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  1. Article: Tube Dependence

    Dunitz-Scheer, Marguerite / Sabine Marinschek / Hannes Beckenbach / Elisabeth Kratky / Almuthe Hauer / Peter Scheer

    Infant, child & adolescent nutrition. , v. 3, no. 4

    A Reactive Eating Behavior Disorder

    2011  

    Abstract: This article focuses on the issue of tube dependence (TD) in infancy and early childhood. The condition occurs in patients after temporary tube feeding and must be considered as an unintended side effect of modern treatment practices affecting young ... ...

    Abstract This article focuses on the issue of tube dependence (TD) in infancy and early childhood. The condition occurs in patients after temporary tube feeding and must be considered as an unintended side effect of modern treatment practices affecting young patients reactively. Whereas some recent literature has described small samples of enterally fed children being exposed to certain weaning programs, the particular phenomenon of unintentional dependence has not been discussed. A tube-dependent child remains tube fed although his/her medical condition and developmental potential would allow the transition to oral nutrition. Children with TD show characteristic symptoms such as food refusal and opposition to any oral feeding attempts. They often suffer from additional episodes of vomiting, nausea, gagging, and retching and in some cases develop severe failure to thrive. Parents of affected children get involved as codependents engaged in constant preparations of the next tube feeds. In this situation, families can become obsessed about wanting their child to learn to eat by himself/herself, ending up in intrusive feeding patterns. Professionals tend to make parents responsible for the behavioral aspects of the condition, but the diagnostic shift of TD into a behavioral category will not help solve the problem. The development of TD can be prevented if typical symptoms are recognized early and effective tube weaning is implemented. Because therapeutic programs exist, the fate of remaining tube dependence should be prevented. This article presents a first overview of a large sample of tube-dependent infants who had been referred specifically for the exclusive sake of tube weaning.
    Keywords adverse effects ; childhood ; children ; failure to thrive ; infancy ; infants ; nausea ; parents ; patients ; professionals ; tube feeding ; vomiting ; weaning
    Language English
    Dates of publication 2011-08
    Size p. 209-215.
    Publishing place SAGE Publications
    Document type Article
    ISSN 1941-4072
    DOI 10.1177/1941406411416359
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Antibodies in the diagnosis of coeliac disease

    Johannes Wolf / Dirk Hasenclever / David Petroff / Thomas Richter / Holm H Uhlig / Martin W Laaß / Almuthe Hauer / Martin Stern / Xavier Bossuyt / Jan de Laffolie / Gunter Flemming / Danilo Villalta / Wolfgang Schlumberger / Thomas Mothes

    PLoS ONE, Vol 9, Iss 5, p e

    a biopsy-controlled, international, multicentre study of 376 children with coeliac disease and 695 controls.

    2014  Volume 97853

    Abstract: Diagnosis of coeliac disease (CD) relies on a combination of clinical, genetic, serological and duodenal morphological findings. The ESPGHAN suggested that biopsy may not be necessary in all cases. New guidelines include omission of biopsy if the ... ...

    Abstract Diagnosis of coeliac disease (CD) relies on a combination of clinical, genetic, serological and duodenal morphological findings. The ESPGHAN suggested that biopsy may not be necessary in all cases. New guidelines include omission of biopsy if the concentration of CD-specific antibodies exceeds 10 times the upper limit of normal (10 ULN) and other criteria are met. We analysed the 10 ULN criterion and investigated multiple antibody-assays. Serum was collected from 1071 children with duodenal biopsy (376 CD patients, 695 disease-controls). IgA-antibodies to tissue transglutaminase (IgA-aTTG), IgG-antibodies to deamidated gliadin peptides (IgG-aDGL) and IgA-endomysium antibodies (IgA-EMA) were measured centrally. We considered 3 outcomes for antibody test procedures utilizing IgA-aTTG and/or IgG-aDGL: positive (≥10 ULN, recommend gluten-free diet), negative (<1 ULN, no gluten-free diet) or unclear (perform biopsy). Positive (PPV) and negative (NPV) predictive values were based on clear test results. We required that they and their lower confidence bounds (LCB) be simultaneously very high (LCB >90% and PPV/NPV >95%). These stringent conditions were met for appropriate antibody-procedures over a prevalence range of 9-57%. By combining IgG-aDGL with IgA-aTTG, one could do without assaying total IgA. The PPV of IgG-aDGL was estimated to be extremely high, although more studies are necessary to narrow down the LCB. The proportion of patients requiring a biopsy was <11%. The procedures were either equivalent or even better in children <2 years compared to older children. All 310 of the IgA-aTTG positive children were also IgA-EMA positive. Antibody-assays could render biopsies unnecessary in most children, if experienced paediatric gastroenterologists evaluate the case. This suggestion only applies to the kits used here and should be verified for other available assays. Confirming IgA-aTTG positivity (≥10 ULN) by EMA-testing is unnecessary if performed on the same blood sample. Prospective studies are needed.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Prevention and Treatment of Tube Dependency in Infancy and Early Childhood

