity at low concentrations and decreasing it at higher levels. Rosmarinic acid may collaborate with sage extracts activity on melanogenesis, although other compounds may be involved. This is the first time that a dual action of rosmarinic acid on melanogenesis is reported, which may be useful in further studies for therapeutic formulations to treat skin pigmentation disorders.
    Keywords melanin ; melanogenesis ; rosmarinic acid ; Salvia officinalis ; tyrosinase ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 571 ; 500
    Language Portuguese
    Publishing date 2012-01-01T00:00:00Z
    Publisher Sociedade Brasileira de Farmacognosia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Leishmanicidal, antibacterial, and antioxidant activities of Caryocar brasiliense Cambess leaves hydroethanolic extract Atividades leishmanicida, bactericida e antioxidante do extrato hidroetanólico das folhas de Caryocar brasiliense Cambess

    Waldemar de Paula-Ju / Fabiana H. Rocha / Lucélia Donatti / Cyntia M.T. Fadel-Picheth / Almeriane M. Weffort-Santos

    Revista Brasileira de Farmacognosia, Vol 16, Pp 625-

    2006  Volume 630

    Abstract: The antimicrobial and antioxidant activities of the hydroethanolic extract from Caryocar brasiliense leaves were evaluated. The extract showed leishmanicidal effect against Leishmania amazonensis promastigote forms and bactericidal activity against some ... ...

    Abstract The antimicrobial and antioxidant activities of the hydroethanolic extract from Caryocar brasiliense leaves were evaluated. The extract showed leishmanicidal effect against Leishmania amazonensis promastigote forms and bactericidal activity against some pathogenic bacteria. The extract also showed relevant antioxidant activity, similar to that of vitamin C and rutin. As atividades antimicrobiana e antioxidante do extrato hidroetanólico das folhas de Caryocar brasiliense foram estudadas. O extrato demonstrou efeito leishmanicida sobre formas promastigotas de Leishmania amazonensis e atividade bactericida sobre estirpes de bactérias patogênicas para o homem. Além disso, o extrato demonstrou relevante capacidade antioxidante, similar às atividades da vitamina C e da rutina.
    Keywords Caryocar brasiliense ; Caryocaraceae ; piqui ; atividade leishmanicida ; atividade antioxidante ; DPPH ; leishmaniose ; leishmanicidal activity ; antioxidant activity ; leishmaniasis ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2006-12-01T00:00:00Z
    Publisher Sociedade Brasileira de Farmacognosia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Potencial antiinflamatório de Annona glabra, Annonaceae Anti-inflammatory potential of Annona glabra, Annonaceae

    Christian A. Siebra / Jeanine M. Nardin / Angela Florão / Fabiana H. Rocha / Denise Z. Bastos / Brás H. Oliveira / Almeriane M. Weffort-Santos

    Revista Brasileira de Farmacognosia, Vol 19, Iss 1a, Pp 82-

    2009  Volume 88

    Abstract: Annona glabra Linneau, Annonaceae, é uma árvore de pequeno porte encontrada em todo território brasileiro, principalmente nas áreas costeiras e conhecida popularmente como araticum-do-brejo e araticum-bravo. Este trabalho teve como objetivos investigar ... ...

    Abstract Annona glabra Linneau, Annonaceae, é uma árvore de pequeno porte encontrada em todo território brasileiro, principalmente nas áreas costeiras e conhecida popularmente como araticum-do-brejo e araticum-bravo. Este trabalho teve como objetivos investigar os efeitos do extrato de A. glabra e do ácido caurenóico dele purificado sobre a migração de granulócitos humanos e seu potencial imunomodulatório. Os resultados demonstraram que o extrato de A. glabra inibe a migração natural de granulócitos, de acordo com a dose, sugerindo potencial antiinflamatório, enquanto o ácido caurenóico demonstrou estimulá-la de forma significativa. Em contraste, nenhum efeito foi observado com relação a imunomodulação. Os efeitos apresentados ainda não foram descritos e, dessa forma, contribuem para ampliar a lista de atividades biológicas descritas não só do extrato de A. glabra, como também para o ácido caurenóico. Annona glabra Linneau, Annonaceae, is a small tree that grows over the Brazilian territory particularly in its coast, and is known as "araticum-do-brejo" and "araticum-bravo". The aim of this study was to evaluate the effects of the extract of A. glabra and its purified kaurenoic acid on the locomotion of human granulocytes and their immunomodulatory potential. The results herein presented showed a dose-dependent inhibition of the granulocyte migration for the extract, suggesting an anti-inflammatory activity, in contrast with a striking stimulation observed for the kaurenoic acid. When focusing immunomodulation properties, no activity could be drawn. The effects presented in this work are reported for the first time and extend the list of biological activities already described for the A. glabra extract as well as for the kaurenoic acid.
    Keywords Annona glabra ; Annonaceae ; ácido caurenóico ; leucócitos humanos ; quimiotaxia ; imunomodulação ; kaurenoic acid ; human leukocytes ; chemotaxis ; immunomodulation ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2009-03-01T00:00:00Z
    Publisher Sociedade Brasileira de Farmacognosia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A citometria de fluxo como instrumento de avaliação da atividade imunomodulatória de extratos e substâncias isoladas de plantas medicinais Flow cytometry as instrument for evaluating the immunopotential of medicinal plant extracts and their isolated compounds

