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Article ; Online: Infectious Endocarditis Caused by

Lacalzada-Almeida, Juan / Izquierdo-Gomez, Maria Manuela / Duque-Gonzalez, Amelia / Alonso-Socas, Maria Del Mar / Munoz-Rodriguez, Rebeca

Journal of medical cases

2022 Volume 13, Issue 6, Page(s) 297–301

Abstract: We report the case of a 53-year-old man with psoriatic arthritis, suffering from a malignant and recidivant myoepithelioma in his right axilla and arm, and undergoing two surgeries, with the last one being performed a month prior to actual admission. ... ...

Abstract	We report the case of a 53-year-old man with psoriatic arthritis, suffering from a malignant and recidivant myoepithelioma in his right axilla and arm, and undergoing two surgeries, with the last one being performed a month prior to actual admission. After the last surgery, he was admitted to hospital with fever without a source. After physical examination, laboratory tests, blood cultures and transthoracic and transesophageal echocardiography, he was diagnosed with infectious endocarditis (IE) on a bicuspid aortic valve (BAV) caused by
Language	English
Publishing date	2022-06-11
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2586383-6
ISSN	1923-4163 ; 1923-4163
ISSN (online)	1923-4163
ISSN	1923-4163
DOI	10.14740/jmc3943
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Article ; Online: Brief Report: Patients' Experiences and Opinions After Desimplification of Their Single-Tablet Regimens for the Treatment of HIV Infection: A Survey in a Multicentre Cohort.

Suárez-García, Inés / Ruiz-Algueró, Marta / Alejos, Belén / García-Yubero, Cristina / Belza, Mª José / Espacio, Ramón / Hernández, Juanse / Muñoz Sánchez, Josefa / Garaialde, Ainhoa / Alonso Socas, María Del Mar / Alcaraz, Antonia / Pierola Ruiz de Galarreta, Beatriz / Martínez Madrid, Onofre Juan / Gutiérrez Cuéllar, Isabel / Gómez-Ayerbe, Cristina / Olalla, Julián / Jarrín, Inma

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 90, Issue 1, Page(s) 62–68

Abstract: Objectives: The aims of this study were to describe patients' experiences after single-tablet regimen (STR) desimplification and its impact on self-reported treatment adherence and quality of life.: Methods: We performed a survey among all patients ... ...

Abstract	Objectives: The aims of this study were to describe patients' experiences after single-tablet regimen (STR) desimplification and its impact on self-reported treatment adherence and quality of life. Methods: We performed a survey among all patients from the multicenter cohort of the Spanish HIV/AIDS Network who had desimplified the STRs dolutegravir/abacavir/lamivudine (DGT/ABC/3TC) or rilpivirine/tenofovir disoproxil fumarate/emtricitabine to their separate components (DTG + generic ABC/3TC or RPV + generic TDF/FTC) between December 2016 and November 2018. Results: Among 216 patients who fulfilled inclusion criteria, 138 (63.9%) completed the questionnaire. Most of the patients (78.3%) knew what generic drugs are, only 8.7% believed that treatment with 2 pills is less effective than treatment with an STR, and 67.4% agreed that it is reasonable to take 2 pills instead of 1 for HIV treatment to decrease costs for the health care system. After desimplification, 13.0% of the patients stated they had more secondary effects, 8.0% had forgotten one or more doses more frequently than before, and 10.9% had sometimes forgotten to take 1 pill, but not the other. A proportion of 30.4% reported not being happy to take more pills a day, and 10.1% experienced a worse quality of life after the treatment desimplification. Conclusions: After STR desimplification, most of the patients had a fair knowledge about generic antiretrovirals, and they agreed to desimplify their STR to decrease costs. Although almost a third of the respondents were not happy to take 2 pills a day, only a minority reported worse adherence or quality of life.
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Drug Combinations ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; Humans ; Lamivudine/therapeutic use ; Quality of Life ; Surveys and Questionnaires ; Tablets ; Tenofovir/therapeutic use
Chemical Substances	Anti-HIV Agents ; Drug Combinations ; Tablets ; Lamivudine (2T8Q726O95) ; Tenofovir (99YXE507IL) ; Emtricitabine (G70B4ETF4S)
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002923
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Article ; Online: Clinical features and outcomes of bacteraemia due to OXA-48-like carbapenemase-producing Klebsiella pneumoniae in a tertiary hospital.

Madueño, Ana / González-García, Jonathan / Alonso Socas, María Del Mar / Miguel Gómez, María Antonia / Lecuona, María

Enfermedades infecciosas y microbiologia clinica (English ed.)