    Dunitz-Scheer, Marguerite / Arie Levine / Yehuda Roth / Elisabeth Kratky / Hannes Beckenbach / Christian Braegger / Almuthe Hauer / Markus Wilken / Jean Wittenberg / Thomas Trabi / Peter Jaron Scheer

    Infant, child & adolescent nutrition. 2009 Apr., v. 1, no. 2

    2009  

    Abstract: Tube dependency is recognized as an unintended result of long-term tube feeding in infants and young children. The condition involves disturbing side effects such as vomiting, gagging, and active food refusal. It prevents infants from making the ... ...

    Abstract Tube dependency is recognized as an unintended result of long-term tube feeding in infants and young children. The condition involves disturbing side effects such as vomiting, gagging, and active food refusal. It prevents infants from making the transition from tube to oral feeding and from starting to learn to eat in the absence of any medical indication for continuation of enteral feeding. Tube dependency can have a destructive impact on the child's development, even in cases when the nutritional influence might be beneficial. The authors set up recommendations for the prevention of tube dependency and suggest guidelines for weaning tube-dependent children based on the results of the Graz program and satellite programs using a similar model. A sample of 221 tube-dependent patients aged 4 months to 15 years of age provided the clinical study group on which this article is based. Begun in 1987, a comprehensive tube-weaning program was developed on the basis of clinical experience and encounters with more than 430 tube-dependent children in 20 years, resulting in a success rate of 78/81 (96% for 2007) and 79/84 (94% for 2008). Placement must be preceded by clear criteria and a decision as to the indicated nutritional goal and time of use. The placement of a temporary tube must generate a plan covering maintenance issues, including time, method, and team for weaning. Aspects of tube feeding that go beyond purely medical and nutritional issues need to be considered to minimize the frequency and severity of unintended tube dependency in early childhood.
    Keywords adverse effects ; childhood ; children ; guidelines ; infancy ; infants ; models ; patients ; tube feeding ; vomiting ; weaning
    Language English
    Dates of publication 2009-04
    Size p. 73-82.
    Publishing place SAGE Publications
    Document type Article
    ISSN 1941-4072
    DOI 10.1177/1941406409333988
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