    Julio C. Machado Junior / Angela Florão / Fernanda V.R. Mattana / Fabiana H. Rocha / Cid A.M. Santos / Almeriane M. Weffort-Santos

    Revista Brasileira de Farmacognosia, Vol 16, Pp 645-

    2006  Volume 655

    Abstract: A citometria de fluxo vem se consolidando como metodologia para vários estudos de atividade celular e, nesse trabalho, ela foi empregada para avaliar as ações da fitohemaglutinina, dos alcalóides vimblastina e vindolina e dos extratos de Chamomilla ... ...

    Abstract A citometria de fluxo vem se consolidando como metodologia para vários estudos de atividade celular e, nesse trabalho, ela foi empregada para avaliar as ações da fitohemaglutinina, dos alcalóides vimblastina e vindolina e dos extratos de Chamomilla recutita (L.) Rauschert, Bauhinia microstachya (Raddi) Machr. e Himatanthus lancifolius (Muell. Arg.) Woodson, conhecidos popularmente no Brasil como camomila, escada-de-macaco e agoniada, respectivamente, sobre a imunomodulação de células mononucleares humanas, comparando-se o desempenho obtido com as alterações morfológicas relacionadas à ativação e proliferação dessas células in vitro. Os resultados demonstram que foi possível identificar, pela metodologia proposta, os efeitos proliferativos estimulantes já descritos para a fitohemaglutinina e para o extrato de C. recutita, assim como para o extrato de B. microstachya, observado pela primeira vez nesse trabalho. A conhecida atividade inibitória da vimblastina sobre a proliferação de linfócitos induzida por fitohemaglutinina, em contraste como a ausência de efeitos da vindolina, também puderam ser evidenciadas. Efeito inibitório foi observado para o extrato de H. lancifolius devido à sua ação tóxica sobre o sistema. Os resultados apresentados sugerem que a citometria de fluxo pode ser usada como uma alternativa metodológica quando se deseja investigar a ação de substâncias puras ou de extratos de plantas sobre a imunomodulação de células mononucleares humanas. Flow cytometry has been widely applied for studying several cellular activities. In this work it has been used to evaluate the effects of phytohemagglutinin, vinblastine, and vindoline upon human mononuclear cells immunomodulation. The same protocol was used to investigate the effects of extracts prepared from Chamomilla recutita (L.) Rauschert, Bauhinia microstachya (Raddi) Machr., and Himatanthus lancifolius (Muell. Arg.) Woodson, plants popularly known in Brazil as camomila, escada-de-macaco, and agoniada, respectively. The activity was then compared with the in vitro cellular morphological changes. By the results herein presented, the proposed method allowed the identification of the already known phytohemagglutinin and C. recutita extract proliferative effects, as well as for the B. microstachya extract, reported for the first time. The inhibition of vinblastine upon the proliferation of phytohemagglutin-stimulated cells and the lack of effects of vindoline were also evident. Exposition to H. lancifolius extract has led to inhibition of lymphocyte proliferation as a result of the high toxicity of the extract upon the system. Results presented strongly suggest flow cytometry as a useful instrument to evaluatethe immunomodulation effects of pure compounds or complex mixtures such as plant extracts upon human mononuclear cells.
    Keywords Citometria de fluxo ; imunomodulação ; plantas medicinais ; alcalóides indólicos ; Chamomilla recutita ; Bauhinia microstachya ; Himatanthus lancifolius ; Flow cytometry ; immunomodulation ; medicinal plants ; indol alkaloids ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2006-12-01T00:00:00Z
    Publisher Sociedade Brasileira de Farmacognosia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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