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Article: Social Distress among Cancer Patients: Differential Effects of Risk Factors and Attenuating Role of Culturally Specific Social Support.

Da'ar, Omar B / Jradi, Hoda / Alkaiyat, Mohammad / Alolayan, Ashwaq / Jazieh, Abdul Rahman

2023 Volume 11, Issue 13

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11131876
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Article: Cardiac Morbidity and Mortality in Patients with Sarcoma: A Population-Based Study.

Alanazi, Rakan / Aljizeeri, Ahmed / Alsaileek, Ahmed / Alrashid, Azzam / Alolayan, Ashwaq / Alkaiyat, Mohammad / Alenazy, Basel / Shehata, Hussam / Alqahtani, Joud / Ardah, Husam / Alshammari, Kanan

Clinical Medicine Insights. Oncology

2024 Volume 18, Page(s) 11795549241237703

Abstract: Background: Soft tissue sarcoma (STS) is a rare malignancy that affects soft tissues. It encompasses various subtypes and requires different treatment strategies. Doxorubicin is a commonly used anthracycline in the management of localized and metastatic ...

Abstract	Background: Soft tissue sarcoma (STS) is a rare malignancy that affects soft tissues. It encompasses various subtypes and requires different treatment strategies. Doxorubicin is a commonly used anthracycline in the management of localized and metastatic STS. However, high doses of doxorubicin are associated with cardiotoxicity, which can significantly impact patients' long-term outcomes. This study aimed to evaluate doxorubicin's effect on cardiac function in patients with sarcoma and to correlate the frequency of cardiotoxicity with potential risk factors. Methods: A retrospective analysis was conducted on patients with sarcoma who were treated with doxorubicin between 2016 and 2022 at King Abdulaziz Medical City in Saudi Arabia. Patient demographic information, comorbidities, cardiac measurements, laboratory values, systemic therapy, and treatment outcomes were collected from electronic medical records. A statistical analysis was performed to assess the association between cardiotoxicity and various factors. Results: A total of 133 patients were included in the study, with a median age of 30 years. Cardiotoxicity was observed in 9% of the patients. Female patients had a significantly higher risk of developing cardiotoxicity. Patients with a higher Eastern Cooperative Oncology Group (ECOG) performance status and lower troponin I levels also had an increased risk of cardiotoxicity. However, there was no significant association between cardiotoxicity and the number of chemotherapy cycles, total cumulative dose of doxorubicin, or history of radiation. Furthermore, patients with cardiotoxicity had a higher risk of mortality. The overall survival of the patients was 18 months. Conclusion: Doxorubicin-associated cardiotoxicity is a concern for patients with sarcoma. Female patients and patients with a higher ECOG performance status are at an increased risk of developing cardiotoxicity. Careful monitoring and risk assessment are crucial for mitigating the adverse effects of doxorubicin treatment in patients with sarcoma. Future studies are warranted to validate these findings and explore preventive strategies for doxorubicin-induced cardiotoxicity in patients with sarcoma.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2577877-8
ISSN	1179-5549
ISSN	1179-5549
DOI	10.1177/11795549241237703
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Article ; Online: Developing, Implementing, and Validating a Social Toxicity Assessment Tool of Cancer.

Jazieh, Abdul-Rahman / Jradi, Hoda / Da'ar, Omar B / Alkaiyat, Mohammad / Zafar, Yousuf / Alolayan, Ashwaq

JCO global oncology

2021 Volume 7, Page(s) 1522–1528

Abstract: Purpose: The social impact of cancer on patients and their family is well known. Yet, unlike with physical and financial toxicities, no validated tools are available to measure this impact. This study aimed at developing, validating, and implementing a ... ...

Abstract	Purpose: The social impact of cancer on patients and their family is well known. Yet, unlike with physical and financial toxicities, no validated tools are available to measure this impact. This study aimed at developing, validating, and implementing a novel social toxicity assessment tool for patients with cancer diagnosis (STAT-C). Methods: Questions were generated through multiple steps including focus groups of patients, their families, and oncology care professionals. These steps along with relevant literature resulted in the development of an initial 20-item questionnaire. Content validity and relevance of the tool were assessed using Content Validity Index for individual items and Content Validity Index for the entire scale. Following expert examination, the constructed STAT-C tool consisted of 14 items grouped into three domains-social relations, social activities, and economic impact. Based on the total possible score for the survey in 150 patients for all the items, three levels of a socioeconomic toxicity were determined-severe social toxicity, mild social toxicity, and no social toxicity. Results: The 14 items were marked as relevant, and the Content Validity Index for individual items ranged between 0.80 and 1.00. An overall average Content Validity Index for the entire scale of 0.87 showed high content validity of the constructed tool. Exploratory factor analysis revealed retention of 13 items of the constructed STAT-C Tool, which loaded across three factors that mapped groupings into measures of Conclusion: Our study revealed that STAT-C is a valid, reliable tool, and well captures and measures unique and pertinent social toxicity constructs for Arabic-speaking patients. The tool should enable oncology professionals to deliver better patient-centered care as a component of a comprehensive approach.
MeSH term(s)	Factor Analysis, Statistical ; Humans ; Neoplasms/diagnosis ; Patient-Centered Care ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.21.00170
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Article: Antibiotic Exposure Concurrently with Anti-PD1 Blockade Therapy Reduces Overall Survival in Patients with Child-Pugh Class A Advanced Hepatocellular Carcinoma.

