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Article ; Online: Treatment of dental plaque biofilms using photodynamic therapy: a randomised controlled study.

Alsaif, A / Tahmassebi, J F / Wood, S R

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2021 Volume 22, Issue 5, Page(s) 791–800

Abstract: Introduction: Photodynamic therapy (PDT) is a treatment modality involving a dye that is activated by exposure to light of a specific wavelength in the presence of oxygen to form oxygen species causing localised damage to microorganisms.: Aim: To ... ...

Abstract	Introduction: Photodynamic therapy (PDT) is a treatment modality involving a dye that is activated by exposure to light of a specific wavelength in the presence of oxygen to form oxygen species causing localised damage to microorganisms. Aim: To determine the most effective bactericidal incubation and irradiation times of erythrosine-based PDT on in vivo-formed dental plaque biofilms. Methods: A randomised controlled study; 18-healthy adult participants wearing intraoral appliances with human enamel slabs to collect dental plaque samples in two separate periods of two weeks each for use in arm-1 and arm-2. These accumulated dental plaque samples were treated with PDT under different experimental conditions. Incubation times with photosensitiser (erythrosine) of 15 min and 2 min were used in arm-1 and arm-2, respectively, followed by light irradiation for either 15 min (continuous) or as a fractionated dose (5 × 30 sec). Following treatment, percentage reductions of total bacterial counts were compared between the different groups. In addition, confocal laser scanning microscopy (CLSM) and LIVE/DEAD® BacLight™ Bacterial Viability Kit were used to visualise the effect of PDT on in vivo-formed biofilms. Results: Significant reductions in the percentage of total bacterial counts (~93-95%) of in vivo-formed biofilms were found when using either 2 min or 15min incubation times and applying 15 min continuous light. Although when applying fractionated light, there was more cell death when 15 min incubation time was used (~ 91%) compared with the 2 min incubation time (~ 64%). CLSM results supported these findings. Conclusion: Improving the clinical usefulness of PDT by reducing its overall treatment time seems to be promising and effective in killing in vivo-formed dental plaque biofilms.
MeSH term(s)	Biofilms ; Dental Plaque ; Erythrosine ; Humans ; Photochemotherapy ; Photosensitizing Agents/therapeutic use
Chemical Substances	Photosensitizing Agents ; Erythrosine (PN2ZH5LOQY)
Language	English
Publishing date	2021-06-05
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-021-00637-y
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Zs.A 6730: Show issues

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Article ; Online: Ultrasonography-guided Drainage Versus Surgical Drainage for Deep Neck Space Abscesses: A Systematic Review and Meta-analysis.

Alzaid, Mohammad / Ramadhan, Mohammed / Abul, Ahmad / Karam, Mohammad / Alsaif, Abdulmalik / Stapleton, Emma

The Journal of laryngology and otology

2024 , Page(s) 1–28

Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215124000501
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Article ; Online: Knowledge and attitudes about obstructive sleep apnea among otorhinolaryngology trainee residents in Saudi Arabia: A survey-based cross-sectional study.

Alsaif, Abdulrahman / Aldilaijan, Khalid / Almasoud, Mai / Jebakumar, Arulanantham Zechariah

MedEdPublish (2016)

2022 Volume 12, Page(s) 58

Abstract: Background: Obstructive sleep apnea is a common disorder frequently encountered in otorhinolaryngology practice. This study was conducted to assess the knowledge and attitudes toward obstructive sleep apnea among otorhinolaryngology trainees in Saudi ... ...

