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  1. Article: Pharmacological Methods of Pain Management: Narrative Review of Medication Used.

    Alorfi, Nasser M

    International journal of general medicine

    2023  Volume 16, Page(s) 3247–3256

    Abstract: Background: Pain management is a critical aspect of healthcare, aimed at alleviating discomfort and improving the quality of life for individuals experiencing acute or chronic pain. Pharmacological methods constitute a primary approach to pain ... ...

    Abstract Background: Pain management is a critical aspect of healthcare, aimed at alleviating discomfort and improving the quality of life for individuals experiencing acute or chronic pain. Pharmacological methods constitute a primary approach to pain management, including a diverse array of drugs that work through different mechanisms.
    Aim: Identifying medications commonly employed in pain management, focusing on their mechanism of actions, uses, efficacy and pharmacological applications.
    Methods: The methodology involved a systematic search of scientific literature using various databases, including PubMed, Scopus, and Google Scholar. Relevant articles published between 2000 and 2023 were screened for inclusion. The selected studies encompassed original research, review articles, therapeutic guidelines and randomized controlled trials.
    Results: The findings of this review suggest that a multimodal approach combining various analgesics can enhance pain relief while minimizing adverse effects. It emphasizes the importance of assessing pain intensity, determining the underlying etiology, and utilizing evidence-based guidelines to optimize pain management outcomes.
    Conclusion: Pharmacological methods of pain management are an essential component of pain management strategies to achieve optimal pain relief while minimizing adverse effects. The article concludes with a discussion on emerging trends and future directions in pharmacological pain management, including novel drug targets and advances in drug delivery systems.
    Language English
    Publishing date 2023-07-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S419239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Public Awareness of Alzheimer's Disease: A Cross-Sectional Study from Saudi Arabia.

    Alorfi, Nasser M

    International journal of general medicine

    2022  Volume 15, Page(s) 7535–7546

    Abstract: Background: Alzheimer's disease is considered the most common neurodegenerative and progressive illness. It is also a common type of dementia characterized by brain atrophy, neuronal tissue loss, and the formation of amyloid plaques. Mild memory loss is ...

    Abstract Background: Alzheimer's disease is considered the most common neurodegenerative and progressive illness. It is also a common type of dementia characterized by brain atrophy, neuronal tissue loss, and the formation of amyloid plaques. Mild memory loss is a commonly expected start of the disease, which can progress to loss of capacity to carry on a conversation and react to certain situations.
    Objective: This study aimed to measure knowledge about Alzheimer's disease in Saudi Arabia through the use of the Alzheimer's Disease Knowledge Scale (ADKS) and measure the association between the ADKS with relevant demographic variables.
    Methods: A pre-validated questionnaire containing 30 questions was distributed electronically to anyone older than 18 years old living in Saudi Arabia. Items regarding socio-demographic characteristics and the Alzheimer's Disease Knowledge Scale (ADKS) were also included.
    Results: Participants did not have a high enough mean score to be regarded as appropriately knowledgeable (mean = 17.35). Higher knowledge scores on Life impact, Risk factors, Assessment and diagnosis, Caregiving, Treatment and management, and ADKS were associated with the female gender. Higher knowledge of caregiving was associated with a postgraduate academic qualification. Higher knowledge on Assessment and Diagnosis was associated with higher age. Higher knowledge on risk factors was associated with having relatives diagnosed with Alzheimer's disease. Higher knowledge on life impact was associated with having newspaper and journal articles as the source of medical information.
    Conclusion: National awareness campaigns for the community and continuing education courses for caregivers must be placed to aid in increasing awareness regarding Alzheimer's disease.
    Language English
    Publishing date 2022-09-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S373447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pharmacological treatments of fibromyalgia in adults; overview of phase IV clinical trials.

    Alorfi, Nasser M

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1017129

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1017129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats.

    Alshehri, Fahad S / Alorfi, Nasser M

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1130670

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1130670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Usage of Glucagon-Like Peptide-1 for Obesity in Children; Updated Review of Clinicaltrials.gov.

    Alorfi, Nasser M / Alshehri, Fahad S

    Journal of multidisciplinary healthcare

    2023  Volume 16, Page(s) 2179–2187

    Abstract: Background: Obesity in both adults and children is a primary health concern that can lead to many complications at a young age, including insulin resistance, type 2 diabetes, and other diseases. Glucagon-like peptide-1 receptor agonists (GLP-1) are ... ...

