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Article ; Online: Mesenchymal stem cells and their extracellular vesicles as emerging therapeutic tools in the treatment of ischemic stroke.

Pratiwi, Dewi Indah Noviana / Alhajlah, Sharif / Alawadi, Ahmed / Hjazi, Ahmed / Alawsi, Taif / Almalki, Sami G / Alsalamy, Ali / Kumar, Abhinav

Tissue & cell

2024 Volume 87, Page(s) 102320

Abstract: Ischemic stroke (IS) is a neurological condition characterized by severe long-term consequences and an unfavorable prognosis for numerous patients. Despite advancements in stroke treatment, existing therapeutic approaches possess certain limitations. ... ...

Abstract	Ischemic stroke (IS) is a neurological condition characterized by severe long-term consequences and an unfavorable prognosis for numerous patients. Despite advancements in stroke treatment, existing therapeutic approaches possess certain limitations. However, accumulating evidence suggests that mesenchymal stem/stromal cells (MSCs) hold promise as a potential therapy for various neurological disorders, including IS, owing to their advantageous properties, such as immunomodulation and tissue regeneration. Additionally, MSCs primarily exert their therapeutic effects through the release of extracellular vesicles (EVs), highlighting the significance of their paracrine activities. These EVs are small double-layered phospholipid membrane vesicles, carrying a diverse cargo of proteins, lipids, and miRNAs that enable effective cell-to-cell communication. Notably, EVs have emerged as attractive substitutes for stem cell therapy due to their reduced immunogenicity, lower tumorigenic potential, and ease of administration and handling. Hence, this review summarizes the current preclinical and clinical studies performed to investigate the safety and therapeutic potential of MSCs and their EVs derived from different sources, including bone marrow, adipose tissue, umbilical cord blood, and Wharton's jelly in IS.
MeSH term(s)	Humans ; Ischemic Stroke/metabolism ; Extracellular Vesicles/metabolism ; MicroRNAs/metabolism ; Wharton Jelly ; Mesenchymal Stem Cells/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-02-02
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2024.102320
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Article ; Online: Isolation and Identification of Phenol-Degrading Bacteria from Iranian Soil and Leaf Samples.

Mortazavi, Atefehsadat / Hassanshahian, Mehdi / Ali, Eyhab / Fenjan, Mohammed N / Alawadi, Ahmed / Alsalamy, Ali

Frontiers in bioscience (Elite edition)

2023 Volume 15, Issue 4, Page(s) 29

Abstract: Background: By considering the importance and role of soil in the health of humanity, it is important to remove the presence of harmful compounds, such as phenol.: Methods: In this study, four types of soil and leaf samples were collected from Kerman, ...

Abstract	Background: By considering the importance and role of soil in the health of humanity, it is important to remove the presence of harmful compounds, such as phenol. Methods: In this study, four types of soil and leaf samples were collected from Kerman, Iran, and the amounts of heterotrophic and degradation bacteria were determined using the serial dilution and most probable number (MPN) methods. The amount of removed phenol was investigated using the Gibbs method with different concentrations of phenol. Then, an isolate with the highest percentage of phenol degradation was identified as the superior strain using 16 sRNA sequencing. The effects of the different factors, such as the carbon source (1% molasses and 1 g glucose), nitrogen source (0.1 g yeast extract), mixed culture, and time (14 and 28 days), on the biodegradation ability of the superior strain was investigated. Results: A total of 18 bacterial strains were isolated from the samples. Isolate B3 had the highest rate (75%) of phenol degradation, at a concentration of 1000 ppm, meaning it was identified as the superior strain. The molecular analysis results identified this isolate as the Conclusions: C. testosteroni
MeSH term(s)	Phenol/metabolism ; Iran ; Phenols ; Bacteria/genetics ; Bacteria/metabolism ; Biodegradation, Environmental ; Carbon/metabolism
Chemical Substances	Phenol (339NCG44TV) ; Phenols ; Carbon (7440-44-0)
Language	English
Publishing date	2023-12-30
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2565080-4
ISSN	1945-0508 ; 1945-0494
ISSN (online)	1945-0508
ISSN	1945-0494
DOI	10.31083/j.fbe1504029
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Article: Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms.