Abstract	Background: Obstructive sleep apnea is a common disorder frequently encountered in otorhinolaryngology practice. This study was conducted to assess the knowledge and attitudes toward obstructive sleep apnea among otorhinolaryngology trainees in Saudi Arabia. Methods: This was a survey-based cross-sectional study. An online questionnaire was sent in July 2020 via email and WhatsApp instant messaging to all otorhinolaryngology trainee residents in Saudi Arabia. We utilized the previously validated obstructive sleep apnea knowledge and attitudes questionnaire (OSAKA). Results: 32.4% of all email recipients completed the questionnaire and met the inclusion criteria. 66.7% were males, thirty-two participants (53.3%) were at the junior level (R2-R3), and twenty-eight (46.7%) were at the senior level (R4-R5). The mean total knowledge score was 13.98/18. Senior residents had a higher mean total knowledge score than junior residents. Senior residents had a higher mean total attitude score than junior residents. Age, gender, residency program area, and years of previous otorhinolaryngology practice showed no significant differences in terms of knowledge levels and attitudes toward obstructive sleep apnea. Exposure to obstructive sleep apnea surgery and awareness of sleep disorders other than sleep apnea were found to be associated with an increased level of confidence in identifying patients at risk of obstructive sleep apnea and in the ability to manage them. Conclusions: This study describes the current condition of obstructive sleep apnea knowledge and attitudes among otorhinolaryngology residents in Saudi Arabia. Addressing studied elements may improve training outcomes.
Language	English
Publishing date	2022-08-17
Publishing country	Scotland
Document type	Journal Article
ISSN	2312-7996
ISSN (online)	2312-7996
DOI	10.12688/mep.19245.1
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Article: Juvenile ossifying fibroma in anterior ethmoidal sinus in B-cell acute lymphoblastic leukemia and MHC class II deficiency patient: Case report.

Alnasser, Abdulaziz Ali / Alsaif, Abdurhman / Alassiri, Ali H / M Alenezi, Mazyad / Alshammari, Jaber

International journal of surgery case reports

2023 Volume 106, Page(s) 108133

Abstract: Introduction and importance: Juvenile ossifying fibromas (JOF) are rare benign tumors affecting the craniofacial area, and they present more in younger age groups. JOFs are aggressive lesions and have a high tendency for recurring after surgical ... ...

Abstract	Introduction and importance: Juvenile ossifying fibromas (JOF) are rare benign tumors affecting the craniofacial area, and they present more in younger age groups. JOFs are aggressive lesions and have a high tendency for recurring after surgical resection. Case presentation: A 9-years-old female who was a known case of major histocompatibility complex class II deficiency since birth and post hematopoietic stem cell transplant was diagnosed with B-cell acute lymphoblastic leukemia (ALL). Right anterior ethmoidal sinus opacification with mucosal thickening found on sinus imaging was initially thought to be infectious in origin due to the patient's immunodeficiency. However, further investigation and endoscopic sinus surgery with lesion debridement and biopsy revealed psammomatoid JOF. Follow up and imaging results urged the need for a second surgery, but no recurrence was detected. As the patient's ALL was being treated, the case was followed up for two months with imaging showing opacification in multiple sinuses which was suspected to be fungal infection due to immunodeficiency. The complicated character of the case may have hindered any additional invasive management. Opacification persisted despite conservative management. Unfortunately, the patient suffered from disease complication, infections, and died from multi-organ failure. Clinical discussion: This case highlights the importance of a thorough diagnostic workup and management strategy for immunodeficient patients with JOF. JOF's recurrent nature along with the pre-existing immunodeficiency made this case difficult to manage as the patient had other life-threatening condition. Conclusion: Specific management considerations should take place in immunocompromised patients. Post-operative long-term follow-ups are needed for early detection of recurrence.
Language	English
Publishing date	2023-04-07
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2023.108133
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Article: The Uses of Photodynamic Therapy Versus Anti-vascular Endothelial Growth Factor in the Management of Acute Central Serous Chorioretinopathy: A Systematic Review and Meta-Analysis.

Seraj, Hadeel / Alhamoud, Mustafa / Khoshhal, Mohammed S / Alhashim, Hassan / Alsaif, Anas / Abukhashabah, Amro

Cureus

2023 Volume 15, Issue 9, Page(s) e46100

Abstract: Central serous chorioretinopathy (CSCR) is an idiopathic chorioretinal disease characterized by localized serous detachment of the neurosensory retina at the macula. To date, there is no high-quality evidence of recent updates on treating acute CSCR, ... ...

