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Article: Application of Artificial Intelligence in Discovery and Development of Anticancer and Antidiabetic Therapeutic Agents.

Alqahtani, Amal

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 6201067

Abstract: Spectacular developments in molecular and cellular biology have led to important discoveries in cancer research. Despite cancer is one of the major causes of morbidity and mortality globally, diabetes is one of the most leading sources of group of ... ...

Abstract	Spectacular developments in molecular and cellular biology have led to important discoveries in cancer research. Despite cancer is one of the major causes of morbidity and mortality globally, diabetes is one of the most leading sources of group of disorders. Artificial intelligence (AI) has been considered the fourth industrial revolution machine. The most major hurdles in drug discovery and development are the time and expenditures required to sustain the drug research pipeline. Large amounts of data can be explored and generated by AI, which can then be converted into useful knowledge. Because of this, the world's largest drug companies have already begun to use AI in their drug development research. In the present era, AI has a huge amount of potential for the rapid discovery and development of new anticancer drugs. Clinical studies, electronic medical records, high-resolution medical imaging, and genomic assessments are just a few of the tools that could aid drug development. Large data sets are available to researchers in the pharmaceutical and medical fields, which can be analyzed by advanced AI systems. This review looked at how computational biology and AI technologies may be utilized in cancer precision drug development by combining knowledge of cancer medicines, drug resistance, and structural biology. This review also highlighted a realistic assessment of the potential for AI in understanding and managing diabetes.
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Review ; Retracted Publication
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/6201067
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Article: Psychological Impact of Acne Vulgaris on the Young Saudi Population.

Alqahtani, Amal / Alsaab, Wafa I / Altulahi, Bader

Cureus

2021 Volume 13, Issue 12, Page(s) e20509

Abstract: Background Acne is a chronic inflammatory skin disease caused by bacterial colonization that damages the pilosebaceous gland on the face and other parts of the body. It is one of the most frequent dermatologic diseases in the young population. Acne ... ...

Abstract	Background Acne is a chronic inflammatory skin disease caused by bacterial colonization that damages the pilosebaceous gland on the face and other parts of the body. It is one of the most frequent dermatologic diseases in the young population. Acne vulgaris is a devastating disease, and it has a significant impact on a patient's quality of life, influencing their self-esteem as well as their psychosocial development. This study aimed to explore the psychological symptoms associated with patients with acne, its impact on their quality of life according to their personal characteristics, and to raise the importance of observing and managing psychological symptoms during acne treatment. Methods In this cross-sectional study, data were collected through a paper questionnaire. The questionnaire was composed of two parts, the first includes data about demographics and general health while the second has details about the Dermatology Life Quality Index (DQLI); the Arabic validated version was used for data collection. Data were analyzed using SPSS version 20 (IBM Corp., Armonk, NY). Results According to the impact of acne on respondents' lives, 40.0% have no effect at all, 31.0% have small effects, 19.0% have moderate effects,9.0% have large effects, and 0.7% have extremely large effects. Conclusions Acne is a major problem that affects the quality of life of young patients. Its effect is significantly higher among less educated patients and those with a longer duration of disease.
Language	English
Publishing date	2021-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.20509
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Article ; Online: Constitutional

Al-Moghrabi, Nisreen / Al-Showimi, Maram / Alqahtani, Amal / Almalik, Osama / Alhusaini, Hamed / Almalki, Ghdah / Saad, Ajawhara / Alsunayi, Elaf

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: Breast cancer (BC) and ovarian cancer (OC) are rapidly increasing in Saudi Arabia. ...

Abstract	Breast cancer (BC) and ovarian cancer (OC) are rapidly increasing in Saudi Arabia.
MeSH term(s)	Female ; Humans ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Saudi Arabia/epidemiology ; Promoter Regions, Genetic ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; DNA Methylation ; Risk Factors ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Genetic Predisposition to Disease ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism
Chemical Substances	BRCA1 Protein ; RNA, Messenger ; BRCA1 protein, human ; MGMT protein, human (EC 2.1.1.63) ; DNA Modification Methylases (EC 2.1.1.-) ; Tumor Suppressor Proteins ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063108
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Article: Ovarian Volume of Saudi Children and Adolescents in the Southern Region Based on Ultrasound Imaging.