    Abstract Background: Obesity in both adults and children is a primary health concern that can lead to many complications at a young age, including insulin resistance, type 2 diabetes, and other diseases. Glucagon-like peptide-1 receptor agonists (GLP-1) are drugs utilized to treat diabetes, but they are also approved as an adjunct to a low-calorie diet to reduce body weight and to enhance the metabolic profile readings for diabetic and non-diabetic patients. However, their efficacy and safety in children have not been extensively examined.
    Aim: To identify glucagon-like peptide-1 medications for obesity in pediatric participants (aged up to 17 years old).
    Methods: Analysis of all clinical trials registered on ClinicalTrials.gov for obesity using GLP-1 as a treatment for children.
    Results: As of January 26th, 2023, 10,828 clinical trials were found. The search included childhood obesity using GLP-1. The number of trials on the use of GLP-1 to treat childhood obesity is limited. The final number of analyzed trials was 19. GLP-1 has been shown to result in the effective management of body gain among children.
    Conclusion: Exenatide, semaglutide, and liraglutide were the only GLP-1 medications used as the pharmacotherapy option. It has been studied in many circumstances eg, to treat children with severe obesity, PCOS, hypothalamic obesity, glucose tolerance, and as a complementary treatment alongside behavior-lifestyle change and surgery for obesity.
    Language English
    Publishing date 2023-07-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S419245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Saudi Adults' Understanding and Views of Weight Management Practices and Obesity.

    Alshehri, Fahad S / Alorfi, Nasser M

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 3513–3531

    Abstract: Background and objective: The rising prevalence of overweight and obesity presents a significant global challenge. This study aimed to investigate the understanding and views of weight management practices and obesity among Saudi adults.: Methodology!# ...

    Abstract Background and objective: The rising prevalence of overweight and obesity presents a significant global challenge. This study aimed to investigate the understanding and views of weight management practices and obesity among Saudi adults.
    Methodology: A cross-sectional online survey was conducted from October 2022 to January 2023 among adults residing in Saudi Arabia. Participants completed a self-administered 41-item questionnaire designed to assess their understanding and views regarding weight management practices and obesity.
    Results: A total of 1066 participants completed the survey. Gender distribution showed a majority of males (55.7%). Age-wise, the majority fell below 51 years, with 37.7% (young) between 18-24, 32.7% (young adult) between 25-33, and 21.3% (adult) between 34-51. Employment was reported by one-third (n = 315) of respondents, while 22.0% (n = 234) had a history of chronic diseases. Furthermore, 77.3% (n = 824) engaged in regular physical activity.The study results revealed that participants' mean score for understanding obesity was 3.28 ± 2.37 (range 0-6), while the average views score was 28.08 ± 8.79 (range 0-34). Furthermore, females displayed a higher level of understanding compared to males. Employment status also played a significant role, with employed individuals having a better understanding of obesity than those who were unemployed. Moreover, participants with higher qualifications demonstrated a more comprehensive understanding of obesity compared to those with lower qualifications. Additionally, individuals with higher monthly income levels displayed a greater understanding of obesity compared to those with lower incomes. Lastly, participants who engaged in regular physical activity exhibited a higher level of understanding compared to those who were physically inactive.
    Conclusion: The study indicates that factors such as being older, being female, being employed, having higher education and income, and engaging in regular physical activity are associated with increased understanding and favorable views regarding weight management practices and obesity.
    Language English
    Publishing date 2023-11-06
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S433721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Impact of Intermittent Fasting on Non-Alcoholic Fatty Liver Disease in Older Adults: A Review of Clinicaltrials.gov Registry.

    Alorfi, Nasser M / Ashour, Ahmed M

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2023  Volume 16, Page(s) 3115–3121

    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a predominant health condition across the world due to its rising prevalence and association with various metabolic disorders. Intermittent fasting (IF) has attracted increasing attention as a ... ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is a predominant health condition across the world due to its rising prevalence and association with various metabolic disorders. Intermittent fasting (IF) has attracted increasing attention as a dietary approach to addressing weight management and enhancing metabolic well-being, and its potential effects on NAFLD have been a topic of growing research interest.
    Aim: This review aims to critically evaluate the current evidence on IF's impact on NAFLD, including the mechanisms underlying the observed effects in older adults (65+).
    Methods: A comprehensive search of Clinicaltrials.gov was conducted to identify relevant studies that investigated the effects of IF on NAFLD in older adults (65+). Data on study design, sample size, intervention details, and outcomes related to NAFLD were extracted and analyzed.
    Results: As of April 12th, 2023, there were 1304 clinical trials on NAFLD. Most of these were interventional studies. The investigation focused on completed studies and found that limited clinical trials were identified with limited interventional measures. Only five out of the 1304 studies on NAFLD involved IF. Basic and advanced outcome measures were examined.
    Conclusion: Although some studies suggest that IF may have potential benefits for NAFLD, the evidence is still limited and inconclusive.
    Language English
    Publishing date 2023-10-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S430740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review.