Abstract	Central serous chorioretinopathy (CSCR) is an idiopathic chorioretinal disease characterized by localized serous detachment of the neurosensory retina at the macula. To date, there is no high-quality evidence of recent updates on treating acute CSCR, focusing on photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF). Hence, this review aims to conduct a comprehensive systematic review of the most recent therapeutic approaches for acute CSCR using the following electronic databases for a comprehensive and systematic literature review: MEDLINE, EMBASE, and Cochrane. In addition, we analyzed studies comparing PDT with placebo, anti-VEGF with placebo, or PDT with anti-VEGF in treating acute CSC eyes with no previous intervention. Seven studies were included, with a total of 292 eyes. The overall positive results were significantly higher among patients who received PDT compared to control groups (odds ratio [OR] = 7.96, 95% confidence interval [CI], 3.02 to 20.95, p < 0.001). The proportions of positive results were 81.0% and 97.1% among patients who received anti-VEGF and PDT, respectively, with no statistically significant differences between the groups. In addition, there were no significant differences between anti-VEGF and control groups. In contrast, PDT was significantly associated with lower recurrence odds than the control groups (OR = 0.12, 95% CI, 0.04 to 0.39, p = 0.042). According to our findings, PDT showed higher positive results than anti-VEGF in acute CSCR. In addition, PDT was significantly associated with a lower recurrence rate than the control group. However, the analysis needs to be confirmed and updated by large-scale, well-designed randomized clinical trials.
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46100
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Article ; Online: Muller's muscle conjunctival resection versus external levator advancement for ptosis repair: systematic review and meta-analysis.

Karam, Mohammad / Alsaif, Abdulmalik / Abul, Ahmad / Alkhabbaz, Ali / Alotaibi, Abdulaziz / Shareef, Eiman / Behbehani, Raed

International ophthalmology

2023 Volume 43, Issue 7, Page(s) 2563–2573

Abstract: Purpose: To compare the outcome of Muller's muscle conjunctival resection (MMCR) versus external levator advancement (ELA) in patients undergoing ptosis surgery.: Methods: A systematic review and meta-analysis were performed as per the Preferred ... ...

Abstract	Purpose: To compare the outcome of Muller's muscle conjunctival resection (MMCR) versus external levator advancement (ELA) in patients undergoing ptosis surgery. Methods: A systematic review and meta-analysis were performed as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, and a search of electronic information was conducted to identify all comparative studies of MMCR versus ELA in ptosis repair. The primary outcome measures were the post-operative marginal reflex distance (MRD1), ptosis under-correction, over-correction, and re-operation rate. Secondary outcome measures included cosmetic appearance, complications, operative time, and learning curve. Fixed-effect modelling was used for the analysis. Results: Seven studies that enrolled 1038 eyelids were identified in the literature. There was no statistically significant difference between the MMCR and ELA groups in post-operative MRD1 (Mean Difference [MD] = 0.13, P = 0.28) and the rate of under-correction odds ratio [OR] = 0.49, P = 0.14). However, ELA had a significantly higher rate of over-correction (OR = 0.17, P = 0.04) and re-operations (OR = 0.26, P = 0.0001) compared to MMCR. For secondary outcomes, MMCR had an improved cosmetic appearance, lower total number of complications and shorter operation time (MD = - 10.96, P < 0.00001). Finally, the two techniques had no significant difference in the learning curves. Conclusion: Both MMCR and ELA are effective techniques for the surgical correction of ptosis; however, MMCR surgery is a more predictable and robust technique compared to, ELA with lower rates of over-correction and re-operation.
MeSH term(s)	Humans ; Eyelids/surgery ; Blepharoplasty/methods ; Conjunctiva/surgery ; Blepharoptosis/surgery ; Oculomotor Muscles/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-01-24
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-023-02633-1
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Zs.A 1479: Show issues

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Article: Synchronous incidental double parathyroid adenomas and papillary thyroid carcinoma: A case report with literature review.

Alghamdi, M A / Alsaif, A / Altwijri, A S / Alsaif, F A / Alsunitan, R I / Almoagal, R O

Nigerian journal of clinical practice

2021 Volume 24, Issue 6, Page(s) 954–963

Abstract: The association between parathyroid and thyroid diseases is not uncommon; however, the concurrent presence of parathyroid adenoma and thyroid cancer is rare. Awareness of this situation will enable clinicians to consider possible parathyroid pathology in ...

