LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Global Biobank Meta-analysis Initiative: How can global health benefit by its use?

    Alpeeva, Elena V / Sharov, Konstantin S

    Journal of global health

    2023  Volume 13, Page(s) 3054

    MeSH term(s) Humans ; Biological Specimen Banks ; Global Health
    Language English
    Publishing date 2023-10-27
    Publishing country Scotland
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.13.03054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Russian Biodiversity Collections: A Professional Opinion Survey.

    Alpeeva, Elena V / Sharova, Natalia P / Sharov, Konstantin S / Vorotelyak, Ekaterina A

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 24

    Abstract: Biodiversity collections are important vehicles for protecting endangered wildlife in situations of adverse anthropogenic influence. In Russia, there are currently a number of institution- and museum-based biological collections, but there are no nation- ... ...

    Abstract Biodiversity collections are important vehicles for protecting endangered wildlife in situations of adverse anthropogenic influence. In Russia, there are currently a number of institution- and museum-based biological collections, but there are no nation-wide centres of biodiversity collections. In this paper, we report on the results of our survey of 324 bioconservation, big-data, and ecology specialists from different regions of Russia in regard to the necessity to create several large national biodiversity centres of wildlife protection. The survey revealed specific goals that have to be fulfilled during the development of these centres for the protection and restoration of endangered wildlife species. The top three problems/tasks (topics) are the following: (1) the necessity to create large national centres for different types of specimens; (2) the full sequencing and creation of different "omic" (genomic, proteomic, transcriptomic, etc.) databases; (3) full digitisation of a biodiversity collection/centre. These goals may constitute a guideline for the future of biodiversity collections in Russia that would be targeted at protecting and restoring endangered species. With the due network service level, the translation of the website into English, and permission from the regulator (Ministry of Science and Higher Education of Russian Federation), it can also become an international project.
    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13243777
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer.

    Chermnykh, Elina S / Alpeeva, Elena V / Vorotelyak, Ekaterina A

    Cells

    2020  Volume 9, Issue 9

    Abstract: Transglutaminases (TGMs) contribute to the formation of rigid, insoluble macromolecular complexes, which are essential for the epidermis and hair follicles to perform protective and barrier functions against the environment. During differentiation, ... ...

    Abstract Transglutaminases (TGMs) contribute to the formation of rigid, insoluble macromolecular complexes, which are essential for the epidermis and hair follicles to perform protective and barrier functions against the environment. During differentiation, epidermal keratinocytes undergo structural alterations being transformed into cornified cells, which constitute a highly tough outermost layer of the epidermis, the stratum corneum. Similar processes occur during the hardening of the hair follicle and the hair shaft, which is provided by the enzymatic cross-linking of the structural proteins and keratin intermediate filaments. TGM3, also known as epidermal TGM, is one of the pivotal enzymes responsible for the formation of protein polymers in the epidermis and the hair follicle. Numerous studies have shown that TGM3 is extensively involved in epidermal and hair follicle physiology and pathology. However, the roles of TGM3, its substrates, and its importance for the integument system are not fully understood. Here, we summarize the main advances that have recently been achieved in TGM3 analyses in skin and hair follicle biology and also in understanding the functional role of TGM3 in human tumor pathology as well as the reliability of its prognostic clinical usage as a cancer diagnosis biomarker. This review also focuses on human and murine hair follicle abnormalities connected with TGM3 mutations.
    MeSH term(s) Animals ; Cell Differentiation ; Disease Models, Animal ; Epithelial Cells/metabolism ; Humans ; Mice ; Neoplasms/genetics ; Transglutaminases/metabolism
    Chemical Substances Transglutaminases (EC 2.3.2.13)
    Language English
    Publishing date 2020-08-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091996
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Alveologenesis: What Governs Secondary Septa Formation.

    Rippa, Alexandra L / Alpeeva, Elena V / Vasiliev, Andrey V / Vorotelyak, Ekaterina A

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the ... ...

