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  1. Article ; Online: Knowledge and use of the International Classification of Functioning, disability and health (ICF) and ICF Core Sets for musculoskeletal conditions among saudi physical therapists.

    Almutairi, Norah A / Almarwani, Maha M

    Musculoskeletal science & practice

    2022  Volume 60, Page(s) 102573

    Abstract: Background: The International Classification of Functioning, Disability, and Health (ICF) provides a coherent biopsychosocial view of health states. The ICF Core Sets were developed to facilitate and encourage the use of the ICF in clinical practice and ...

    Abstract Background: The International Classification of Functioning, Disability, and Health (ICF) provides a coherent biopsychosocial view of health states. The ICF Core Sets were developed to facilitate and encourage the use of the ICF in clinical practice and research.
    Objective: To examine the level of knowledge and use of the ICF and ICF Core Sets for musculoskeletal conditions among Saudi physical therapists.
    Design: Cross-sectional study.
    Method: We approached Saudi physical therapists (PTs) involved in managing patients with musculoskeletal conditions. Data were collected through an electronic survey consisting of multiple-choice questions related to the knowledge of the ICF, general ICF Core Sets and ICF Core Sets for musculoskeletal conditions.
    Results: A total of 203 PTs participated in this study. Seventy percent of PTs knew about the meaning of ICF, but only 33% recognized aspects of the ICF. For the osteoarthritis (OA) ICF Core Set, 71.9% had poor knowledge, and for the low back pain (LBP) ICF Core Set, 61.8% had poor knowledge.
    Conclusions: The Saudi PTs surveyed in this study had a good level of knowledge about the meaning of the ICF; however, this knowledge appeared to be limited when they were asked about aspects of the ICF. They had poor knowledge of musculoskeletal ICF Core Sets but seemed to be more familiar with the LBP ICF Core Set compared to the OA ICF Core Set.
    MeSH term(s) Cross-Sectional Studies ; Disability Evaluation ; Humans ; International Classification of Functioning, Disability and Health ; Low Back Pain/diagnosis ; Musculoskeletal Diseases ; Osteoarthritis ; Physical Therapists ; Saudi Arabia
    Language English
    Publishing date 2022-05-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2888772-4
    ISSN 2468-7812
    ISSN (online) 2468-7812
    DOI 10.1016/j.msksp.2022.102573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5783: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Stage-specific exposure of Caenorhabditis elegans to cadmium identifies unique transcriptomic response cascades and an uncharacterized cadmium responsive transcript.

    Almutairi, Norah / Khan, Naema / Harrison-Smith, Alexandra / Arlt, Volker M / Stürzenbaum, Stephen R

    Metallomics : integrated biometal science

    2024  Volume 16, Issue 5

    Abstract: Age/stage sensitivity is considered a significant factor in toxicity assessments. Previous studies investigated cadmium (Cd) toxicosis in Caenorhabditis elegans, and a plethora of metal-responsive genes/proteins have been identified and characterized in ... ...

    Abstract Age/stage sensitivity is considered a significant factor in toxicity assessments. Previous studies investigated cadmium (Cd) toxicosis in Caenorhabditis elegans, and a plethora of metal-responsive genes/proteins have been identified and characterized in fine detail; however, most of these studies neglected age sensitivity and stage-specific response to toxicants at the molecular level. This present study compared the transcriptome response between C. elegans L3 vs L4 larvae exposed to 20 µM Cd to explore the transcriptional hallmarks of stage sensitivity. The results showed that the transcriptome of the L3 stage, despite being exposed to Cd for a shorter period, was more affected than the L4 stage, as demonstrated by differences in transcriptional changes and magnitude of induction. Additionally, T08G5.1, a hitherto uncharacterized gene located upstream of metallothionein (mtl-2), was transcriptionally hyperresponsive to Cd exposure. Deletion of one or both metallothioneins (mtl-1 and/or mtl-2) increased T08G5.1 expression, suggesting that its expression is linked to the loss of metallothionein. The generation of an extrachromosomal transgene (PT08G5.1:: GFP) revealed that T08G5.1 is constitutively expressed in the head neurons and induced in gut cells upon Cd exposure, not unlike mtl-1 and mtl-2. The low abundance of cysteine residues in T08G5.1 suggests, however, that it may not be involved directly in Cd sequestration to limit its toxicity like metallothionein, but might be associated with a parallel pathway, possibly an oxidative stress response.
    MeSH term(s) Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Cadmium/toxicity ; Cadmium/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Caenorhabditis elegans Proteins/genetics ; Transcriptome/drug effects ; Metallothionein/genetics ; Metallothionein/metabolism ; Larva/drug effects ; Larva/genetics ; Larva/metabolism
    Chemical Substances Cadmium (00BH33GNGH) ; Caenorhabditis elegans Proteins ; Metallothionein (9038-94-2)
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1093/mtomcs/mfae016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence, Microbiological Profile, and Risk Factors of Surgical Site Infections in Saudi Patients with Colorectal Cancer.

