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  1. Article: Evaluation of phytochemical, anti-oxidant and cardiac depressant effect of Rumex dentatus by using Langendorff's isolated heart apparatus.

    Alyami, Bandar Ali / Akhtar, Suneela / Alamgeer, - / Ahmad, Taseer / Alqarni, Ali Omar / Alqahtani, Yahya Saeed / Mahnashi, Mater Hussen / Qasim, Sumera / Irfan, Hafiz Muhammad / Akram, Muhammad / Riaz, Humayun / Anwar, Rukhsana

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 2(Supplementary), Page(s) 671–677

    Abstract: Rumex dentatus has been used traditionally for ailment of cardiovascular diseases. The aim of the present study was to assess cardiovascular effects in isolated perfused rabbit heart. Aqueous and n-butanolic fractions were assessed for their effect on ... ...

    Abstract Rumex dentatus has been used traditionally for ailment of cardiovascular diseases. The aim of the present study was to assess cardiovascular effects in isolated perfused rabbit heart. Aqueous and n-butanolic fractions were assessed for their effect on perfusion pressure (PP), force of contraction (FC) and heart rate (HR) of rabbit heart using Langendorff's method. The possible mechanisms of action of extracts/fraction were assessed with and without application of different agonist/antagonist. Phytochemical, toxicity and anti-oxidant activities were also determined. Both extracts at 1mg/mL dose produced a highly significant decrease in FC and HR but PP remained unchanged. Moreover, aqueous fraction of Rumex dentatus at 0.001mg/mL dose produced a highly significant decrease in FC and HR but no significant change in PP was observed. Atropine 10
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Atropine/pharmacology ; Calcium Chloride/pharmacology ; Cardiovascular Agents/adverse effects ; Cardiovascular Agents/pharmacology ; Epinephrine/pharmacology ; Female ; Heart/drug effects ; Heart Rate/drug effects ; Isolated Heart Preparation/methods ; Male ; Mice ; Myocardial Contraction/drug effects ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Rumex/adverse effects ; Rumex/chemistry
    Chemical Substances Antioxidants ; Cardiovascular Agents ; Plant Extracts ; Atropine (7C0697DR9I) ; Calcium Chloride (M4I0D6VV5M) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2021-06-30
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Endothelium independent calcium channel blocking pathways mediate antihypertensive effect of morus nigra.

    Chaudhry, Mueen Ahmad / Alamgeer, - / Mushtaq, Muhammad Naveed / Alqarni, Ali Omar / Alyami, Bandar Ali / Mahnashi, Mater Hussen / Alqahtani, Yahya Saeed / Akram, Muhammad / Irfan, Hafiz Muhammad / Riaz, Humayun / Qasim, Sumera

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 2(Supplementary), Page(s) 781–785

    Abstract: Present study was conducted to validate the folkloric claims of morus nigra l. (moraceae) using invasive blood pressure measuring and ex vivo vasorelaxant experimental techniques. Intravenous administration of mn. Aq in 0.01-30 mg/kg doses caused ... ...

    Abstract Present study was conducted to validate the folkloric claims of morus nigra l. (moraceae) using invasive blood pressure measuring and ex vivo vasorelaxant experimental techniques. Intravenous administration of mn. Aq in 0.01-30 mg/kg doses caused significant decrease in mean arterial pressure and heart rate in fructose-induced hypertensive rats. It also showed relaxation in high k
    MeSH term(s) Administration, Intravenous ; Animals ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Calcium Channels/drug effects ; Disease Models, Animal ; Endothelium, Vascular/drug effects ; Fruit/chemistry ; Heart Rate/drug effects ; Hypertension/drug therapy ; Male ; Morus/chemistry ; Plant Extracts/pharmacology ; Rats
    Chemical Substances Antihypertensive Agents ; Calcium Channels ; Plant Extracts
    Language English
    Publishing date 2021-06-30
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Appraisal of hypotensive effect of natural monoterpene: Bornyl acetate and in-silico molecular docking analysis.