2017 Volume 36, Issue 8, Page(s) 498–501

Abstract: Introduction: Limited therapeutic options and high mortality make the management of OXA-48-like carbapenemase-producing Klebsiella pneumoniae (KPOXA-48) bacteraemia complicated. The aim of the study was to describe the clinical characteristics of KPOXA- ... ...

Title translation	Características y evolución clínica de las bacteriemias por Klebsiella pneumoniae productora de carbapenemasa tipo OXA-48 en un hospital de tercer nivel.
Abstract	Introduction: Limited therapeutic options and high mortality make the management of OXA-48-like carbapenemase-producing Klebsiella pneumoniae (KPOXA-48) bacteraemia complicated. The aim of the study was to describe the clinical characteristics of KPOXA-48 bacteraemia between October 2013 and December 2016. Material and methods: The variables to analyse were retrospectively collected from medical records. Carbapenemase production was confirmed by phenotypic and molecular methods. Results: A total of 38 patients with bacteraemia were included, mainly classified as hospital-acquired (n=31). The majority of cases were secondary bacteraemia (n=26), most commonly arising from the urinary tract (n=11). All isolates presented a multidrug-resistant profile with the extended spectrum beta-lactamase CTX-M-15 and the carbapenemase OXA-48-like production. The crude mortality rate with adequate targeted antibiotic therapy was 0%, rising to 55% with inadequate treatment (p=0.0015). Conclusions: This study highlights the importance of identifying this resistance mechanism, the patient factors, type of bacteraemia and adequacy of antibiotic therapy in the outcome of bacteraemia.
MeSH term(s)	Aged ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Bacterial Proteins/biosynthesis ; Female ; Humans ; Klebsiella Infections/diagnosis ; Klebsiella Infections/drug therapy ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/enzymology ; Male ; Retrospective Studies ; Tertiary Care Centers ; beta-Lactamases/biosynthesis
Chemical Substances	Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6) ; oxacillinase (EC 3.5.2.6)
Language	Spanish
Publishing date	2017-11-13
Document type	Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2017.09.013
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Article ; Online: Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors.

Díez-Fuertes, Francisco / De La Torre-Tarazona, Humberto Erick / Calonge, Esther / Pernas, Maria / Alonso-Socas, María Del Mar / Capa, Laura / García-Pérez, Javier / Sakuntabhai, Anavaj / Alcamí, José

Scientific reports

2019 Volume 9, Issue 1, Page(s) 14265

Abstract: The elite controller (EC)-long term non-progressor (LTNP) phenotype represent a spontaneous and advantageous model of HIV-1 control in the absence of therapy. The transcriptome of peripheral blood mononuclear cells (PBMCs) collected from EC-LTNPs was ... ...

Abstract	The elite controller (EC)-long term non-progressor (LTNP) phenotype represent a spontaneous and advantageous model of HIV-1 control in the absence of therapy. The transcriptome of peripheral blood mononuclear cells (PBMCs) collected from EC-LTNPs was sequenced by RNA-Seq and compared with the transcriptomes from other phenotypes of disease progression. The transcript abundance estimation combined with the use of supervised classification algorithms allowed the selection of 20 genes and pseudogenes, mainly involved in interferon-regulated antiviral mechanisms and cell machineries of transcription and translation, as the best predictive genes of disease progression. Differential expression analyses between phenotypes showed an altered calcium homeostasis in EC-LTNPs evidenced by the upregulation of several membrane receptors implicated in calcium-signaling cascades and intracellular calcium-mobilization and by the overrepresentation of NFAT1/Elk-1-binding sites in the promoters of the genes differentially expressed in these individuals. A coordinated upregulation of host genes associated with HIV-1 reverse transcription and viral transcription was also observed in EC-LTNPs -i.e. p21/CDKN1A, TNF, IER3 and GADD45B. We also found an upregulation of ANKRD54 in EC-LTNPs and viremic LTNPs in comparison with typical progressors and a clear alteration of type-I interferon signaling as a consequence of viremia in typical progressors before and after receiving antiretroviral therapy.
MeSH term(s)	Female ; HIV Infections/genetics ; HIV Infections/metabolism ; HIV Long-Term Survivors ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Protein Interaction Maps ; Transcriptome ; Virus Replication
Language	English
Publishing date	2019-10-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-50642-x
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Article ; Online: Pulmonary Infective Endocarditis.