Sukmana, Bayu Indra / Saleh, Raed Obaid / Najim, Maryam Abdulrahman / Al-Ghamdi, Hasan S / Achmad, Harun / Al-Hamdani, Mais Mazin / Taher, Abbas Ay / Alsalamy, Ali / Khaledi, Mansoor / Javadi, Kasra

Frontiers in oncology

2024 Volume 14, Page(s) 1319777

Abstract: Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic ... ...

Abstract	Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1319777
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Article ; Online: Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis.

Ramaiah, Pushpamala / Baljon, Kamilya Jamel / Hjazi, Ahmed / Qasim, Maytham T / Salih Al-Ani, Omar Abdulwahid / Imad, Shad / Hussien, Beneen M / Alsalamy, Ali / Garousi, Nazila

BMC endocrine disorders

2024 Volume 24, Issue 1, Page(s) 26

Abstract: Background: Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary ... ...

Abstract	Background: Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available evidence is contradictory. The aim of this meta-analysis was to assess the association between dietary intake of polyphenols and the odds of MetS. Methods: The PubMed and Scopus databases were systematically searched to obtain eligible studies. The risk of MetS for the highest versus the lowest intakes of total, subclasses and individual polyphenols were examined by pooling odds ratios (OR) and 95% confidence intervals (95%CI) using the random effects model. Results: A total of 14 studies (6 cohort and 8 cross-sectional studies) involving a total of 50,366 participants with 10,879 cases of MetS were included. When various polyphenol compounds were pooled, they were significantly related to a 22% decreased odds of MetS (([5 studies]; OR: 0.78; 95%CI: 0.72-0.85). Higher intakes of total flavonoids (([9 studies]; OR: 0.78; 95%CI: 0.72-0.85), flavan-3-ols (([2 studies]; OR: 0.64; 95%CI: 0.43-0.94), isoflavones (([3 studies]; OR: 0.84; 95%CI: 0.75-0.93), stilbenes (([4 studies]; OR: 0.86; 95%CI: 0.76-0.97), flavones (([2 studies]; OR: 0.79; 95%CI: 0.71-0.89), and quercetin (([2 studies]; OR: 0.63; 95%CI: 0.43-0.93) were also significantly associated with a decreased risk of MetS. The associations were not modified by the age of the participants. No association was found for total polyphenols, phenolic acids, lignans, anthocyanins, and flavonols. Conclusion: The results of this meta-analysis supported that higher polyphenol intake can lower the risk of MetS.
MeSH term(s)	Humans ; Anthocyanins ; Diet ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/prevention & control ; Polyphenols
Chemical Substances	Anthocyanins ; Polyphenols
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-024-01556-x
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Article ; Online: Aptamer-Magnetic Nanoparticle Complexes for Powerful Biosensing: A Comprehensive Review.

Altalbawy, Farag M A / Ali, Eyhab / N Fenjan, Mohammed / Fakri Mustafa, Yasser / Mansouri, Sofiene / D O, Bokov / Gulnikhol Idiyevna, Sharipova / Misra, Neeti / Alawadi, Ahmed Hussien / Alsalamy, Ali

Critical reviews in analytical chemistry

2024 , Page(s) 1–14

Abstract: The selective and sensitive diagnosis of diseases is a significant matter in the early stages of the cure of illnesses. To elaborate, although several types of probes have been broadly applied in clinics, magnetic nanomaterials-aptamers, as new- ... ...

Abstract	The selective and sensitive diagnosis of diseases is a significant matter in the early stages of the cure of illnesses. To elaborate, although several types of probes have been broadly applied in clinics, magnetic nanomaterials-aptamers, as new-generation probes, are becoming more and more attractive. The presence of magnetic nanomaterials brings about quantification, purification, and quantitative analysis of biomedical, especially in complex samples. Elaborately, the superparamagnetic properties and numerous functionalized groups of magnetic nanomaterials are considered two main matters for providing separation ability and immobilization substrate, respectively. In addition, the selectivity and stability of aptamer can present a high potential recognition element. Importantly, the integration of aptamer and magnetic nanomaterials benefits can boost the performance of biosensors for biomedical analysis by introducing efficient and compact probes that need low patient samples and fast diagnosis, user-friendly application, and high repeatability in the quantification of biomolecules. The primary aim of this review is to suggest a summary of the effect of the employed other types of nanomaterials in the fabrication of novel aptasensors-based magnetic nanomaterials and to carefully explore various applications of these probes in the quantification of bioagents. Furthermore, the application of these versatile and high-potential probes in terms of the detection of cancer cells and biomarkers, proteins, drugs, bacteria, and nucleoside were discussed. Besides, research gaps and restrictions in the field of biomedical analysis by magnetic nanomaterials-aptamers will be discussed.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2030019-0
ISSN	1547-6510 ; 1040-8347
ISSN (online)	1547-6510
ISSN	1040-8347
DOI	10.1080/10408347.2023.2298328
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Article: Choline chloride/urea as a green and efficient deep eutectic solvent in three-component and four-component synthesis of novel pyrazole and pyrano[2,3-c] pyrazole derivatives with antibacterial and antifungal activity.