Alshammari, Kanan / Alotaibi, Faizah M / Alsugheir, Futoon / Aldawoud, Mohammad / Alolayan, Ashwaq / Algarni, Mohammed Ahmad / Sabatin, Fouad / Mohammad, Mohammad F / Alosaimi, Abdulaziz / Sanai, Faisal M / Odah, Hassan / Alshehri, Ahmed Saleh / Aldibasi, Omar S / Alrehaily, Samah / Al Saleh, Abdullah S

Cancers

2023 Volume 16, Issue 1

Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide with a poor prognosis. Treatment with immune checkpoint inhibitors (ICIs) has improved overall survival in patients with HCC. However, not all patients benefit from the ... ...

Abstract	Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide with a poor prognosis. Treatment with immune checkpoint inhibitors (ICIs) has improved overall survival in patients with HCC. However, not all patients benefit from the treatment. In this study, 59 patients with HCC were enrolled from two medical centers in Saudi Arabia, with 34% using antibiotics concurrently with their Nivolumab (anti-PD1 blockade). The impact of antibiotic use on the clinical outcomes of patients with HCC undergoing treatment with anti-PD1 blockade was examined. The patients' overall survival (OS) was 5 months (95% CI: 3.2, 6.7) compared to 10 months (95% CI: 0, 22.2) (
Language	English
Publishing date	2023-12-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16010133
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Article ; Online: Reducing Futile Acute Care Services for Terminally Ill Patients With Cancer: The Dignity Project.

Salama, Hind / Al Mutairi, Nashmia / Damlaj, Moussab / Alolayan, Ashwaq / Binahmed, Ahmed / Salama, Hagir / Tlayjeh, Haytham / Alhejazi, Ayman / Lawrence, Myer / Shehata, Hussam / Shami, Mona / Alkaiyat, Mohammad / Jazieh, Abdul Rahman

JCO oncology practice

2021 Volume 17, Issue 11, Page(s) e1794–e1802

Abstract: Purpose: Patients with terminal diseases frequently undergo interventions that are futile and may be detrimental to their quality of life. We conducted a quality improvement project aimed to reduce the utilization of futile acute care services (ACSs) ... ...

Abstract	Purpose: Patients with terminal diseases frequently undergo interventions that are futile and may be detrimental to their quality of life. We conducted a quality improvement project aimed to reduce the utilization of futile acute care services (ACSs) for patients with cancer treated with a palliative intent. Methods: A multidisciplinary team reviewed the records of terminally ill patients with cancer who died between November 2017 and May 2018, during their admission at our institution. The review aimed to assess the magnitude of improper utilization of ACSs and admission to the intensive care unit (ICU). Lack of timely documentation of the goals of care (GOCs) was the main reason for this problem. We defined timely documentation as the availability of electronic documentation of patients' GOC before the need for ACSs. Interventions were implemented to improve the process; postintervention data were captured and compared with the baseline data. Results: After the delivery of staff education and the implementation of mandatory documentation of the GOCs in the healthcare electronic record system, the timely documentation of the GOCs for patients with a palliative intent increased significantly from 59% at baseline to 83% in the postintervention phase. The impact of this intervention led to a decrease in admissions to the ICU from 26% to 12% and an estimated annual cost saving of $777,600 in US dollars. Conclusion: Our interventions resulted in improved documentation of the GOCs and decrease in the utilization of ACSs including ICU admissions and the associated cost.
MeSH term(s)	Humans ; Neoplasms/therapy ; Palliative Care ; Quality of Life ; Respect ; Terminally Ill
Language	English
Publishing date	2021-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.20.00922
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Article: Improving physician's hand over among oncology staff using standardized communication tool.

Alolayan, Ashwaq / Alkaiyat, Mohammad / Ali, Yosra / Alshami, Mona / Al-Surimi, Khaled / Jazieh, Abdul-Rahman

BMJ quality improvement reports

2017 Volume 6, Issue 1

Abstract: Cancer patients are frequently admitted to hospital for many reasons. During their hospitalization they are handled by different physicians and other care providers. Maintaining good communication among physicians is essential to assure patient safety ... ...