    Esther Willems / Jolein Gloerich / Anouk Suppers / Michiel van der Flier / Lambert P. van den Heuvel / Nicole van de Kar / Ria H.L.A. Philipsen / Maurice van Dael / Myrsini Kaforou / Victoria J. Wright / Jethro A. Herberg / Federico Martinon Torres / Michael Levin / Ronald de Groot / Alain J. van Gool / Dirk J. Lefeber / Hans J.C.T. Wessels / Marien I. de Jonge / Amina Abdulla /
    Christoph Aebi / Koen van Aerde / Rachel Agbeko / Philipp Agyeman / Umberto D’alessandro / Ladan Ali / Wynand Alkema / Karen Allen / Fernando Álvez González / Suzanne Anderson / Imran Ansari / Tasnim Araf / Tanja Avramoska / Bryan Baas / Natalija Bahovec / Cristina Balo Farto / Anda Balode / A.M. Barendregt / Ruth Barral-Arca / María Barreiro Castro / Arta Bārzdiņa / David Bath / Sebastian Bauchinger / Lucas Baumard / Hinrich Baumgart / Frances Baxter / Ashley Bell / Kathryn Bell / Xabier Bello / Evangelos Bellos / Martin Benesch / Mirian Ben García / Joshua Bennet / Christoph Berger / J.M. van den Berg / Sara Bernhard-Stirnemann / Sagida Bibi / Christoph Bidlingmaier / Alexander Binder / Vera Binder / Kalifa Bojang / Dorine M. Borensztajn / Ulrich von Both / Karen Brengel-Pesce / Bryan van den Broek / Judith Buschbeck / Leo Calvo-Bado / Sandra Carnota / Enitan D. Carrol / Michael J. Carter / Miriam Cebey-López / Samba Ceesay / Astrid Ceolotto / Adora Chan / Elizabeth Cocklin / Kalvin Collings / Stephen Crulley / Aubrey Cunnington / María José Curras-Tuala / Katharina Danhauser / Saffiatou Darboe / Sarah Darnell / Tisham De / Dārta Deksne / Kirsty Devine / Juan Emmanuel Dewez / Julia Dudley / Carlos Durán Suárez / Ernst Eber / Irini Eleftheriou / Marieke Emonts / Daniel Fabian / Tobias Feuchtinger / Katy Fidler / Colin Fink / A.M. van Furth / Rachel Galassini / Siegfried Gallistl / Luisa García Vicente / Dace Gardovska / J. Geissler / G.P.J.M. Gerrits / Eric Giannoni / Ilona van der Giessen / Alberto Gómez-Carballa / Jose Gómez Rial / Gunther Gores / Dagne Grāvele / Matthias Griese / Ilze Grope / Meeru Gurung / L. de Haan / Nikolaus Haas / Dominic Habgood-Coote / Nienke N. Hagedoorn / Harald Haidl / Shea Hamilton / Almuthe Hauer / J. Heidema / Ulrich Heininger / Stefanie Henriet / Jethro Herberg / Clive Hoggart / Susanne Hösele / Sara Hourmat / Christa Hude / Martijn Huijnen / Heather Jackson / Rebecca Jennings / Joanne Johnston / Ilse Jongerius / Rikke Jorgensen / Christian Kahlert / Rama Kandasamy / Matthias Kappler / Julia Keil / Markus Keldorfer / Dominic F. Kell / Eunjung Kim / Sharon King / Lieke Kloosterhuis / Daniela S. Kohlfürst / Benno Kohlmaier / Laura Kolberg / Mojca Kolnik / Larissa Krenn / Taco Kuijpers / M. van der Kuip / Pilar Leboráns Iglesias / Simon Leigh / Manuel Leitner / M. van Leur / Emma Lim / Naomi Lin / Ching-Chuan Liu / Sabine Löffler / Eberhard Lurz / Ian Maconochie / Christine Mackerness / François Mallet / Federico Martinón-Torres / Antonis Marmarinos / Alex Martin / Mike Martin / José María Martinón Sánchez / Nazareth Martinón-Torres / Paul McAlinden / Anne McDonnell / Sam McDonald / C.J. Miedema / Anija Meiere / Stephanie Menikou / G. van Mierlo / Alec Miners / Ravi Mistry / Henriëtte A. Moll / Marine Mommert / Belén Mosquera Pérez / David R. Murdoch / Sobia Mustafa / Giancarlo Natalucci / C. Neeleman / Karen Newall / Samuel Nichols / Tobias Niedrist / Anita Niederer-Loher / Ruud Nijman / Ieva Nokalna / Urzula Nora Urbāne / Gudrun Nordberg / C.C. Obihara / Daniel O'Connor / Wilma Oosthoek / Veronika Osterman / Alexandre Pachot / D. Pajkrt / Jacobo Pardo-Seco / Stéphane Paulus / Jana Pavāre / Ivonne Pena Paz / Salina Persand / Andreas Pfleger / Klaus Pfurtscheller / Ria Philipsen / Ailsa Pickering / Benjamin Pierce / Heidemarie Pilch / Lidia Piñeiro Rodríguez / Sara Pischedda / Tina Plankar Srovin / Marko Pokorn / Andrew J. Pollard / Lena Pölz / Klara M. Posfay-Barbe / Petra Prunk / Zanda Pučuka / Glorija Rajic / Aqeela Rashid / Lorenzo Redondo-Collazo / Christa Relly / Irene Rivero Calle / Sara Rey Vázquez / Mathew Rhodes / Vivien Richmond / Thomas Riedel / Anna RocaIsatou Sarr / Siegfried Rödl / Carmen Rodríguez-Tenreiro / Sam Romaine / Emily Rowlands / Miguel Sadiki Ora / Manfred G. Sagmeister / Momodou Saidykhan / Antonio Salas / Luregn J. Schlapbach / D. Schonenberg / Fatou Secka / Katrīna Selecka / Sonia Serén Fernández / Cristina Serén Trasorras / Priyen Shah / Ching-Fen Shen / Shrijana Shrestha / Aleksandra Sidorova / Andrea Skrabl-Baumgartner / Giselle D’Souza / Matthias Sperl / Evelien Sprenkeler / Nina A. Schweintzger / Laura Stampfer / Molly Stevens / Martin Stocker / Volker Strenger / Dace Svile / Kelly Syggelou / Maria Tambouratzi / Chantal Tan / Emma Tavliavini / Evelyn Thomson / Stephen Thorson / Holger Till / G.A. Tramper-Stranders / Andreas Trobisch / Maria Tsolia / Effua Usuf / Lucille Valentine / Clementien L. Vermont / Marisol Vilas Iglesias / Katarina Vincek / Marie Voice / Gabriella de Vries / Diane Wallia / Shih-Min Wang / Clare Wilson / Amanda Wood / Phil Woodsford / Victoria Wright / Marietta Xagorari / Shunmay Yeung / Joany Zachariasse / Dace Zavadska / Syed M.A. Zaman / Judith Zandstra / Werner Zenz / Christoph Zurl / Manuela Zwerenz

    iScience, Vol 26, Iss 8, Pp 107257- (2023)

    2023  

    Abstract: Summary: Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an ... ...

    Abstract Summary: Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection.
    Keywords Health sciences ; Glycobiology ; Immunology ; Glycomics ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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