Soliman, Sarah A / Algatheradi, Mohammad A / Alqahtani, Amal M / Osluf, Abeer S / Ali, Nahid I / Abbdellatif, Souad E

Cureus

2023 Volume 15, Issue 6, Page(s) e40147

Abstract: Introduction Sonography is a non-invasive and painless technique used for assessing pelvic anatomy and disorder in children and adolescents. Ovarian growth patterns during infancy and puberty are not completely understood. No consensus exists about the ... ...

Abstract	Introduction Sonography is a non-invasive and painless technique used for assessing pelvic anatomy and disorder in children and adolescents. Ovarian growth patterns during infancy and puberty are not completely understood. No consensus exists about the normal measures and morphologic appearance of the ovaries in the southern region of Saudi Arabia. Therefore, this study determined the pattern of ovarian and uterine sizes among Saudi girls and their correlation with age. Methods This study was conducted in the radiology department at Abha Maternity and Children Hospital among girls between 0-13 years. All the participants underwent transabdominal ultrasound, and we measured ovarian volume, uterine length, and endometrial thickness to correlate with chronologic age using the Chi-squared test. Results A Total of 152 females were included in this study. The median age was 72 months, with a minimum of one month and a maximum of 156 months. The Chi-squared test showed a significant correlation between age and ovarian measurement. Age was positively associated with ovarian volume, uterine length, and endometrial thickness (p<0.001). Conclusion The study concluded that age strongly correlated with the size of the uterus and ovaries, which is crucial in interpreting ultrasound measurements of the pelvic organs correctly.
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40147
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Article: A New Octagonal Close Ring Resonator Based Dumbbell-Shaped Tuning Fork Perfect Metamaterial Absorber for C- and Ku-Band Applications.

Afsar, Md Salah Uddin / Faruque, Mohammad Rashed Iqbal / Hossain, Md Bellal / Siddiky, Air Mohammad / Khandaker, Mayeen Uddin / Alqahtani, Amal / Bradley, D A

Micromachines

2022 Volume 13, Issue 2

Abstract: In this paper, a new octagonal close ring resonator (OCRR)-based dumbbell-shaped tuning fork perfect metamaterial absorber for C- and Ku-band applications is presented. This design is a new combination of an octagonal ring close ring resonator with two ... ...

Abstract	In this paper, a new octagonal close ring resonator (OCRR)-based dumbbell-shaped tuning fork perfect metamaterial absorber for C- and Ku-band applications is presented. This design is a new combination of an octagonal ring close ring resonator with two dumbbell-shaped tuning forks metal strips integrated on epoxy resin dielectric substrate. The proposed perfect metamaterial absorber (PMA) is assessed by finite-integration technique (FIT)-based electromagnetic simulator-Computer simulation technology (CST) software. The anticipated assembly reveals dual resonance frequencies of 6.45 GHz and 14.89 GHz at 99.15% and 99.76% absorption, respectively, for TE incidence. The projected design is augmented through various types of parametric studies, such as design optimization, the effect of the octagonal ring resonator width, and varying the split gap of the double tuning fork. The numerical results are also investigated and verified using the equivalent circuit model, another electromagnetic simulator high frequency structural simulator (HFSS), and different array combinations that showed very negligible disparity. The TE polarization wave is applied to analyze the absorption separately and oblique incidence angle showing polarization insensitivity up to 30° and wide incident angle up to 60°. The presented metamaterial absorber is suitable for satellite communication bands, stealth-coating technology, and defense and security applications.
Language	English
Publishing date	2022-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13020162
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Article: Development and Analysis of Coding and Tailored Metamaterial for Terahertz Frequency Applications.

Ramachandran, Tayaallen / Faruque, Mohammad Rashed Iqbal / Islam, Mohammad Tariqul / Khandaker, Mayeen Uddin / Alqahtani, Amal / Bradley, D A

Materials (Basel, Switzerland)

2022 Volume 15, Issue 8

Abstract: This study represents the development and analysis of the types of metamaterial structures for terahertz frequency. Recently, investigations about unique coding metamaterial have become well-known among the scientific community since it can manipulate ... ...

