Article ; Online: Time from symptoms onset to remdesivir is associated with the risk of ICU admission: a multicentric analyses.
2023 Volume 23, Issue 1, Page(s) 286
Abstract: Background: Shorter duration of symptoms before remdesivir has been associated with better outcomes. Our goal was to evaluate variables associated with the need of ICU admission in a cohort of hospitalized patients for COVID-19 under remdesivir ... ...
| Abstract | Background: Shorter duration of symptoms before remdesivir has been associated with better outcomes. Our goal was to evaluate variables associated with the need of ICU admission in a cohort of hospitalized patients for COVID-19 under remdesivir including the period from symptoms onset to remdesivir. Methods: We conducted a retrospective multicentric study analysing all patients admitted with COVID-19 in 9 Spanish hospitals who received treatment with remdesivir in October 2020. The main outcome was the need of ICU admission after 24 h of the first dose of remdesivir. Results: In our cohort of 497 patients, the median of days from symptom onset to remdesivir was 5 days, and 70 of them (14.1%) were later admitted into ICU. The clinical outcomes associated with ICU admission were days from symptoms onset (5 vs. 6; p = 0.023), clinical signs of severe disease (respiratory rate, neutrophil count, ferritin levels and very-high mortality rate in SEIMC-Score) and the use of corticosteroids and anti-inflammatory drugs before ICU. The only variable significatively associated with risk reduction in the Cox-regression analyses was ≤ 5 days from symptoms onset to RDV (HR: 0.54, CI95%: 0.31-0.92; p = 0.024). Conclusion: For patients admitted to the hospital with COVID-19, the prescription of remdesivir within 5 days from symptoms onset diminishes the need of ICU admission. |
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| MeSH term(s) | Humans ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; COVID-19 Drug Treatment ; Intensive Care Units |
| Chemical Substances | remdesivir (3QKI37EEHE) |
| Language | English |
| Publishing date | 2023-05-04 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2041550-3 |
| ISSN | 1471-2334 ; 1471-2334 |
| ISSN (online) | 1471-2334 |
| ISSN | 1471-2334 |
| DOI | 10.1186/s12879-023-08222-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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