Abstract	Cancer patients are frequently admitted to hospital for many reasons. During their hospitalization they are handled by different physicians and other care providers. Maintaining good communication among physicians is essential to assure patient safety and the delivery of quality patient care. Several incidents of miscommunication issues have been reported due to lack of a standardized communication tool for patients' hand over among physicians at our oncology department. Hence, this improvement project aims at assessing the impact of using a standardized communication tool on improving patients' hand over and quality of patient care. A quality improvement team has been formed to address the issue of cancer patients' hand over. We adopted specific hand over tool to be used by physicians. This tool was developed based on well-known and validated communication tool called ISBAR - Identify, Situation, Background, Assessment and Recommendation, which contains pertinent information about the patient's condition. The form should be shared at a specific point in time during the handover process. We monitored the compliance of physician's with this tool over 16 weeks embedded by four 'purposive' and 'sequential' Plan-Do-Study-Act (PDSA) cycles; where each PDSA cycle was developed based on the challenges faced and lessons learned in each step and the result of the previous PDSA cycle. Physicians compliance rate of using the tool had improved significantly from 45% (baseline) to 100% after the fourth PDSA cycle. Other process measure was measuring acknowledgment of hand over receipt email at two checkpoints at 8:00 - 9:00 a.m. and 4:00 - 5:00 p.m. The project showed that using a standardized handover form as a daily communication method between physicians is a useful idea and feasible to improve cancer patients handover with positive impact on many aspects of healthcare process and outcomes.
Language	English
Publishing date	2017-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2677829-4
ISSN	2050-1315
ISSN	2050-1315
DOI	10.1136/bmjquality.u211844.w6141
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Article ; Online: Enhancing the performance of gastrointestinal tumour board by improving documentation.

Alsuhaibani, Roaa Saleh / Alzahrani, Hajer / Algwaiz, Ghada / Alfarhan, Haneen / Alolayan, Ashwaq / Abdelhafiz, Nafisa / Ali, Yosra / Jazieh, Abdul Rahman

BMJ open quality

2018 Volume 7, Issue 1, Page(s) e000168

Abstract: Tumour board contributes to providing better patient care by using a multidisciplinary team approach. In the efforts of evaluating the performance of the gastrointestinal tumour board at our institution, it was difficult to assess past performance due to ...

Abstract	Tumour board contributes to providing better patient care by using a multidisciplinary team approach. In the efforts of evaluating the performance of the gastrointestinal tumour board at our institution, it was difficult to assess past performance due to lack of proper use of standardised documentation tool. This project aimed at improving adherence to the documentation tool and its recommendations in order to obtain performance measures for the tumour board. A multidisciplinary team and a plan were developed to improve documentation. Four rapid improvement cycles, Plan-Do-Study-Act (PDSA) cycles, were conducted. The first cycle focused on updating the case discussion summary form (CDSF) based on experts' input and previous identified deficiencies to enhance documentation and improve performance. The second PDSA cycle aimed at incorporating the CDSF into the electronic medical records system and assessing its functionality. The third cycle was to orient and train staff on using the form and launching it. The fourth PDSA cycle aimed at assessing the ability to obtain tumour board performance measures. Adherence to completion of the CDSF improved from 82% (baseline) to 94% after the fourth PDSA cycle. Over 104 consecutive cases discussed in the tumour board between January and July 2016 and 76 cases discussed in 2015, results were as follows: adherence to National Comprehensive Cancer Network guidelines in 2016 was observed in 141 (95%) recommendations, while it was observed in 90 (92%) recommendations in 2015. Changes in the management plans were observed in 37 (36%) cases in 2016 and in 6 (8%) cases in 2015. Regarding tumour board recommendations, 87% were done within 3 months of tumour board discussion in 2016, while 69% were done in 2015. Implementing electronic standardised documentation tool improved communication among the team and enabled getting accurate data about performance measures of the tumour board with positive impact on healthcare process and outcomes.
Language	English
Publishing date	2018
Publishing country	England
Document type	Journal Article
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2017-000168
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Article ; Online: Saudi Association for the Study of Liver diseases and Transplantation practice guidelines on the diagnosis and management of hepatocellular carcinoma.

Alqahtani, Saleh A / Sanai, Faisal M / Alolayan, Ashwaq / Abaalkhail, Faisal / Alsuhaibani, Hamad / Hassanain, Mazen / Alhazzani, Waleed / Alsuhaibani, Abdullah / Algarni, Abdullah / Forner, Alejandro / Finn, Richard S / Al-Hamoudi, Waleed K

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

2020 Volume 26, Issue Suppl 1, Page(s) S1–S40

MeSH term(s)	Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/therapy ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/therapy ; Saudi Arabia/epidemiology
Language	English
Publishing date	2020-10-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2299174-8
ISSN	1998-4049 ; 1319-3767
ISSN (online)	1998-4049
ISSN	1319-3767
DOI	10.4103/sjg.SJG_477_20
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Article ; Online: The first Middle East and North Africa expert consensus recommendations for the management of advanced colorectal cancer.