    Noor, Nabeela / Alamgeer, - / Alyami, Bandar Ali / Alqarni, Ali Omar / Alqahtani, Yahya Saeed / Mahnashi, Mater Hussen / Akram, Muhammad / Qasim, Sumera / Younis, Waqas / Ali, Ejaz / Shamim, Rahat

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 2(Supplementary), Page(s) 731–735

    Abstract: The modern trend of research is highly focused on finding new bioactive molecules from medicinal plants. As a functional bicyclic monoterpene, Bornyl acetate (BA) has displayed antioxidant and anti-inflammatory properties in different types of cells and ... ...

    Abstract The modern trend of research is highly focused on finding new bioactive molecules from medicinal plants. As a functional bicyclic monoterpene, Bornyl acetate (BA) has displayed antioxidant and anti-inflammatory properties in different types of cells and tissues. The purpose of this research was to evaluate the probable hypotensive effect of BA, an underlying mechanism(s) backboned by in-silico studies. Mean arterial pressure and heart rate were recorded via invasive blood pressure measuring technique in normotensive Sprague-Dawley rats following the administration of BA (1-80mg/kg). Docking studies were carried out with various targets involved in the pathophysiology of hypertension.RO5 and ADMET properties were also evaluated. In the current study dose-dependent reduction in systolic, diastolic and mean arterial pressure was observed. Pretreatment with atropine and captopril significantly (p<0.001) reduced the hypotensive effect produced by BA. On the other hand docking studies showed pronounced interactions with M2 mAch receptor in an agonistic way and ACE protein in an antagonistic way. BA justified all cut-off limits of RO5 and had an acceptable predicted computational toxicity profile. Results postulate that dose-dependent hypotensive effect of BA is mediated through the muscarinic pathway and ACE inhibitory activity corresponding well with findings of in-silico studies.
    MeSH term(s) Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Camphanes/chemistry ; Camphanes/pharmacology ; Computer Simulation ; Heart Rate/drug effects ; Molecular Docking Simulation ; Molecular Structure ; Monoterpenes/chemistry ; Monoterpenes/pharmacology ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Antihypertensive Agents ; Camphanes ; Monoterpenes ; bornyl acetate (213431586X)
    Language English
    Publishing date 2021-06-30
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article: Antihypertensive and safety studies of Cydonia oblonga M.

    Ur Rahman, Muhammad Shafeeq / Saleem, Muhammad / Alamgeer, - / Mahnashi, Mater Hussen / Alqahtani, Yahya Saeed / Alqarni, Ali Omar / Alyami, Bandar Ali / Mushtaq, Muhammad Naveed / Qasim, Sumera

    Pakistan journal of pharmaceutical sciences

    2021  Volume 34, Issue 2(Supplementary), Page(s) 687–691

    Abstract: Antihypertensive studies on aqueous-methanolic extract prepared from seeds of Cydonia oblonga M. were carried out. The test extract in 200, 400 and 600 mg/kg doses was investigated in normotensive, high cholesterol and glucose fed hypertensive rats ... ...

    Abstract Antihypertensive studies on aqueous-methanolic extract prepared from seeds of Cydonia oblonga M. were carried out. The test extract in 200, 400 and 600 mg/kg doses was investigated in normotensive, high cholesterol and glucose fed hypertensive rats through non-invasive blood pressure measuring technique. Acute and sub-chronic toxicity studies were conducted in mice and rats, respectively. The test extract significantly decreased dose dependently the systolic, diastolic and mean arterial pressures. The test extract in 600mg/kg dose produced maximum effect and prevented rise in blood pressure of high cholesterol diet and glucose fed rats as compare to control in 21 days studies. The extract was found safe up to 4g/kg dose in mice. In sub-chronic toxicity study, no significant alteration in blood chemistry of extract treated rats was observed except reduction in the low density cholesterol levels. It is concluded that Cydonia oblonga seeds extract possess antihypertensive effect which supports its use in folklore.
    MeSH term(s) Animals ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Hypertension/drug therapy ; Male ; Mice ; Plant Extracts/adverse effects ; Plant Extracts/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Rosaceae/adverse effects ; Rosaceae/chemistry ; Seeds/adverse effects ; Seeds/chemistry
    Chemical Substances Antihypertensive Agents ; Plant Extracts
    Language English
    Publishing date 2021-06-30
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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