Abstract	This study represents the development and analysis of the types of metamaterial structures for terahertz frequency. Recently, investigations about unique coding metamaterial have become well-known among the scientific community since it can manipulate electromagnetic (EM) waves by utilizing various coding sequences. Therefore, several coding and tailored metamaterial designs were compared and numerically analyzed the performances in this research work. The 1-bit coding metamaterial made up of only "0" and "1" elements by adopting two types of unit cells with 0 and π phase responses were analyzed for the coding metamaterial. Moreover, for the numerical simulation analyses, the well-known Computer Simulation Technology (CST) Microwave Studio software was adopted. This investigation focused on the frequency ranges from 0 to 5 THz. On the other hand, the proposed designs were simulated to find their scattering parameter behavior. The comparison of coding and tailored metamaterial revealed slight differences in the RCS values. The coding metamaterial designs manifested RCS values less than -50 dBm
Language	English
Publishing date	2022-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15082777
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Article ; Online: The effectiveness of ornamental building materials (tiles) for retrospective thermoluminescence dosimetry.

Yasmin, Sabina / Khandaker, Mayeen Uddin / Nawi, Siti Nurasiah Mat / Sani, Siti Fairus Abdul / Bradley, D A / Alqahtani, Amal / Faruque, Mohammad Rashed Iqbal

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2022 Volume 184, Page(s) 110218

Abstract: Like many other decorative building materials, tiles are one of the most precious ornamental ingredients for making a lucrative building image. It not only offers beauty and luxury but also added value by protecting/monitoring ionizing radiation. In this ...

Abstract	Like many other decorative building materials, tiles are one of the most precious ornamental ingredients for making a lucrative building image. It not only offers beauty and luxury but also added value by protecting/monitoring ionizing radiation. In this study, the utmost regular use of seven varieties of tile samples has been considered for retrospective thermoluminescence dosimetry. To observe the potentials of tiles for retrospective dosimetry, the major thermoluminescence properties (such as dose-response, energy dependence, self-sensitivity, relative sensitivity, glow curves, repeatability, fading, and also effective atomic number) has been investigated following the annealing - irradiation - readout cycles. Making an allowance for the various TL parameters, White Horse (Mirror Polish) tiles demonstrate suitability to be used as emergency TL dosimeter in 0.5-100 Gy dose array. Comparing the values of Z
MeSH term(s)	Construction Materials ; Radiation Dosimeters ; Radiometry/methods ; Retrospective Studies ; Thermoluminescent Dosimetry/methods
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2022.110218
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Article ; Online: Low-cost commercial borosilicate glass slides for passive radiation dosimetry.

Abdul Sani, S F / Othman, M H U / Alqahtani, Amal / Almugren, K S / Alkallas, F H / Bradley, D A

PloS one

2020 Volume 15, Issue 12, Page(s) e0241550

Abstract: For x- and gamma- irradiations delivering entrance doses from 2- up to 1000 Gy to commercial 1.0 mm thick borosilicate glass microscope slides, study has been made of their thermoluminescence yield. With an effective atomic number of 10.6 (approximating ... ...

Abstract	For x- and gamma- irradiations delivering entrance doses from 2- up to 1000 Gy to commercial 1.0 mm thick borosilicate glass microscope slides, study has been made of their thermoluminescence yield. With an effective atomic number of 10.6 (approximating bone equivalence), photon energy dependency is apparent in the low x-ray energy range, with interplay between the photoelectric effect and attenuation. As an example, over the examined dose range, at 120 kVp the photon sensitivity has been found to be some 5× that of 60Co gamma irradiations, also with repeatability to within ~1%. The glow-curves, taking the form of a single prominent broad peak, have been deconvolved yielding at best fit a total of five peaks, the associated activation energies and frequency factors also being obtained. The results indicate borosilicate glass slides to offer promising performance as a low-cost passive radiation dosimeter, with utility for both radiotherapy and industrial applications.
MeSH term(s)	Boron Compounds/chemistry ; Boron Compounds/radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Humans ; Photons ; Radiation Dosage ; Radiation Dosimeters ; Silicates/chemistry ; Silicates/radiation effects ; Thermoluminescent Dosimetry/instrumentation ; Thermoluminescent Dosimetry/methods ; X-Rays
Chemical Substances	Boron Compounds ; Silicates
Language	English
Publishing date	2020-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0241550
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Article ; Online: Microscope cover-slip glass for TLD applications.