Prieto-Arévalo, Raquel / Muñoz, Patricia / Cuerpo, Gregorio / Marí-Hualde, Amaia / Castelo-Corral, Laura / Navas-Elorza, Enrique / Cifuentes-Luna, Carmen / Alonso-Socas, Maria Del Mar / Boix-Palop, Lucía / Martínez-Sellés, Manuel

Journal of the American College of Cardiology

2019 Volume 73, Issue 21, Page(s) 2782–2784

MeSH term(s)	Adult ; Aged ; Endocarditis/microbiology ; Endocarditis/mortality ; Female ; Heart Valve Diseases/microbiology ; Heart Valve Diseases/mortality ; Heart Valve Prosthesis/adverse effects ; Humans ; Male ; Middle Aged ; Prosthesis-Related Infections/microbiology ; Pulmonary Valve ; Retrospective Studies ; Spain/epidemiology
Language	English
Publishing date	2019-05-27
Publishing country	United States
Document type	Letter
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2019.03.480
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Article: Bartonella

García-Álvarez, Lara / García-García, Concepción / Muñoz, Patricia / Fariñas-Álvarez, María Del Carmen / Cuadra, Manuel Gutiérrez / Fernández-Hidalgo, Nuria / García-Vázquez, Elisa / Moral-Escudero, Encarnación / Alonso-Socas, María Del Mar / García-Rosado, Dácil / Hidalgo-Tenorio, Carmen / Domínguez, Fernando / Goikoetxea-Agirre, Josune / Gainzarain, Juan Carlos / Rodríguez-Esteban, María Ángeles / Bosch-Guerra, Xerach / Oteo, José A / On Behalf Of Grupo de Apoyo Al Manejo de la Endocarditis Infecciosa En España Games

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such ... ...

Abstract	Blood culture negative endocarditis (BCNE) is frequent in infective endocarditis (IE). One of the causes of BCNE is fastidious microorganisms, such as
Language	English
Publishing date	2022-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11050561
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Article ; Online: Tropheryma whipplei endocarditis in Spain: Case reports of 17 prospective cases.

García-Álvarez, Lara / Sanz, María Mercedes / Marín, Mercedes / Fariñas, MCarmen / Montejo, Miguel / Goikoetxea, Josune / Rodríguez García, Raquel / de Alarcón, Arístides / Almela, Manuel / Fernández-Hidalgo, Núria / Alonso Socas, María Del Mar / Goenaga, Miguel Ángel / Navas, Enrique / Vicioso, Luis / Oteo, José Antonio

Medicine

2016 Volume 95, Issue 26, Page(s) e4058

Abstract: Tropheryma whipplei endocarditis is an uncommon condition with very few series and <90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei ... ...

Abstract	Tropheryma whipplei endocarditis is an uncommon condition with very few series and <90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España.From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3.5% of these had T. whipplei endocarditis. This condition was more frequent in men. The average age was 60.3 years. Previous cardiac condition was present in 35.3% of the cases. The main clinical manifestation was cardiac failure (76.5%) while fever was only present in the 35.3%. Ecocardiography showed vegetations in 64.7% of patients. Surgery was performed in all but 1 cases and it allowed the diagnosis when molecular assays were performed. A broad range rRNA 16S polymerase chain reaction was used for first instance in all laboratories and different specific targets for T. whipplei were employed for confirmation. A concomitant Whipple disease was diagnosed in 11.9% of patients. All patients received specific antimicrobial treatment for at least 1 year, with no relapse and complete recovery.T. whipplei endocarditis is an uncommon condition with an atypical presentation that must be considered in the diagnosis of BCNE. The prognosis is very good when an appropriate surgical management and antimicrobial-specific treatment is given.
MeSH term(s)	Actinomycetales Infections ; Aged ; Endocarditis, Bacterial/microbiology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Spain ; Tropheryma
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000004058
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Article: Endocarditis y espondilodiscitis por Streptococcus suis.

Alonso-Socas, Maria del Mar / Alemán-Valls, Remedios / Roldán-Delgado, Héctor / Gómez-Sirvent, Juan Luis

Enfermedades infecciosas y microbiologia clinica

2006 Volume 24, Issue 5, Page(s) 354–355

Title translation	Endocarditis and spondylodiscitis caused by Streptococcus suis.
MeSH term(s)	Animals ; Aortic Valve/microbiology ; Atlantic Islands/epidemiology ; Discitis/microbiology ; Endocarditis, Bacterial/microbiology ; Food Contamination ; Food Handling ; Food Microbiology ; Humans ; Lumbar Vertebrae/microbiology ; Male ; Meat/microbiology ; Middle Aged ; Mitral Valve/microbiology ; Occupational Diseases/microbiology ; Restaurants ; Spain/epidemiology ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcal Infections/transmission ; Streptococcus suis/isolation & purification ; Sus scrofa/microbiology
Language	Spanish
Publishing date	2006-05-31
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1070941-1
ISSN	1578-1852 ; 0213-005X
ISSN (online)	1578-1852
ISSN	0213-005X
DOI	10.1157/13089675
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Article ; Online: Similar inflammatory response in alcoholic and non-alcoholic sepsis patients.