    Aldriwesh, Marwh Gassim / Alnodley, Abrar / Almutairi, Norah / Algarni, Mohammed / Alqarni, Ayyob / Albdah, Bayan / Mashraqi, Mutaib

    Saudi journal of medicine & medical sciences

    2023  Volume 11, Issue 3, Page(s) 208–218

    Abstract: Background: Resection surgery in patients with colorectal cancer (CRC) patients is associated with potential complications, including surgical site infection (SSI).: Objectives: To estimate the prevalence rate of SSI, identify the common pathogens ... ...

    Abstract Background: Resection surgery in patients with colorectal cancer (CRC) patients is associated with potential complications, including surgical site infection (SSI).
    Objectives: To estimate the prevalence rate of SSI, identify the common pathogens responsible for SSI, and determine potential risk factors for SSI development in a cohort from Saudi Arabia.
    Materials and methods: Patients with CRC who underwent bowel resection surgery at King Abdulaziz Medical City, Riyadh, between January 01, 2016, and December 31, 2019, were retrospectively included. Demographics, comorbidities, surgical procedure data, and the results of preoperative laboratory tests were retrospectively collected from medical records through the health information system. The study population was divided into two groups: those who developed SSI and those who did not.
    Results: A total of 92 patients with CRC who underwent resection surgery were included, of which 54 (58.7%) were males. The median age was 65 (IQR 55.5-75.0) years. SSI was observed in 25 (27.2%) patients. The most frequently isolated organisms were
    Conclusion: The study found a notable prevalence of SSI among the included patients. Gram-negative bacteria were more involved in SSI events and were also associated with drug-resistance patterns. Gut microbiota bacteria were most commonly involved in SSIs. Low preoperative serum albumin levels predicted the development of postoperative SSI, and thus its close monitoring and management before surgery could reduce the SSIs.
    Language English
    Publishing date 2023-07-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2734896-9
    ISSN 2321-4856 ; 2321-4856
    ISSN (online) 2321-4856
    ISSN 2321-4856
    DOI 10.4103/sjmms.sjmms_3_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Juggling cadmium detoxification and zinc homeostasis: A division of labour between the two C. elegans metallothioneins.

    Essig, Yona J / Leszczyszyn, Oksana I / Almutairi, Norah / Harrison-Smith, Alexandra / Blease, Alix / Zeitoun-Ghandour, Sukaina / Webb, Sam M / Blindauer, Claudia A / Stürzenbaum, Stephen R

    Chemosphere

    2023  Volume 350, Page(s) 141021

    Abstract: The chemical properties of toxic cadmium and essential zinc are very similar, and organisms require intricate mechanisms that drive selective handling of metals. Previously regarded as unspecific "metal sponges", metallothioneins (MTLs) are emerging as ... ...