    Abstract The simplification of alveoli leads to various lung pathologies such as bronchopulmonary dysplasia and emphysema. Deep insight into the process of emergence of the secondary septa during development and regeneration after pneumonectomy, and into the contribution of the drivers of alveologenesis and neo-alveolarization is required in an efficient search for therapeutic approaches. In this review, we describe the formation of the gas exchange units of the lung as a multifactorial process, which includes changes in the actomyosin cytoskeleton of alveocytes and myofibroblasts, elastogenesis, retinoic acid signaling, and the contribution of alveolar mesenchymal cells in secondary septation. Knowledge of the mechanistic context of alveologenesis remains incomplete. The characterization of the mechanisms that govern the emergence and depletion of αSMA will allow for an understanding of how the niche of fibroblasts is changing. Taking into account the intense studies that have been performed on the pool of lung mesenchymal cells, we present data on the typing of interstitial fibroblasts and their role in the formation and maintenance of alveoli. On the whole, when identifying cell subpopulations in lung mesenchyme, one has to consider the developmental context, the changing cellular functions, and the lability of gene signatures.
    MeSH term(s) Actomyosin/genetics ; Bronchopulmonary Dysplasia/genetics ; Bronchopulmonary Dysplasia/pathology ; Cell Lineage/genetics ; Cytoskeleton/genetics ; Emphysema/genetics ; Emphysema/pathology ; Gases/metabolism ; Humans ; Lung/growth & development ; Lung/pathology ; Mesoderm/cytology ; Mesoderm/metabolism ; Myofibroblasts/metabolism ; Myofibroblasts/pathology ; Organogenesis/genetics ; Pulmonary Alveoli/growth & development ; Tretinoin/metabolism
    Chemical Substances Gases ; Tretinoin (5688UTC01R) ; Actomyosin (9013-26-7)
    Language English
    Publishing date 2021-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212107
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: hTERT-Driven Immortalization of RDEB Fibroblast and Keratinocyte Cell Lines Followed by Cre-Mediated Transgene Elimination.

    Evtushenko, Nadezhda A / Beilin, Arkadii K / Dashinimaev, Erdem B / Ziganshin, Rustam H / Kosykh, Anastasiya V / Perfilov, Maxim M / Rippa, Alexandra L / Alpeeva, Elena V / Vasiliev, Andrey V / Vorotelyak, Ekaterina A / Gurskaya, Nadya G

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: The recessive form of dystrophic epidermolysis bullosa (RDEB) is a crippling disease caused by impairments in the junctions of the dermis and the basement membrane of the epidermis. Using ectopic expression of hTERT/hTERT + BMI-1 in primary cells, we ... ...

    Abstract The recessive form of dystrophic epidermolysis bullosa (RDEB) is a crippling disease caused by impairments in the junctions of the dermis and the basement membrane of the epidermis. Using ectopic expression of hTERT/hTERT + BMI-1 in primary cells, we developed expansible cultures of RDEB fibroblasts and keratinocytes. We showed that they display the properties of their founders, including morphology, contraction ability and expression of the respective specific markers including reduced secretion of type VII collagen (C7). The immortalized keratinocytes retained normal stratification in 3D skin equivalents. The comparison of secreted protein patterns from immortalized RDEB and healthy keratinocytes revealed the differences in the contents of the extracellular matrix that were earlier observed specifically for RDEB. We demonstrated the possibility to reverse the genotype of immortalized cells to the state closer to the progenitors by the Cre-dependent hTERT switch off. Increased β-galactosidase activity and reduced proliferation of fibroblasts were shown after splitting out of transgenes. We anticipate our cell lines to be tractable models for studying RDEB from the level of single-cell changes to the evaluation of 3D skin equivalents. Our approach permits the creation of standardized and expandable models of RDEB that can be compared with the models based on primary cell cultures.
    MeSH term(s) Adolescent ; Adult ; Biomarkers ; Cell Line, Transformed ; Cell Proliferation ; Cellular Senescence/genetics ; Child ; Epidermolysis Bullosa Dystrophica/etiology ; Epidermolysis Bullosa Dystrophica/metabolism ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fluorescent Antibody Technique ; Gene Knockdown Techniques ; Gene Order ; Genetic Vectors/genetics ; Homologous Recombination ; Humans ; Immunohistochemistry ; Integrases/metabolism ; Keratinocytes/metabolism ; Male ; Middle Aged ; Mutation ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Primary Cell Culture ; Proteomics/methods ; Telomerase/genetics ; Telomerase/metabolism ; Transgenes ; Young Adult
    Chemical Substances BMI1 protein, human ; Biomarkers ; Polycomb Repressive Complex 1 (EC 2.3.2.27) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2021-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22083809
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top