    Alorfi, Nasser M / Algarni, Alanood S

    Clinical pharmacology : advances and applications

    2022  Volume 14, Page(s) 61–67

    Abstract: Purpose: Obesity and overweight pose a threat to health and are more common than undernutrition among adults. It is categorized by fat accumulation and a body mass index (BMI) of > 30. A significant increase in worldwide obesity has been ongoing over ... ...

    Abstract Purpose: Obesity and overweight pose a threat to health and are more common than undernutrition among adults. It is categorized by fat accumulation and a body mass index (BMI) of > 30. A significant increase in worldwide obesity has been ongoing over several decades. Over the past few years, several strategies have been followed for weight management and to counteract the increasing prevalence of the disease; however, room for improvement with pharmacological options still exists. This review aimed to digest selected past clinical and experimental studies and understand the role of semaglutide treatment for obesity.
    Methods: Articles related to the clinical uses of semaglutide, mechanism of action, pharmacokinetics, pharmacodynamics, and side effects of the drug were identified. Only studies with human subjects who used Semaglutide for obesity management were included and assessed.
    Results: Semaglutide promotes weight loss via appetite and hunger suppression, decreases energy intake, controls eating, and depresses the relative fondness for fatty, energy-dense foods. Moreover, the relationship between obesity and Semaglutide has been widely investigated, and most studies reveal the efficacy of Semaglutide on weight loss. Overall, the pharmacokinetics of semaglutide shows a drop in glycosylated hemoglobin A1c (HbA1c) and total body weight. The usual adverse effects observed in patients treated with Semaglutide include gastrointestinal adverse events, like nausea, vomiting, diarrhea, constipation, and abdominal cramps.
    Conclusion: The findings from the review suggest that semaglutide appears to be beneficial, most notably in its contribution to weight reduction.
    Language English
    Publishing date 2022-08-03
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520726-X
    ISSN 1179-1438
    ISSN 1179-1438
    DOI 10.2147/CPAA.S374741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Biologic Therapy for Refractory Immune Checkpoint Inhibitor Colitis.

    Alorfi, Nasser M / Alourfi, Mansour Marzouq

    Biologics : targets & therapy

    2022  Volume 16, Page(s) 119–127

    Abstract: Immune checkpoint inhibitors (ICI) are treatments for several cancer types. Pathogenesis of ICI-induced colitis is not yet clearly explained as it can be disguised as another form such as inflammatory bowel disease or IBD. Recent studies revealed that ... ...

    Abstract Immune checkpoint inhibitors (ICI) are treatments for several cancer types. Pathogenesis of ICI-induced colitis is not yet clearly explained as it can be disguised as another form such as inflammatory bowel disease or IBD. Recent studies revealed that ICI-induced colitis is a unique form of colitis wherein the synergy of regulatory T cells with the gut microbiome is involved. Diagnosis of colitis can be done via endoscopic lesions and histopathological methods. A patient with colitis can be compared with someone who has IBD. Initial treatment is a corticosteroid. Cooperation between gastroenterologists and oncologists is required to understand further the complete diagnosis and management of different behaviors of ICI-induced colitis. Although immunotherapy provides breakthroughs in treating cancer, adverse effects cannot be prevented and have to be carefully addressed. This study aimed to discuss different biologic therapeutic perspectives in treating refractory immune checkpoint inhibitor-induced colitis. This review provided guidelines, challenges, and suggested protocols for drug immunosuppression.
    Language English
    Publishing date 2022-08-05
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2415708-9
    ISSN 1177-5491 ; 1177-5475
    ISSN (online) 1177-5491
    ISSN 1177-5475
    DOI 10.2147/BTT.S367675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Assessment of community pharmacists' knowledge about drug-drug interactions in Jeddah, Saudi Arabia.

    Alorfi, Nasser M / Alqurashi, Roaya S / Algarni, Alanood S

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1209318

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1209318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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