    Abstract The chemical properties of toxic cadmium and essential zinc are very similar, and organisms require intricate mechanisms that drive selective handling of metals. Previously regarded as unspecific "metal sponges", metallothioneins (MTLs) are emerging as metal selectivity filters. By utilizing C. elegans mtl-1 and mtl-2 knockout strains, metal accumulation in single worms, single copy fluorescent-tagged transgenes, isoform specific qPCR and lifespan studies it was possible to demonstrate that the handling of cadmium and zinc by the two C. elegans metallothioneins differs fundamentally: the MTL-2 protein can handle both zinc and cadmium, but when it becomes unavailable, either via a knockout or by elevated cadmium exposure, MTL-1 takes over zinc handling, leaving MTL-2 to sequester cadmium. This division of labour is reflected in the folding behaviour of the proteins: MTL-1 folded well in presence of zinc but not cadmium, the reverse was the case for MTL-2. These differences are in part mediated by a zinc-specific mononuclear His
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Cadmium/toxicity ; Metallothionein/metabolism ; Zinc/metabolism ; Metals/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
    Chemical Substances Cadmium (00BH33GNGH) ; Metallothionein (9038-94-2) ; Zinc (J41CSQ7QDS) ; Metals ; Protein Isoforms
    Language English
    Publishing date 2023-12-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.141021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A Comprehensive Review on Monkeypox Viral Disease with Potential Diagnostics and Therapeutic Options.

    Rabaan, Ali A / Al-Shwaikh, Seham A / Alfouzan, Wadha A / Al-Bahar, Ali M / Garout, Mohammed / Halwani, Muhammad A / Albayat, Hawra / Almutairi, Norah B / Alsaeed, Mohammed / Alestad, Jeehan H / Al-Mozaini, Maha A / Ashgar, Tala M Al / Alotaibi, Sultan / Abuzaid, Abdulmonem A / Aldawood, Yahya / Alsaleh, Abdulmonem A / Al-Afghani, Hani M / Altowaileb, Jaffar A / Alshukairi, Abeer N /
    Arteaga-Livias, Kovy / Singh, Kirnpal Kaur Banga / Imran, Mohd

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (Mpox), a severe infectious viral disease. Furthermore, this review provides an up-to-date treatment option for Mpox. The monkeypox virus (MPXV) has remained ... ...

    Abstract The purpose of this review is to give an up-to-date, thorough, and timely overview of monkeypox (Mpox), a severe infectious viral disease. Furthermore, this review provides an up-to-date treatment option for Mpox. The monkeypox virus (MPXV) has remained the most virulent poxvirus for humans since the elimination of smallpox approximately 41 years ago, with distribution mainly in central and west Africa. Mpox in humans is a zoonotically transferred disease that results in symptoms like those of smallpox. It had spread throughout west and central Africa when it was first diagnosed in the Republic of Congo in 1970. Mpox has become a major threat to global health security, necessitating a quick response by virologists, veterinarians, public health professionals, doctors, and researchers to create high-efficiency diagnostic tests, vaccinations, antivirals, and other infection control techniques. The emergence of epidemics outside of Africa emphasizes the disease's global significance. A better understanding of Mpox's dynamic epidemiology may be attained by increased surveillance and identification of cases.
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lightsheet fluorescence lifetime imaging microscopy with wide-field time-correlated single photon counting.

    Hirvonen, Liisa M / Nedbal, Jakub / Almutairi, Norah / Phillips, Thomas A / Becker, Wolfgang / Conneely, Thomas / Milnes, James / Cox, Susan / Stürzenbaum, Stephen / Suhling, Klaus

    Journal of biophotonics

    2019  Volume 13, Issue 2, Page(s) e201960099

    Abstract: We report on wide-field time-correlated single photon counting (TCSPC)-based fluorescence lifetime imaging microscopy (FLIM) with lightsheet illumination. A pulsed diode laser is used for excitation, and a crossed delay line anode image intensifier, ... ...

    Abstract We report on wide-field time-correlated single photon counting (TCSPC)-based fluorescence lifetime imaging microscopy (FLIM) with lightsheet illumination. A pulsed diode laser is used for excitation, and a crossed delay line anode image intensifier, effectively a single-photon sensitive camera, is used to record the position and arrival time of the photons with picosecond time resolution, combining low illumination intensity of microwatts with wide-field data collection. We pair this detector with the lightsheet illumination technique, and apply it to 3D FLIM imaging of dye gradients in human cancer cell spheroids, and C. elegans.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Humans ; Lasers ; Microscopy, Fluorescence ; Photons
    Language English
    Publishing date 2019-11-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201960099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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