Habeeb Naser, Israa / Thoulfikar A Alamir, Hassan / Al-Shukarji, Ali Hisham / Ahmed, Batool Ali / Qassem, Talal Aziz / Kamal, Maher / Almeleebia, Tahani M / Alwaily, Enas R / Hasan Kadhum, Eftikhaar / Alawadi, Ahmed / Alsalamy, Ali

Frontiers in chemistry

2024 Volume 12, Page(s) 1342784

Abstract: In this study, choline chloride/urea was used as a green deep eutectic solvent in the three-component reaction of hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrazole derivatives, and in the four-component reaction ... ...

Abstract	In this study, choline chloride/urea was used as a green deep eutectic solvent in the three-component reaction of hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrazole derivatives, and in the four-component reaction of methyl/ethyl acetoacetate, hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrano[2,3-c]pyrazole derivatives. Elemental analysis,
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2024.1342784
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Article ; Online: Optimization by Box-Behnken design for environmental contaminants removal using magnetic nanocomposite.

Buenaño, Luis / Ali, Eyhab / Jafer, Ahmed / Zaki, Shaima Haithem / Hammady, Fathi Jihad / Khayoun Alsaadi, Salima Baqir / Karim, Manal Morad / Ramadan, Montather F / Omran, Alaa A / Alawadi, Ahmed / Alsalamy, Ali / Kazemi, Ali

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6950

Abstract: In this study, a CoO- ... ...

Abstract	In this study, a CoO-Fe
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57616-8
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Article ; Online: Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

Jetti, Raghu / Vaca Cárdenas, Maritza Lucia / Al-Saedi, Haider Falih Shamikh / Hussein, Shaymaa Abed / Abdulridui, Hussam Abdali / Al-Abdeen, Salah Hassan Zain / Radi, Usama Kadem / Abdulkadhim, Adnan Hashim / Hussein, Sahar Balkit / Alawadi, Ahmed / Alsalamy, Ali

Bioprocess and biosystems engineering

2024

Abstract: Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata ... ...

Abstract	Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata extract, repurposed for anticancer and antibacterial use. High-frequency ultrasonic waves enabled the precise self-assembly of DSPE-PEG, Span 40, and cholesterol to form nanocarriers encapsulating the therapeutic extract without the use of toxic solvents, exemplifying green nanotechnology. Leveraging the inherent anticancer and antibacterial properties of Scutellaria barbata, the study demonstrates that lipid encapsulation enhances the bioavailability and controlled release of the extract, which is vital for its therapeutic efficacy. Dynamic light scattering and transmission electron microscopy analyses confirmed the increase in size and successful encapsulation post-loading, along with an augmented negative zeta potential indicating enhanced stability. A high encapsulation efficiency of 91.93% was achieved, and in vitro assays revealed the loaded nanocarriers' optimized release kinetics and improved antimicrobial potency against Pseudomonas aeruginosa, compared to the free extract. The combination of ultrasonic synthesis and Scutellaria barbata in an eco-friendly manufacturing process not only advances green nanotechnology but also contributes to sustainable practices in pharmaceutical manufacturing. The data suggest that this innovative nanocarrier system could provide a robust platform for the development of nanotechnology-based therapeutics, enhancing drug delivery efficacy while aligning with environmental sustainability.
Language	English
Publishing date	2024-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476357-6
ISSN	1615-7605 ; 1432-0797 ; 1615-7591
ISSN (online)	1615-7605 ; 1432-0797
ISSN	1615-7591
DOI	10.1007/s00449-024-03021-4
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Article ; Online: A review of recent advancement in covalent organic framework (COFs) synthesis and characterization with a focus on their applications in antibacterial activity.