Abstract	The association between parathyroid and thyroid diseases is not uncommon; however, the concurrent presence of parathyroid adenoma and thyroid cancer is rare. Awareness of this situation will enable clinicians to consider possible parathyroid pathology in patients with papillary thyroid cancer. The presence of parathyroid adenoma leading to primary hyperparathyroidism and the coexistence of thyroid papillary cancer is rare. We report a case of a 55-year-old female with papillary cancer admitted for surgery. Preoperative laboratory findings revealed normal calcium level and normal intact parathyroid hormone (PTH) level. Thyroidectomy and excision of abnormal enlarged double parathyroid glands were performed. Histological examination revealed parathyroid adenoma. Serum calcium was within the normal range after surgery. We recommend a preoperative check of calcium in patients with thyroid cancer.
MeSH term(s)	Carcinoma, Papillary/surgery ; Female ; Humans ; Middle Aged ; Parathyroid Glands ; Parathyroid Neoplasms/complications ; Parathyroid Neoplasms/surgery ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/surgery
Language	English
Publishing date	2021-06-14
Publishing country	India
Document type	Case Reports ; Review
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_635_19
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Zs.A 4975: Show issues

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Article: Proteomic profiling of thyroid tissue in patients with obesity and benign diffuse goiter.

Benabdelkamel, Hicham / Rafiullah, Mohamed / Masood, Afshan / Alsaif, Abdulaziz / Musambil, Mohthash / Alfadda, Assim A

Frontiers in endocrinology

2022 Volume 13, Page(s) 923465

Abstract: Goiter is a term to describe the enlargement of the thyroid gland. The pathophysiology and molecular changes behind development of diffuse benign goiter remains unclear. The present study targeted to identify and describe the alterations in the thyroid ... ...

Abstract	Goiter is a term to describe the enlargement of the thyroid gland. The pathophysiology and molecular changes behind development of diffuse benign goiter remains unclear. The present study targeted to identify and describe the alterations in the thyroid tissue proteome from patients (obese euthyroid) with benign diffuse goiter (BDG) using proteomics approach. Thyroid tissue samples, from 7 age and sex matched, patients with BDG and 7 controls were obtained at the time of surgery. An untargeted proteomic analysis of the thyroid tissue was performed out utilizing two-dimensional difference (2D-DIGE) in gel electrophoresis followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) for identification of the proteins. Progenesis software was used to identify changes in expression of tissue proteins and found statistically significant differences in abundance in a total of 90 proteins, 46 up and 44 down (1.5-fold change, ANOVA, p ≤ 0.05) in BDG compared to the control group. Bioinformatic analysis using Ingenuity Pathway Analysis (IPA) identified dysregulation of signalling pathways linked to ERK1/2, Glutathione peroxidase and NADPH oxidase associated to organismal injury and abnormalities, endocrine system disorders and cancer. The thyroid tissue proteome in patients with BDG revealed a significant decrease in thyroglobulin along with dysregulation of glycolysis and an increase in prooxidant peroxidase enzymes. Dysregulation of metabolic pathways related to glycolysis, redox proteins, and the proteins associated with maintaining the cytoskeletal structure of the thyrocytes was also identified.
MeSH term(s)	Goiter ; Humans ; Obesity ; Proteome/analysis ; Proteomics/methods
Chemical Substances	Proteome
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.923465
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Article ; Online: Full thickness skin graft versus split thickness skin graft in paediatric patients with hand burns: Systematic review and meta-analysis.

Alsaif, Abdulmalik / Karam, Mohammad / Hayre, Amrit / Abul, Ahmad / Aldubaikhi, Ahmed / Kahlar, Narvair

Burns : journal of the International Society for Burn Injuries

2022 Volume 49, Issue 5, Page(s) 1017–1027

Abstract: Our objective was to compare the outcomes of full thickness skin grafts versus split thickness skin grafts in paediatric hand burn patients. A systematic review and meta-analysis were carried out in accordance with the Preferred Reporting Items for ... ...