Kourie, Hampig R / Ibnshamsah, Fahad / Zouein, Joseph / Naim, Nabih / Abbasi, Salah / Allahloubi, Nasr / Al-Naqqash, Manwar / Alolayan, Ashwaq / Alshehri, Ahmed / Bitar, Nizar / Bounedjar, Adda / Farsi, Abdulaziz Al / Shamsi, Humaid El / Ghali, Ramy / Jaafar, Hassan / Larbaoui, Blaha / Mahrous, Mervat / Mrabti, Hind / Nweir, Abdul Razzak /

Oukkal, Mohamed / Rasul, Kakil / Razavi, Mohsen / Turfa, Rim / Khatib, Sami / Shamseddine, Ali

Future oncology (London, England)

2022 Volume 18, Issue 24, Page(s) 2733–2744

Abstract: Colorectal cancer (CRC) is ranked as the third most prevalent and the second deadliest cancer worldwide. In the Middle East and North Africa (MENA) region, the number of CRC cases increased over the past decades and will nearly double by 2030. The lack ... ...

Abstract	Colorectal cancer (CRC) is ranked as the third most prevalent and the second deadliest cancer worldwide. In the Middle East and North Africa (MENA) region, the number of CRC cases increased over the past decades and will nearly double by 2030. The lack of clear MENA guidelines for the management of patients with CRC represents a step backwards in the fight against this burden. Therefore a panel of 24 MENA experts in the field of gastrointestinal oncology developed, using a Delphi process, the first consensus recommendations for the management of patients with advanced CRC. Forty-seven different statements were formulated in the areas of epidemiology, screening, biomarkers and treatment. These recommendations will guide, standardize and unify the management of this cancer in the MENA region.
MeSH term(s)	Africa, Northern/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; Consensus ; Humans ; Medical Oncology ; Middle East/epidemiology
Language	English
Publishing date	2022-07-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2022-0282
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Article ; Online: Impact of GI Tumor Board on Patient Management and Adherence to Guidelines.

AlFarhan, Haneen A / Algwaiz, Ghada F / Alzahrani, Hajer A / Alsuhaibani, Roaa S / Alolayan, Ashwaq / Abdelhafiz, Nafisa / Ali, Yosra / Boghdadly, Sami / Jazieh, Abdul Rahman

Journal of global oncology

2018 Volume 4, Page(s) 1–8

Abstract: Purpose: As the burden of cancer on the population and the health care system continues to increase with more complicated treatment options, the need for multidisciplinary teams to be as efficient as possible becomes more vital. Our study aimed to ... ...

Abstract	Purpose: As the burden of cancer on the population and the health care system continues to increase with more complicated treatment options, the need for multidisciplinary teams to be as efficient as possible becomes more vital. Our study aimed to evaluate the consistency of GI Tumor Board (GI TB) recommendations with international guidelines, the adherence of physicians involved in patient care to TB recommendations, and the impact on the management of patients. Methods: A prospective cohort study was conducted from January to June 2016 at our institution, which is a major tertiary hospital that provides comprehensive cancer care. All cases presented at the GI TB during this period were included. Data regarding adherence to National Comprehensive Cancer Network guidelines, adherence to TB recommendations, and changes made to the management of patients were collected weekly from the GI TB in a data collection form. Results: Of the 104 patients included, 57 (55%) were males and the median age was 58 (16 to 85) years. Colorectal cancer was the most common diagnosis, in 65 patients (63%). Nearly one-half of cases (45%) were stage IV cancers. Starting new treatment was recommended for 72 patients (69%). Further investigations were requested for 15 patients (14%). For imaging, 24 recommendations (23%) were made. Adherence to National Comprehensive Cancer Network guidelines was observed in 97% of total recommendations. New findings were found in pathology (11%), radiology (13%), and staging (4%). Management plans were changed in 37 cases (36%). Over a 3-month period after presentation to the GI TB, most of the recommendations (87%) were performed. Conclusion: A multidisciplinary tumor board enhances the adherence to guidelines and has an impact on patient management in approximately one-third of patients. Among physicians, adherence to recommendations of the TB was high.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Female ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/epidemiology ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/therapy ; Gastrointestinal Tract/pathology ; Guidelines as Topic ; Humans ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article
ISSN	2378-9506
ISSN (online)	2378-9506
DOI	10.1200/JGO.17.00164
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