Alqahtani, Amal / Sani, S F Abdul / Narissa, N H Amiera / Alanazi, Abdulaziz / Podolyak, Z / Nisbet, A / Bradley, D A

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2020 Volume 160, Page(s) 109132

Abstract: As a result of the various evolving needs, thermoluminescence dosimetry is constantly under development, with applications intended in environmental and personal radiation monitoring through to the sensing of radiotherapy and radiation processing doses. ... ...

Abstract	As a result of the various evolving needs, thermoluminescence dosimetry is constantly under development, with applications intended in environmental and personal radiation monitoring through to the sensing of radiotherapy and radiation processing doses. In radiotherapy dosimetry challenges include small-field profile evaluation, encompassing the fine beams of radiosurgery, evaluations confronting the steep dose gradients of electronic brachytherapy and the high dose rates of FLASH radiotherapy. Current work concerns the thermoluminescent dosimetric properties of commercial low-cost borosilicate glass in the form of thin (sub-mm to a few mm) plates, use being made of microscope cover-slips irradiated using clinical external-beam radiotherapy facilities as well as through use of
MeSH term(s)	Glass ; Microscopy/instrumentation ; Thermoluminescent Dosimetry/instrumentation
Language	English
Publishing date	2020-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2020.109132
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Article: Toxocara Awareness Among Medical Practitioners in Saudi Arabia

Omer, Fakhreldin M. / Awadalla, Nabil J. / Alsaleem, Safar Abadi / Alsaleem, Mohammed Abadi / Moosa, Riyad A. / Alqahtani, Mohamed A. / Asiri, Abdulmageed A. / Alahmari, Ebtesam M. / Alqahtani, Amal N. / Mahfouz, Ahmed A.

EcoHealth. 2021 Mar., v. 18, no. 1

2021

Abstract: Human toxocariasis is a zoonotic infection with global and regional impacts. Worldwide it is underestimated and clinically overlooked. Medical practitioners are generally unaware of the extent of the resulting disease spectrum. The objective of the study ...

Abstract	Human toxocariasis is a zoonotic infection with global and regional impacts. Worldwide it is underestimated and clinically overlooked. Medical practitioners are generally unaware of the extent of the resulting disease spectrum. The objective of the study was to assess knowledge and disease awareness among medical practitioners in Aseer, south-western Saudi Arabia. A questionnaire addressing knowledge about the parasite, its visceral larva migrans and the disease spectrum generated was used to interview participants. The study included 285 participants. In answer to the question what is toxocara, only 27%, answered correctly that it is a nematode, paediatricians being the majority. With regard to years of experience among participants, 56.8% of those who answered correctly had less than 5-year experience, as opposed to 35.4% for those with more than 10-year experience. The cumulative awareness about the disease manifestations and spectrum, i.e. those who knew, was less than 30% across specialties and years of experiences. Lack of awareness regarding Toxocara infection and the disease spectrum it can generate is evident. The consequence for such lack of knowledge within our practising medical community is simply unacceptable as it might translate into misdiagnosis and consequently misguided treatment.
Keywords	Toxocara ; environmental health ; humans ; larva migrans ; parasites ; questionnaires ; toxocariasis ; zoonoses ; Saudi Arabia
Language	English
Dates of publication	2021-03
Size	p. 107-112.
Publishing place	Springer US
Document type	Article
ZDB-ID	2164327-1
ISSN	1612-9210 ; 1612-9202
ISSN (online)	1612-9210
ISSN	1612-9202
DOI	10.1007/s10393-021-01529-9
Database	NAL-Catalogue (AGRICOLA)

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