Al-Dolaimy, F / Saraswat, Shelesh Krishna / Hussein, Baydaa Abed / Hussein, Uday Abdul-Reda / Saeed, Shakir Mahmood / Kareem, Ashwaq Talib / Abdulwahid, Alzahraa S / Mizal, Thair L / Muzammil, Khursheed / Alawadi, Ahmed Hussien / Alsalamy, Ali / Hussin, Farah / Kzarb, Mazin Hadi

Micron (Oxford, England : 1993)

2024 Volume 179, Page(s) 103595

Abstract: The primary objective of this review is to present a comprehensive examination of the synthesis, characterization, and antibacterial applications of covalent organic frameworks (COFs). COFs represent a distinct category of porous materials characterized ... ...

Abstract	The primary objective of this review is to present a comprehensive examination of the synthesis, characterization, and antibacterial applications of covalent organic frameworks (COFs). COFs represent a distinct category of porous materials characterized by a blend of advantageous features, including customizable pore dimensions, substantial surface area, and adaptable chemical properties. These attributes position COFs as promising contenders for various applications, notably in the realm of antibacterial activity. COFs exhibit considerable potential in the domain of antibacterial applications, owing to their amenability to functionalization with antibacterial agents. The scientific community is actively exploring COFs that have been imbued with metal ions, such as copper or silver, given their observed robust antibacterial properties. These investigations strongly suggest that COFs could be harnessed effectively as potent antibacterial agents across a diverse array of applications. Finally, COFs hold immense promise as a novel class of materials for antibacterial applications, shedding light on the synthesis, characterization, and functionalization of COFs tailored for specific purposes. The potential of COFs as effective antibacterial agents beckons further exploration and underscores their potential to revolutionize antibacterial strategies in various domains.
MeSH term(s)	Metal-Organic Frameworks/pharmacology ; Anti-Bacterial Agents/pharmacology ; Silver/pharmacology ; Copper/pharmacology ; Porosity
Chemical Substances	Metal-Organic Frameworks ; Anti-Bacterial Agents ; Silver (3M4G523W1G) ; Copper (789U1901C5)
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	207808-9
ISSN	1878-4291 ; 0047-7206 ; 0968-4328
ISSN (online)	1878-4291
ISSN	0047-7206 ; 0968-4328
DOI	10.1016/j.micron.2024.103595
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Article ; Online: Therapeutic significance of long noncoding RNAs in estrogen receptor-positive breast cancer.

Alzahrani, Abdullah Ali / Saleh, Raed Obaid / Latypova, Amaliya / Bokov, Dmitry Olegovich / Kareem, Anaheed Hussein / Talib, Hayder Abdullah / Hameed, Noora M / Pramanik, Atreyi / Alawadi, Ahmed / Alsalamy, Ali

Cell biochemistry and function

2024 Volume 42, Issue 3, Page(s) e3993

Abstract: About 70% of cases of breast cancer are compromised by Estrogen-positive breast cancer. Through its regulation of several processes, including cell proliferation, cell cycle progression, and apoptosis, Estrogen signaling plays a pivotal role in the ... ...

Abstract	About 70% of cases of breast cancer are compromised by Estrogen-positive breast cancer. Through its regulation of several processes, including cell proliferation, cell cycle progression, and apoptosis, Estrogen signaling plays a pivotal role in the genesis and progression of this particular kind of breast cancer. One of the best treatment strategies for treating Estrogen-positive breast cancer is blocking Estrogen signaling. However, patients' treatment failure is mainly caused by the emergence of resistance and metastases, necessitating the development of novel therapeutic targets. Numerous studies have shown long noncoding RNAs (lncRNAs) to play a role in Estrogen-mediated carcinogenesis. These lncRNAs interact with co-regulators and the Estrogen signaling cascade components, primarily due to Estrogen activation. Vimentin and E-cadherin are examples of epithelial-to-mesenchymal transition markers, and they regulate genes involved in cell cycle progression, such as Cyclins, to affect the growth, proliferation, and metastasis of Estrogen-positive breast cancer. Furthermore, a few of these lncRNAs contribute to developing resistance to chemotherapy, making them more desirable targets for enhancing results. Thus, to shed light on the creation of fresh approaches for treating this cancer, this review attempts to compile recently conducted studies on the relationship between lncRNAs and the advancement of Estrogen-positive breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; RNA, Long Noncoding/genetics ; Estrogens ; Cell Proliferation/genetics ; Receptors, Estrogen/metabolism ; Gene Expression Regulation, Neoplastic
Chemical Substances	RNA, Long Noncoding ; Estrogens ; Receptors, Estrogen
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.3993
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