Abstract	Our objective was to compare the outcomes of full thickness skin grafts versus split thickness skin grafts in paediatric hand burn patients. A systematic review and meta-analysis were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Guidelines, and an electronic search was conducted to identify all Randomised Controlled Trials and non-randomised studies comparing the outcomes of full thickness skin grafts versus split thickness skin grafts in paediatric hand burn patients. Primary outcomes included development of post-graft contracture and the necessity for surgical release. Secondary outcomes consisted of evaluation of function, cosmesis and colour, scar and feeling, hair growth, and other complaints. For the analysis, fixed effects modelling was applied. Results: ten non-randomised trials with a total of 532 grafts were found. Full thickness skin grafts exhibited a statistically significant decrease in the development of post-graft contracture (Odds Ratio [OR] = 0.35, P = 0.0001) and later surgical releases (OR = 0.06, P = 0.00001). For secondary outcomes, full thickness skin grafts outperformed split thickness skin grafts in post-operative functional ability. However, split thickness skin grafts, showed to be superior in scar, aesthetic, and colour assessments, and less hair growth was observed for split thickness skin grafts. No significant difference was seen in sensation and donor or recipient site complaints. Overall, full thickness skin grafts are a better alternative for paediatric hand burns than split thickness skin transplants because they are linked with reduced post-graft contracture and the requirement for surgical release.
MeSH term(s)	Child ; Humans ; Skin Transplantation/adverse effects ; Cicatrix/surgery ; Cicatrix/complications ; Burns/surgery ; Burns/complications ; Contracture/etiology ; Contracture/surgery ; Hand Injuries/surgery ; Hand Injuries/complications ; Wrist Injuries
Language	English
Publishing date	2022-09-29
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2022.09.010
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Zs.A 1250: Show issues

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Article ; Online: Extended Depth of Focus Versus Trifocal for Intraocular Lens Implantation: An Updated Systematic Review and Meta-Analysis.

Karam, Mohammad / Alkhowaiter, Nahlaa / Alkhabbaz, Ali / Aldubaikhi, Ahmed / Alsaif, Abdulmalik / Shareef, Eiman / Alazaz, Rand / Alotaibi, Abdulaziz / Koaik, Mona / Jabbour, Samir

American journal of ophthalmology

2023 Volume 251, Page(s) 52–70

Abstract: Purpose: To compare the extended depth of focus (EDOF) vs trifocal intraocular lenses (IOLs) in patients undergoing IOL implantation.: Design: Systematic review and meta-analysis.: Methods: An electronic search was conducted as per the Preferred ... ...

Abstract	Purpose: To compare the extended depth of focus (EDOF) vs trifocal intraocular lenses (IOLs) in patients undergoing IOL implantation. Design: Systematic review and meta-analysis. Methods: An electronic search was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to include studies comparing EDOF vs trifocal IOLs. Refraction and visual acuity were primary outcomes. Secondary outcomes included defocus curves, intraocular aberrations, contrast sensitivity (CS), quality of vision (QoV) questionnaire score, haloes and glare, spectacle independence, and patient satisfaction. Results: A total of 22 studies enrolling 2200 eyes were identified. Trifocal IOL showed a significant improvement in sphere (mean difference [MD] = -0.23; P = .001) and spherical equivalence (MD = -0.11, P = .0001) compared to EDOF IOL. No difference was observed in cylinder (MD = -0.03, P = .25) or astigmatism. Trifocal IOL had superior near visual acuity outcomes, namely uncorrected near visual acuity (MD = 0.12, P < .00001) and distance-corrected near visual acuity (MD = 0.12, P = .002). Postoperative corrected distance visual acuity (MD = -0.01, P = .01) was significantly improved for the EDOF group, although no difference was noted in postoperative uncorrected distance visual acuity (MD = 0.00, P = .84), uncorrected intermediate visual acuity (MD = 0.01, P = .68) or distance-corrected intermediate visual acuity (MD = -0.01, P = .39). Defocus curve favored trifocal IOLs at near vision and EDOF IOLs at intermediate vision. Ocular aberration, CS, haloes (odds ratio = 0.64, P = .10), glare, and patient satisfaction were not statistically significant between the groups. The trifocal IOL was associated with an improved QoV questionnaire score (MD = 1.24, P = 0.03) and spectacle independence (odds ratio = 0.26, P = .02). Conclusions: Trifocal IOLs improved uncorrected near visual acuity compared to EDOF IOLs. Uncorrected distance and intermediate visual acuity, halos, and glare were not statistically different between both groups.
MeSH term(s)	Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Visual Acuity ; Refraction, Ocular ; Cataract Extraction ; Patient Satisfaction ; Prosthesis Design ; Phacoemulsification ; Pseudophakia
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2023.01.024
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