Santolaria, Francisco / Rodríguez-López, Carmen / Martín-Hernández, Beatriz / Alemán-Valls, María-Remedios / González-Reimers, Emilio / Alonso-Socas, María-Del-Mar / Ros, Rosa / Viña, Juan-José

European cytokine network

2011 Volume 22, Issue 1, Page(s) 1–4

Abstract: Unlabelled: It is well known that alcoholics are prone to severe infections and that the immune system is impaired by chronic ethanol abuse. The aim of this study is to compare serum inflammatory mediators in response to sepsis in chronic alcoholic with ...

Abstract	Unlabelled: It is well known that alcoholics are prone to severe infections and that the immune system is impaired by chronic ethanol abuse. The aim of this study is to compare serum inflammatory mediators in response to sepsis in chronic alcoholic with sepsis, non-alcoholics with sepsis and non-infected alcoholics. Method: We included 25 alcoholics with sepsis, 34 non-alcoholics with sepsis, 34 non-infected alcoholics admitted for programmed withdrawal, and 27 healthy control subjects. After initial evaluation, blood samples were taken for determination of serum cytokine levels. Results: We found similar responses for the inflammatory mediators analyzed among our sepsis patients, regardless of alcohol abuse. The only difference was that alcoholics with sepsis showed lower CRP and G-CSF than non-alcoholic sepsis patients. There were no differences regarding leukocyte count. Alcoholics admitted for programmed withdrawal showed higher IL-6, IFN-γ, IL-10, Il-4 and ICAM-1 serum levels than healthy controls. Serum IL-5 levels were decreased in both alcoholic groups. Conclusion: The inflammatory response of alcoholics with sepsis is similar to that of non-alcoholic sepsis patients. However, the low G-CSF levels in alcoholic sepsis patients might suggest a predisposition to infections in alcohol abusers.
MeSH term(s)	Aged ; Alcoholism/blood ; Alcoholism/complications ; Biomarkers/blood ; Female ; Humans ; Inflammation/blood ; Inflammation/complications ; Male ; Middle Aged ; Sepsis/blood ; Sepsis/complications
Chemical Substances	Biomarkers
Language	English
Publishing date	2011-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1118857-1
ISSN	1952-4005 ; 1148-5493
ISSN (online)	1952-4005
ISSN	1148-5493
DOI	10.1684/ecn.2011.0272_1
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Article: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments

Garriga, César / Pérez-Elías, María Jesús / Delgado, Rafael / Ruiz, Lidia / Nájera, Rafael / Pumarola, Tomàs / Alonso-Socas, María del Mar / García-Bujalance, Silvia / Menéndez-Arias, Luis

Journal of medical virology. 2007 Nov., v. 79, no. 11

2007

Abstract: Human immunodeficiency virus type 1 (HIV-1) antiviral drug resistance is a major consequence of therapy failure and compromises future therapeutic options. Nelfinavir and lopinavir/ritonavir-based therapies have been widely used in the treatment of HIV- ... ...

Abstract	Human immunodeficiency virus type 1 (HIV-1) antiviral drug resistance is a major consequence of therapy failure and compromises future therapeutic options. Nelfinavir and lopinavir/ritonavir-based therapies have been widely used in the treatment of HIV-infected patients, in combination with reverse transcriptase inhibitors. The aim of this observational study was the identification and characterization of mutations or combinations of mutations associated with resistance to nelfinavir and lopinavir/ritonavir in treated patients. Nucleotide sequences of 1,515 subtype B HIV-1 isolates from 1,313 persons with different treatment histories (including naïve and treated patients) were collected in 31 Spanish hospitals over the years 2002-2005. Chi-square contingency tests were performed to detect mutations associated with failure to protease inhibitor-based therapies, and correlated mutations were identified using statistical methods. Virological failure to nelfinavir was associated with two different mutational pathways. D30N and N88D appeared mostly in patients without previous exposure to protease inhibitors, while K20T was identified as a secondary resistance mutation in those patients. On the other hand, L90M together with L10I, I54V, A71V, G73S, and V82A were selected in protease inhibitor-experienced patients. A series of correlated mutations including L10I, M46I, I54V, A71V, G73S, and L90M appeared as a common cluster of amino acid substitutions, associated with failure to lopinavir/ritonavir-based treatments. Despite the relatively high genetic barrier of some protease inhibitors, a relatively small cluster of mutations, previously selected under drug pressure, can seriously compromise the efficiency of nelfinavir- and lopinavir/ritonavir-based therapies. J. Med. Virol. 79:1617-1628, 2007. © 2007 Wiley-Liss, Inc.
Language	English
Dates of publication	2007-11
Size	p. 1617-1628.
Publishing place	Wiley Subscription Services, Inc., A Wiley Company
Document type	Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.20986
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